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Distribution of intimal smooth muscle cell masses and their relationship to early atherosclerosis in the abdominal aortas of young swine.

Abstract：

:In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent in the ventral quandrant than in the dorsal or either lateral quadrant. In the proximal half, intimal cell masses are more frequent in the dorsal quadrant. When experimental atherosclerosis is induced in the abdominal aortas of young swine by either a hypercholesterolemic diet or by aortic ballooning followed by a hypercholesterolemic diet, the distribution of early lesions is similar. The lesions are found predominantly in quadrants where intimal cell masses were found to be most frequent in the control group of swine. The results suggest that most of the lesions, though not necessarily all, arose from pre-existing intimal cell masses beneath the aortic surface.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Scott RF,Thomas WA,Lee WM,Reiner JM,Florentin RA

doi

10.1016/s0021-9150(79)80007-6

subject

Has Abstract

pub_date

1979-11-01 00:00:00

pages

291-301

issue

3

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(79)80007-6

journal_volume

34

pub_type

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