The effect of chlorthalidone on serum lipids and lipoproteins.

Abstract:

:The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased. Our findings suggest that chlorthalidone increases serum concentrations of "atherogenic" lipoproteins (LDL and VLDL), and possibly decreases the levels of a "beneficial" lipoprotein, namely HDL. Thus, the use of this medication may increase a major atherosclerosis risk factor.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Rosenthal T,Holtzman E,Segal P

doi

10.1016/0021-9150(80)90204-x

subject

Has Abstract

pub_date

1980-05-01 00:00:00

pages

111-5

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(80)90204-X

journal_volume

36

pub_type

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