Common promoter polymorphisms of inflammation and thrombosis genes and longevity in older adults: the cardiovascular health study.

abstract：:Baroreceptor sensitivity was studied in twelve young normotensive subjects and forty hypertensive patients, separated into two groups according to their age, severity of hypertension and signs of severe atherosclerotic vascular disease. Under stabilized circulatory conditions, the changes of pulse rate in response to ...

journal_title：Atherosclerosis

authors： Vlachakis ND,Mendlowitz M,DGuia D,DGusman D

更新日期：1976-07-01 00:00:00

abstract：:Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...

journal_title：Atherosclerosis

authors： Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

更新日期：1982-01-01 00:00:00

abstract：:It is still controversial whether circulating soluble form of receptor for AGE (sRAGE) is associated with atherosclerosis in diabetic patients. In this study, we enrolled 276 Japanese type 2 diabetic subjects without history of cardiovascular disease (CVD), assessed their baseline clinical and biochemical data includi...

journal_title：Atherosclerosis

authors： Fujisawa K,Katakami N,Kaneto H,Naka T,Takahara M,Sakamoto F,Irie Y,Miyashita K,Kubo F,Yasuda T,Matsuoka TA,Shimomura I

更新日期：2013-04-01 00:00:00

abstract：:We have previously reported that plasma levels of remnant-like lipoprotein particles (RLP) significantly increased in sudden cardiac death cases with and without coronary atherosclerosis. In this study we have elucidated the major subset of proatherogenic RLP, containing both apoB-48 and apoB-100-carrying remnants, in...

journal_title：Atherosclerosis

authors： Nakajima K,Nakajima Y,Takeichi S,Fujita MQ

更新日期：2007-10-01 00:00:00

abstract：:The relationship of fetal plasma cholesterol levels to aortic free and esterified cholesterol concentration was determined in the rabbit during gestation. Plasma cholesterol levels (mg/dl) in early fetuses were markedly high and decreased at term. While aortic free cholesterol content increased with fetal age, cholest...

journal_title：Atherosclerosis

authors： Cayatte AJ,Subbiah MT

更新日期：1989-04-01 00:00:00

abstract：:The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...

journal_title：Atherosclerosis

authors： Miller VT

更新日期：1994-08-01 00:00:00

abstract：:In the abdominal aortas of young mash-fed swine, intimal cell masses (pads, cushions) are located predominantly away from blood vessel orifices. They are found scattered throughout the aorta but nevertheless have a definite pattern of distribution. In the distal one half of the abdominal aorta, they are more frequent ...

journal_title：Atherosclerosis

authors： Scott RF,Thomas WA,Lee WM,Reiner JM,Florentin RA

更新日期：1979-11-01 00:00:00

abstract：:We studied the effect of probucol on lipoprotein composition and VLDL apo B turnover. In 7 hypercholesterolemic subjects, probucol therapy lowered mean total cholesterol, HDL cholesterol and HDL triglycerides, raised LDL triglycerides and did not change LDL cholesterol. LDL cholesterol:LDL triglycerides mass ratios fe...

journal_title：Atherosclerosis

authors： Lock DR,Kuisk I,Gonen B,Patsch W,Schonfeld G

更新日期：1983-06-01 00:00:00

abstract：SUMMARY:A type of spontaneous arteriosclerosis, described as medial sclerosis and quite distinct from atherosclerosis, was found in the aortas, coronary arteries and aortic branch arteries of free-living elephants (Loxodonta africana) in Uganda and Kenya. The lesions took the form of calcified fibrotic plaques in the i...

journal_title：Atherosclerosis

authors： McCullagh KG

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Non-invasive surrogates of cardiovascular (CV) disease such as endothelial dysfunction (ED) and peripheral arterial stiffness (AS) have been evaluated in systemic lupus erythematosus (SLE) patients. The aim of this study was to systematically review and meta-analyze reports of cardiovascular disease...

journal_title：Atherosclerosis

authors： Mendoza-Pinto C,Rojas-Villarraga A,Molano-González N,García-Carrasco M,Munguía-Realpozo P,Etchegaray-Morales I,Morales-Sánchez H,Berra-Romani R,Cervera R

