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Wall shear stress is lower in the carotid artery responsible for a unilateral ischemic stroke.

Abstract：

:According to the focal nature of atherosclerosis, ischemic stroke is frequently unilateral. Atherosclerotic plaques are favoured by local hemodynamic factors as low wall shear stress and/or elevated circumferential wall tension. Aim of the present study was to investigate the possible association between hemodynamic forces and cerebrovascular disease. Common carotid mean wall shear stress and circumferential wall tension, Peterson's elastic modulus, and blood flow were measured in 25 patients with a recent unilateral large-artery stroke presenting non-stenotic plaques of the carotid arteries (large-artery group), and in 10 patients affected by a recent unilateral cardioembolic stroke without carotid plaques (cardioembolic group). In the large-artery group, atherosclerosis was slightly more evident in the side of cerebral ischemia. All hemodynamic factors were more unfavourable at the affected side in this group (shear stress: 6.2+/-3.0 versus 8.6+/-4.0 dynes/cm2, p<0.0001; wall tension: (7.3+/-1.3)x10(4) versus (6.6+/-1.3)x10(4) dynes/cm, p<0.00001; Peterson's modulus: (16.8+/-11.9)x10(5) versus (12.4+/-5.7)x10(5) dynes/cm2, p=0.06). No difference was detectable in blood flow and in cardioembolic group. The present data demonstrate an unfavourable hemodynamic profile in the common carotid artery supplying the area of a single large-artery stroke and might help to explain the frequent one-sidedness of this disease.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Carallo C,Lucca LF,Ciamei M,Tucci S,de Franceschi MS

doi

10.1016/j.atherosclerosis.2005.05.019

keywords:

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

108-13

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(05)00352-7

journal_volume

185

pub_type

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