Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease.

abstract：:Chylomicron catabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. In rats, triglyceride-rich emulsions can mimic chylomicron metabolism. To further validate this model in man, the emulsion was injected intravenously into fasting and into subjects previously fed ...

journal_title：Atherosclerosis

authors： Maranhão RC,Feres MC,Martins MT,Mesquita CH,Toffoletto O,Vinagre CG,Gianinni SD,Pileggi F

更新日期：1996-09-27 00:00:00

abstract：:Cytosolic Phospholipase A(2) (cPLA(2)) has been implicated in receptor-mediated release of arachidonic acid from membrane phospholipids, the limiting step in prostacyclin and other eicosanoid production. Its activity is controlled by Ca(++) levels and enzymatically regulated phosphorylation. The purpose of this study ...

journal_title：Atherosclerosis

authors： Gudmundsdóttir IJ,Halldórsson H,Magnúsdóttir K,Thorgeirsson G

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Cardiovascular disease (CVD) and cancer are the two leading causes of death in smokers. Lung cancer screening is recommended in a large proportion of smokers. We examined the implication of coronary artery calcium (CAC) score (quantitative and qualitative) for cardiovascular disease (CVD), coronary ...

journal_title：Atherosclerosis

authors： Mirbolouk M,Kianoush S,Dardari Z,Miedema MD,Shaw LJ,Rumberger JA,Berman DS,Budoff MJ,Rozanski A,Al-Mallah MH,McEvoy JW,Nasir K,Blaha MJ

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Decline of cognitive function with age may be due, in part, to atherosclerotic changes. The aim of the present study was to determine the relative contribution of cardiovascular disease (CVD) to cognitive functioning in middle-aged and elderly men. METHODS:In a cross-sectional study, cognitive tests were ad...

journal_title：Atherosclerosis

authors： Muller M,Grobbee DE,Aleman A,Bots M,van der Schouw YT

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Olive oil protects against cardiovascular disease but the underlying mechanism is still unclear. We speculated that olive oil could inhibit oxidative stress, which is believed to be implicated in the atherosclerotic process. METHODS AND RESULTS:Post-prandial oxidative stress and endothelial dysfunction were ...

journal_title：Atherosclerosis

authors： Carnevale R,Pignatelli P,Nocella C,Loffredo L,Pastori D,Vicario T,Petruccioli A,Bartimoccia S,Violi F

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Mac-2 binding protein (M2BP) was reported to be a useful biomarker for liver fibrosis and malignant tumors. We hypothesized that expression of M2BP might also change in the process of atherosclerosis. METHODS:This study included subjects who visited our hospital for a physical checkup. RESULTS:The...

journal_title：Atherosclerosis

authors： Sugiura T,Dohi Y,Takase H,Yamashita S,Murai S,Tsuzuki Y,Ogawa S,Tanaka Y,Ohte N

更新日期：2016-08-01 00:00:00

abstract：:The formation of atherosclerotic lesions requires the migration of vascular smooth muscle cells from the media into the intima of the artery and their proliferation. These events, which are preceded and accompanied by inflammation, are modulated by integrin receptors linking vascular smooth muscle cells to extracellul...

journal_title：Atherosclerosis

authors： Barillari G,Albonici L,Incerpi S,Bogetto L,Pistritto G,Volpi A,Ensoli B,Manzari V

更新日期：2001-02-01 00:00:00

abstract：:Mitral annulus calcification (MAC) is a chronic, non-inflammatory, degenerative process of the fibrous support structure of the mitral valve. It occurs more often in women and the elderly. MAC is associated with known atherosclerotic risk factors such as diabetes mellitus, hypertension and hypercholesterolemia. It is ...

journal_title：Atherosclerosis

authors： Adler Y,Fink N,Spector D,Wiser I,Sagie A

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) have been implicated in development of atherosclerosis. MMPs are activated in patients with acute coronary syndrome (ACS). However, little data exist regarding the correlation between circulating levels of MMPs and plaque volume (PV) in patients with ACS. We therefore evaluat...

journal_title：Atherosclerosis

authors： Ogita M,Miyauchi K,Morimoto T,Daida H,Kimura T,Hiro T,Nakagawa Y,Yamagishi M,Ozaki Y,Matsuzaki M

