当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner.

Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner.

Abstract：

:The response to therapy with hypolipidemic agents shows considerable individual variation. These differences may be due to the interaction of environmental and genetic factors that affect drug bioavailability, receptor function or ligand structure. Our objective was to assess the effect of apolipoprotein (apo) E genotype and gender on lipid-lowering response to the HMG CoA reductase inhibitor, atorvastatin. Genotyping was carried out on DNA from 328 male and female subjects who participated in a multicentric, double-blind clinical trial, and received 10 mg/day of atorvastatin. Our data demonstrate no significant gender differences for LDL cholesterol levels at baseline. Moreover, mean LDL-C lowering was similar in men (-36.2%, range -2.7 to -57.8%) and in women (-38.1%, range -9.5 to -58.5%) as compared to baseline. However, men carrying the epsilon2 allele had a significantly higher mean LDL-C response (-44%) than epsilon3 homozygotes (-37%) and epsilon4 carriers (-34%); P=0.01 for apoE group by treatment interaction. No such gene/treatment interactions were noted in women, with those carrying the epsilon2 allele showing a similar mean response (-34%) as epsilon3 homozygotes (-39%) and epsilon4 carriers (-34%). Mean plasma triglyceride lowering with atorvastatin was 17%. A significant apoE group by treatment interaction (P=0.010) was also observed in men, with epsilon2 carriers being more responsive (-27%) than epsilon3/3 (-13%) and epsilon4 (-22%). This interaction was not observed in women. In summary, atorvastatin treatment had similar effects on plasma lipid levels in both men and women; however, the apoE gene locus was a significant predictor of LDL-C and TG responses to atorvastatin therapy in men, but not in women.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Pedro-Botet J,Schaefer EJ,Bakker-Arkema RG,Black DM,Stein EM,Corella D,Ordovas JM

doi

10.1016/s0021-9150(01)00410-5

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

183-93

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(01)00410-5

journal_volume

158

pub_type

临床试验,杂志文章,随机对照试验

相关文献

ATHEROSCLEROSIS文献大全
  • ABCA1 expression in humans is associated with physical activity and alcohol consumption.

    abstract：:Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53+/-1 yea...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.03.017

    authors： Hoang A,Tefft C,Duffy SJ,Formosa M,Henstridge DC,Kingwell BA,Sviridov D

    更新日期：2008-03-01 00:00:00

  • Association of smoking and low serum bilirubin antioxidant concentrations.

    abstract：:This study sought to examine the association between cigarette smoking and serum bilirubin antioxidant concentrations in 715 middle-aged men undergoing coronary angiography. The study involved 153 current smokers, 251 who quit smoking and 311 who never smoked. Serum bilirubin concentrations were divided into the follo...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00232-3

    authors： Schwertner HA

    更新日期：1998-02-01 00:00:00

  • Characterization of basement membrane collagens of bovine aortae.

    abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(84)90004-2

    authors： Leushner JR,Haust MD

    更新日期：1984-01-01 00:00:00

  • Prostanoid and isoprostanoid pathways in atherogenesis.

    abstract：:Atherosclerosis is a chronic inflammatory disease of the vasculature that is influenced by multiple factors and involves a complex interplay between some components of the bloodstream and the arterial wall. Among different circulating factors implicated in atherogenesis there is a large group of bioactive lipids calle...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2008.04.037

    authors： Praticò D

    更新日期：2008-11-01 00:00:00

  • C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

    abstract：BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation o...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.atherosclerosis.2007.09.038

    authors： Lind L,Siegbahn A,Hulthe J,Elmgren A

    更新日期：2008-07-01 00:00:00

  • The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia.

    abstract：BACKGROUND:Cholesteryl ester transfer protein (CETP) mediates the transfer of neutral lipids between lipoproteins. The role of CETP in atherogenesis is controversial. To better understand the relationships between plasma CETP levels, lipoproteins and atherosclerosis, we assessed these parameters in patients with an enh...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.atherosclerosis.2003.11.020

    authors： de Grooth GJ,Smilde TJ,Van Wissen S,Klerkx AH,Zwinderman AH,Fruchart JC,Kastelein JJ,Stalenhoef AF,Kuivenhoven JA

