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Circulating soluble RAGE as a predictive biomarker of cardiovascular event risk in patients with type 2 diabetes.

Abstract：

:It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data including serum sRAGE levels, and prospectively evaluated the association between these parameters and CVD events. The median follow-up period was 5.6 years and there were 25 new CVD events. The tertile analysis showed that the risk for CVD events was higher as serum sRAGE levels were increased (p for trend = 0.046). A multivariate Cox proportional hazards regression analysis revealed that serum sRAGE levels were independently associated with CVD (HR per 1SD = 1.59, 95% CI 1.04-2.45, p = 0.034), even after adjusting for conventional coronary risk factors. In summary, elevated sRAGE levels were associated with the increased risk of CVD in Japanese type 2 diabetic subjects.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Fujisawa K,Katakami N,Kaneto H,Naka T,Takahara M,Sakamoto F,Irie Y,Miyashita K,Kubo F,Yasuda T,Matsuoka TA,Shimomura I

doi

10.1016/j.atherosclerosis.2013.01.016

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

425-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(13)00051-8

journal_volume

227

pub_type

杂志文章

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