当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Cholesterol absorption efficiency and sterol metabolism in obesity.

Cholesterol absorption efficiency and sterol metabolism in obesity.

Abstract：

:Role of enterohepatic cholesterol metabolism in obesity-induced increase of cholesterol synthesis was studied in healthy lean (BMI <24) and overweight (BMI >31) subjects by measuring serum lipids (including plant sterols, cholestanol and cholesterol precursors), cholesterol absorption % (double-label method), sterol balance and biliary lipids. New aspects of sterol metabolism in obesity were as follows: low efficiency of cholesterol absorption, reduced ratios to cholesterol of serum and biliary plant sterols and cholestanol (5alpha-derivative of cholesterol), and a marked increase of serum and biliary cholesterol precursor sterols. Percent of cholesterol absorption was positively related to serum cholestanol and plant sterols, and negatively to cholesterol synthesis, measured by the sterol balance technique or cholesterol precursor sterols in serum or bile. Total and endogenous cholesterol fluxes into the intestine were increased, but owing to low absorption percent, mass of cholesterol absorption was within control limits in the obese subjects. Thus, per gram of their large liver tissue the entry of intestinal cholesterol may even be subnormal. Percent of cholesterol absorption was insignificantly negatively (r=-0.256) related to intestinal cholesterol pool, but significantly to biliary concentrations of cholesterol (r=-0.581), bile acids (r=-0.513) and phospholipids (r=-0.469). Thus, dilution of labeled dietary cholesterol by expanded intestinal cholesterol pool could have contributed to subnormal efficiency of cholesterol absorption, or transfer of labeled dietary cholesterol from intestinal oil phase to micellar phase may be competitively inhibited by expanded biliary secretion, resulting in reduced absorption of dietary cholesterol. These mechanisms could have contributed to changes in metabolism of non-cholesterol sterols, especially of cholestanol and plant sterols.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Miettinen TA,Gylling H

doi

10.1016/s0021-9150(00)00404-4

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

241-8

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(00)00404-4

journal_volume

153

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice.

    abstract：BACKGROUND AND AIMS:Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency may also influence platelet production at the level of its precursor c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.09.019

    authors： Ouweneel AB,Hoekstra M,van der Wel EJ,Schaftenaar FH,Snip OSC,Hassan J,Korporaal SJA,Van Eck M

    更新日期：2019-03-01 00:00:00

  • Circulating levels of bisphenol A and phthalates are related to carotid atherosclerosis in the elderly.

    abstract：BACKGROUND AND OBJECTIVE:Bisphenol A (BPA) levels have previously been associated with coronary heart disease (CHD). Since CHD is an atherosclerotic disease, we investigated if circulating levels of BPA and phthalate metabolites are related to atherosclerosis in a cross-sectional study. METHODS:In the population-based...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.05.001

    authors： Lind PM,Lind L

    更新日期：2011-09-01 00:00:00

  • Postprandial regulation of blood lipids and adipose tissue lipoprotein lipase in type 2 diabetes patients and healthy control subjects.

    abstract：BACKGROUND/AIM:In type 2 diabetes and other insulin-resistant conditions, postprandial hypertriglyceridaemia is an important metabolic perturbation. To further elucidate alterations in the clearance of triglyceride-rich lipoproteins in type 2 diabetes we focused on the nutritional regulation of adipose tissue lipoprote...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(02)00366-0

    authors： Eriksson JW,Burén J,Svensson M,Olivecrona T,Olivecrona G

    更新日期：2003-02-01 00:00:00

  • Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: a novel target for the prevention of neointimal hyperplasia.

    abstract：:Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in the development of neointima following vascular injury. In this study, we found that CD9 is constitutively expressed in the VSMC of the neointima of injured carotid arteries. The in vitro migration and proliferation of human coronary...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.07.036

    authors： Kotha J,Zhang C,Longhurst CM,Lu Y,Jacobs J,Cheng Y,Jennings LK

    更新日期：2009-04-01 00:00:00

  • Enhanced RAGE-mediated NFkappaB stimulation in inflamed hemodialysis patients.

    abstract：:Advanced glycation end-products (AGEs), a group of carbohydrate-derived compounds formed by non-enzymatic glycation and oxidation, are markedly elevated in end-stage renal disease (ESRD) and may be related to both inflammation and oxidative stress. The cellular effects of AGE are largely mediated by their interaction ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2004.12.007

    authors： Rodríguez-Ayala E,Anderstam B,Suliman ME,Seeberger A,Heimbürger O,Lindholm B,Stenvinkel P

    更新日期：2005-06-01 00:00:00

  • Influence of specific mutations at the LDL-receptor gene locus on the response to simvastatin therapy in Afrikaner patients with heterozygous familial hypercholesterolaemia.

    abstract：:Simvastatin, an inhibitor of HMG CoA reductase, lowers the plasma total cholesterol and LDL-cholesterol concentration in familial hypercholesterolemic patients. The efficacy of the drug shows considerable inter-individual variation, however. In this study we have assessed the influence of certain LDL-receptor gene mut...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(93)90222-g

    authors： Jeenah M,September W,Graadt van Roggen F,de Villiers W,Seftel H,Marais D

