Detection and localization of tumor necrosis factor-alpha in WHHL rabbit arteries.

Abstract:

:Tumor necrosis factor-alpha (TNF-alpha) is known to be a secretory product of activated macrophages. TNF-alpha activates endothelial cells, stimulates angiogenesis and induces proliferation of smooth muscle cells (SMCs). Therefore, TNF-alpha has been suggested to be actively involved in the inflammatory events associated with atherosclerosis. Previous ultrastructural and immunocytochemical studies have shown that macrophages as well as SMCs are constituents of atherosclerotic lesions in the Watanabe heritable hyperlipidemic (WHHL) rabbit. Recently, we have shown that TNF-alpha mRNA levels in aorta of 18-month-old WHHL rabbits were significantly higher than that of 6-month-old WHHL rabbits and New Zealand White (NZW) rabbits by quantitative RT-PCR [1]. However, it remains unclear as to the cell type(s) responsible for the increased TNF-alpha mRNA levels in atherosclerotic lesions. In this study, we provided evidence showing the expression of the TNF-alpha gene in the medial SMCs as well as cells of intimal lesions in arteries of WHHL rabbits by in situ transcription (IST). TNF-alpha protein was also detected in the cytoplasm of the intimal and medial SMCs and macrophages by immunocytochemistry using a monoclonal antibody against rabbit TNF-alpha. In contrast, the expression of TNF-alpha mRNA and protein can not be detected in the arteries from healthy New Zealand White (NZW) rabbits. Our results suggest that the expression of TNF-alpha in both intimal and medial SMCs and macrophages is associated with the progression of atherosclerosis.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Lei X,Buja LM

doi

10.1016/0021-9150(96)05863-7

subject

Has Abstract

pub_date

1996-08-23 00:00:00

pages

81-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(96)05863-7

journal_volume

125

pub_type

杂志文章
  • Pre- and post-natal development of lipoprotein lipase and hepatic triglyceride hydrolase activity in rat tissues.

    abstract::The ontogenic development of lipoprotein lipase and liver triglyceride hydrolase was studied in the rat. The enzyme activity measured in extrahepatic tissues fulfilled the criteria of lipoprotein lipase from the onset of measurable activity, i.e. it was inhibited by protamine and 1 M NaCl and showed requirement for se...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(77)90122-8

    authors: Chajek T,Stein O,Stein Y

    更新日期:1977-04-01 00:00:00

  • The prognostic value of the serum eicosapentaenoic acid to arachidonic acid ratio in relation to clinical outcomes after endovascular therapy in patients with peripheral artery disease caused by femoropopliteal artery lesions.

    abstract:BACKGROUND:The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery l...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.02.035

    authors: Hishikari K,Kimura S,Yamakami Y,Kojima K,Sagawa Y,Otani H,Sugiyama T,Kuwahara T,Hikita H,Takahashi A,Isobe M

    更新日期:2015-04-01 00:00:00

  • Ezetimibe improves postprandial hyperlipemia and its induced endothelial dysfunction.

    abstract:OBJECTIVE:Postprandial hyperlipemia has been shown to impair endothelial function and contribute to the development of atherosclerosis. We investigated the association between postprandial lipid profiles and endothelial function, and we examined the effects of ezetimibe on postprandial hyperlipemia and lipemia-induced ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2011.04.019

    authors: Yunoki K,Nakamura K,Miyoshi T,Enko K,Kohno K,Morita H,Kusano KF,Ito H

    更新日期:2011-08-01 00:00:00

  • Removal of fatty acid labelled cholesterol ester, phospholipid and triglyceride from atherosclerotic rabbit aorta in vitro.

    abstract::An organ culture technique was used to investigate the removal of fatty acids incorporated into various lipid fractions in intimal segments of atherosclerotic rabbit aorta. Segments of aorta were pulse-labelled in vitro with [9,10-3H]oleic acid and [1-14C]linoleic acid for 24 h. The incubation medium was replaced with...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(77)90069-7

    authors: Hudson K,Day AJ,Horsch AK

    更新日期:1977-12-01 00:00:00

  • Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm.

    abstract:BACKGROUND:Abdominal aortic aneurysm (AAA) is characterized by vascular remodeling with increased infiltration of inflammatory cells and apoptosis/modulation of vascular smooth muscle cells (SMCs). Imatinib is a selective inhibitor of several tyrosine kinases, including PDGF receptors, Abl, and c-kit. The objective of ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2016.04.006

    authors: Vorkapic E,Dugic E,Vikingsson S,Roy J,Mäyränpää MI,Eriksson P,Wågsäter D

