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Time from diagnosis of type 2 diabetes to initiation of insulin therapy is related to carotid artery intima-media thickness.

Abstract：

:To investigate the association between time from diagnosis of type 2 diabetes to initiation of insulin therapy (pre-exogenous insulin period) and intima-media thickness (IMT) of the common carotid artery (CCA), a cross-sectional analysis was conducted among 98 males and 193 females (90% Hispanic) with type 2 diabetes, aged 30-70 years old. The association between the pre-exogenous insulin period and the primary outcome was examined in men and women using analysis of covariance (ANCOVA) with adjustment for current age, duration of insulin therapy, low-density lipoprotein (LDL) cholesterol, systolic blood pressure and hemoglobin A1c. The pre-exogenous insulin period was significantly and linearly associated with mean IMT of the CCA in men. In women, the linear trend was not significant while a significant quadratic trend was noted across three categories of the pre-exogenous insulin period (0-5, 6-10, 11-24 years). Longitudinal data are needed to determine the effect of early initiation of insulin therapy on the progression of subclinical atherosclerosis among persons with diabetes.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Zheng L,Buchanan TA,Hodis HN,Li Y,Torres M,Mack WJ

doi

10.1016/s0021-9150(03)00291-0

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

293-9

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(03)00291-0

journal_volume

170

pub_type

杂志文章

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