Visceral adipose tissue as a source of inflammation and promoter of atherosclerosis.

abstract：:Endurance exercise training is known to produce favorable changes in the metabolic profile including reduced plasma triglyceride (TG) and increased high-density lipoprotein (HDL) cholesterol concentrations. These metabolic improvements are likely to contribute to the reduced coronary heart disease (CHD) risk often obs...

journal_title：Atherosclerosis

authors： Bergeron J,Couillard C,Després JP,Gagnon J,Leon AS,Rao DC,Skinner JS,Wilmore JH,Bouchard C

更新日期：2001-12-01 00:00:00

abstract：:The arterial endothelial intercellular cleft (AEC) and its associated junctional complex (JC) are the determinants of permeability to macromolecules. This study analyzed frequencies of AEC and JC profile types in the rat thoracic aorta at 1 and 12 months after feeding the animals with a normal or a high-cholesterol di...

journal_title：Atherosclerosis

authors： Lee WC,Chao WT,Yang VC

更新日期：2001-04-01 00:00:00

abstract：:Advanced glycation end-products (AGEs), a group of carbohydrate-derived compounds formed by non-enzymatic glycation and oxidation, are markedly elevated in end-stage renal disease (ESRD) and may be related to both inflammation and oxidative stress. The cellular effects of AGE are largely mediated by their interaction ...

journal_title：Atherosclerosis

authors： Rodríguez-Ayala E,Anderstam B,Suliman ME,Seeberger A,Heimbürger O,Lindholm B,Stenvinkel P

更新日期：2005-06-01 00:00:00

abstract：AIM:To determine the prevalence of non-fatal coronary artery disease (CAD) in kindred with Familial Combined Hyperlipidemia (FCHL) in relation to various cardiovascular risk factors and DNA variation in the apo AI-CIII-AIV gene cluster. METHODS AND RESULTS:Data were collected from 18 Dutch FCHL probands, 202 living fi...

journal_title：Atherosclerosis

authors： Voors-Pette C,de Bruin TW

更新日期：2001-08-01 00:00:00

abstract：:Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...

journal_title：Atherosclerosis

authors： Fernandez AZ,López F,Tablante A,Romano E,Hurt-Camejo E,Camejo G,Apitz-Castro R

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Recent studies indicate that subclavian stenosis (SS), diagnosed by a large systolic blood pressure difference (SBPD) between the right and left brachial arteries, is associated with cardiovascular disease (CVD) risk factors and outcomes. We sought to describe the epidemiology of SS and determine its associa...

journal_title：Atherosclerosis

authors： Aboyans V,Kamineni A,Allison MA,McDermott MM,Crouse JR,Ni H,Szklo M,Criqui MH

更新日期：2010-07-01 00:00:00

abstract：:The effects of the artificial triglyceride-phospholipid emulsion (10% intralipid) on HDL subfraction were studied in vivo. After a 14-h fast, subjects received intralipid via a 4-h infusion. Serum lipoproteins were analyzed before and at 4 and 6 h after the start of the infusion. At 4-h the following acute changes by ...

journal_title：Atherosclerosis

authors： Sakuma N,Lin C,Matsumoto Y,Ikeuchi R,Ichikawa T,Hirata H,Noguchi Y,Fujinami T

更新日期：1988-11-01 00:00:00

abstract：:Vascular endothelial cell death contributes to the progression of atherosclerotic lesion, and several transcriptional regulators are involved in the process. Activating transcription factor 3/liver regenerating factor-1 (ATF3/LRF-1), a stress-inducible transcriptional repressor, was shown to be highly expressed in vas...

journal_title：Atherosclerosis

authors： Nawa T,Nawa MT,Adachi MT,Uchimura I,Shimokawa R,Fujisawa K,Tanaka A,Numano F,Kitajima S

更新日期：2002-04-01 00:00:00

abstract：:Homocysteine may promote atherogenesis and thrombogenesis by enhancing leukocyte-endothelium interactions. We explored this hypothesis in an acute hyperhomocysteinemia rat model, which was created by a continuous venous homocysteine infusion (4 ml/h/kg body weight) with 2.5 and 10 mg/ml D,L-homocysteine upto 90 min. V...

journal_title：Atherosclerosis

authors： Fu WY,Dudman NP,Perry MA,Wang XL

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C→G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation is regulated by epinephrine...

