Erythrocyte membrane fatty acid composition as a marker of dietary compliance in hyperlipidaemic subjects.

Abstract:

:Dietary intervention is the first treatment step in management of hyperlipidaemia, but there are few objective criteria of compliance. Whether intensive dietary intervention would produce a detectable change in erythrocyte membrane fatty acid composition which could be used as a marker of compliance was examined in 31 new hyperlipidaemic patients. Over a 6 month period, body mass index fell from 29.0 to 26.9 kg/m2 (P < 0.001) and total cholesterol by 19% from 8.16 to 6.58 mmol/l (P < 0.001). The energy derived from fat was reduced from 38.5% to 29.6% (P < 0.001), and the ratio of dietary polyunsaturated to saturated (P:S) fatty acids in the diet increased from 0.45 to 0.66 (P < 0.01). Small but significant changes were recorded in several red cell membrane fatty acids, and the P:S ratio increased from 0.91 to 1.13 (P < 0.001). It would appear, therefore, that red cell membrane changes parallel dietary changes and hence are a potential marker for compliance with dietary changes.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Tynan MB,Nicholls DP,Maguire SM,Steele IC,McMaster C,Moore R,Trimble ER,Pearce J

doi

10.1016/0021-9150(95)05578-k

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

245-52

issue

2

eissn

0021-9150

issn

1879-1484

pii

0021-9150(95)05578-K

journal_volume

117

pub_type

杂志文章
  • Topology of protease activities reflects atherothrombotic plaque complexity.

    abstract::The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. Here, we investigated the release of active proteases by human carotid plaques in relation to (1) the degree of lesion complexity and (2) their compartment...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.04.011

    authors: Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

    更新日期:2007-03-01 00:00:00

  • Brachial artery diameter as a marker for cardiovascular risk assessment: FMD-J study.

    abstract:BACKGROUND AND AIMS:Baseline brachial artery (BBA) diameter has been reported to be a potential confounding factor of flow-mediated vasodilation (FMD). The purpose of this study was to evaluate the relationships between BBA diameter and cardiovascular risk factors and compare the diagnostic accuracy of BBA diameter in ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2017.11.022

    authors: Maruhashi T,Soga J,Fujimura N,Idei N,Mikami S,Iwamoto Y,Iwamoto A,Kajikawa M,Matsumoto T,Oda N,Kishimoto S,Matsui S,Hashimoto H,Aibara Y,Yusoff FM,Hidaka T,Kihara Y,Chayama K,Noma K,Nakashima A,Goto C,Tomiyama H

    更新日期:2018-01-01 00:00:00

  • Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways.

    abstract:OBJECTIVE:Recent studies have demonstrated that palmitic acid (PA) could regulate endothelial progenitor cells (EPCs) function (migration, proliferation, survival and angiogenesis) via various signal pathways, but the effect of PA on EPCs apoptosis and associated mechanisms are still elusive. METHODS:The human EPCs we...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2009.10.032

    authors: Jiang H,Liang C,Liu X,Jiang Q,He Z,Wu J,Pan X,Ren Y,Fan M,Li M,Wu Z

    更新日期:2010-05-01 00:00:00

  • PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH.

    abstract:BACKGROUND:Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are complex pathologies characterized by lipid accumulation, chronic inflammation and extensive tissue remodelling. Microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, might not only be biomarkers, but also fun...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.03.009

    authors: Baron M,Leroyer AS,Majd Z,Lalloyer F,Vallez E,Bantubungi K,Chinetti-Gbaguidi G,Delerive P,Boulanger CM,Staels B,Tailleux A

    更新日期:2011-09-01 00:00:00

  • LDL-induced cytotoxicity and its inhibition by anti-oxidant treatment in cultured human endothelial cells and fibroblasts.

    abstract::Low density lipoproteins (LDL) isolated by ultracentrifugation induce cytotoxic changes in cultured human endothelial cells (EC) and fibroblasts if the ratio between LDL cholesterol and the final protein concentration of the culture medium exceeds 0.10-0.12 mmol/g protein. In order to investigate if reactive oxygen sp...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(83)90004-7

    authors: Evensen SA,Galdal KS,Nilsen E

    更新日期:1983-10-01 00:00:00

  • Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid.

