Interleukin-6 promoter polymorphism and cardiovascular risk factors: the Health 2000 Survey.

abstract：:To examine the relationship between metabolic syndrome and endothelial dysfunction, we investigated cross-sectionally the correlation between metabolic risk factors and urinary excretion of cyclic guanosine 3',5'-monophosphate (cGMP), a second messenger of nitric oxide (NO), in 1541 Japanese men and women aged 40-79 y...

journal_title：Atherosclerosis

authors： Cui R,Iso H,Pi J,Kumagai Y,Yamagishi K,Tanigawa T,Shimamoto T

更新日期：2007-02-01 00:00:00

abstract：:Incubated human peripheral blood monocytes release a factor(s) which specifically stimulates homologous vascular smooth muscle (SMC) but not endothelial cells (EC) to proliferate in vitro. Conditioned medium from activated monocytes significantly (P less than 0.001) stimulated proliferation of SMC within 6 days of cul...

journal_title：Atherosclerosis

authors： Ziats NP,Robertson AL Jr

更新日期：1981-02-01 00:00:00

abstract：:To assess the risk for homocyst(e)ine-associated vascular disease, overt hyperhomocyst(e)inemia should be demonstrated. In nonhomocystinuric subjects, clinical vascular disease must have developed after 40 or more years of persistent hyperhomocyst(e)inemia which may not be present without a genetic defect(s). Nongenet...

journal_title：Atherosclerosis

authors： Kang SS,Wong PW

更新日期：1996-01-26 00:00:00

abstract：OBJECTIVE:Microvascular mechanisms are increasingly recognized as being involved in a significant proportion of coronary artery disease (CAD) cases, but their exact contribution or role is unclear. We aimed to define the association between retinal microvascular signs and both CAD extent and severity. METHODS:1120 par...

journal_title：Atherosclerosis

authors： Gopinath B,Chiha J,Plant AJ,Thiagalingam A,Burlutsky G,Kovoor P,Liew G,Mitchell P

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:To evaluate the impact of familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) on arterial properties and the effects of statins. METHODS:We meta-analyzed 51 studies providing data for 4,057 FH patients and 732 FCH patients with random-effects models, meta-regression analysis and pu...

journal_title：Atherosclerosis

authors： Masoura C,Pitsavos C,Aznaouridis K,Skoumas I,Vlachopoulos C,Stefanadis C

更新日期：2011-01-01 00:00:00

abstract：:HMG-CoA reductase inhibitors have been shown to be effective in primary and secondary prevention of coronary heart disease. Their mechanism of action is attributed to their cholesterol lowering activity but recent results seem to indicate additional effects related to the modulation of other processes that regulate th...

journal_title：Atherosclerosis

authors： Alfon J,Guasch JF,Berrozpe M,Badimon L

更新日期：1999-08-01 00:00:00

abstract：AIMS:To assess efficacy and safety of HMG-CoA reductase inhibitor (statin) treatment in children and adolescents with heterozygous familial hypercholesterolaemia. METHODS:MEDLINE, EMBASE, COCHRANE and Current Controlled Trials databases were searched. Study design, efficacy, and safety outcome-measures were extracted....

journal_title：Atherosclerosis

authors： Arambepola C,Farmer AJ,Perera R,Neil HA

更新日期：2007-12-01 00:00:00

abstract：:We determined the effects of different dialysis conditions on the antioxidant content, duration of the lag phase and oxidation rate of LDL. Dialysis for 22 h resulted in a 56%--66% reduction in the concentrations of beta-carotene, lycopene and alpha-tocopherol. The lag phase of copper-induced oxidation of freshly isol...

journal_title：Atherosclerosis

authors： Scheek LM,Wiseman SA,Tijburg LB,van Tol A

更新日期：1995-09-01 00:00:00

abstract：:Acute myocardial infarction is associated with profound alterations in the plasma lipoprotein profile. The mechanism of these alterations is not clear, and both cholesterol biosynthesis up- and downregulation could possibly be a consequence of acute myocardial infarction. We determined plasma lipids, lipoproteins, apo...

journal_title：Atherosclerosis

authors： Pfohl M,Schreiber I,Liebich HM,Häring HU,Hoffmeister HM

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:In acute myocardial infarction (AMI) treated conservatively or with thrombolysis, marked increases of C-reactive protein (CRP) and fibrinogen have been observed. No data are however available concerning a possible relation between CRP and fibrinogen levels on admission and markers of infarct size after obtai...

