Protein content and composition of human high density lipoprotein subfractions.

abstract：:The aim of this work was to study how CETP expression affects whole body cholesterol homeostasis. Thus, tissue uptake and plasma removal rates of labeled HDL-cholesteryl ester (CE), VLDL secretion rates, and biliary lipid secretion and fecal bile acid content were compared between human CETP transgenic (Tg) and non-tr...

journal_title：Atherosclerosis

authors： Harada LM,Amigo L,Cazita PM,Salerno AG,Rigotti AA,Quintão EC,Oliveira HC

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:In elderly patients traditional cardiovascular (CV) risk factors are poorly correlated with mortality and few data are available on determinants and consequences of supra-ventricular arrhythmia. In a cohort of 331 hospitalized elderly patients (mean age+/-SD=85+/-7 years), we assessed which CV characteristic...

journal_title：Atherosclerosis

authors： Vesin C,Protogerou AD,Lieber A,Safar H,Iaria P,Ducimetière P,Safar ME,Blacher J

更新日期：2009-12-01 00:00:00

abstract：:A solid phase radioimmunoassay (RIA) has been developed for apolipoprotein B (apoB), a major constituent of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in man. Antisera were prepared against apoB in goats and rabbits, coupled to bromoacetyle cellulose, and the complex was incubated with [125I...

journal_title：Atherosclerosis

authors： Thompson GR,Birnbaumer ME,Levy RI,Gotto AM Jr

更新日期：1976-07-01 00:00:00

abstract：:We investigated the possibility that established atherosclerosis and xanthomas in mature WHHL rabbits could be suppressed or even regressed when their serum cholesterol levels were kept extremely low. Ten-month-old WHHL rabbits were divided into 3 groups, i.e. control rabbits, sacrificed at age 10 months, and placebo ...

journal_title：Atherosclerosis

authors： Shiomi M,Ito T,Watanabe Y,Tsujita Y,Kuroda M,Arai M,Fukami M,Fukushige J,Tamura A

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:Lowering low-density lipoprotein cholesterol (LDL-C) with statins reduces cardiovascular events and slows plaque progression. While this therapeutic approach has been reported to favorably modify plaque composition, this is not well characterized in humans. Also, the benefit of achieving LDL-C levels below cu...

journal_title：Atherosclerosis

authors： Kataoka Y,Hammadah M,Puri R,Duggal B,Uno K,Kapadia SR,Murat Tuzcu E,Nissen SE,Nicholls SJ

更新日期：2015-10-01 00:00:00

abstract：:The effect of methyl prednisolone and colchicine on the development of both the early proliferative and advanced atherosclerotic lesion in swine aorta was studied. In order to accelerate the development of atherosclerosis, the abdominal aortic endothelium was partially denuded by a balloon before the animals were plac...

journal_title：Atherosclerosis

authors： Lee WM,Morrison ES,Scott RF,Lee KT,Kroms M

更新日期：1976-11-01 00:00:00

abstract：:The effect of administering blackgram (Phaseolus mungo) fiber (isolated as neutral detergent residue) at the 30% dietary level has been studied with regard to lipid concentration in the tissues and that of biliary and fecal bile acids and sterols. Rats were fed a high fat-cholesterol diet and compared with those fed a...

journal_title：Atherosclerosis

authors： Jayakumari N,Kurup PA

更新日期：1979-05-01 00:00:00

abstract：:Cilostazol is an antiplatelet drug, which has beneficial effects in treatment of intermittent claudication and decreases serum triacyiglycerol level in these patients. In this study, we examined adipogenic potency of cilostazol using 3T3-L1 preadipocyte cell line because cilostazol is one of the tissue specific phosph...

journal_title：Atherosclerosis

authors： Hirose T,Kurebayashi S,Kasayama S

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenu...

journal_title：Atherosclerosis

authors： Ganbaatar B,Fukuda D,Salim HM,Nishimoto S,Tanaka K,Higashikuni Y,Hirata Y,Yagi S,Soeki T,Sata M