    abstract::Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00544-x

    authors: Lindstedt L,Lee M,Kovanen PT

    更新日期:2001-03-01 00:00:00

  • Modification of the effects of estrogen therapy on HDL cholesterol levels by polymorphisms of the HDL-C receptor, SR-BI: the Rancho Bernardo Study.

    abstract:BACKGROUND:Previous studies have found polymorphisms of the HDL receptor, SR-BI, to be associated with plasma HDL-C in women, but not men, suggesting a modifying role of estrogen. We examined whether the association between SR-BI genotypes and HDL-C is modified by use of unopposed estrogen in community-dwelling postmen...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.12.013

    authors: Richard E,von Muhlen D,Barrett-Connor E,Alcaraz J,Davis R,McCarthy JJ

    更新日期:2005-06-01 00:00:00

  • The influence of low intake of n-3 fatty acids on platelets in elderly people.

    abstract::A total of ten healthy elderly subjects ingested one capsule of 600 mg (corresponding to 150 mg docosahexaenoic acid and 30 mg eicosapentaenoic acid) RO-PUFA triglycerides per day and ten others ingested one capsule of 600 mg sunflower oil as a placebo for 42 days. In the n-3 polyunsaturated fatty acids (PUFA) group, ...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0021-9150(99)00171-9

    authors: Véricel E,Calzada C,Chapuy P,Lagarde M

    更新日期:1999-11-01 00:00:00

  • Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.

    abstract:BACKGROUND:Fenofibrate, a PPAR-α agonist and rosiglitazone, a PPAR-γ agonist, reduce triglycerides and fatty acids in humans and in animal disease models. The efficacy of PPAR-α agonists in mouse model of human atherosclerosis disease has shown mixed results, and efficacy of PPAR-γ and liver X receptor (LXR) agonists h...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.10.033

    authors: Srivastava RA

    更新日期:2011-01-01 00:00:00

  • Effect of ursodeoxycholic acid on hepatic LDL binding and uptake in dietary hypercholesterolemic hamsters.

    abstract::Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00396-8

    authors: Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

    更新日期:2000-11-01 00:00:00

  • The influence of lifestyle modification on carotid artery intima-media thickness in a suburban Japanese population.

    abstract::To evaluate the influence of lifestyle modification with and without lipid-lowering drug therapy on the carotid arterial wall, we did a 2 year prospective ultrasound study of carotid intima-media thickness (IMT) in 1390 male and female residents of a suburban Japanese town. According to total cholesterol (TC) level at...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2003.12.025

    authors: Okada K,Maeda N,Tatsukawa M,Shimizu C,Sawayama Y,Hayashi J

    更新日期:2004-04-01 00:00:00

  • Different expression of modified low density lipoprotein receptors in rabbit peritoneal macrophages and Kupffer cells.

    abstract::We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(93)90098-f

    authors: Ueda Y,Arai H,Kawashima A,Nagano Y,Cho M,Tanaka M,Kita T

    更新日期:1993-06-01 00:00:00

  • Benefits of salmon eating on traditional and novel vascular risk factors in young, non-obese healthy subjects.

    abstract:AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.06.018

    authors: Lara JJ,Economou M,Wallace AM,Rumley A,Lowe G,Slater C,Caslake M,Sattar N,Lean ME

    更新日期:2007-07-01 00:00:00

  • Atherosclerosis in vascular grafts for peripheral vascular disease. Part 1. Autogenous vein grafts.

    abstract::29 autogenous vein grafts, from 26 patients with peripheral arterial disease, were studied. 4 grafts of Group I (less than 3 months duration) were patent and removed for reasons other than graft failure. These showed 'arterialisation' only; 4 grafts of Group II (duration 5-18 months) showed thrombotic occlusion; 21 gr...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(85)90153-4

    authors: Walton KW,Slaney G,Ashton F

    更新日期:1985-01-01 00:00:00

  • Risks for cardiovascular disease, stroke, ischaemic heart disease, and diabetes mellitus associated with the metabolic syndrome using the new harmonised definition: findings from nationally representative longitudinal data from an Asian population.