    更新日期:2016-06-01 00:00:00

  • Animal models for Chlamydia pneumoniae infection.

    abstract::Animal models are used extensively in the ongoing investigation of a possible causal link between Chlamydia pneumoniae infection and conditions such as asthma and cardiovascular disease. Respiratory infections have been studied in monkeys, while mouse and rabbit models have been used to study both respiratory and card...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/s0021-9150(98)00115-4

    authors: Saikku P,Laitinen K,Leinonen M

    更新日期:1998-10-01 00:00:00

  • Angiopoietins, abdominal aortic aneurysm and atherosclerosis.

    abstract::Abdominal aortic aneurysm (AAA) and atherosclerosis are common causes of mortality and morbidity in an aging population. Angiogenesis is believed to contribute to the development and progression of these diseases. Angiopoietins (angpts) are known to be important regulators of angiogenesis. Angpts can also influence in...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2010.08.051

    authors: Trollope AF,Golledge J

    更新日期:2011-02-01 00:00:00

  • Kinetics of HDL-apo A-I in the WHHL rabbit, an animal model of familial hypercholesterolemia.

    abstract::Plasma high density lipoproteins (HDL) and their major protein, apolipoprotein (apo) A-I, are deficient in homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits. As the pathophysiology of subnormal HDL-apo A-I is unclear, we examined kinetic parameters of HDL-apo A-I in WHHL rabbits and normolipidemic Japanese W...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(89)90127-5

    authors: Saku K,Yamamoto K,Sakai T,Yanagida T,Hidaka K,Sasaki J,Arakawa K

    更新日期:1989-10-01 00:00:00

  • Infra-renal abdominal aortic calcification volume does not predict small abdominal aortic aneurysm growth.

    abstract:BACKGROUND:Vascular calcification is a common finding in abdominal aortic aneurysms (AAA) however whether it predicts aneurysm expansion is controversial. OBJECTIVES:1) To establish a reproducible method of assessing AAA calcification using computed tomography (CT); 2) To investigate the association between AAA calcif...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.07.027

    authors: Hendy K,Gunnarsson R,Cronin O,Golledge J

    更新日期:2015-11-01 00:00:00

  • Metabolic responses following isoproterenol-induced myocardial infarction in arteriosclerotic breeder vs. non-arteriosclerotic virgin and ovariectomized female rats.

    abstract::Intact and ovariectomized, non-arteriosclerotic female rats and arteriosclerotic, breeder female rats were subjected to myocardial infarction by the administration of 2 subcutaneous injections, 24 hr apart, of the beta-adrenergic stimulator, isoproterenol. The animals were sacrificed at regular hourly intervals follow...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(75)90049-0

    authors: Lewis BK,Wexler BC

    更新日期:1975-05-01 00:00:00

  • Cholesterol efflux capacity is impaired in subjects with an elevated Fatty Liver Index, a proxy of non-alcoholic fatty liver disease.

    abstract:BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) parallels the obesity epidemic and associates with components of the metabolic syndrome (MetS). Cholesterol efflux capacity (CEC) represents a key metric of high density lipoprotein (HDL) function which may predict atherosclerotic cardiovascular disease (CVD...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.07.028

    authors: van den Berg EH,Gruppen EG,Ebtehaj S,Bakker SJL,Tietge UJF,Dullaart RPF

    更新日期:2018-10-01 00:00:00

  • Elevated serum uric acid is associated with peripheral endothelial dysfunction in women.

    abstract:BACKGROUND AND AIMS:Both elevated serum uric acid (SUA) and peripheral endothelial dysfunction (PED) are associated independently with cardiovascular disease (CVD). However, the association between SUA and PED is yet to be established. We hypothesized that high normal range of SUA is associated with PED. METHODS:We pe...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2019.07.013

    authors: Taher R,Sara JD,Prasad M,Kolluri N,Toya T,Lerman LO,Lerman A

    更新日期:2019-11-01 00:00:00

  • Conjugated and non-conjugated octadecaenoic acids affect differently intestinal acyl coenzyme A: cholesterol acyltransferase activity.

    abstract::We investigated the relative hypocholesterolemic activity of linoleic acid (LA), conjugated linoleic acid (CLA), alpha-linolenic acid (LN) and conjugated linolenic acid (CLN) in hamsters. Five groups of hamsters (n=10 each) were fed either the control diet or one of the four fatty acids-supplemented diets for 6 weeks....

