当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > In concomitant coronary and peripheral arterial disease, inflammation of the affected limbs predicts coronary artery endothelial dysfunction.

In concomitant coronary and peripheral arterial disease, inflammation of the affected limbs predicts coronary artery endothelial dysfunction.

Abstract：

BACKGROUND:In coronary artery disease (CAD), concomitant peripheral arterial disease (PAD) entails more severe coronary atherosclerosis. We investigated whether the inflammatory status of affected limbs impairs coronary artery endothelial function (CAEF). METHODS:We measured the neutrophil myeloperoxidase content (NMPOxC) and plasma levels of interleukin-6 and C-reactive protein in the aorta, femoral vein, and coronary sinus of 22 CAD+PAD and 18 CAD-alone patients. CAEF was assessed by the cold pressure test. Human coronary artery endothelial cells (HCAECs) were incubated with serum from the femoral vein and aorta of CAD+PAD patients to determine whether blood leaving the affected limb activates HCAECs. RESULTS:In CAD+PAD patients, NMPOxC was higher across the femoral circulation than across the coronary circulation (p<0.01); it was also higher than across healthy femoral circulation of CAD patients (p<0.01). These findings apply also to interleukin-6, but not to C-reactive protein. The transfemoral gradient of NMPOxC and interleukin-6 significantly correlated with CAEF. The NMPOxC/CAEF relationship was much greater after exercise (R=0.79, p<0.001), which increased neutrophil activation across the affected circulation. The post-exercise association remained significant after adjustment for potential confounders (p<0.01). Serum from the affected limb of CAD+PAD patients induced, in vitro, a significant release of MCP-1 from HCAECs versus serum from the aorta of the same patients (630 [550-740] vs. 547 [490-620]; p<0.05). CONCLUSIONS:In CAD+PAD, triggers from the affected circulation may activate the endothelium at distant sites. Thus, PAD, besides being a marker of cardiovascular risk, could exert a mechanistic function in CAD progression.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Brevetti G,Piscione F,Cirillo P,Galasso G,Schiano V,Barbato E,Scopacasa F,Chiariello M

doi

10.1016/j.atherosclerosis.2008.01.014

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

440-6

issue

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(08)00079-8

journal_volume

201

pub_type

杂志文章

在线工具

In concomitant coronary and peripheral arterial disease, inflammation of the affected limbs predicts coronary artery endothelial dysfunction.