当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients.

Lipid-lowering therapy with fluvastatin inhibits oxidative modification of low density lipoprotein and improves vascular endothelial function in hypercholesterolemic patients.

Abstract：

:This prospective randomized trial was designed to elucidate clinically the effect of fluvastatin on inhibiting oxidation of the low density lipoprotein (LDL) and improving the vascular endothelial function as well as its lipid-lowering effects, in comparison with pravastatin. Of 64 consecutive dyslipidemic patients, 40 patients, whose level of total cholesterol or LDL-cholesterol maintained the criteria of the hypercholesterolemia in spite of 12-week dietary therapy, were randomly assigned to receive either fluvastatin (n=20) or pravastatin (n=20). We assessed the titer of antibody against oxidized LDL (anti-Ox-LDL) as a biomarker for LDL-oxidation, and the forearm blood flow response during reactive hyperemia by venous occlusion plethysmography, which indicates the endothelium-dependent vasodilator capacity. After the 16-week lipid-lowering therapy, the anti-Ox-LDL titer significantly decreased in the fluvastatin group (P<0.01) but did not change in the pravastatin group. The percent increase in the forearm blood flow at the peak reactive hyperemia from the baseline value (%RH) significantly increased in the fluvastatin group (P<0.001) but did not change in the pravastatin group. The ratio of the %RH after the therapy over the baseline value negatively correlated with that of the anti-Ox-LDL titer (R=0.73, P<0.001) in all patients. Fluvastatin may serve as an ideal drug for reducing the risk of atherosclerosis, not only by its cholesterol-lowering effect but also by its unique effects of inhibiting LDL oxidation and improving the vascular endothelial function.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Inoue T,Hayashi M,Takayanagi K,Morooka S

doi

10.1016/s0021-9150(01)00585-8

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

369-76

issue

2

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(01)00585-8

journal_volume

160

pub_type

临床试验,杂志文章,随机对照试验

相关文献

ATHEROSCLEROSIS文献大全
  • The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis.

    abstract：BACKGROUND AND PURPOSE:γ-butyrobetaine (γBB) is a metabolite from dietary Carnitine, involved in the gut microbiota-dependent conversion from Carnitine to the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO). Orally ingested γBB has a pro-atherogenic effect in experimental studies, but γBB has not been studied ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.01.033

    authors： Skagen K,Trøseid M,Ueland T,Holm S,Abbas A,Gregersen I,Kummen M,Bjerkeli V,Reier-Nilsen F,Russell D,Svardal A,Karlsen TH,Aukrust P,Berge RK,Hov JE,Halvorsen B,Skjelland M

    更新日期：2016-04-01 00:00:00

  • Lovastatin therapy in familial dysbetalipoproteinemia: effects on kinetics of apolipoprotein B.

    abstract：:Familial dysbetalipoproteinemia is characterized by hyperlipidemia, increases in beta-migrating, very low density lipoproteins (beta-VLDL), and homozygosity for apolipoprotein E2 (apo E2). In this study, 3 patients with familial dysbetalipoproteinemia were treated with lovastatin, and kinetics for apolipoprotein B (ap...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90107-4

    authors： Vega GL,East C,Grundy SM

    更新日期：1988-03-01 00:00:00

  • Evidence for an inverse relation between plasma triglyceride and aortic cholesterol in the coconut oil/cholesterol-fed rabbit.

    abstract：:Rabbits fed a commercial chow diet containing 0.5% cholesterol and 14% coconut oil developed more severe hyperlipidemia and atherosclerosis than rabbits fed the same diet containing olive oil in place of coconut oil. Average plasma cholesterol was twice as high in the coconut oil/cholesterol-fed rabbits than in olive ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(88)90142-6

    authors： Van Heek M,Zilversmit DB

    更新日期：1988-06-01 00:00:00

  • Antibodies to Chlamydia pneumoniae and clinical course in patients with unstable angina pectoris.

    abstract：:Inflammation is one of the most important mechanisms that contribute to coronary artery disease (CAD). One of the micro-organisms that is mentioned as a source of the inflammation is Chlamydia pneumoniae. In this study, we investigated the relationship between titres of IgG and IgA antibodies to C. pneumoniae and the ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00436-6

    authors： de Maat MP,Ossewaarde JM,Verheggen PW,Kluft C,Cats VM,Haverkate F

    更新日期：2000-12-01 00:00:00

  • Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events.

