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Lipid metabolism after an oral fat test meal is affected by age-associated features of metabolic syndrome, but not by age.

Abstract：

OBJECTIVE:Postprandial lipemia influences the development of atherosclerosis. Age has been defined as a regulating factor of the extent of postprandial lipemia, but its independence of other age-associated phenotypic features, such as metabolic syndrome, has not been fully elucidated. METHODS:To investigate if age is an independent factor influencing postprandial lipemia, we compared the lipemic response to a rich fatty meal (60% fat) of 88 healthy young men (<30 years old) and 97 older participants (77 metabolic syndrome patients aged > 40; and 20 healthy people > 65) (all ApoE3/E3), at fasting state and at 2nd and 4th postprandial hours. RESULTS:We didn't find differences between the healthy young men and the healthy elderly. The metabolic syndrome patients displayed a higher postprandial TG area below the curve than the other two cohorts p < 0.001. ANOVA for repeated measurements confirmed that these differences were significant at every time-point (fasting, 2 h and 4 h). Concomitant higher responses for Large and Small TRL-carried TG and Chol were found in these metabolic syndrome patients. Interestingly, the most significant differences were found for Small-TRL-carried particles, which suggest that this fact may be mainly due to impaired lipid clearance. CONCLUSION:Metabolic syndrome may account for the differences in postprandial lipemia that have been attributed to age. In our study, there were no significant differences in postprandial lipemia between a young population (mean age 22.6 years) and a healthy people >65 years one (67.2 years) without metabolic syndrome.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Perez-Caballero AI,Alcala-Diaz JF,Perez-Martinez P,Garcia-Rios A,Delgado-Casado N,Marin C,Yubero-Serrano E,Camargo A,Caballero J,Malagon MM,Tinahones FJ,Perez-Jimenez F,Lopez-Miranda J,Delgado-Lista J

doi

10.1016/j.atherosclerosis.2012.10.052

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

258-62

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(12)00738-1

journal_volume

226

pub_type

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