更新日期：2013-01-01 00:00:00

abstract：:Elevated serum ferritin concentrations between 200 and 500 microg/l have been found to be a strong risk factor for acute myocardial infarction in Finnish men, but the reason for this association is still uncertain. In the Finnish population ferritin concentrations correlated with factors of insulin resistance syndrome...

journal_title：Atherosclerosis

authors： Halle M,König D,Berg A,Keul J,Baumstark MW

更新日期：1997-02-10 00:00:00

abstract：:Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells. We investigated whether or not these deaminated products from methylamine can exert potentially hazardous toxic effects in vivo. Lon...

journal_title：Atherosclerosis

authors： Yu PH,Zuo DM

更新日期：1996-02-01 00:00:00

abstract：PURPOSE:Metabolic Syndrome as defined by ATP III criteria, a constellation of risk factors associated with insulin resistance, predisposes to premature atherosclerosis and early coronary events. Whether that negative risk profile is associated with endothelial dysfunction remains to be established. MATERIALS AND METHO...

journal_title：Atherosclerosis

authors： Dell'Omo G,Penno G,Pucci L,Mariani M,Del Prato S,Pedrinelli R

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians. RESEARCH DESIGN AND METHODS:The present investigation was conducted to replicate this previous association, and to further examine the potential associatio...

journal_title：Atherosclerosis

authors： Zee RY,Germer S,Thomas A,Raji A,Rhees B,Ridker PM,Lindpaintner K,Williams GH,Nathan DM,Martin M

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:To analyze paraoxonase 1 (PON1) effect on monocyte-to-macrophage differentiation. METHODS AND RESULTS:THP-1 monocytic cell-line and mouse peritoneal macrophages (MPM) were studied. Markers for monocytes differentiation included: morphological changes, CD11b and CD36 expression, and cellular oxidative stress....

journal_title：Atherosclerosis

authors： Rosenblat M,Volkova N,Ward J,Aviram M

更新日期：2011-11-01 00:00:00

abstract：:Lipoprotein(a) (Lp(a)) is regarded as an independent risk factor for Atherosclerotic cardiovascular disease. The objectives of this study were: to determine the effects of diet and exercise on Lp(a) and to evaluate the relation of Lp(a) with the lipid profile (total serum cholesterol (TC), triglycerides (TG), low dens...

journal_title：Atherosclerosis

authors： Randall OS,Feseha HB,Illoh K,Xu S,Ketete M,Kwagyan J,Tilghman C,Wrenn M

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine implicated in atherosclerotic plaque formation. We investigated whether circulating TNFalpha is prospectively associated with myocardial infarction (MI) or stroke in the older general population, independently of established cardiovascula...

journal_title：Atherosclerosis

authors： Jefferis BJ,Whincup PH,Welsh P,Wannamethee SG,Rumley A,Lennon LT,Thomson AG,Carson C,Ebrahim S,Lowe GD

更新日期：2009-07-01 00:00:00

abstract：:Hypertriglyceridemia affects approximately 33% of the US population. Elevated triglyceride levels are independently associated with cardiovascular disease (CVD) risk, and severe hypertriglyceridemia is a risk factor for acute pancreatitis. Guidelines for the management of severe hypertriglyceridemia (≥5.6 mmol/L [≥500...

journal_title：Atherosclerosis

authors： Ito MK

更新日期：2015-10-01 00:00:00

abstract：:Animal models are used extensively in the ongoing investigation of a possible causal link between Chlamydia pneumoniae infection and conditions such as asthma and cardiovascular disease. Respiratory infections have been studied in monkeys, while mouse and rabbit models have been used to study both respiratory and card...

journal_title：Atherosclerosis

authors： Saikku P,Laitinen K,Leinonen M

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVES:Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation cou...

journal_title：Atherosclerosis

authors： Caselli C,De Graaf MA,Lorenzoni V,Rovai D,Marinelli M,Del Ry S,Giannessi D,Bax JJ,Neglia D,Scholte AJ

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is a common inherited disorder of low density lipoprotein-cholesterol (LDL-C) metabolism. It is associated with higher risk of premature coronary heart disease. Around 60% of patients with a clinical diagnosis of FH do not have a detectable mutation in the genes ca...

journal_title：Atherosclerosis

authors： Sharifi M,Higginson E,Bos S,Gallivan A,Harvey D,Li KW,Abeysekera A,Haddon A,Ashby H,Shipman KE,Cooper JA,Futema M,Roeters van Lennep JE,Sijbrands EJG,Labib M,Nair D,Humphries SE