    abstract：BACKGROUND:Tissue proportions of long chain n-6 [especially arachidonic acid (AA)] and n-3 fatty acids [FA; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) acids], or some ratio of these may be markers of risk for coronary heart disease (CHD). The purpose of this paper is to evaluate the published associatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2007.03.018

    authors： Harris WS,Poston WC,Haddock CK

    更新日期：2007-07-01 00:00:00

  • Effects of stimulation of nitric oxide synthesis on large artery stiffness in patients with peripheral arterial disease.

    abstract：:The role of endothelium-derived nitric oxide (NO) in modulation of large artery stiffness in patients with peripheral arterial disease (PAD) is unexplored. The aim of this study was to evaluate, using pulse wave analysis (PWA), changes in aortic and systemic arterial stiffness following administration of nitroglycerin...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.06.014

    authors： Kals J,Kampus P,Kals M,Pulges A,Teesalu R,Zilmer M

    更新日期：2006-04-01 00:00:00

  • CD59 (homologous restriction factor 20), a plasma membrane protein that protects against complement C5b-9 attack, in human atherosclerotic lesions.

    abstract：:Blood cells express a cell membrane protein, termed homologous restriction factor 20 (HRF20) and identical to CD59, that can inhibit complement C5b-9 insertion into their membranes. In this report, we investigated by immunohistochemistry whether CD59 was present on cells in human atherosclerotic lesions since membrano...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(92)90060-t

    authors： Seifert PS,Roth I,Schmiedt W,Oelert H,Okada N,Okada H,Bhakdi S

    更新日期：1992-10-01 00:00:00

  • Room for depressed and exhausted mood as a risk predictor for all-cause and cardiovascular mortality beyond the contribution of the classical somatic risk factors in men.

    abstract：BACKGROUND AND AIMS:Depressed mood and exhaustion (DEEX) have gained attention as a risk predictor for cardiovascular disease (CVD). Studies to estimate its ranking in prediction models are sparse. METHODS:The study included 3428 men aged 45-74 years who participated in one of three population-based MONICA/KORA Augsbu...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.12.003

    authors： Ladwig KH,Baumert J,Marten-Mittag B,Lukaschek K,Johar H,Fang X,Ronel J,Meisinger C,Peters A,KORA Investigators.

    更新日期：2017-02-01 00:00:00

  • Serum cholesterol levels in patients with familial hypercholesterolemia confirmed by tissue culture.

    abstract：:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(81)90088-5

    authors： Keller C,Harders-Spengel K,Spengel F,Wieczorek A,Wolfram G,Zöllner N

    更新日期：1981-04-01 00:00:00

  • Accelerated atherosclerosis in subjects with some minor deviations from the common type of distribution of human coronary arteries.

    abstract：:Gross dissection of the coronary arteries of 566 subjects aged 0--45 years from an unselected population sample of Bucharest revealed the presence of a similar anatomical branching pattern in 58% of cases. Starting from this common type of distribution of coronary arteries, some minor deviations were detected coexisti...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(81)90141-6

    authors： Velican D,Velican C

    更新日期：1981-11-01 00:00:00

  • Recombinant proapoA-I(Lys107del) shows impaired lipid binding associated with reduced binding to plasma high density lipoprotein.

    abstract：:In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation. Dimyristoyl phosphatidylcholine (DMPC) binding...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00496-8

    authors： Huang W,Matsunaga A,Li W,Han H,Hoang A,Kugi M,Koga T,Sviridov D,Fidge N,Sasaki J

    更新日期：2001-11-01 00:00:00

  • Clinical study of niceritrol on serum lipids in the treatment of hyperlipidemia.

    abstract：:The effects of niceritrol, a nicotinic acid derivative, on the levels of HDL-cholesterol (HDL-Ch) and a mixture of VLDL- and LDL-Ch (VLDL- + LDL-Ch) were studied in hyperlipidemic patients. Serum total cholesterol (sTC) and serum triglyceride (sTG) were significantly reduced during niceritrol administration. Lipoprote...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(80)90137-9

    authors： Kibata M,Ishida M,Asano K,Uehara H,Saito K,Fuchimoto T,Ugaki K,Murakami H,Matoba K,Kotakemori Y,Shirai K,Yoshioka H,Nanba M,Yasuda M,Ishizaki M,Kitagawa N,Ikejiri K,Inohara R,Lee BJ,Saino S,Sakado J,Matuzaka H,

    更新日期：1980-11-01 00:00:00

  • Atheroprotective mechanisms of HDL.

