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Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor.

Abstract：

:The effect of prostaglandins (PG) on initiation of DNA synthesis in arterial smooth muscle cells (SMC) stimulated with platelet-derived growth factor (PDGF) was examined. A concentration of 10 ng/ml PGE1 inhibited DNA synthesis, measured as autoradiographically labeled nuclei, by about 70%. Similar results were obtained with PGE2 and PGD2 but at concentrations 10-20 times higher, whereas PGF2 alpha lacked effect. The inhibitory action of the prostaglandins was restricted to the first 6 h of the lag phase. Treatment with PGE1 also raised the intracellular concentration of cyclic AMP, indicating that the inhibition may be mediated via changes in the levels of cyclic nucleotides.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Nilsson J,Olsson AG

doi

10.1016/0021-9150(84)90107-2

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

77-82

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(84)90107-2

journal_volume

53

pub_type

杂志文章

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