journal_title：Atherosclerosis

authors： De Sutter J,De Buyzere M,Gheeraert P,Van de Wiele C,Voet J,De Pauw M,Dierckx R,De Backer G,Taeymans Y

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Recent studies suggest that long-term endurance training may be damaging to the heart, thus increasing cardiovascular disease (CVD) risk. However, studies utilizing cardiac imaging are conflicting and lack measures of central and peripheral vascular structure and function, which are also independent...

journal_title：Atherosclerosis

authors： Bachman NP,Terwoord JD,Richards JC,Braun B,Green CP,Luckasen GJ,Dinenno FA

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND AND PURPOSES:Pulse wave analysis (PWV), a marker of aortic stiffness, has independent predictive value for cardiovascular morbidity and mortality in both healthy and high-risk populations, especially fatal stroke, and for long-term functional stroke prognosis. Whether arterial stiffness and wave reflection a...

journal_title：Atherosclerosis

authors： Gąsecki D,Rojek A,Kwarciany M,Kowalczyk K,Boutouyrie P,Nyka W,Laurent S,Narkiewicz K

更新日期：2012-12-01 00:00:00

abstract：:Paraoxanase (PON 1), a high-density lipoprotein-associated enzyme, exerts an antiatherogenic effect by protecting low-density lipoproteins (LDL) against oxidation. A common polymorphism at codon 192(Q/R) of the PON 1 gene has been shown to be associated with an adverse lipoprotein profile and increased coronary artery...

journal_title：Atherosclerosis

authors： Srinivasan SR,Li S,Chen W,Tang R,Bond MG,Boerwinkle E,Berenson GS

更新日期：2004-11-01 00:00:00

abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

journal_title：Atherosclerosis

authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

更新日期：2008-03-01 00:00:00

abstract：:SR-12813 inhibits cholesterol biosynthesis in Hep G2 cells via an enhanced degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Here we also show that SR-12813 inhibits cholesterol biosynthesis in vivo. A sterol balance study was performed in normolipemic beagle dogs. The dogs were given SR-12813 ...

journal_title：Atherosclerosis

authors： Berkhout TA,Simon HM,Jackson B,Yates J,Pearce N,Groot PH,Bentzen C,Niesor E,Kerns WD,Suckling KE

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To investigate cross-sectional and longitudinal associations between serum total bilirubin (TB) and dyslipidemia. METHODS:Odds ratios (ORs) of prevalent dyslipidemia for TB were calculated in 2113 men and 1265 women. Correlation coefficients between baseline TB as well as the change in TB over 5 years and ba...

journal_title：Atherosclerosis

authors： Oda E

更新日期：2015-03-01 00:00:00

abstract：:Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have ide...

journal_title：Atherosclerosis

authors： Cho KI,Sakuma I,Sohn IS,Jo SH,Koh KK

更新日期：2018-10-01 00:00:00

abstract：:The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...

journal_title：Atherosclerosis

authors： Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:Recent failures of clinical trials promoting HDL-elevating therapies have prompted research groups to focus on its functional activity in disease. Endothelial effects of HDL can be measured with in vitro cell assays. The reproducibility and biological relevance of these assays have not been explored both in ...

journal_title：Atherosclerosis

authors： O'Neill F,McLoughlin E,Riwanto M,Manz J,Adler A,Sutill E,Khan T,Haywood R,Kay CW,D'Aiuto F,Charakida M,Landmesser U,Deanfield J

更新日期：2015-08-01 00:00:00

abstract：:This is a study to define the profile of chemokine receptors expressed on isolated infiltrating lymphocytes in human abdominal aortic aneurysms (AAAs), and to examine their role in lymphoid recruitment. AAA T-lymphocytes were CXCR4-positive, CCR7-negative and partially CXCR3 and CCR5-positive. Functionally, AAA T-cell...

journal_title：Atherosclerosis

authors： Ocaña E,Pérez-Requena J,Bohórquez JC,Brieva JA,Rodríguez C

更新日期：2008-10-01 00:00:00

abstract：:To test if the prevalence of genetic risk factors for coronary heart disease (CHD) is low in individuals who have reached an extremely old age, the allele frequencies of apolipoprotein E (apo E) and B (apo B) polymorphisms and plasma lipoprotein(a) levels were investigated in nonagenarians and in younger control group...

