当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Dose-dependent effect of rosuvastatin on apolipoprotein B-100 kinetics in the metabolic syndrome.

Dose-dependent effect of rosuvastatin on apolipoprotein B-100 kinetics in the metabolic syndrome.

Abstract：

:In a randomized, double-blind, crossover trial of 5-week treatment period with placebo or rosuvastatin (10 or 40 mg/day) with 2-week placebo wash-outs between treatments, the dose-dependent effect of rosuvastatin on apolipoprotein (apo) B-100 kinetics in metabolic syndrome subjects were studied. Compared with placebo, there was a significant dose-dependent decrease with rosuvastatin in plasma cholesterol, triglycerides, LDL cholesterol, apoB and apoC-III concentrations and in the apoB/apoA-I ratio, lathosterol:cholesterol ratio, HDL cholesterol concentration and campesterol:cholesterol ratio also increased significantly. Rosuvastatin significantly increased the fractional catabolic rates (FCR) of very-low density lipoprotein (VLDL), intermediate density lipoprotein (IDL) and LDL-apoB and decreased the corresponding pool sizes, with evidence of a dose-related effect. LDL apoB production rate (PR) fell significantly with rosuvastatin 40 mg/day with no change in VLDL and IDL-apoB PR. Changes in triglycerides were significantly correlated with changes in VLDL apoB FCR and apoC-III concentration, and changes in lathosterol:cholesterol ratio were correlated with changes in LDL apoB FCR, the associations being more significant with the higher dose of rosuvastatin. In the metabolic syndrome, rosuvastatin decreases the plasma concentration of apoB-containing lipoproteins by a dose-dependent mechanism that increases their rates of catabolism. Higher dose rosuvastatin may also decrease LDL apoB production. The findings provide a dose-related mechanism for the benefits of rosuvastatin on cardiovascular disease in the metabolic syndrome.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Ooi EM,Barrett PH,Chan DC,Nestel PJ,Watts GF

doi

10.1016/j.atherosclerosis.2007.03.004

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

139-46

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(07)00167-0

journal_volume

197

pub_type

杂志文章,随机对照试验

相关文献

ATHEROSCLEROSIS文献大全
  • Prevalence and predictors of subclinical atherosclerosis among asymptomatic "low risk" individuals in a multiethnic population.

    abstract：BACKGROUND:Current approaches to cardiovascular (CV) risk assessment have limitations. Subclinical atherosclerosis (SCA) as determined by carotid ultrasound is an independent predictor of myocardial infarction and stroke and can refine CV risk assessment. OBJECTIVES:We aimed to determine the prevalence and predictors ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.06.020

    authors： Grewal J,Anand S,Islam S,Lonn E,SHARE and SHARE-AP Investigators.

    更新日期：2008-03-01 00:00:00

  • Prevention of focal intimal hyperplasia in rat vein grafts by using a tissue engineering approach.

    abstract：:The present study focused on the role of blood flow in the formation of focal intimal hyperplasia in vein grafts, as well as the development of an engineering approach that can be used to eliminate disturbed blood flow and prevent blood flow-related focal intimal hyperplasia. A rat vein graft model was constructed by ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(98)00143-9

    authors： Liu SQ

    更新日期：1998-10-01 00:00:00

  • Exercise tolerance test for predicting coronary heart disease in asymptomatic individuals: A review.

    abstract：:In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of E...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2008.12.034

    authors： Mégnien JL,Simon A

    更新日期：2009-08-01 00:00:00

  • Allometric scaling of diameter change in the original flow-mediated dilation protocol.

    abstract：:The negative correlation between percent flow-mediated dilation (FMD%) and baseline diameter (D(base)) has only recently been recognised as a fundamental ratio-scaling problem, which is not resolved by significance-testing of D(base) inequality between groups/conditions, nor by covariate-adjusting FMD% itself by D(bas...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.11.027

    authors： Atkinson G,Batterham AM

    更新日期：2013-02-01 00:00:00

  • Progesterone abolishes estrogen and/or atorvastatin endothelium dependent vasodilatory effects.

    abstract：UNLABELLED:This double blind randomized placebo controlled study assessed the effects of atorvastatin, estradiol and norethisterone, isolated and in combination, on the lipid profile and on vascular reactivity, in post-menopausal women with hypercholesterolemia and arterial hypertension. Ninety-four women aged 50-65 we...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2004.05.030

    authors： Faludi AA,Aldrighi JM,Bertolami MC,Saleh MH,Silva RA,Nakamura Y,Pereira IR,Abdalla DS,Ramires JA,Sousa JE