    abstract:OBJECTIVE:We examined the risk of cardiovascular disease, stroke, ischaemic heart disease, and diabetes with the metabolic syndrome according to the new harmonised definition and its components using a national longitudinal data set from an Asian population. METHODS:Data of 9791 men and women aged 20+ from 1998 and 20...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.09.009

    authors: Khang YH,Cho SI,Kim HR

    更新日期:2010-12-01 00:00:00

  • The determination of carotid intima medial thickness in adults--a population-based twin study.

    abstract:INTRODUCTION:Although cardiovascular events are known to cluster in families it is unclear the extent to which atherosclerosis per se is genetically determined. The aim of this study was to assess the heritability of carotid intima media thickness (IMT) measurements, a surrogate marker of early atherosclerosis, using a...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(02)00317-9

    authors: Swan L,Birnie DH,Inglis G,Connell JM,Hillis WS

    更新日期:2003-01-01 00:00:00

  • Egg consumption and coronary artery calcification in asymptomatic men and women.

    abstract:OBJECTIVE:The association of egg consumption with subclinical coronary atherosclerosis remains unknown. Our aim was to examine the association between egg consumption and prevalence of coronary artery calcium (CAC). METHODS:Cross-sectional study of 23,417 asymptomatic adult men and women without a history of cardiovas...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.05.036

    authors: Choi Y,Chang Y,Lee JE,Chun S,Cho J,Sung E,Suh BS,Rampal S,Zhao D,Zhang Y,Pastor-Barriuso R,Lima JA,Shin H,Ryu S,Guallar E

    更新日期:2015-08-01 00:00:00

  • Comparison of various lipid, lipoprotein, and bilirubin combinations as risk factors for predicting coronary artery disease.

    abstract::Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(99)00387-1

    authors: Schwertner HA,Fischer JR Jr

    更新日期:2000-06-01 00:00:00

  • Effects of high-cholesterol diet on the interendothelial clefts and the associated junctional complexes in rat aorta.

    abstract::The arterial endothelial intercellular cleft (AEC) and its associated junctional complex (JC) are the determinants of permeability to macromolecules. This study analyzed frequencies of AEC and JC profile types in the rat thoracic aorta at 1 and 12 months after feeding the animals with a normal or a high-cholesterol di...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00578-5

    authors: Lee WC,Chao WT,Yang VC

    更新日期:2001-04-01 00:00:00

  • Different apoprotein(a) isoform proportions in serum and carotid plaque.

    abstract:INTRODUCTION:Cardio- and/or cerebro-vascular risk are associated with high lipoprotein (a) [Lp(a)] levels and low-molecular-weight (LMW) apo(a) isoforms. Aims of this study were to evaluate the deposition of apo(a) isoforms and apoprotein B (apo B) in atherosclerotic plaque from patients (males and females) who had car...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.06.006

    authors: Baldo G,Giunco S,Kontothanassis D,Baiocchi MR,Valerio A,Frego M

    更新日期:2007-07-01 00:00:00

  • Expression, location and cross-reactivity of two antigenic sites on the amino terminal region of rabbit and human apolipoprotein A-I.

    abstract::Rabbit apolipoprotein A-I (apo A-I) of molecular weight 27,612 contained 241 amino acids. In contrast to its human counterpart which has 3 methionine residues, the rabbit protein possesses only one and therefore produces 2 fragments after CNBr cleavage (CNBr I and II, NH2- and COOH-terminal, respectively). From a seri...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(89)90028-2

    authors: Leroy A,Vu-Dac N,Theret N,Pio F,Fruchart JC

    更新日期:1989-09-01 00:00:00

  • AT1-receptor blockade with irbesartan improves peripheral but not coronary endothelial dysfunction in patients with stable coronary artery disease.

    abstract::Activation of the renin-angiotensin-aldosterone system plays an important role in the pathogenesis of endothelial dysfunction and atherosclerosis. Studies evaluating the effect of AT1-receptor blockers on endothelial dysfunction in patients with coronary artery disease (CAD) revealed mixed results. Studies addressing ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2006.08.034

    authors: Warnholtz A,Ostad MA,Heitzer T,Thuneke F,Fröhlich M,Tschentscher P,Schwedhelm E,Böger R,Meinertz T,Munzel T