journal_title：Atherosclerosis

authors： Kervinen K,Savolainen MJ,Salokannel J,Hynninen A,Heikkinen J,Ehnholm C,Koistinen MJ,Kesäniemi YA

更新日期：1994-01-01 00:00:00

abstract：:The presence of Chlamydia pneumoniae in the human arterial system has mainly been determined in atherosclerotic plaque, whereas the adventitia has remained relatively unexplored. We assessed the presence of C. pneumoniae in all three vessel wall layers of coronary (n=72) and brachial (n=48) arteries in relation to loc...

journal_title：Atherosclerosis

authors： Vink A,Pasterkamp G,Poppen M,Schoneveld AH,de Kleijn DP,Roholl PJ,Fontijn J,Plomp S,Borst C

更新日期：2001-07-01 00:00:00

abstract：:Some baboons accumulate appreciable amounts of large apoE-rich HDLs (HDL(1)) which are similar to those reported in humans with several different dyslipoproteinemias. We estimated HDL(1) cholesterol concentrations by gradient gel electrophoresis of serum samples obtained from 634 pedigreed baboons fed with three diets...

journal_title：Atherosclerosis

authors： Rainwater DL,Kammerer CM,Cox LA,Rogers J,Carey KD,Dyke B,Mahaney MC,McGill HC Jr,VandeBerg JL

更新日期：2002-08-01 00:00:00

abstract：:Oxidized low-density lipoprotein (oxLDL) exhibits many atherogenic effects, including the promotion of monocyte recruitment to the arterial endothelium and the induction of scavenger receptor expression. However, while atherosclerosis involves chronic inflammation within the arterial intima, it is unclear whether oxLD...

journal_title：Atherosclerosis

authors： Kavanagh IC,Symes CE,Renaudin P,Nova E,Mesa MD,Boukouvalas G,Leake DS,Yaqoob P

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Uric acid is frequently elevated in hypertension. In addition to renal and metabolic disturbances, lower limb ischemia might contribute to hyperuricemia among hypertensives complicated by peripheral arterial disease (PAD). OBJECTIVE:To test the hypothesis that uric acid status is related to lower limb funct...

journal_title：Atherosclerosis

authors： Langlois M,De Bacquer D,Duprez D,De Buyzere M,Delanghe J,Blaton V

更新日期：2003-05-01 00:00:00

abstract：:The composition of very low density lipoproteins (VLDL: d less than 1.019) of New Zealand male rabbits reciving cholesterol (2 g/day) and metformin (135 mg/kg/day) is investigated. These rabbits, while showing only a slight reduction of plasma cholesterol levels, as compared to cholesterol-fed (h.c.) animals, show a m...

journal_title：Atherosclerosis

authors： Sirtori CR,Catapano A,Ghiselli GC,Innocenti AL,Rodriguez J

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Cathepsin L (CatL), cathepsin K (CatK), and cathepsin V (CatV) are potent elastases implicated in human arterial wall remodeling. Whether plasma levels of these cathepsins are altered in patients with abdominal aortic aneurysms (AAAs) remains unknown. METHODS AND RESULTS:Plasma samples were collected from 4...

journal_title：Atherosclerosis

authors： Lv BJ,Lindholt JS,Wang J,Cheng X,Shi GP

更新日期：2013-09-01 00:00:00

abstract：:A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. The risk associated with the ...

journal_title：Atherosclerosis

authors： Steeds RP,Wardle A,Smith PD,Martin D,Channer KS,Samani NJ

更新日期：2001-01-01 00:00:00

abstract：AIMS:Apolipoprotein C-III (apoC-III) has been recognized as a useful marker of triglyceride-rich lipoproteins (TRLs) metabolism and proposed as an indicator of prognosis for coronary risk in healthy subjects. We studied cross-sectionally in a population having low cholesterol levels, but a high prevalence of the metabo...

journal_title：Atherosclerosis

authors： Onat A,Hergenç G,Sansoy V,Fobker M,Ceyhan K,Toprak S,Assmann G

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:We undertook a study to determine whether peripheral vascular disease of the lower extremity (PVD) per se affects the arterial viscoelastic properties and intima-media thickness (IMT) of the carotid and femoral arteries. METHODS:Thirty-five patients with PVD, 35 age- and gender-matched control subjects were...

journal_title：Atherosclerosis

authors： Cheng KS,Tiwari A,Baker CR,Morris R,Hamilton G,Seifalian AM

更新日期：2002-09-01 00:00:00