    abstract：:The aim of this review was to bring together results obtained from studies on different aspects of HDL as related to CHD and atherosclerosis. As atherosclerosis is a multistep process, the various components of HDL can intervene at different stages, such as induction of monocyte adhesion molecules, prevention of LDL m...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/s0021-9150(99)00065-9

    authors： Stein O,Stein Y

    更新日期：1999-06-01 00:00:00

  • Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease.

    abstract：:Although triglycerides (TG) are a major risk factor for coronary artery disease (CAD), their exact role is still controversial. Recently, a T/C polymorphism in the promoter region of the apoA5 gene at position 1131 has been found that is associated with an increased plasma TG concentration. We investigated the role of...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2003.12.003

    authors： Szalai C,Keszei M,Duba J,Prohászka Z,Kozma GT,Császár A,Balogh S,Almássy Z,Fust G,Czinner A

    更新日期：2004-03-01 00:00:00

  • Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study.

    abstract：:Studies on the clinical consequences of different low-density lipoprotein (LDL) receptor genotypes in adult patients have yielded conflicting results. We hypothesized that children with familial hypercholesterolemia (FH) provide a better model to perform genotype-phenotype analyses than adults. We tested this hypothes...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.10.042

    authors： Koeijvoets KC,Wiegman A,Rodenburg J,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期：2005-05-01 00:00:00

  • Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist.

    abstract：:MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) that is being developed for the treatment of dyslipidemia. The safety profile and tolerability of THR-β agonist MGL-3196 was assessed in first-in humans studies, including a single ascending dose study (NCT01367873) in whi...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2013.07.056

    authors： Taub R,Chiang E,Chabot-Blanchet M,Kelly MJ,Reeves RA,Guertin MC,Tardif JC

    更新日期：2013-10-01 00:00:00

  • Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid.

    abstract：AIM:Serum paraoxonase 1 (PON1) is an HDL-associated lipolactonase and its association with hypertension is controversial. We studied the possible role of PON1 in blood pressure (BP) regulation, by using PON1 knockout (PON1KO) mice. METHODS AND RESULTS:Both, systolic and diastolic BPs were lower in PON1KO compared to W...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.01.047

    authors： Gamliel-Lazarovich A,Abassi Z,Khatib S,Tavori H,Vaya J,Aviram M,Keidar S

    更新日期：2012-05-01 00:00:00

  • Periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation.

    abstract：OBJECTIVE:Epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. Several human studies have detected bacterial DNA corresponding to periodontal pathogens in cardiovascular samples. Intraplaque hemorrhage has been associated with a higher risk of atherosc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.07.034

    authors： Rangé H,Labreuche J,Louedec L,Rondeau P,Planesse C,Sebbag U,Bourdon E,Michel JB,Bouchard P,Meilhac O

    更新日期：2014-10-01 00:00:00

  • Induction of calcification in rabbit aortas by high cholesterol diets: roles of calcifiable vesicles in dystrophic calcification.

    abstract：:Atherosclerotic calcification may weaken the aorta wall and thereby lead to rupture of the vessel. The mechanism whereby aortas undergo calcification remains unclear. Previous reports in this laboratory showed that, after 2 months of cholesterol-supplemental feeding, an increase in calcifiability of membrane vesicles ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00623-2

    authors： Hsu HH,Camacho NC,Tawfik O,Sun F

    更新日期：2002-03-01 00:00:00

  • Effects of estrogen on growth and smooth muscle differentiation of vascular wall-resident CD34(+) stem/progenitor cells.

    abstract：OBJECTIVES:To investigate the effects of estrogen on growth and smooth muscle cell (SMC)-differentiation of vascular wall-resident CD34(+) stem/progenitor cells (VRS/Pcs). METHODS AND RESULTS:The existence of CD34(+) VRS/Pcs was confirmed by immunohistochemistry in the adventitia of arteries of young (2-month-old) and...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.04.008

    authors： Wu Y,Shen Y,Kang K,Zhang Y,Ao F,Wan Y,Song J

    更新日期：2015-06-01 00:00:00

  • Low density lipoprotein metabolism by cultured skin fibroblasts from atherosclerotic patients.

    abstract：:The aim of this study was to determine whether an abnormality in low density lipoprotein (LDL) metabolism could be demonstrated in fibroblasts cultured from normolipidaemic subjects with atherosclerosis. Seventeen male subjects aged 30-55 years with normal plasma lipid concentrations were divided into 2 groups on the ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(82)90148-4

    authors： Behrman RG,Wynn V

    更新日期：1982-04-01 00:00:00

  • Brain microangiopathy and macroangiopathy share common risk factors and biomarkers.