    更新日期：2004-04-01 00:00:00

  • Serum lipoproteins, sex hormones and sex hormone binding globulin in middle-aged men of different physical fitness and risk of coronary heart disease.

    abstract：:Serum concentrations of lipoproteins, apolipoprotein A-I (Apo A-I), androgens, including biologically active free testosterone (free T), and sex hormone binding globulin (SHBG) and their associations were studied in 3 groups of men of different physical fitness and risk of CHD, consisting of male CHD patients, joggers...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(87)90275-9

    authors： Hämäläinen E,Tikkanen H,Härkönen M,Näveri H,Adlercreutz H

    更新日期：1987-10-01 00:00:00

  • Profound resolution of early atherosclerosis with conjugated linoleic acid.

    abstract：:Conjugated linoleic acid (CLA) refers to a group of positional and geometric isomers of linoleic acid and has been shown to suppress the development of atherosclerosis in experimental models. However, the mechanism involved is unclear although it is believed it may act as a cyclooxygenase inhibitor or as an agonist of...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.08.024

    authors： Toomey S,Harhen B,Roche HM,Fitzgerald D,Belton O

    更新日期：2006-07-01 00:00:00

  • Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.

    abstract：OBJECTIVE:The plasma level of soluble CD40 ligand (sCD40L), which induces pro-inflammatory and pro-atherogenic responses, is known to be elevated in atherosclerotic patients. In this study, we investigated the mechanism of sCD40L release from human platelets, focusing on the involvement of thromboxane (TX) A(2). METHO...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.10.024

    authors： Enomoto Y,Adachi S,Matsushima-Nishiwaki R,Doi T,Niwa M,Akamatsu S,Tokuda H,Ogura S,Yoshimura S,Iwama T,Kozawa O

    更新日期：2010-04-01 00:00:00

  • Relation of N-glycosylation of apolipoprotein B-100 to cellular metabolism of low density lipoprotein.

    abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90040-x

    authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

    更新日期：1994-07-01 00:00:00

  • Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in nonhuman primates.

    abstract：:The hypolipidemic response of rice bran oil (RBO) was investigated in nonhuman primates fed semi-purified diets containing blends of oils which included RBO at 0-35% Kcals as dietary fat. The studies demonstrated the following: (a) the degree of reduction of serum total cholesterol (TC) and low density lipoprotein cho...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(91)90075-e

    authors： Nicolosi RJ,Ausman LM,Hegsted DM

    更新日期：1991-06-01 00:00:00

  • The state of macrophage differentiation determines the TNF alpha response to nitrated lipoprotein uptake.

    abstract：:Inflammatory cytokine synthesis by monocyte-macrophages in the developing plaque represents an important amplification point in atherosclerotic disease progression. Here we have investigated whether the state of monocyte-macrophage differentiation can influence TNF alpha synthesis in response to scavenged modified low...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(03)00285-5

    authors： Smythe CD,Skinner VO,Bruckdorfer KR,Haskard DO,Landis RC

    更新日期：2003-10-01 00:00:00

  • Familial ligand-defective apolipoprotein B-100: detection, biochemical features and haplotype analysis of the R3531C mutation in the UK.

    abstract：:Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by the substitution of glutamine for arginine at codon 3500 of the apo B gene (apo B R3500Q), resulting in decreased binding of low density lipoprotein (LDL) to the ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)06029-7

    authors： Wenham PR,Henderson BG,Penney MD,Ashby JP,Rae PW,Walker SW

    更新日期：1997-03-21 00:00:00

  • Hammerhead ribozyme targeting human platelet-derived growth factor A-chain mRNA inhibited the proliferation of human vascular smooth muscle cells.