journal_title：Atherosclerosis

authors： Ranganathan G,Unal R,Pokrovskaya ID,Tripathi P,Rotter JI,Goodarzi MO,Kern PA

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To determine whether endogenous sex hormones (estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)) are longitudinally associated with progression of atherosclerosis among women at midlife. METHODS:249 Pre- or early peri-menopausal women (42-57 years) ...

journal_title：Atherosclerosis

authors： El Khoudary SR,Wildman RP,Matthews K,Thurston RC,Bromberger JT,Sutton-Tyrrell K

更新日期：2012-11-01 00:00:00

abstract：:Atherosclerotic calcification may weaken the aorta wall and thereby lead to rupture of the vessel. The mechanism whereby aortas undergo calcification remains unclear. Previous reports in this laboratory showed that, after 2 months of cholesterol-supplemental feeding, an increase in calcifiability of membrane vesicles ...

journal_title：Atherosclerosis

authors： Hsu HH,Camacho NC,Tawfik O,Sun F

更新日期：2002-03-01 00:00:00

abstract：:Men with ankylosing spondylitis (AS) and females with systemic lupus erythematosus (SLE) were found to have low total serum lipid concentrations similar to results previously obtained in patients with rheumatoid arthritis (RA). In AS men total serum TG was about 50% of control values and in AS men and SLE women total ...

journal_title：Atherosclerosis

authors： Rössner S

更新日期：1978-09-01 00:00:00

abstract：:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...

journal_title：Atherosclerosis

authors： Rosenthal T,Holtzman E,Segal P

更新日期：1980-05-01 00:00:00

abstract：:We studied the effect of gemfibrozil on the compositions of VLDL, LDL and distribution of LDL subspecies in type II hyperlipidemic patients. Gemfibrozil significantly lowered serum triglyceride levels in this group of patients who had normal to moderately elevated triglyceride prior to therapy. Gemfibrozil also change...

journal_title：Atherosclerosis

authors： Tsai MY,Yuan J,Hunninghake DB

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. ...

journal_title：Atherosclerosis

authors： do Vale GT,Simplicio JA,Gonzaga NA,Yokota R,Ribeiro AA,Casarini DE,de Martinis BS,Tirapelli CR

更新日期：2018-07-01 00:00:00

abstract：:Hypercholesterolemia impairs endothelial function. However, the production/release of nitric oxide from the hypercholesterolemic aorta is reported to be enhanced rather than impaired in animal studies. L-arginine improves endothelial function in hypercholesterolemic subjects. The goal of the present study was to inves...

journal_title：Atherosclerosis

authors： Kawano H,Motoyama T,Hirai N,Kugiyama K,Yasue H,Ogawa H

更新日期：2002-04-01 00:00:00

abstract：:Hypertension is associated with an increased incidence of generalized vascular disease. Antihypertensive drug therapy, while decreasing overall mortality due to cerebral hemorrhage, myocardial hypertrophy or renal failure, paradoxically does not appear to reduce the incidence of coronary atherosclerosis. This study in...

journal_title：Atherosclerosis

authors： Bailey JM,Randazzo R

更新日期：1977-01-01 00:00:00

abstract：:The effect of the apolipoprotein C-II/C-III1 ratio on the capacity of purified bovine milk lipoprotein lipase to hydrolyse triglycerides was measured in a controlled model of pyrene-labeled nonanoyltriglycerides (1-2 ditetradecyl 3-pyrene nonanoyl glyceride) monolayer vesicles. Monolayer was composed of triglycerides,...

journal_title：Atherosclerosis

authors： Lambert DA,Catapano AL,Smith LC,Sparrow JT,Gotto AM Jr

更新日期：1996-12-20 00:00:00

abstract：:The postheparin plasma lipoprotein lipase (LPL) activity and plasma HDL and LDL cholesterol concentrations, decreases significantly during probucol treatment of the rat. The reduction of the LPL activity obviously took place in adipose tissue. The activity of hepatic lipase and the in vitro synthesis of cholesterol in...

journal_title：Atherosclerosis

authors： Strandberg T,Kuusi T,Tilvis R,Miettinen TA

更新日期：1981-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Recent studies have unveiled an association between ADAMTS7 gene variation and coronary artery disease (CAD) caused by atherosclerosis. We investigated if the ADAMTS7 Serine214-to-Proline substitution arising from a CAD-associated variant affected angiogenesis, since neovascularization plays an impo...