    更新日期：2004-11-01 00:00:00

  • Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy.

    abstract：OBJECTIVE:The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction. METHODS AND RESULTS:Coronary endothelial function was assessed in 490 patients between November 1993 and February 2...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2009.04.039

    authors： Ford MA,McConnell JP,Lavi S,Rihal CS,Prasad A,Sandhu GS,Hartman SJ,Lerman LO,Lerman A

    更新日期：2009-11-01 00:00:00

  • Opposite effects on serum cholesteryl ester transfer protein levels between long-term treatments with pravastatin and probucol in patients with primary hypercholesterolemia and xanthoma.

    abstract：:Long-term effects of pravastatin and probucol on serum cholesteryl ester transfer protein (CETP) and xanthoma/xanthelasma size were compared. Twenty-three patients with primary hypercholesterolemia and xanthoma/xanthelasma, including 11 patients with heterozygous familial hypercholesterolemia, were treated with pravas...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00088-x

    authors： Inazu A,Koizumi J,Kajinami K,Kiyohar T,Chichibu K,Mabuchi H

    更新日期：1999-08-01 00:00:00

  • Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects.

    abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0021-9150(02)00424-0

    authors： Rivellese AA,Maffettone A,Vessby B,Uusitupa M,Hermansen K,Berglund L,Louheranta A,Meyer BJ,Riccardi G

    更新日期：2003-03-01 00:00:00

  • Diabetes mellitus abolishes ethnic differences in cardiovascular risk factors: lessons from a multi-ethnic population.

    abstract：AIMS:To compare cardiovascular risk factors in diabetic subjects of different ethnic groups, and between new and known diabetic subjects, in the Singapore National Health Survey '92. METHODS:Disproportionate stratified sampling followed by systematic sampling were used in 3568 (total) respondents of whom 2743 were non...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00534-7

    authors： Tan CE,Emmanuel SC,Tan BY,Tai ES,Chew SK

    更新日期：2001-03-01 00:00:00

  • C/EBPβ in bone marrow is essential for diet induced inflammation, cholesterol balance, and atherosclerosis.

    abstract：BACKGROUND AND OBJECTIVE:Atherosclerosis is both a chronic inflammatory disease and a lipid metabolism disorder. C/EBPβ is well documented for its role in the development of hematopoietic cells and integration of lipid metabolism. However, C/EBPβ's role in atherosclerotic progression has not been examined. We assessed ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.03.040

    authors： Rahman SM,Baquero KC,Choudhury M,Janssen RC,de la Houssaye BA,Sun M,Miyazaki-Anzai S,Wang S,Moustaid-Moussa N,Miyazaki M,Friedman JE

    更新日期：2016-07-01 00:00:00

  • Linoleic acid increases monocyte deformation and adhesion to endothelium.

    abstract：:Fatty acids have been implicated in having both anti- or pro-inflammatory actions, which may contribute to the progression and severity of atherosclerosis. Linoleic acid has been shown by others to decrease CD18 expression and leukocyte adhesion under static conditions. We investigated the effect of steric acid (18:0)...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.07.017

    authors： Rinker KD,Kirkpatrick AP,Ting-Beall HP,Shepherd RD,Levin JD,Irick J,Thomas JL,Truskey GA

    更新日期：2004-12-01 00:00:00

  • Characterization of atherosclerosis in a patient with familial high-density lipoprotein deficiency.

    abstract：:We describe the cardiovascular state of a 60-year-old homozygous patient with familial HDL deficiency (Tangier disease). The patient was examined by coronary angiography and intravascular ultrasound because of chest pain at rest and on exertion. We found a normal left ventricular function, moderately diffuse coronary ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90205-4

    authors： Walter M,Kerber S,Fechtrup C,Seedorf U,Breithardt G,Assmann G

    更新日期：1994-10-01 00:00:00

  • Coronary CT angiography versus standard of care strategies to evaluate patients with potential coronary artery disease; effect on long term clinical outcomes.

    abstract：BACKGROUND:Previous studies have shown that computed tomography coronary angiography (CTA) in patients with suspected coronary artery disease (CAD) predicts short term adverse events. However, there is no current data on whether identifying atherosclerosis on CTA impacts outcomes. We performed a case-control study to a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.09.038

    authors： Budoff MJ,Liu S,Chow D,Flores F,Hsieh B,Gebow D,DeFrance T,Ahmadi N

    更新日期：2014-12-01 00:00:00

  • Alcohol consumption and atherosclerotic burden in the proximal thoracic aorta.