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2007.11.001

    authors: Lam CK,Chen J,Cao Y,Yang L,Wong YM,Yeung SY,Yao X,Huang Y,Chen ZY

    更新日期:2008-05-01 00:00:00

  • Vitamin D modulates the association of circulating insulin-like growth factor-1 with carotid artery intima-media thickness.

    abstract:OBJECTIVE:Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological s...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.08.022

    authors: Ameri P,Canepa M,Fabbi P,Leoncini G,Milaneschi Y,Mussap M,AlGhatrif M,Balbi M,Viazzi F,Murialdo G,Pontremoli R,Brunelli C,Ferrucci L

    更新日期:2014-10-01 00:00:00

  • Species variation in ABCG1 isoform expression: implications for the use of animal models in elucidating ABCG1 function.

    abstract::The ATP-binding cassette transporter G1 (ABCG1) plays an important role in reverse cholesterol transport by exporting cholesterol to high density lipoproteins (HDL). Two major ABCG1 isoforms exist in humans, which differ by the presence or absence of twelve amino acids between the ATP cassette and the transmembrane do...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2012.12.009

    authors: Burns V,Sharpe LJ,Gelissen IC,Brown AJ

    更新日期:2013-02-01 00:00:00

  • Cholesterol absorption efficiency and sterol metabolism in obesity.

    abstract::Role of enterohepatic cholesterol metabolism in obesity-induced increase of cholesterol synthesis was studied in healthy lean (BMI <24) and overweight (BMI >31) subjects by measuring serum lipids (including plant sterols, cholestanol and cholesterol precursors), cholesterol absorption % (double-label method), sterol b...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00404-4

    authors: Miettinen TA,Gylling H

    更新日期:2000-11-01 00:00:00

  • Circulating malondialdehyde-modified LDL and atherogenic lipoprotein profiles measured by nuclear magnetic resonance spectroscopy in patients with coronary artery disease.

    abstract:OBJECTIVE:Recent studies have suggested that circulating malondialdehyde-modified low-density lipoprotein (MDA-LDL) is a useful marker for the identification of patients with coronary artery disease (CAD). However, the role of MDA-LDL in atherogenic mechanisms has not yet been fully determined. METHOD AND RESULTS:We i...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.09.013

    authors: Miyazaki T,Shimada K,Sato O,Kotani K,Kume A,Sumiyoshi K,Sato Y,Ohmura H,Watanabe Y,Mokuno H,Daida H

    更新日期:2005-03-01 00:00:00

  • Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

    abstract::ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, significantly reduced both serum cholesterol and phospholipid levels in dogs, when used at a dosage higher than 10 mg/kg per day. Triglyceride levels were not consistently changed, but beta- and pre-beta-lipoproteins were preferentially redu...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(79)90174-6

    authors: Tsujita Y,Kuroda M,Tanzawa K,Kitano N,Endo A

    更新日期:1979-03-01 00:00:00

  • Ticagrelor, a P2Y12 antagonist, attenuates vascular dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient mice.

    abstract:BACKGROUND AND AIMS:Ticagrelor reduces cardiovascular events in patients with acute coronary syndrome (ACS). Recent studies demonstrated the expression of P2Y12 on vascular cells including endothelial cells, as well as platelets, and suggested its contribution to atherogenesis. We investigated whether ticagrelor attenu...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.05.053

    authors: Ganbaatar B,Fukuda D,Salim HM,Nishimoto S,Tanaka K,Higashikuni Y,Hirata Y,Yagi S,Soeki T,Sata M

    更新日期:2018-08-01 00:00:00

  • Role of transglutaminases in cuff-induced atherosclerotic lesion formation in femoral arteries of ApoE3 Leiden mice.

    abstract:UNLABELLED:Transglutaminases play an important role in vascular remodeling, calcification, cell adhesion and endothelial barrier function. In this study we investigate the influence of combined inhibition of both tissue-type transglutaminase (TG2) and the plasma transglutaminase FXIIIA on early lesion development. MET...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2010.07.054

    authors: Matlung HL,VanBavel E,van den Akker J,de Vries CJ,Bakker EN

    更新日期:2010-11-01 00:00:00

  • Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study.