更新日期：2020-03-01 00:00:00

abstract：:We previously identified a G>A single nucleotide polymorphism (SNP) between C57BL/6J (B6) and C3H/HeJ (C3H) mouse strains at position 2077 in the coding region of Vcam1 that leads to substitution of an amino acid from aspartic acid (D) to asparagine (N) in the protein product. In the present study, we investigated the...

journal_title：Atherosclerosis

authors： Miyoshi T,Yuan Z,Shi W

更新日期：2008-01-01 00:00:00

abstract：:Recent studies suggest that the beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) in reducing cardiovascular events may in part, be independent of their capacity to lower plasma lipids. To test this hypothesis, simvastatin (50 mg/kg/d) was administered to 30-week-old ...

journal_title：Atherosclerosis

authors： Bea F,Blessing E,Shelley MI,Shultz JM,Rosenfeld ME

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of pioglitazone on endothelial and adipose tissue dysfunction in newly detected IGT patients with CAD. METHODS AND DESIGN:Participants (n=25) were randomized to treatment with either placebo or pioglitazone (30 mg/day) for 12 weeks. Before and after treatment we evaluated endothelia...

journal_title：Atherosclerosis

authors： Rizza S,Cardellini M,Porzio O,Pecchioli C,Savo A,Cardolini I,Senese N,Lauro D,Sbraccia P,Lauro R,Federici M

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVE:To compare the prevalence of lower extremity peripheral artery disease (PAD) and to assess whether age-associated progression in ankle-brachial index (ABI) differs between individuals with chronic immune-mediated inflammatory diseases (CIID) and the general population. METHODS:Pooled analysis with data from ...

journal_title：Atherosclerosis

authors： Agüero F,González-Zobl G,Baena-Díez JM,Dégano IR,Garcia-Gil M,Alzamora MT,Marrugat J,Comas-Cufí M,Pera G,Elosua R,Ramos R,Grau M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Lipoprotein Lp(a) has been shown to be an independent risk factor for coronary artery disease (CAD). However, its association with CAD burden in patients with ACS is largely unknown, as well as the association of Lp(a) with lipid rich plaques prone to rupture. AIM:We aim at assessing CAD burden by coronary ...

journal_title：Atherosclerosis

authors： Niccoli G,Cin D,Scalone G,Panebianco M,Abbolito S,Cosentino N,Jacoangeli F,Refaat H,Gallo G,Salerno G,Volpe M,Crea F,De Biase L

更新日期：2016-03-01 00:00:00

abstract：:The role of prostaglandin I2 (PGI2) in the control of DNA synthesis during the cell cycle was investigated in cultured rabbit aortic smooth muscle cells (SMC). SMC at confluency in the G0 state reached the S phase about 16 h after stimulation with serum, as judged by measurement of [3H]thymidine incorporation into DNA...

journal_title：Atherosclerosis

authors： Morisaki N,Kanzaki T,Motoyama N,Saito Y,Yoshida S

更新日期：1988-06-01 00:00:00

abstract：:Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...

journal_title：Atherosclerosis

authors： Lindstedt L,Lee M,Kovanen PT

更新日期：2001-03-01 00:00:00

abstract：:LDL and HDL became more fluid when health, free-living, premenopausal women were fed reduced fat diets with higher proportions of polyunsaturated fatty acids. Lipoproteins were isolated from plasma of 31 female subjects fed one of two sets of diets from typical U.S.A. foods with P/S ratios of 0.3 or 1.0. All subjects ...

journal_title：Atherosclerosis

authors： Berlin E,Judd JT,Nair PP,Jones DY,Taylor PR

更新日期：1991-02-01 00:00:00

abstract：:Recent studies demonstrate important roles for inflammation in development of atherosclerosis with current attention focusing on interactions of inflammation with traditional lipoprotein risk factors. Since the nature of such relationships is largely unknown, we sought to investigate interactions of inflammation with ...

journal_title：Atherosclerosis

authors： Corsetti JP,Zareba W,Moss AJ,Rainwater DL,Sparks CE

更新日期：2006-07-01 00:00:00

abstract：:The emergence of pathophysiological, epidemiologic, and genetic data strongly supports the causality for lipoprotein(a) [Lp(a)] in cardiovascular disease (CVD) and calcific aortic valve disease (CAVD). In parallel, novel Lp(a) lowering approaches have been developed that have re-invigorated clinical interest in Lp(a)....

