Abstract：
:The postheparin plasma lipoprotein lipase (LPL) activity and plasma HDL and LDL cholesterol concentrations, decreases significantly during probucol treatment of the rat. The reduction of the LPL activity obviously took place in adipose tissue. The activity of hepatic lipase and the in vitro synthesis of cholesterol in the liver or isolated jejunal villous cells were unaffected by the probucol treatment. Plasma triglyceride and VLDL cholesterol concentrations remained similar in the control and probucol groups despite the difference in the LPL activity, whereas the esterified VLDL cholesterol level was significantly reduced in the probucol group. The results suggest that the HDL lowering action of probucol is contributed by the reduced LPL activity probably via impaired VLDL metabolism.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Strandberg T,Kuusi T,Tilvis R,Miettinen TAdoi
10.1016/0021-9150(81)90130-1subject
Has Abstractpub_date
1981-11-01 00:00:00pages
193-201issue
3-4eissn
0021-9150issn
1879-1484pii
0021-9150(81)90130-1journal_volume
40pub_type
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