    abstract：:Platelet-derived growth factor (PDGF) A-chain contributes to the pathogenesis of cardiovascular proliferative diseases, such as hypertensive vascular disease, atherosclerosis, and re-stenosis of an artery after angioplasty. To develop a ribozyme against human PDGF A-chain mRNA as a gene therapy for human arterial prol...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00451-8

    authors： Hu WY,Fukuda N,Kishioka H,Nakayama M,Satoh C,Kanmatsuse K

    更新日期：2001-10-01 00:00:00

  • Ultrasonography of achilles tendons in primary hypercholesterolemia. Comparison with computed tomography.

    abstract：:Tendon xanthoma are a hallmark of familial hypercholesterolemia and are among its earliest clinical manifestations. Achilles tendon size, advanced to a generally accepted marker, is virtually specific for the disease and easily accessible for measurement. Hypercholesterolemic patients with coronary heart disease have ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90242-0

    authors： Steinmetz A,Schmitt W,Schuler P,Kleinsorge F,Schneider J,Kaffarnik H

    更新日期：1988-12-01 00:00:00

  • Identification of a cytoplasmic linker protein as a potential target for neovascularization.

    abstract：OBJECTIVE:Atherosclerosis and other cardiovascular diseases are serious threats to human health and become the leading cause of death in the world. Emerging evidence reveals that inhibition of plaque neovascularization could be an effective approach for the treatment of atherosclerosis. This study was conducted to iden...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.01.009

    authors： Xie S,Dong B,Sun X,Tala,He X,Zhou J,Liu M,Li D

    更新日期：2014-04-01 00:00:00

  • Lp(a) levels and antiestrogen antibodies in women with and without thrombosis in the course of oral contraception.

    abstract：:Several reports have shown that lipoprotein(a) is associated with ischemic diseases. Two characteristics might explain this association. Firstly, Lp(a) is an LDL-like lipoprotein which may be implicated in the atherosclerotic process and secondly, Lp(a) possesses an additional apolipoprotein(a) whose structure is clos...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90204-8

    authors： Delplanque B,Beaumont V,Lemort N,Beaumont JL

    更新日期：1993-05-01 00:00:00

  • The influence of low intake of n-3 fatty acids on platelets in elderly people.

    abstract：:A total of ten healthy elderly subjects ingested one capsule of 600 mg (corresponding to 150 mg docosahexaenoic acid and 30 mg eicosapentaenoic acid) RO-PUFA triglycerides per day and ten others ingested one capsule of 600 mg sunflower oil as a placebo for 42 days. In the n-3 polyunsaturated fatty acids (PUFA) group, ...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(99)00171-9

    authors： Véricel E,Calzada C,Chapuy P,Lagarde M

    更新日期：1999-11-01 00:00:00

  • Binding properties of circulating Evans blue in rabbits as determined by disc electrophoresis.

    abstract：:Following injections of Evans blue (1-200 mg/kg) into rabbits, polyacrylamide gel disc electrophoresis showed that Evans blue binds to two protein fractions. The greater part was bound to albumin and the remainder to a plasma protein in the postalbumin fraction. Unbound Evans blue was present in each plasma sample ana...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90040-5

    authors： Lindner V,Heinle H

    更新日期：1982-06-01 00:00:00

  • A monoclonal antibody that recognizes hyaluronic acid binding region of aorta proteoglycans.

    abstract：:A chondroitin sulfate-dermatan sulfate proteoglycan was isolated from bovine aorta intima by extraction of the tissue with 4 M guanidine hydrochloride. The proteoglycan was purified by CsCl isopycnic centrifugation followed by gel filtration and ion exchange chromatography. A monoclonal antibody C8F4 was developed to ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90127-g

    authors： Radhakrishnamurthy B,Jeansonne N,Tracy RE,Berenson GS

    更新日期：1993-01-25 00:00:00

  • ACE insert/delete polymorphism and atherosclerosis.

    abstract：:We report on the results of a large autopsy study focusing upon the hypothesis that deletion of the Alu insert in the angiotensin converting enzyme (ACE) gene is associated with: (a) greater prevalence or extent of atherosclerosis in the aorta and coronary arteries; and (b) microscopic qualities of established atheros...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.09.019

    authors： Scheer WD,Boudreau DA,Hixson JE,McGill HC,Newman WP 3rd,Tracy RE,Zieske AW,Strong JP

