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Triglyceride-rich lipoproteins from apolipoprotein E3/2 subjects with hypertriglyceridemia enhance cholesteryl ester synthesis in human macrophages.

Abstract：

:The ability of triglyceride (TG)-rich lipoproteins from apolipoprotein (apo) E2 heterozygote, apo E3/2 which is relatively common, to stimulate cholesteryl ester synthesis in human monocyte-derived macrophages was studied to clarify the atherogenicity of apo E3/2. Twenty-three subjects were randomly sampled from our hospitals, and divided into the following 4 groups: 7 apo E3/3 subjects with normolipidemia, 6 apo E3/3 subjects with hypertriglyceridemia (HTG), 5 apo E3/2 subjects with normolipidemia and 5 apo E3/2 subjects with HTG. Plasma levels of TG and total cholesterol (chol) were significantly (P < 0.001) higher in apo E3/3 and apo E3/2 subjects with HTG than in apo E3/3 and apo E3/2 subjects with normolipidemia, but plasma levels of TG and total chol were not significantly different between apo E3/3 and apo E3/2 subjects with HTG. [14C]oleate incorporation into cholesteryl esters in macrophages was significantly (P < 0.001) higher in apo E3/2 subjects with HTG (0.661 nmol/mg cell protein) than in apo E3/3 subjects with normolipidemia (0.228) and with HTG (0.325) and in apo E3/2 subjects with normolipidemia (0.257). It is concluded that TG-rich lipoproteins from apolipoprotein E3/2 subjects with HTG enhance cholesteryl ester synthesis in human macrophages.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Saito M,Eto M,Makino I

doi

10.1016/s0021-9150(96)06026-1

subject

Has Abstract

pub_date

1997-02-28 00:00:00

pages

73-7

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(96)06026-1

journal_volume

129

pub_type

杂志文章

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