    abstract：AIMS:Besides carotid or cardiac embolism, stroke can occur via microangiopathy (small arterial disease [SAD]) and macroangiopathy (intracranial atherosclerotic stroke [ICAS]) of the intracranial vasculature. There have been efforts to identify risk factors specific to microangiopathy and macroangiopathy, including vasc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.12.040

    authors： Bang OY,Chung JW,Ryoo S,Moon GJ,Kim GM,Chung CS,Lee KH

    更新日期：2016-03-01 00:00:00

  • Research integrity and publication ethics.

    abstract：:The basic principle for professional conduct of science in all countries and all disciplines is honesty towards oneself and towards others. Therefore it is utmost important that the scientific community prevents scientific misconduct by fostering research integrity. This commentary reports on the experience of a Germa...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.01.050

    authors： Beisiegel U

    更新日期：2010-10-01 00:00:00

  • Coadministration of colesevelam hydrochloride with atorvastatin lowers LDL cholesterol additively.

    abstract：:Colesevelam hydrochloride is a novel, potent, non-absorbed lipid-lowering agent previously shown to reduce low density lipoprotein (LDL) cholesterol. To examine the efficacy and safety of coadministration of colesevelam and atorvastatin, administration of these agents alone or in combination was examined in a double-b...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(01)00437-3

    authors： Hunninghake D,Insull W Jr,Toth P,Davidson D,Donovan JM,Burke SK

    更新日期：2001-10-01 00:00:00

  • Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL.

    abstract：:High density lipoproteins (HDL) induce prostacyclin (PGI(2)) release in vascular smooth muscle cells (VSMC) by up-regulation of cyclooxygenase-2 (Cox-2). Our goal was to analyse the mechanisms underlying this effect, and its potential modulation by HMG-CoA reductase inhibition in human VSMC. The contribution of mitoge...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.01.037

    authors： Martínez-González J,Escudero I,Badimon L

    更新日期：2004-06-01 00:00:00

  • Triglyceride-rich lipoproteins from apolipoprotein E3/2 subjects with hypertriglyceridemia enhance cholesteryl ester synthesis in human macrophages.

    abstract：:The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly sampled from our h...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)06026-1

    authors： Saito M,Eto M,Makino I

    更新日期：1997-02-28 00:00:00

  • Atherosclerosis imaging to refine cardiovascular risk assessment in diabetic patients: Computed tomography and positron emission tomography applications.

    abstract：:The lifetime cardiovascular risk of a diabetic patient is approximately 4-5 times higher than that of an age and sex matched individual without diabetes mellitus. Despite the well-publicized cardiovascular risk equivalence of diabetes mellitus, it has become apparent that not all diabetic patients are equally at high-...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2018.02.021

    authors： Raggi P

    更新日期：2018-04-01 00:00:00

  • Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits.

    abstract：:We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(87)90081-5

    authors： Thiery J,Seidel D

    更新日期：1987-01-01 00:00:00

  • Apolipoprotein B release from activated human platelets.

    abstract：:Apolipoprotein B (apoB) release from activated washed human platelets was measured by enzyme-linked immunosorbent assay (ELISA) using monospecific rabbit antibodies to human low density lipoprotein (LDL). Activation of platelets with thrombin, Ca2+-ionophore A23187 or stable analogue of prostaglandin endoperoxides U46...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(86)90140-1

    authors： Preobrazhensky SN,Podrez EA,Tsibulsky VP,Fuki IV,Mazurov AV,Repin VS,Smirnov VN

    更新日期：1986-09-01 00:00:00

  • Relationships of night/day heart rate ratio with carotid intima media thickness and markers of arterial stiffness.

    abstract：OBJECTIVES:To analyze the relationship between office and ambulatory heart rate, and its variability, and arterial stiffness in patients with primary arterial hypertension. METHODS:A cross-sectional study was conducted in a primary care setting, with the inclusion of 356 hypertensive patients aged 30-80 years. Office ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.03.037

    authors： García-Ortiz L,García-García A,Ramos-Delgado E,Patino-Alonso MC,Recio-Rodríguez JI,Rodríguez-Sánchez E,Gómez-Marcos MA

    更新日期：2011-08-01 00:00:00