Increased urinary cystatin C indicated higher risk of cardiovascular death in a community cohort.


OBJECTIVES:Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death. METHODS:The association between u-CysC and cardiovascular mortality was investigated in a Swedish community-based cohort of 604 men aged 78 years. During follow-up (mean 6.7 years), 203 participants died, of which 90 due to cardiovascular causes. RESULTS:High u-CysC (>0.029 mg/mmol Cr) was associated with a more than 2-fold risk of cardiovascular death (multivariable hazard ratio for quintile 5 vs. 1: 2.5, 95% CI 1.2-5.2, P < 0.05) in Cox regression models independent of cardiovascular risk factors, glomerular filtration rate (eGFR) and urinary Albumin. Participants with low eGFR (≤60 mL/min), albuminuria (≥3 mg/mmol Cr) and high u-CysC (>0.029 mg/mmol Cr) combined had a significantly higher cardiovascular mortality risk compared to participants with one or two of these biomarkers normal (hazard ratio 15, 95% CI: 6.7-36, P < 0.001, compared to all three biomarkers normal). CONCLUSIONS:This study is the first to show that increased concentrations of the tubular kidney biomarker u-CysC indicated risk of cardiovascular death independently of other cardiovascular risk factors, glomerular filtration and albuminuria. Additional research is needed to further establish the usefulness of u-CysC in clinical practice.






Helmersson-Karlqvist J,Ärnlöv J,Carlsson AC,Härmä J,Larsson A




Has Abstract


2014-05-01 00:00:00














  • Chemokine expression in coronary circulation after coronary angioplasty as a prognostic factor for restenosis.

    abstract::Recent studies have clarified the significance of chemokines in cardiovascular diseases, such as development of atherosclerosis, atheromatous plaque rupture and restenosis after coronary angioplasty. We investigated changes in chemokine expression in the coronary circulation induced by percutaneous transluminal corona...


    pub_type: 杂志文章


    authors: Hojo Y,Ikeda U,Katsuki T,Mizuno O,Fukazawa H,Fujikawa H,Shimada K

    更新日期:2001-05-01 00:00:00

  • Paraoxonase 1 (PON1) inhibits monocyte-to-macrophage differentiation.

    abstract:OBJECTIVE:To analyze paraoxonase 1 (PON1) effect on monocyte-to-macrophage differentiation. METHODS AND RESULTS:THP-1 monocytic cell-line and mouse peritoneal macrophages (MPM) were studied. Markers for monocytes differentiation included: morphological changes, CD11b and CD36 expression, and cellular oxidative stress....


    pub_type: 杂志文章


    authors: Rosenblat M,Volkova N,Ward J,Aviram M

    更新日期:2011-11-01 00:00:00

  • Cigarette smoke is an endothelial stressor and leads to cell cycle arrest.

    abstract::The molecular mechanisms underlying the atherogenic activity of cigarette smoke have yet to be fully elucidated. In the present study, genome-wide microarray analysis was performed on endothelial cells exposed to an aqueous cigarette smoke extract (CSE) for 3, 7, and 24 h, to obtain a better insight into how smoking m...


    pub_type: 杂志文章


    authors: Henderson B,Csordas A,Backovic A,Kind M,Bernhard D,Wick G

    更新日期:2008-12-01 00:00:00

  • Changes of apolipoprotein A-IV in the human neonate: evidence for different inductions of apolipoproteins A-IV and A-I in the postpartum period.

    abstract::The levels, isoforms and distribution of apolipoprotein A-IV (apo A-IV) were investigated in 127 term human umbilical cord sera. In addition, apo A-IV levels and isoforms were determined on the 3rd (n = 82) and 6th (n = 68) day following parturition and compared to apo A-I concentrations. Levels of apo A-IV were low i...


    pub_type: 杂志文章


    authors: Steinmetz A,Czekelius P,Thiemann E,Motzny S,Kaffarnik H

    更新日期:1988-01-01 00:00:00

  • Lipoprotein lipase gene polymorphism rs1059611 functionally influences serum lipid concentrations.

    abstract:OBJECTIVE:Dozens of single nucleotide polymorphisms (SNPs) in the lipoprotein lipase (LPL) gene have been reported to be associated with lipid concentrations. The aim of this study was to validate the association between rs1059611 in the LPL gene and serum lipid concentrations in the Chinese Han population and explore ...


    pub_type: 杂志文章


    authors: Mo X,Liu X,Wang L,Li H,Lu X,Huang J,Chen J,Cao J,Li J,Chen S,Tang Y,Peng X,Gu D