更新日期：2018-08-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) is known to be a secretory product of activated macrophages. TNF-alpha activates endothelial cells, stimulates angiogenesis and induces proliferation of smooth muscle cells (SMCs). Therefore, TNF-alpha has been suggested to be actively involved in the inflammatory events associa...

journal_title：Atherosclerosis

authors： Lei X,Buja LM

更新日期：1996-08-23 00:00:00

abstract：:Atherosclerosis is responsible for approximately 50% of all mortalities in the USA, Europe, and Japan. An innovative approach for investigating atherosclerotic lesions using a thermodynamic model and a boundary value model and an analytical example of a human abdominal aorta vessel with an initial lesion are presented...

journal_title：Atherosclerosis

authors： Wang HH

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Toll-like receptor (TLR)-4 signalling has been shown to accelerate atherosclerosis. As oxidised phospholipids are present in atherosclerotic plaque and have been shown to modulate TLR4 signalling, we investigated the role of oxidised 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (OxPAPC) in the reg...

journal_title：Atherosclerosis

authors： Erridge C,Webb DJ,Spickett CM

更新日期：2007-07-01 00:00:00

abstract：:The effect of immunological injury upon the early in vivo changes in aortic connective tissue metabolism was studied. It was found that a single antigen (bovine serum albumin), when administered in multiple doses, activated collagen synthesis and increased the rate of lgycosaminoglycan synthesis in the arterial wall. ...

journal_title：Atherosclerosis

authors： Rokosova B,Bentley JP

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:High homocysteine level is a risk factor for atherosclerosis and has been associated with lacunar infarcts (LIs), white matter lesions (WML) and cognitive dysfunction. It is unclear whether homocysteine is associated with cerebral small vessel disease (cSVD) on top of pre-existent atherosclerosis. We evaluate...

journal_title：Atherosclerosis

authors： Kloppenborg RP,Nederkoorn PJ,van der Graaf Y,Geerlings MI

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Sarpogrelate, a 5-hydroxytryptamine type 2A antagonist, is a potential antiplatelet agent. We performed a randomized study to evaluate the effect of sarpogrelate on vascular health in Korean patients with diabetes. METHODS:Forty diabetic patients aged 58.6 ± 6.8 years with 10-75% coronary artery st...

journal_title：Atherosclerosis

authors： Lee DH,Chun EJ,Hur JH,Min SH,Lee JE,Oh TJ,Kim KM,Jang HC,Han SJ,Kang DK,Kim HJ,Lim S

更新日期：2017-02-01 00:00:00

abstract：:Monocyte chemoattractant protein-1 (MCP-1) recruits monocytes into atherosclerotic plaques. A single nucleotide polymorphism in the MCP-1 gene promoter (-2578A>G) results in greater production of MCP-1 protein. We examined the association of this polymorphism with occult coronary artery disease (CAD) and its interacti...

journal_title：Atherosclerosis

authors： Kim MP,Wahl LM,Yanek LR,Becker DM,Becker LC

更新日期：2007-08-01 00:00:00

abstract：:High serum concentrations of soluble adhesion molecules are present in diabetics, but whether similar levels are present in patients with impaired glucose tolerance (IGT) is unclear. We measured serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), an...

journal_title：Atherosclerosis

authors： Matsumoto K,Miyake S,Yano M,Ueki Y,Tominaga Y

更新日期：2000-10-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) is expressed in atherosclerotic plaques. It is generally recognized that CTGF contributes to atherosclerosis by stimulating vascular smooth muscle cell (VSMC) proliferation and extracellular matrix production during the development of atherosclerosis. Recent studies indicate that...

journal_title：Atherosclerosis

authors： Game BA,He L,Jarido V,Nareika A,Jaffa AA,Lopes-Virella MF,Huang Y

更新日期：2007-05-01 00:00:00

abstract：:Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnormal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese W...

journal_title：Atherosclerosis

authors： Saku K,Yamamoto K,Sakai T,Yanagida T,Hidaka K,Sasaki J,Arakawa K

更新日期：1989-10-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：:83 pairs of twins, aged 50-74 years, were studied with respect to their serum apoproteins (A-I, A-II, B, C-II, C-III and E) and cholesterol concentrations. Each of the variables showed a higher intraclass correlation in the MZ twins than in the DZ twins. HDL cholesterol showed the highest intraclass correlation among ...