    更新日期：2005-02-01 00:00:00

  • Application of real-time RT-PCR to quantifying gene expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human abdominal aortic aneurysm.

    abstract：BACKGROUND:The relative expression levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), key regulators in remodeling of extracellular matrix, are considered to play a pivotal role in the development of abdominal aortic aneurysm (AAA). However, few data exist regarding quantita...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.07.013

    authors： Higashikata T,Yamagishi M,Sasaki H,Minatoya K,Ogino H,Ishibashi-Ueda H,Hao H,Nagaya N,Tomoike H,Sakamoto A

    更新日期：2004-12-01 00:00:00

  • Impact of retrograde shear rate on brachial and superficial femoral artery flow-mediated dilation in older subjects.

    abstract：UNLABELLED:An inverse, dose-dependent relationship between retrograde shear rate and brachial artery endothelial function exists in young subjects. This relationship has not been investigated in older adults, who have been related to lower endothelial function, higher resting retrograde shear rate and higher risk of ca...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.04.017

    authors： Schreuder TH,Green DJ,Hopman MT,Thijssen DH

    更新日期：2015-07-01 00:00:00

  • Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension.

    abstract：BACKGROUND AND AIMS:Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.01.031

    authors： Pereira SC,Parente JM,Belo VA,Mendes AS,Gonzaga NA,do Vale GT,Ceron CS,Tanus-Santos JE,Tirapelli CR,Castro MM

    更新日期：2018-03-01 00:00:00

  • The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese.

    abstract：:The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00252-6

    authors： Nabika T,Nasreen S,Kobayashi S,Masuda J

    更新日期：2002-12-01 00:00:00

  • Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals.

    abstract：BACKGROUND:Risk factors of cardiovascular disease such as lipid aberrations, hypertension, abdominal adiposity and elevations in systemic inflammation, are prominent aetiologies in hyperlipidemia. Supplementation with n-3 PUFA is associated with a reduction in cardiovascular events through its hypotriglyceridemic, anti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2008.09.020

    authors： Micallef MA,Garg ML

    更新日期：2009-06-01 00:00:00

  • Heart valve calcification in young patients with systemic lupus erythematosus: a window to premature atherosclerotic vascular morbidity and a risk factor for all-cause mortality.

    abstract：:The objective of the study was to evaluate the association between heart valve calcification and atherosclerosis and outcome in systemic lupus erythematosus (SLE). One-hundred and seven patients with SLE (mean age 45.9 +/- 14.7 years) were studied by 2D transthoracic echocardiography. Mitral annulus calcification (MAC...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.06.021

    authors： Molad Y,Levin-Iaina N,Vaturi M,Sulkes J,Sagie A

    更新日期：2006-04-01 00:00:00

  • Impaired adaptive vascular growth in hypercholesterolemic rabbit.

    abstract：:Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00073-2

    authors： Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

    更新日期：1998-08-01 00:00:00

  • Associations of physical activity and sedentary time with lipoprotein subclasses in Norwegian schoolchildren: The Active Smarter Kids (ASK) study.

    abstract：BACKGROUND AND AIMS:Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known. Here we examine cross-sectional associations between objectively measured physical activity and sedentary time with ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.05.023

    authors： Jones PR,Rajalahti T,Resaland GK,Aadland E,Steene-Johannessen J,Anderssen SA,Bathen TF,Andreassen T,Kvalheim OM,Ekelund U

    更新日期：2019-09-01 00:00:00

  • Factor analysis of plasma lipoprotein components.

    abstract：:Serum phospholipids were analyzed for their content of long-chained fatty acids together with other components of lipoproteins (total- and HDL-cholesterol, apolipoproteins A-I and B, triglycerides), in 60 coronary heart disease patients and 30 control individuals. Some of the individual variations in content of the va...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90017-2

    authors： Aursnes I,Smith P,Christiansen EN,Berg K

    更新日期：1988-02-01 00:00:00