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Plasma kinetics of a chylomicron-like emulsion in patients with coronary artery disease.

Abstract：

:Chylomicron catabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. In rats, triglyceride-rich emulsions can mimic chylomicron metabolism. To further validate this model in man, the emulsion was injected intravenously into fasting and into subjects previously fed a test fatty meal. The plasma kinetic curves of the emulsion 3H-triglyceride and 14C-cholesteryl ester were determined. The fractional clearance rate (FCR) of both labels was markedly reduced in the fed subjects (triglycerides: fed = 0.018 +/- 0.007; fasting = 0.105 +/- 0.013 min-1, P < 0.001; cholesteryl ester: fed = 0.016 +/- 0.001; fasting = 0.040 +/- 0.006 min-1; P < 0.05) indicating that the emulsion and chylomicrons generated from the testinal lipid absorption compete for the same catabolic processes, confirming the validity of the method. The emulsion was injected into 11 patients with CAD and into 11 controls. All had plasma cholesterol < 240 and triglycerides < 250 mg/dl. FCR of triglycerides was 5-fold smaller in CAD compared to controls (0.028 +/- 0.004 and 0.141 +/- 0.069 min-1, respectively, P < 0.01). FCR of cholesteryl ester was 4-fold smaller in CAD than in controls (0.015 +/- 0.004 and 0.056 +/- 0.067 min-1 respectively, P < 0.05). These results indicate that both chylomicron lipolysis and remnant removal are diminished in CAD.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Maranhão RC,Feres MC,Martins MT,Mesquita CH,Toffoletto O,Vinagre CG,Gianinni SD,Pileggi F

doi

10.1016/0021-9150(96)05889-3

subject

Has Abstract

pub_date

1996-09-27 00:00:00

pages

15-25

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(96)05889-3

journal_volume

126

pub_type

临床试验,杂志文章

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