    更新日期:2013-08-01 00:00:00

  • Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor.

    abstract::The effect of prostaglandins (PG) on initiation of DNA synthesis in arterial smooth muscle cells (SMC) stimulated with platelet-derived growth factor (PDGF) was examined. A concentration of 10 ng/ml PGE1 inhibited DNA synthesis, measured as autoradiographically labeled nuclei, by about 70%. Similar results were obtain...


    pub_type: 杂志文章


    authors: Nilsson J,Olsson AG

    更新日期:1984-10-01 00:00:00

  • Impaired adaptive vascular growth in hypercholesterolemic rabbit.

    abstract::Occlusive arterial disease stimulates compensatory growth of pre-existent and new arterial channels which help to maintain organ perfusion. Previous studies characterizing compensatory or collateral vascular growth have been performed in normocholesterolemic animals. Because hyperlipidemic states alter vascular regula...


    pub_type: 杂志文章


    authors: Bucay M,Nguy J,Barrios R,Chen CH,Henry PD

    更新日期:1998-08-01 00:00:00

  • Enhanced vasoconstrictor effect of big endothelin-1 in patients with atherosclerosis: relation to conversion to endothelin-1.

    abstract::The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...


    pub_type: 杂志文章


    authors: Böhm F,Johansson BL,Hedin U,Alving K,Pernow J

    更新日期:2002-01-01 00:00:00

  • Expression of platelet-derived growth factor B-chain in neointimal smooth muscle cells of balloon injured rabbit femoral arteries.

    abstract::In order to obtain information about the developmental mechanisms of restenosis after angioplasty, we investigated an association between the expression of platelet-derived growth factors (PDGFs) and neointimal cell accumulation in rabbit femoral arteries subjected to balloon angioplasty. Northern analysis demonstrate...


    pub_type: 杂志文章


    authors: Uchida K,Sasahara M,Morigami N,Hazama F,Kinoshita M

    更新日期:1996-07-01 00:00:00

  • Berberine inhibits rat vascular smooth muscle cell proliferation and migration in vitro and improves neointima formation after balloon injury in vivo. Berberine improves neointima formation in a rat model.

    abstract::Berberine, an alkaloid isolated from Chinese medicinal herbs, long been known for its anti-microbial activity and used to treat various infectious disorders in traditional Chinese medicine. In the present study, we have tested the hypothesis that berberine could inhibit vascular smooth muscle cell (VSMC) proliferation...


    pub_type: 杂志文章


    authors: Lee S,Lim HJ,Park HY,Lee KS,Park JH,Jang Y

    更新日期:2006-05-01 00:00:00

  • Impact of gender on the density of intraplaque neovascularization: a quantitative contrast-enhanced ultrasound study.

    abstract:OBJECTIVE:Atherosclerosis is the main underlying cause of the majority of cardiovascular events. Although cardiovascular diseases (CVD) are a major challenge in both males and females, gender specific differences in the prevalence of CVD have been observed. This may indicate that there are differences in the developmen...


    pub_type: 杂志文章


    authors: van den Oord SCH,van der Burg J,Akkus Z,Bosch JG,van Domburg RT,Sijbrands EJG,van der Steen AFW,Schinkel AFL

    更新日期:2014-04-01 00:00:00

  • Genital Chlamydia infection in hyperlipidemic mouse models exacerbates atherosclerosis.

    abstract:BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease, and recent studies have shown that infection at remote sites can contribute to the progression of atherosclerosis in hyperlipidemic mouse models. In this report, we tested the hypothesis that genital Chlamydia infection could accelerate the onset an...


    pub_type: 杂志文章


    authors: Nagarajan UM,Sikes JD,Burris RL,Jha R,Popovic B,Fraungruber P,Hennings L,Haggerty CL,Nagarajan S

    更新日期:2019-11-01 00:00:00

  • Accelerated atherosclerosis in subjects with some minor deviations from the common type of distribution of human coronary arteries.

    abstract::Gross dissection of the coronary arteries of 566 subjects aged 0--45 years from an unselected population sample of Bucharest revealed the presence of a similar anatomical branching pattern in 58% of cases. Starting from this common type of distribution of coronary arteries, some minor deviations were detected coexisti...


    pub_type: 杂志文章


    authors: Velican D,Velican C

    更新日期:1981-11-01 00:00:00

  • Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

    abstract:BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...