journal_title：Atherosclerosis

authors： Hayakawa K,Shimizu T,Ohba Y,Tomioka S

更新日期：1987-07-01 00:00:00

abstract：:The current epidemic of obesity with the associated increasing incidence of insulin resistance, diabetes mellitus and atherosclerosis affecting a large proportion of the North American and Western populations, has generated a strong interest in the potential role of visceral adipose tissue in the development of athero...

journal_title：Atherosclerosis

authors： Alexopoulos N,Katritsis D,Raggi P

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:To evaluate the impact of familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCH) on arterial properties and the effects of statins. METHODS:We meta-analyzed 51 studies providing data for 4,057 FH patients and 732 FCH patients with random-effects models, meta-regression analysis and pu...

journal_title：Atherosclerosis

authors： Masoura C,Pitsavos C,Aznaouridis K,Skoumas I,Vlachopoulos C,Stefanadis C

更新日期：2011-01-01 00:00:00

abstract：:A comparative study was made of 36 aortic enzyme activities (E.A.) and 6 macromelecular substances at different stages of ontogenesis in 49 male rats. In the foetal aorta (19th day) the E.Z. were moderate or weak and restricted to a few metabolic pathways: glycolysis, diaphorases, esterolysis of some nucleotides and g...

journal_title：Atherosclerosis

authors： Hadjiisky P,Renais J,Scebat L

更新日期：1975-07-01 00:00:00

abstract：:Statins produce cholesterol-independent, anti-inflammatory effects, which result at least in part from increased endothelial nitric oxide production. These effects may be modulated by polymorphisms in the endothelial nitric oxide synthase (eNOS) gene. Here, we examined whether the T-786C polymorphism of eNOS gene affe...

journal_title：Atherosclerosis

authors： Souza-Costa DC,Sandrim VC,Lopes LF,Gerlach RF,Rego EM,Tanus-Santos JE

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. Several human studies have detected bacterial DNA corresponding to periodontal pathogens in cardiovascular samples. Intraplaque hemorrhage has been associated with a higher risk of atherosc...

journal_title：Atherosclerosis

authors： Rangé H,Labreuche J,Louedec L,Rondeau P,Planesse C,Sebbag U,Bourdon E,Michel JB,Bouchard P,Meilhac O

更新日期：2014-10-01 00:00:00

abstract：:We present the case of a 42-year-old male with familial hypercholesterolemia (FH) who had received long-term low-density lipoprotein (LDL)-apheresis before death occurred, presumably from an arrhythmia. He had been treated with double filtration plasmapheresis (DFPP) for 4 years and selective LDL adsorbent plasmaphere...

journal_title：Atherosclerosis

authors： Koga N,Iwata Y

更新日期：1991-09-01 00:00:00

abstract：:The elevated carbon monoxide level found in tobacco smokers has been suggested as one etiologic factor linking it with atherosclerosis. Unquestionably carbon monoxide does induce some arterial wall hypoxia, which has been established as an atherogenic factor, but without knowing the extent and location of this hypoxia...

journal_title：Atherosclerosis

authors： Schneiderman G,Goldstick TK

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVE:In addition to being a risk marker for cardiovascular disease, recent data suggests that C-reactive protein (CRP) induces endothelial dysfunction and promotes oxidative stress. We evaluated the effects of two conformers of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) on vessel func...

journal_title：Atherosclerosis

authors： Schwedler SB,Kuhlencordt PJ,Ponnuswamy PP,Hatiboglu G,Quaschning T,Widder J,Wanner C,Potempa LA,Galle J

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Only a few previous studies have investigated endothelium-dependent vasodilation in the metabolic syndrome (MetS). In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, different techniques to assess vasodilation in conduit and resistance arteries were evaluated in relation to the Met...

journal_title：Atherosclerosis

authors： Lind L

更新日期：2008-02-01 00:00:00