Abstract:
OBJECTIVE:We examined the use of lipid lowering medications and control of dyslipidemia among US adults in 1999-2006. METHODS:Data were extracted from the National Health and Nutrition Examination Survey 1999-2006. RESULTS:The mean low-density lipoprotein-cholesterol (LDL-C) level significantly decreased from 3.25+/-0.03 mmol/L in 1999-2002 to 3.02+/-0.02 mmol/L in 2003-2006 in men, and from 3.11+/-0.03 to 2.98+/-0.03 mmol/L in women (p<0.001). Statins and fibrates were the most commonly used medications. Among those diagnosed with hypercholesterolemia, the proportion on treatment increased from 32.4% to 38.9% (p=0.001) in the 8-year period. The proportion of participants with a history of diabetes treated with a statin increased from 20.9+/-2.2% in 1999-2002 to 37.6+/-2.5% in 2003-2006 (p<0.001). However, only 39.9% of people with diabetes and 45.4% of people with ischemic heart disease (IHD) achieved LDL-C target levels. CONCLUSIONS:Between 1999 and 2006, LDL-C level decreased in US adults and use of lipid lowering medications increased. More effort is still needed to detect and treat dyslipidemia in the community, particularly in people at high cardiovascular risk.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Li M,Ong KL,Tse HF,Cheung BMdoi
10.1016/j.atherosclerosis.2009.08.001subject
Has Abstractpub_date
2010-02-01 00:00:00pages
456-60issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(09)00622-4journal_volume
208pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract:BACKGROUND AND AIMS:Treatment of severe peripheral arterial occlusive disease requires percutaneous revascularization. However, little is known about risk factors or predictors for reocclusion/restenosis. Cysteinyl leukotrienes are highly bioactive lipid mediators of inflammation. Their intravascular production may tak...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.04.013
更新日期:2016-06-01 00:00:00
abstract:AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.06.018
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To investigate cross-sectional and longitudinal associations between serum total bilirubin (TB) and dyslipidemia. METHODS:Odds ratios (ORs) of prevalent dyslipidemia for TB were calculated in 2113 men and 1265 women. Correlation coefficients between baseline TB as well as the change in TB over 5 years and ba...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.12.053
更新日期:2015-03-01 00:00:00
abstract::Serum HDL-cholesterol (HDLc) levels were studied on 2399 healthy urban inhabitants, from newborn to 78 years of age, in Shanghai. The results were as follows. (1) Frequency distribution of serum HDLc levels in most groups was approximately normal after age 20. (2) The serum HDLc levels and HDLc/total cholesterol ratio...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(83)90018-7
更新日期:1983-07-01 00:00:00
abstract::Mild hyperhomocysteinemia is considered an important risk factor for vascular disease. A common polymorphism (677C-->T) in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with a decreased enzyme activity and consequent higher circulating levels of homocysteine. We hypothesized that the serum levels ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.10.016
更新日期:2005-04-01 00:00:00
abstract::Statins are widely used for treatment of hypercholesterolemia. Recent experimental studies revealed that these drugs also exert anti-inflammatory effects. The aim of this study was to assess immunomodulatory effects of statins in humans in vivo. Twenty-seven healthy volunteers were analyzed for serum cytokines and acu...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.atherosclerosis.2004.02.016
更新日期:2004-07-01 00:00:00
abstract::The effect of short-term dietary restriction on plasma cholesterol and cholesterol balance was examined in young While Carneau pigeons. Dietary restriction of 1 month increased plasma cholesterol significantly and subsequently decreased to initial levels at 3 months. The fecal excretion of neutral sterols was signific...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(76)90143-x
更新日期:1976-09-01 00:00:00
abstract::The effect of guar (15.6 g/day), a dietary fibre, and simultaneous administration of bezafibrate (600 mg/day) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia (corresponding to the HLP type IIa pattern). Either bezafibrate alone...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0021-9150(82)90230-1
更新日期:1982-12-01 00:00:00
abstract::The effect of 4 months of low-dose probucol treatment (250 mg/day) on LDL oxidation and on plasma-HDL cholesterol was studied in a prospective, double-blind, randomized, placebo-controlled trial involving 26 male volunteers. LDL samples isolated at baseline and at 4 months were subjected to in vitro tests of LDL oxida...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0021-9150(92)90046-j
更新日期:1992-11-01 00:00:00
abstract::Coronary arteries with and without atheroma are compared histologically to ask what kind of artery encourages atheroma. When atheroma obliterates the structures that preceded and invited its intrusion, the sites remaining for observation form a censored data set. How to assess media-like island effects using the censo...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2004.08.011
更新日期:2005-01-01 00:00:00
abstract::The oxidation of low density lipoprotein (LDL) is believed to be an important process in the development and progression of atherosclerosis. In this study, human subjects were supplemented daily with one of: 6 g raw garlic; 2.4 g aged garlic extract (AGE); or 0.8 g DL-alpha-tocopherol acetate for 7 days to determine t...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0021-9150(98)00293-7
更新日期:1999-04-01 00:00:00
abstract::To test the hypothesis of altered energy production in aortic sites predisposed to lesion formation, both coupled oxidative phosphorylation (evaluated from P/O ratios) and control of the energy-linked (ATP) NADH transhydrogenase were examined in muscular cushions at the celiac artery bifurcation. Comparisons were made...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(80)90230-0
更新日期:1980-06-01 00:00:00
abstract::Atherosclerosis causing cardiovascular disease is the most common cause of death in the developed world. Early precursors of vascular changes - subclinical atherosclerosis - warrant special attention as this process can be stabilized or even reversed if treated in time. Sonographic Intima Media Thickness measurement o...
