Abstract:
:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased. Our findings suggest that chlorthalidone increases serum concentrations of "atherogenic" lipoproteins (LDL and VLDL), and possibly decreases the levels of a "beneficial" lipoprotein, namely HDL. Thus, the use of this medication may increase a major atherosclerosis risk factor.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Rosenthal T,Holtzman E,Segal Pdoi
10.1016/0021-9150(80)90204-xsubject
Has Abstractpub_date
1980-05-01 00:00:00pages
111-5issue
1eissn
0021-9150issn
1879-1484pii
0021-9150(80)90204-Xjournal_volume
36pub_type
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