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Metaformin: an antiatherosclerotic agent modifying very low density lipoproteins in rabbits.

Abstract：

:The composition of very low density lipoproteins (VLDL: d less than 1.019) of New Zealand male rabbits reciving cholesterol (2 g/day) and metformin (135 mg/kg/day) is investigated. These rabbits, while showing only a slight reduction of plasma cholesterol levels, as compared to cholesterol-fed (h.c.) animals, show a marked decrease of the aortic cholesterol esters and atheromatous process. VLDL from the cholesterol + metformin group (h.c. + met), as compared to the h.c. animals, are homogenous in size and not separable into VLDL-1 and VLDL-2 subfractions by Sepharose 4B chromatography. These findings are confirmed by electron microscopy, which shows homogeneity of particle size, as well a decreased tendency of h.c. + met VLDL to aggregate. Chemical composition of h.c. + met VLDL is characterized by increased triglycerides and phospholipids, while the percentage of cholesterol esters is not significantly decreased. Phospholipid distribution of h.c. + met VLDL shows a significant decrease of sphingomyelin and increased phosphatidylinositol, the latter both as compared to h.c. and control VLDL. Apoprotein pattern of h.c. + met VLDL in polyacrylamide gels shows a relative increase of peptides with C mobility and a decrease of proteins corresponding to the arg-rich peptides. These findings exemplify a case of altered lipoprotein composition and decreased atheromatosis, in the presence of marked hypercholesteremia.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Sirtori CR,Catapano A,Ghiselli GC,Innocenti AL,Rodriguez J

doi

10.1016/0021-9150(77)90142-3

subject

Has Abstract

pub_date

1977-01-01 00:00:00

pages

79-89

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(77)90142-3

journal_volume

26

pub_type

杂志文章

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