    pub_type: 杂志文章


    authors: Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

    更新日期:2012-08-01 00:00:00

  • Effects of ADP and epinephrine on macaque and human platelets. Implications for studies on human atherosclerosis.

    abstract::The ranges for near-threshold ADP concentrations for the aggregation of macaque and human citrated platelets overlapped. The minimum concentrations of epinephrine, 0.05 microM to 1.0 microM, that at least doubled the aggregation response at threshold ADP concentrations were comparable for macaque and human citrated pl...


    pub_type: 杂志文章


    authors: Beatty CH,Howard CF Jr,Caruso V

    更新日期:1986-05-01 00:00:00

  • The clinical importance of serum γ-glutamyltransferase level as an early predictor of obesity development in Korean men.

    abstract:BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...


    pub_type: 杂志文章


    authors: Suh YJ,Park SK,Choi JM,Ryoo JH

    更新日期:2013-04-01 00:00:00

  • Sex differences in risk factors, etiology, and short-term outcome of cerebral infarction in young patients.

    abstract::Investigations to date have demonstrated that the underlying etiology, causes and burden of stroke may be different for women and men. However, data regarding sex differences among young cerebral ischemic stroke patients remains scarce. We conducted this study in 669 young Chinese adults with acute ischemic stroke as ...


    pub_type: 杂志文章


    authors: Zhang B,Pu S,Zhang W,Yang N,Shen G,Yin J,Yi Y,Gao Q,Gao C

    更新日期:2011-06-01 00:00:00

  • Aspirin inhibits monocyte chemoattractant protein-1 and interleukin-8 expression in TNF-alpha stimulated human umbilical vein endothelial cells.

    abstract::Atherosclerosis and its complications such as stroke, myocardial infraction and peripheral vascular disease, remain the major causes of morbidity and mortality in the world. Studies have showed that chemokines and adhesion molecules are involved in causing atherosclerosis by promoting directed migration of inflammator...


    pub_type: 杂志文章


    authors: Yang YY,Hu CJ,Chang SM,Tai TY,Leu SJ

    更新日期:2004-06-01 00:00:00

  • Inflammatory and metabolic mechanisms underlying the calcific aortic valve disease.

    abstract::Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have ide...


    pub_type: 杂志文章,评审


    authors: Cho KI,Sakuma I,Sohn IS,Jo SH,Koh KK

    更新日期:2018-10-01 00:00:00

  • Micro-ultrasound imaging assessment of carotid plaque characteristics in apolipoprotein-E knockout mice.

    abstract::This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...


    pub_type: 杂志文章


    authors: Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

    更新日期:2008-03-01 00:00:00

  • Monitoring of aortic and coronary atherosclerosis in native and non-native males of Yakutsk over 40 years.

    abstract::We have analyzed the development of aortic and coronary atherosclerosis over 40 years in native and non-native males of Yakutsk by comparing the data obtained in 1963-1965, 1985-1987 and 2001-2003. The research was carried out in compliance with the WHO program for the atherosclerosis epidemiology studies using autops...


    pub_type: 杂志文章


    authors: Zhdanov VS,Sternby NH,Voronova OV,Galakhov IE,Argunov VA

    更新日期:2007-02-01 00:00:00

  • Sterol-regulatory-element binding protein inhibits upstream stimulatory factor-stimulated hepatic lipase gene expression.

    abstract::Hepatic lipase (HL) not only plays an important role in plasma lipoprotein transport, but may also affect intracellular lipid metabolism. We hypothesize that HL expression is regulated as an integral part of intracellular lipid homeostasis. Addition of oleate (1 mM) to HepG2 cells increased HL secretion to 134+/-14% o...


    pub_type: 杂志文章


    authors: Botma GJ,van Deursen D,Vieira D,van Hoek M,Jansen H,Verhoeven AJ

    更新日期:2005-03-01 00:00:00

  • Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.

    abstract:OBJECTIVE:25-Hydroxycholesterol (25HC) and its sulfated metabolite, 25-hydroxycholesterol-3-sulfate (25HC3S), regulate certain aspects of lipid metabolism in opposite ways. Hence, the enzyme for the biosynthesis of 25HC3S, oxysterol sulfotransferase (SULT2B1b), may play a crucial role in regulating lipid metabolism. We...


    pub_type: 杂志文章


    authors: Bai Q,Xu L,Kakiyama G,Runge-Morris MA,Hylemon PB,Yin L,Pandak WM,Ren S

    更新日期:2011-02-01 00:00:00

  • NT-proBNP is associated with coronary heart disease risk in healthy older women but fails to enhance prediction beyond established risk factors: results from the British Women's Heart and Health Study.