更新日期：2017-08-01 00:00:00

abstract：:This study examined the effects of lovastatin supplementation (25 mg/kg per day) in conjunction with an atherogenic diet (10% coconut oil (w/w), 0.05% cholesterol) on regression of pre-existing foam cells and on hepatic and intestinal LDL receptor and HMG CoA reductase mRNA levels. F1B hamsters fed the atherogenic die...

journal_title：Atherosclerosis

authors： Pitman WA,Osgood DP,Smith D,Schaefer EJ,Ordovas JM

更新日期：1998-05-01 00:00:00

abstract：:The effect of low dose (600 mg/day) alpha-tocopheryl nicotinate on serum lipoprotein(a) (Lp(a] concentration was studied in 28 hyperlipidaemic patients. Serum lipids, lipoproteins and apolipoproteins, except for Lp(a), tended to increase after treatment. In particular, the changes in HDL-cholesterol and apo C-II level...

journal_title：Atherosclerosis

authors： Noma A,Maeda S,Okuno M,Abe A,Muto Y

更新日期：1990-10-01 00:00:00

abstract：:In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of E...

journal_title：Atherosclerosis

authors： Mégnien JL,Simon A

更新日期：2009-08-01 00:00:00

abstract：:Contrasting observations have been made between serum urate and ischemic stroke outcomes in studies involving Caucasian populations. To assess the hypothesis that urate is associated with stroke outcomes, a prospective follow-up study was performed in a cohort of Asian patients with ischemic stroke. Patients diagnosed...

journal_title：Atherosclerosis

authors： Seet RC,Kasiman K,Gruber J,Tang SY,Wong MC,Chang HM,Chan YH,Halliwell B,Chen CP

更新日期：2010-03-01 00:00:00

abstract：:Fractional esterification rate of cholesterol in high density lipoprotein (HDL) (FER[HDL]) can predict the size distribution and physicochemical characteristics of HDL in plasma. In the present study, we investigated the correlation of FER(HDL) with the particle size of low density lipoprotein (LDL) (LDL-size) in 111 ...

journal_title：Atherosclerosis

authors： Ohta T,Saku K,Takata K,Nagata N,Maung KK,Matsuda I

更新日期：1997-12-01 00:00:00

abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...

journal_title：Atherosclerosis

authors： Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

更新日期：1991-04-01 00:00:00

abstract：:The effectiveness of a new, almost l-thyroxine free preparation of d-thyroxine (Dynothel) was tested in 15 patients with Type IIa and 4 patients with Type IIb hyperlipoproteinemia. Eleven patients with Type IIa and 3 with Type IIb were responsive to treatment and showed an average 26% decrease in plasma TC. This decre...

journal_title：Atherosclerosis

authors： Rakow AD,Klor HU,Kuter E,Ditschuneit HH,Ditschuneit H

更新日期：1976-09-01 00:00:00

abstract：:The effects of atorvastatin (Lipitor) were evaluated in 40 patients with familial hypercholesterolemia (FH). Following a 6 week drug-free baseline period 20 male and 20 female patients were treated with atorvastatin 40 mg once daily (QD) for the initial 6 weeks increasing to 80 mg QD during the following 6 weeks. Ator...

journal_title：Atherosclerosis

authors： Hoogerbrugge N,Jansen H

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Monocyte recruitment into the vessel wall is a crucial initial step in vascular repair, arteriogenesis and atherogenesis. Two distinct human monocyte subpopulations can be classified according to their CD14/16 surface expression, namely CD14++CD16-monocytes (CD16-mo) and CD14+CD16+ monocytes (CD16+mo). We in...

journal_title：Atherosclerosis

authors： Czepluch FS,Olieslagers S,van Hulten R,Vöö SA,Waltenberger J

更新日期：2011-04-01 00:00:00

abstract：AIMS:To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population. METHODS:Three thousand and twenty men and 7,256 women aged 50-85 years were recruited and received a medical check-up including measurement of complete blood count, blood pressure, obesity i...

journal_title：Atherosclerosis

authors： Lao XQ,Neil Thomas G,Jiang C,Zhang W,Adab P,Lam TH,Cheng KK

更新日期：2008-12-01 00:00:00