    更新日期:2007-10-01 00:00:00

  • Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

    abstract::Epidemiological and autopsy studies suggest a close link between aging and the clinical manifestation of atherosclerosis. Several experiments show increased arterial susceptibility to atherogenetic stimuli in aged subjects. All together, these findings support the concept that aging represents an independent atherogen...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2006.01.018

    authors: Orlandi A,Bochaton-Piallat ML,Gabbiani G,Spagnoli LG

    更新日期:2006-10-01 00:00:00

  • Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men.

    abstract:BACKGROUND:Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking. METHODS:The subjects were 4492 male employees aged 40-59 years who worked fo...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.09.002

    authors: Imano H,Sato S,Kitamura A,Kiyama M,Ohira T,Shimamoto T,Iso H

    更新日期:2007-11-01 00:00:00

  • In vitro production of beta-very low density lipoproteins and small, dense low density lipoproteins in mildly hypertriglyceridemic plasma: role of activities of lecithin:cholester acyltransferase, cholesterylester transfer proteins and lipoprotein lipase.

    abstract::As a model for the formation of beta-very low density lipoproteins (VLDL) and small, dense LDL by the intraplasma metabolic activities in vivo, lipoproteins in fresh plasma were interacted in vitro with endogenous lecithin:cholesterol acyltransferase (LCAT) and cholesterylester transfer proteins (CETP) and subsequentl...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(98)00169-5

    authors: Chung BH,Segrest JP,Franklin F

    更新日期:1998-12-01 00:00:00

  • Correlation of clinical history with quantitative histology of lower extremity atheroma biopsies obtained with the Simpson atherectomy catheter.

    abstract::The purpose of this study was to compare the histologic variability of atheromas resected from patients with various risk factors for vascular disease. Twenty-seven plaques obtained using the Simpson atherectomy catheter were studied. The results of this light and electron microscopic study indicate that patients with...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(89)90222-0

    authors: Barbano EF,Newman GE,McCann RL,Hackel DB,Stack RS,Palmos LE,Mikat EM

    更新日期:1989-08-01 00:00:00

  • Hemoglobin, iron metabolism and angiographic coronary artery disease (The Ludwigshafen Risk and Cardiovascular Health Study).

    abstract:BACKGROUND:Anemia has been shown to be a risk factor for coronary artery disease and mortality. The involvement of body iron stores in the development of CAD remains controversial. So far, studies that examined hemoglobin and parameters of iron metabolism simultaneously do not exist. METHODS AND RESULTS:Hemoglobin and...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.07.002

    authors: Grammer TB,Kleber ME,Silbernagel G,Pilz S,Scharnagl H,Tomaschitz A,König W,März W

    更新日期:2014-10-01 00:00:00

  • Multiple metabolic risk factors and total and cardiovascular mortality in men with low prevalence of obesity.

    abstract::We investigated the association between the multiple metabolic risk factors and cardiovascular and overall mortality among Korean men, a population with a low prevalence of obesity. This prospective cohort study involved 682,597 Korean men, aged 30-69 years at baseline (1992), who were initially without cancer or debi...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2005.08.027

    authors: Park HS,Cho SI,Song YM,Sung J

    更新日期:2006-07-01 00:00:00

  • Protein, glycoprotein and glycolipid profiles of human arterial and venous tissues.

    abstract::Selected normal human arteries and veins were solubilized with detergents, neutral salt buffers and organic solvents. Comparative sodium dodecyl sulphate polyacrylamide gels and thin layer chromatographic plates were developed and the patterns compared. The low molecular weight periodic acid--Schiff positive band seen...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(80)90125-2

    authors: Moore CR,Gilbert DB

    更新日期:1980-03-01 00:00:00

  • Age and sex mediated changes in epicardial fat adipokines.

    abstract::Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived me...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.06.044

    authors: Fei J,Cook C,Blough E,Santanam N

    更新日期:2010-10-01 00:00:00