    abstract:OBJECTIVE:Limited evidence suggests NT-proBNP improves prediction of coronary heart disease (CHD) events but further data are needed, especially in people without pre-existing CHD and in women. METHODS:We measured NT-proBNP in serum from 162 women with incident CHD events and 1226 controls (60-79 years) in a case-cont...


    pub_type: 杂志文章


    authors: Sattar N,Welsh P,Sarwar N,Danesh J,Di Angelantonio E,Gudnason V,Davey Smith G,Ebrahim S,Lawlor DA

    更新日期:2010-03-01 00:00:00

  • Development of transplant vasculopathy in aortic allografts correlates with neointimal smooth muscle cell proliferative capacity and fibrocyte frequency.

    abstract:OBJECTIVE:Transplant vasculopathy consists of neointima formation in graft vasculature resulting from vascular smooth muscle cell recruitment and proliferation. Variation in the severity of vasculopathy has been demonstrated. Genetic predisposition is suggested as a putative cause of this variation, although cellular m...


    pub_type: 杂志文章


    authors: Onuta G,van Ark J,Rienstra H,Boer MW,Klatter FA,Bruggeman CA,Zeebregts CJ,Rozing J,Hillebrands JL

    更新日期:2010-04-01 00:00:00

  • The effect of hypercholesterolemia on aortic endothelium studied en face.

    abstract::The aortic endothelium of rabbits fed a stock diet containing 1 or 2% cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol. The endothelium was examined en face using the Häutchen technique. The aortic endothelium of the experimental animals reveal...


    pub_type: 杂志文章


    authors: Silkworth JB,McLean B,Stehbens WE

    更新日期:1975-11-01 00:00:00

  • Carotid atherosclerosis and risk for ischemic stroke in patients with atrial fibrillation on oral anticoagulant treatment.

    abstract:BACKGROUND AND AIMS:Whether carotid atherosclerosis is associated with an increased risk for ischemic stroke in patients with atrial fibrillation (AF) on anticoagulant treatment is undefined. To explore this association, patients with AF on treatment with vitamin K antagonists were included in a multicenter, prospectiv...


    pub_type: 杂志文章,多中心研究


    authors: Becattini C,Dentali F,Camporese G,Sembolini A,Rancan E,Tonello C,Manina G,Padayattil S,Agnelli G

    更新日期:2018-04-01 00:00:00

  • Stimulatory effects of insulin and insulin-like growth factor I on migration and tube formation by vascular endothelial cells.

    abstract::The effects of insulin and insulin-like growth factor I (IGF-I) on migration, proliferation and tube-forming activity of endothelial cells were investigated, by using bovine carotid artery endothelial cells. Migration was assayed by a filter membrane technique and tube formation was assayed by a quantitative angiogene...


    pub_type: 杂志文章


    authors: Nakao-Hayashi J,Ito H,Kanayasu T,Morita I,Murota S

    更新日期:1992-02-01 00:00:00

  • Shared and discrepant susceptibility for carotid artery and aortic arch calcification: A genetic association study.

    abstract::Genome-wide association studies (GWASs) have identified several risk loci for coronary artery calcification. Four single-nucleotide polymorphisms (SNPs, rs1537370, rs1333049, rs2026458 and rs9349379) were associated with coronary artery calcification with P values less than 5 × 10(-8) in GWASs. It is unclear if these ...


    pub_type: 杂志文章


    authors: Zhang Y,Wang L,Zhang Z,Zhang Z,Zhou S,Cao L,Cai B,Liu K,Bai W,Xie X,Fan W,Liu X,Lu G,Xu G

    更新日期:2015-08-01 00:00:00

  • NT-proBNP and the anti-inflammatory cytokines are correlated with endothelial progenitor cells' response to cardiac surgery.

    abstract:OBJECTIVE:We used cardiac surgery as a model of acute inflammatory response to evaluate the role of the inflammatory mediators in influencing the number of circulating endothelial progenitor cells (EPCs). METHODS:In 38 coronary artery by-pass grafting (CABG) [28M/10F] and in 54 valvular [28M/26F] patients the numbers ...


    pub_type: 杂志文章


    authors: Cesari F,Caporale R,Marcucci R,Caciolli S,Stefano PL,Capalbo A,Macchi C,Vannucci M,Gensini GF,Abbate R,Gori AM

    更新日期:2008-07-01 00:00:00