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Fibrinogen, factor VII clotting activity and coronary artery disease severity.

Abstract：

:To asses the relationship between fibrinogen, factor VII coagulant (VIIc) activity and extent of coronary artery disease, we studied 43 white males shown to have greater than 50% stenosis of at least one major coronary artery. Thirty six had a definite history of myocardial infarction at least 3 months earlier and were classified as having 1, 2 or 3 vessel disease while 7 had 2 or 3 vessel disease, but no prior infarction. Groups were similar with regard to age, body mass index and blood pressure. In those with documented prior infarction, there was a significant relationship between the extent of atheroma and coagulation variables factor VIIc and fibrinogen. However, given a similar degree of atheroma, patients with prior infarction had significantly higher levels of factor VIIc activity compared with patients without such a history. These results corroborate those from prospective studies confirming a significant role for the coagulation system in the clinical manifestation of coronary artery disease.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Broadhurst P,Kelleher C,Hughes L,Imeson JD,Raftery EB

doi

10.1016/0021-9150(90)90108-u

subject

Has Abstract

pub_date

1990-12-01 00:00:00

pages

169-73

issue

2-3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(90)90108-U

journal_volume

85

pub_type

杂志文章

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