journal_title：Atherosclerosis

authors： Tsimikas S,Stroes ESG

更新日期：2020-05-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due to their ability to reduce atherosclerosis and exhibit antioxidant, anti-inflammatory, and hypolipidemic properties. In this study, we tested whether three distinct and unrelated cationic peptides would inhibit...

journal_title：Atherosclerosis

authors： Aluganti Narasimhulu C,Selvarajan K,Brown M,Parthasarathy S

更新日期：2014-09-01 00:00:00

abstract：:Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

journal_title：Atherosclerosis

authors： Blann AD,Miller JP,McCollum CN

更新日期：1997-07-25 00:00:00

abstract：BACKGROUND:The CHA(2)DS(2)-VASc (congestive heart failure, hypertension, age ≥ 75 years (doubled), type 2 diabetes, previous stroke, transient ischemic attack, or thromboembolism (doubled), vascular disease, age 65-75 years, and sex category) score was published as a predictive scoring model for stroke in atrial fibril...

journal_title：Atherosclerosis

authors： Gary T,Belaj K,Hafner F,Hackl G,Froehlich H,Pilger E,Brodmann M

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin increase serum total and high molecular weight adiponectin levels and impr...

journal_title：Atherosclerosis

authors： Kim JH,Lee MR,Shin JA,Lee SS,Lee JM,You SJ,Yoon KH,Chang SA

更新日期：2013-04-01 00:00:00

abstract：AIMS:Leukocyte telomere length (LTL) is shortened in patients with clinical atherosclerosis (AS). Here we aimed to explore the contribution of elevated homocysteine (Hcy) level to LTL shortening in AS patients and the underlying mechanism. METHODS:Circulating leukocytes were collected from 197 patients with AS and 165...

journal_title：Atherosclerosis

authors： Zhang D,Wen X,Wu W,Xu E,Zhang Y,Cui W

更新日期：2013-11-01 00:00:00

abstract：:We studied the functional role of N-linked sugar chains of apolipoprotein (apo) B-100 of low density lipoprotein (LDL) in cholesterol metabolism. The N-linked sugar chains of apo B-100 of LDL obtained from four homozygous Watanabe heritable hyperlipidemic (WHHL) rabbits were liberated by hydrazinolysis, followed by Na...

journal_title：Atherosclerosis

authors： Fujioka Y,Taniguchi T,Ishikawa Y,Shiomi M,Yokoyama M

更新日期：1994-07-01 00:00:00

abstract：:We investigated the effect of transmembrane form of tumor necrosis factor-alpha (TNF) on atherosclerosis in mice. We compared the development of early atherosclerotic lesions in the aortic sinus of (1) TNF-deficient mice that express only a non-cleavable transmembrane form of TNF (tmTNF), (2) wild-type (WT) C57BL/6 mi...

journal_title：Atherosclerosis

authors： Canault M,Peiretti F,Mueller C,Kopp F,Morange P,Rihs S,Portugal H,Juhan-Vague I,Nalbone G

更新日期：2004-02-01 00:00:00

abstract：:The pathological remodeling of the arterial wall in atherosclerosis involves protease activities, which play a major role in complications, through plaque rupture. Here, we investigated the release of active proteases by human carotid plaques in relation to (1) the degree of lesion complexity and (2) their compartment...

journal_title：Atherosclerosis

authors： Leclercq A,Houard X,Loyau S,Philippe M,Sebbag U,Meilhac O,Michel JB

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hypothesis that genital Chlamydia infection could accelerate the onset an...

journal_title：Atherosclerosis

authors： Nagarajan UM,Sikes JD,Burris RL,Jha R,Popovic B,Fraungruber P,Hennings L,Haggerty CL,Nagarajan S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND AND AIMS:The European Society of Cardiology developed prediction models (SCORE) for low- and high-risk populations in the European countries. However, whether or not these models are valid in different ethnicities is unknown. We aimed to evaluate the performance of the low-risk SCORE model in the general Jap...

journal_title：Atherosclerosis

authors： Sawano M,Kohsaka S,Okamura T,Inohara T,Sugiyama D,Watanabe M,Nakamura Y,Higashiyama A,Kadota A,Okud N,Murakami Y,Ohkubo T,Fujiyoshi A,Miura K,Okayama A,Ueshima H,National Integrated Project for Prospective Observation of

更新日期：2016-09-01 00:00:00