journal_title:Atherosclerosis
pub_type: 杂志文章,实务指引,评审
doi:10.1016/j.atherosclerosis.2014.12.029
更新日期:2015-02-01 00:00:00
abstract::The involvement of endothelium-derived hyperpolarizing factor (EDHF) in the protective effect of 17beta-estradiol was investigated on the phenylephrine-precontracted carotid artery from cholesterol fed rabbits. Animals were fed for 8 weeks as follows: control group, standard chow; (control+estradiol) group, standard c...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00450-5
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:As apoE(-/-) and LDL-Receptor(-/-) mice are commonly used in atherosclerosis research; our objective was to point out the differences in HDL metabolism between mice and humans regarding the roles of apoE and LDLR. METHODS:We examined HDL particles obtained from wild type (WT), LDLR(-/-), and apoE(-/-) mice, ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.11.080
更新日期:2014-03-01 00:00:00
abstract::The effect of prostaglandins (PG) on initiation of DNA synthesis in arterial smooth muscle cells (SMC) stimulated with platelet-derived growth factor (PDGF) was examined. A concentration of 10 ng/ml PGE1 inhibited DNA synthesis, measured as autoradiographically labeled nuclei, by about 70%. Similar results were obtain...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(84)90107-2
更新日期:1984-10-01 00:00:00
abstract::The heavy and light subfractions of low density lipoprotein (LDL) were bound to the same extent and with the same affinity by the LDL receptors of cultured human fibroblasts, both when assayed at 4 degrees C and when assayed at 37 degrees C. They were also degraded similarly by the low affinity, LDL-receptor-mediated ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(86)90125-5
更新日期:1986-03-01 00:00:00
abstract::Paraoxonase (PON) is an HDL-bound enzyme capable of hydrolyzing lipid peroxides and believed to be in part responsible for the protective effect of HDL against LDL oxidation. Its activity is mainly determined by a gene polymorphism of the PON 1 gene (Glu-Arg 192). Low activity has been related to an elevated incidence...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(98)00031-8
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Recent reports have suggested that dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonists are associated with adverse cardiovascular events. This study aimed to investigate the actions of the non-thiazolidinedione PPARalpha/gamma agonist, compound 3q, on plaque development in the apolipop...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2006.11.021
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(01)00601-3
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Aortic atherosclerosis is an aggregate marker of vascular risk factor exposure and has been associated with intracranial atherosclerosis and stroke. We hypothesized that atherosclerosis of the descending aorta (DAo) could be a risk marker for brain aging and injury. METHODS:We evaluated 1527 partic...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2017.06.919
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Only one study has examined endothelial function in subjects with acute ischemic stroke and no study has yet assessed arterial stiffness and reactive hyperemia peripheral arterial tonometry (RH-PAT) in ischemic stroke and its clinical subtypes. Our study aimed to evaluate arterial stiffness and endo...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.10.044
更新日期:2017-01-01 00:00:00
abstract::The effect of 50 mg/kg body weight Xantinol-nicotinate (XN) on serum lipids and on non-esterified fatty acids (NEFA) was tested in 94 out-patients with hyperlipoproteinemia Types IIa, IIb, IV and V. The lipids were measured before treatment, during a 3-week period of drug administration and 10 days after rejection. In...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(80)90095-7
更新日期:1980-09-01 00:00:00
abstract:OBJECTIVE:Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological s...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.08.022
更新日期:2014-10-01 00:00:00
abstract::Fifty-seven sections of human vessels, collected in the Pathobiological Determinants of Atherosclerosis in Youth study from individuals aged 25-34, were stained with two monoclonal antibodies to oxidatively-modified lysine. Intensity and extent of immunoreactivity were graded by three pathologists. Aorta from a Watana...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(99)00271-3
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:Hemodynamic forces are potential determinants of aortic atherosclerosis. Aortic regurgitation (AR) alters the flow pattern in the aorta. However, the association between AR and aortic atherosclerosis is not well known. METHODS:We assessed the presence, extent and distribution of atherosclerotic lesions in th...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2011.05.026
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:We evaluated family history as a predictor of incident and progressive coronary artery calcium (CAC) using data from the Multi-Ethnic Study of Atherosclerosis (MESA). BACKGROUND:MESA is a multi-center prospective study of 6814 asymptomatic individuals. The relationship between family history of coronary hear...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2013.11.042
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Endothelium inflammation, which can lead to endothelial activation and dysfunction, is widely accepted as the major event in multiple vascular disorders. The lncRNA HOXA-AS2 was previously reported to be involved in multiple inflammation-linked cancers. However, the role of HOXA-AS2 in endothelium i...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.12.012
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To study the influence of polyvascular atherothrombotic disease on stroke patient prognosis, its relation with inflammatory markers, and to analyze the progression of atherothrombotic disease. METHODS:MITICO is a multi-centered prospective observational study recruiting non-anticoagulated ischemic stroke pat...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2009.07.041
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Familial hypercholesterolemia (FH), which leads to premature cardiovascular events, still remains underrecognized and undertreated in most countries. Untreated FH individuals aged 20-39 years are at 100-fold higher risk of mortality from coronary heart disease compared to those of a general populati...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.03.025
更新日期:2016-06-01 00:00:00