    abstract::The fatty acid composition of adipose tissue from 4114 men and women across 22 districts of Scotland is described. A biopsy of subcutaneous adipose tissue was obtained from the upper arm using a skin biopsy punch. Overall the proportion of saturated fatty acids was lower in women and those of monounsaturated and polyu...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(92)90241-8

    authors: Tavendale R,Lee AJ,Smith WC,Tunstall-Pedoe H

    更新日期:1992-06-01 00:00:00

  • Inverse relationship between cardiorespiratory fitness and carotid atherosclerosis.

    abstract::The association between cardiorespiratory fitness (VO2max) and carotid atherosclerosis was analyzed in 163 men, aged 50 to 60 years. VO2max was assessed using breath-by-breath respiratory gas analyses during maximal exercise stress test. Atherosclerosis was evaluated quantitatively as intima-media thickness (IMT) of t...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)05416-g

    authors: Rauramaa R,Rankinen T,Tuomainen P,Väisänen S,Mercuri M

    更新日期:1995-01-20 00:00:00

  • Cardiorespiratory fitness and coronary artery calcification in young adults: The CARDIA Study.

    abstract::Whether cardiorespiratory fitness relates to early subclinical atherosclerotic vascular disease remains unknown. We investigated the relation of cardiorespiratory fitness to coronary artery calcification (CAC) in 2373 African-American and White young adults from the Coronary Artery Risk Development in Young Adults (CA...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2008.06.012

    authors: Lee CD,Jacobs DR Jr,Hankinson A,Iribarren C,Sidney S

    更新日期:2009-03-01 00:00:00

  • The novel adipokine CTRP1 is significantly associated with the incidence of major adverse cardiovascular events.

    abstract:BACKGROUND AND AIMS:The recently identified adiponectin paralogue C1q and tumor necrosis factor-related protein 1 (CTRP1) has been associated with obesity-linked disorders and coronary atherosclerosis. So far, the impact of circulating CTRP1 on the incidence of future cardiovascular events is unclear. Therefore, we aim...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2019.04.222

    authors: Muendlein A,Leiherer A,Saely C,Ebner J,Geiger K,Brandtner EM,Vonbank A,Fraunberger P,Drexel H

    更新日期:2019-07-01 00:00:00

  • Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis.

    abstract:OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.atherosclerosis.2011.06.044

    authors: Inaba Y,Chen JA,Bergmann SR

    更新日期:2012-01-01 00:00:00

  • Rebound inflammatory response during the acute phase of myocardial infarction after simvastatin withdrawal.

    abstract:OBJECTIVE:The present study aimed to verify the existence of a rebound inflammatory effect after statin withdrawal in the acute phase of myocardial infarction (MI). METHODS:In a prospective observational cohort, changes in C-reactive protein (CRP) between the first and the fifth day after MI were evaluated in 249 cons...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2009.04.008

    authors: Sposito AC,Carvalho LS,Cintra RM,Araújo AL,Ono AH,Andrade JM,Coelho OR,Quinaglia e Silva JC,Brasilia Heart Study Group.

    更新日期:2009-11-01 00:00:00

  • Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease.

    abstract::In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 yea...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(95)05591-j

    authors: Sanderson KJ,van Rij AM,Wade CR,Sutherland WH

    更新日期:1995-11-01 00:00:00

  • The HMG-CoA reductase inhibitor rosuvastatin inhibits plasminogen activator inhibitor-1 expression and secretion in human adipocytes.

    abstract::Human preadipocytes and adipocytes are known to produce the proatherogenic factor PAI-1 and proinflammatory cytokines, and obesity was found to be state of increased adipose production of these factors. In the present study, we investigated the effect of rosuvastatin on the regulation of PAI-1 gene expression in human...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2007.06.005

    authors: Laumen H,Skurk T,Hauner H

    更新日期:2008-02-01 00:00:00

  • APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease.

    abstract::Variation in the APOA5 gene has been shown to be associated with triglyceride levels in several independent population studies. It was our objective to determine if a relationship existed between selected genotypes or haplotypes of the APOA5 gene and findings on selective coronary angiography (SCA) in an independent c...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.04.024

    authors: Lee KW,Ayyobi AF,Frohlich JJ,Hill JS

    更新日期:2004-09-01 00:00:00

  • Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?

    abstract::The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages. Macrophages from human atherosclerotic subjects (n=15) showed elevate...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.03.020

    authors: Hägg D,Sjöberg S,Hultén LM,Fagerberg B,Wiklund O,Rosengren A,Carlsson LM,Borén J,Svensson PA,Krettek A

    更新日期:2007-02-01 00:00:00