journal_title：Atherosclerosis

authors： Pu X,Chan K,Yang W,Xiao Q,Zhang L,Moore AD,Liu C,Webb TR,Caulfield MJ,Samani NJ,Zhu J,Ye S

更新日期：2020-03-01 00:00:00

abstract：:Plasma cholesterol was lower in spontaneously hypertensive rats (SHR), while plasma triglyceride and free fatty acid were increased in comparison with control normotensive Wistar-Kyoto (WK) rats. Correspondingly, [1-14C]-acetate incorporation into liver cholesterol was clearly decreased in SHR as compared with WK. As ...

journal_title：Atherosclerosis

authors： Iritani N,Fukuda E,Nara Y,Yamori Y

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Non-invasive surrogates of cardiovascular (CV) disease such as endothelial dysfunction (ED) and peripheral arterial stiffness (AS) have been evaluated in systemic lupus erythematosus (SLE) patients. The aim of this study was to systematically review and meta-analyze reports of cardiovascular disease...

journal_title：Atherosclerosis

authors： Mendoza-Pinto C,Rojas-Villarraga A,Molano-González N,García-Carrasco M,Munguía-Realpozo P,Etchegaray-Morales I,Morales-Sánchez H,Berra-Romani R,Cervera R

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To investigate associations between blood low-density lipoprotein cholesterol (LDL-C) levels and the prevalence of acquired color vision impairment (ACVI) in middle-aged Japanese men. METHODS:Participants in this cross-sectional study underwent color vision testing, ophthalmic examination, a standardized int...

journal_title：Atherosclerosis

authors： Shoji T,Sakurai Y,Sato H,Chihara E,Ishida M,Omae K

更新日期：2010-06-01 00:00:00

abstract：:The association between cigarette smoking and atherogenesis is well established. Inflammatory cells may participate in atherogenesis via activation of the NADPH oxidase and the subsequent production of reactive oxygen species (ROS), which exacerbates endothelial injury. However, little is known about the ability of ci...

journal_title：Atherosclerosis

authors： Dunn JS,Freed BM,Gustafson DL,Stringer KA

更新日期：2005-04-01 00:00:00

abstract：:To study the association of alcohol consumption and lipid-based cardiovascular risk factors among middle-age women, cross-sectional analysis among 274 middle-aged healthy women with different drinking habits and a follow-up analysis of alcoholic women during abstinence was performed. Serum total cholesterol, low and h...

journal_title：Atherosclerosis

authors： Sillanaukee P,Koivula T,Jokela H,Pitkäjärvi T,Seppä K

更新日期：2000-10-01 00:00:00

abstract：BACKGROUND:Soluble intercellular adhesion molecule-1 (sICAM-1) is a transmembrane protein involved in the migration and adhesion of leukocytes to the vascular endothelium. While some studies indicate that elevated baseline sICAM-1 levels predict cardiovascular events, most of these studies were done in men; moreover, u...

journal_title：Atherosclerosis

authors： Albert MA,Glynn RJ,Buring JE,Ridker PM

更新日期：2008-03-01 00:00:00

abstract：:In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent ...

journal_title：Atherosclerosis

authors： Scott RF,Thomas WA,Lee WM,Reiner JM,Florentin RA

更新日期：1979-11-01 00:00:00

abstract：:Hypertriglyceridemia affects approximately 33% of the US population. Elevated triglyceride levels are independently associated with cardiovascular disease (CVD) risk, and severe hypertriglyceridemia is a risk factor for acute pancreatitis. Guidelines for the management of severe hypertriglyceridemia (≥5.6 mmol/L [≥500...

journal_title：Atherosclerosis

authors： Ito MK

更新日期：2015-10-01 00:00:00

abstract：:The relations between triglyceride-rich lipoproteins, alimentary lipaemia and coronary heart disease (CHD) have remained obscure and much debated. We studied the basal and postprandial plasma levels of chylomicron remnants and very low density lipoproteins (VLDL) of varying particle size in 32 male postinfarction pati...

journal_title：Atherosclerosis

authors： Karpe F,Steiner G,Uffelman K,Olivecrona T,Hamsten A

更新日期：1994-03-01 00:00:00