    abstract：BACKGROUND:The relationship between alcohol consumption and ischemic stroke or aortic atherosclerosis is unclear, but a protective effect of moderate consumption on stroke risk has been suggested. We conducted a cross-sectional analysis in a population-based sample to evaluate the possible association between alcohol c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.07.129

    authors： Kohsaka S,Jin Z,Rundek T,Homma S,Sacco RL,Di Tullio MR

    更新日期：2011-12-01 00:00:00

  • C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

    abstract：OBJECTIVE:C-reactive protein (CRP) gene variation, in particular an rs2794521 variant was recently associated with type 2 diabetes mellitus (T2DM) in Pima Indians. RESEARCH DESIGN AND METHODS:The present investigation was conducted to replicate this previous association, and to further examine the potential associatio...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.08.013

    authors： Zee RY,Germer S,Thomas A,Raji A,Rhees B,Ridker PM,Lindpaintner K,Williams GH,Nathan DM,Martin M

    更新日期：2008-04-01 00:00:00

  • Protein content and composition of human high density lipoprotein subfractions.

    abstract：:High density lipoprotein (HDL) was fractionated by ion exchange column chromatography using a continuous NaCl gradient of 0.06--0.13 M. It was found that, on the basic C apoprotein content, HDL is comprised of 3 subfractions. All 3 subfractions contain apo A-I and apo A-II but the apo A-I/apo A-II ratio is different i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(79)90034-0

    authors： Rubenstein B

    更新日期：1979-08-01 00:00:00

  • Radiolabeled cholesteryl ethers trace LDL cholesteryl esters but not HDL cholesteryl esters in the rat.

    abstract：:The intravascular metabolism of cholesteryl [1-14C]oleoyl ester and [1,2-3H(N)]cholesteryl palmityl ether was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). The tracers had identical plasma disappearance rates when they were incorporated into human or rat low density ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)05390-5

    authors： Terpstra AH

    更新日期：1995-01-06 00:00:00

  • Infra-renal abdominal aortic calcification volume does not predict small abdominal aortic aneurysm growth.

    abstract：BACKGROUND:Vascular calcification is a common finding in abdominal aortic aneurysms (AAA) however whether it predicts aneurysm expansion is controversial. OBJECTIVES:1) To establish a reproducible method of assessing AAA calcification using computed tomography (CT); 2) To investigate the association between AAA calcif...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.07.027

    authors： Hendy K,Gunnarsson R,Cronin O,Golledge J

    更新日期：2015-11-01 00:00:00

  • Folate status is the major determinant of fasting total plasma homocysteine levels in maintenance dialysis patients.

    abstract：:Limited data are available on the determinants of homocysteinemia or the association between plasma homocysteine (Hcy) levels and prevalent cardiovascular disease (CVD) in maintenance dialysis patients. We assessed etiology of renal failure, residual renal function and dialysis adequacy-related variables, and vitamin ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(96)05809-1

    authors： Bostom AG,Shemin D,Lapane KL,Nadeau MR,Sutherland P,Chan J,Rozen R,Yoburn D,Jacques PF,Selhub J,Rosenberg IH

    更新日期：1996-06-01 00:00:00

  • Oxidisability of low density lipoproteins in patients with carotid or femoral artery atherosclerosis.

    abstract：:Oxidation of low density lipoprotein (LDL) is implicated in the pathogenesis of atherosclerosis. In this study the susceptibility to oxidation of LDL (from patients with atherosclerosis) is related to the progression of the disease. LDL were isolated from 37 patients with demonstrable atherosclerotic plaques. The susc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)05401-4

    authors： Andrews B,Burnand K,Paganga G,Browse N,Rice-Evans C,Sommerville K,Leake D,Taub N

    更新日期：1995-01-06 00:00:00

  • Coronary artery calcium and cardiovascular risk in diabetes.

    abstract：:Measurement of coronary artery calcium score (CACS) by electron beam tomography has been shown to a powerful predictor of coronary heart disease events in asymptomatic non-diabetic subjects. In type 2 diabetes, measurement of CACS was found to be a powerful predictor of cardiovascular events which could enhance predic...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,评审

    doi：10.1016/j.atherosclerosis.2009.11.026

    authors： Elkeles RS

    更新日期：2010-06-01 00:00:00

  • Asymmetrical dimethylarginine (ADMA) and coronary endothelial function in patients with coronary artery disease and mild hypercholesterolemia.

    abstract：OBJECTIVE:To investigate the association of the endogenous nitric oxide synthase inhibitor asymmetrical dimethylarginine (ADMA) and coronary endothelial function. METHODS AND RESULTS:In 289 patients with coronary artery disease we assessed coronary endothelium-dependent and -independent vascular responses to intracoro...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.03.024

    authors： Maas R,Quitzau K,Schwedhelm E,Spieker L,Rafflenbeul W,Steenpass A,Lüscher TF,Böger RH

    更新日期：2007-03-01 00:00:00

  • Sex hormones and high density lipoproteins in healthy males.

    abstract：:The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(79)90067-4

    authors： Nordøy A,Aakvaag A,Thelle D

    更新日期：1979-12-01 00:00:00

  • The atheroprotective role of lipoxin A4 prevents oxLDL-induced apoptotic signaling in macrophages via JNK pathway.

    abstract：BACKGROUND AND AIMS:We examined whether the inflammation resolution mediator lipoxin A4 (LXA4) inhibits foam cell formation and oxidized low-density lipoprotein (oxLDL)-induced apoptotic signaling in macrophages and the role of circulating/local LXA4 biosynthesis in atherogenesis. METHODS:LXA4 levels were measured by ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.09.025

    authors： Mai J,Liu W,Fang Y,Zhang S,Qiu Q,Yang Y,Wang X,Huang T,Zhang H,Xie Y,Lin M,Chen Y,Wang J

    更新日期：2018-11-01 00:00:00

  • Triglycerides and carotid intima-media thickness in ischemic stroke patients.

    abstract：BACKGROUND:Common carotid artery intima-media thickness (CCA-IMT) is an established marker for atherosclerosis. The role of triglycerides in CCA-IMT remains controversial. We sought to determine if elevated fasting and post-challenge triglycerides are associated with CCA-IMT. METHODS:All acute ischemic stroke patients...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.09.003

    authors： Batluk J,Leonards CO,Grittner U,Lange KS,Schreiber SJ,Endres M,Ebinger M

    更新日期：2015-11-01 00:00:00

  • Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study.

    abstract：:Studies on the clinical consequences of different low-density lipoprotein (LDL) receptor genotypes in adult patients have yielded conflicting results. We hypothesized that children with familial hypercholesterolemia (FH) provide a better model to perform genotype-phenotype analyses than adults. We tested this hypothes...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.10.042

    authors： Koeijvoets KC,Wiegman A,Rodenburg J,Defesche JC,Kastelein JJ,Sijbrands EJ

    更新日期：2005-05-01 00:00:00

  • Fractional esterification rate of cholesterol in high density lipoprotein (HDL) can predict the particle size of low density lipoprotein and HDL in patients with coronary heart disease.

    abstract：:Fractional esterification rate of cholesterol in high density lipoprotein (HDL) (FER[HDL]) can predict the size distribution and physicochemical characteristics of HDL in plasma. In the present study, we investigated the correlation of FER(HDL) with the particle size of low density lipoprotein (LDL) (LDL-size) in 111 ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00163-9

    authors： Ohta T,Saku K,Takata K,Nagata N,Maung KK,Matsuda I

    更新日期：1997-12-01 00:00:00

  • Effect of dietary restriction on plasma cholesterol and cholesterol excretion in the White Carneau pigeon.

    abstract：:The effect of short-term dietary restriction on plasma cholesterol and cholesterol balance was examined in young While Carneau pigeons. Dietary restriction of 1 month increased plasma cholesterol significantly and subsequently decreased to initial levels at 3 months. The fecal excretion of neutral sterols was signific...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(76)90143-x

    authors： Subbiah MT,Connelly PW

    更新日期：1976-09-01 00:00:00

  • Paraoxonase 1 (PON1) inhibits monocyte-to-macrophage differentiation.

    abstract：OBJECTIVE:To analyze paraoxonase 1 (PON1) effect on monocyte-to-macrophage differentiation. METHODS AND RESULTS:THP-1 monocytic cell-line and mouse peritoneal macrophages (MPM) were studied. Markers for monocytes differentiation included: morphological changes, CD11b and CD36 expression, and cellular oxidative stress....

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.06.054

    authors： Rosenblat M,Volkova N,Ward J,Aviram M

    更新日期：2011-11-01 00:00:00

  • Passive smoking and mortality from aortic dissection or aneurysm.

    abstract：BACKGROUND AND AIMS:Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. METHODS:The Japan Collaborative Cohort (JACC) Study is a prospective comm...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.06.022

    authors： Kihara T,Yamagishi K,Iso H,Tamakoshi A,JACC Study Group.

    更新日期：2017-08-01 00:00:00