    更新日期：1993-01-04 00:00:00

  • Lipoprotein lipase gene polymorphism rs1059611 functionally influences serum lipid concentrations.

    abstract：OBJECTIVE:Dozens of single nucleotide polymorphisms (SNPs) in the lipoprotein lipase (LPL) gene have been reported to be associated with lipid concentrations. The aim of this study was to validate the association between rs1059611 in the LPL gene and serum lipid concentrations in the Chinese Han population and explore ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.05.005

    authors： Mo X,Liu X,Wang L,Li H,Lu X,Huang J,Chen J,Cao J,Li J,Chen S,Tang Y,Peng X,Gu D

    更新日期：2013-08-01 00:00:00

  • Coarctation of the aorta. A risk factor in children for the development of arteriosclerosis.

    abstract：:Pressure recordings in 120 patients, aged 0-35 years, undergoing operation for coarctation of the aorta, show a slow but steady rise in both systolic and diastolic peak pressures, the highest peak registered being in patients aged 16-18 years. The finding of significant morphological changes in the aorta in this age g...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(81)90023-x

    authors： Anyanwu E,Dittrich H,Jelesijević V,Drüen B,Krefting ER,Höhling H

    更新日期：1981-06-01 00:00:00

  • Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population.

    abstract：:Caucasian carriers of the T allele at R46L in the proprotein convertase subtilisin/kexin type 9 (PCSK9) locus have been reported to have 15% lower low-density lipoprotein (LDL) cholesterol (C) levels and 47% lower coronary heart disease (CHD) risk. Our objective was to examine two PCSK9 single nucleotide polymorphisms...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2007.12.005

    authors： Polisecki E,Peter I,Robertson M,McMahon AD,Ford I,Packard C,Shepherd J,Jukema JW,Blauw GJ,Westendorp RG,de Craen AJ,Trompet S,Buckley BM,Murphy MB,Ordovas JM,Schaefer EJ,PROSPER Study Group.

    更新日期：2008-09-01 00:00:00

  • Baseline and on-statin treatment lipoprotein(a) levels for predicting cardiovascular events in patients with familial hypercholesterolemia.

    abstract：BACKGROUND AND AIMS:Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. However, no systemic analysis is currently available regarding the relation of plasma Lp(a) levels to cardiovascular events (CVEs) i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2019.10.010

    authors： Cao YX,Jin JL,Guo YL,Sun D,Liu HH,Wu NQ,Xu RX,Zhu CG,Liu G,Dong Q,Sun J,Li JJ

    更新日期：2019-12-01 00:00:00

  • CETP expression enhances liver HDL-cholesteryl ester uptake but does not alter VLDL and biliary lipid secretion.

    abstract：:The aim of this work was to study how CETP expression affects whole body cholesterol homeostasis. Thus, tissue uptake and plasma removal rates of labeled HDL-cholesteryl ester (CE), VLDL secretion rates, and biliary lipid secretion and fecal bile acid content were compared between human CETP transgenic (Tg) and non-tr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.05.036

    authors： Harada LM,Amigo L,Cazita PM,Salerno AG,Rigotti AA,Quintão EC,Oliveira HC

    更新日期：2007-04-01 00:00:00

  • Effect of probucol on the composition of lipoproteins and on VLDL apoprotein B turnover.

    abstract：:We studied the effect of probucol on lipoprotein composition and VLDL apo B turnover. In 7 hypercholesterolemic subjects, probucol therapy lowered mean total cholesterol, HDL cholesterol and HDL triglycerides, raised LDL triglycerides and did not change LDL cholesterol. LDL cholesterol:LDL triglycerides mass ratios fe...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(83)90058-8

    authors： Lock DR,Kuisk I,Gonen B,Patsch W,Schonfeld G

    更新日期：1983-06-01 00:00:00

  • The density of calcified plaques and the volume of calcium predict mortality in hemodialysis patients.

    abstract：BACKGROUND AND AIM:In the general population lipid-rich plaques are prone to rupture and healing of the plaque involves calcification. Patients undergoing hemodialysis have a severe derangement of mineral metabolism and calcification of the arterial tree may have different implications. METHODS:Between 2004 and 2005, ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.03.034

    authors： Bellasi A,Ferramosca E,Ratti C,Block G,Raggi P

    更新日期：2016-07-01 00:00:00

  • Global vasomotor dysfunction and accelerated vascular aging in beta-thalassemia major.

    abstract：BACKGROUND:Patients with beta-thalassemia major (beta-TM) demonstrate an increased incidence of vascular complications, which are thought to result from a procoagulant/proinflammatory environment. We investigated the arterial vasorelaxing capacity and sought for early carotid atherosclerosis and underlying pathophysiol...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.09.030

    authors： Hahalis G,Kremastinos DT,Terzis G,Kalogeropoulos AP,Chrysanthopoulou A,Karakantza M,Kourakli A,Adamopoulos S,Tselepis AD,Grapsas N,Siablis D,Zoumbos NC,Alexopoulos D

    更新日期：2008-06-01 00:00:00

  • Background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility.

    abstract：OBJECTIVE:Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are l...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.10.006

    authors： Dale MA,Suh MK,Zhao S,Meisinger T,Gu L,Swier VJ,Agrawal DK,Greiner TC,Carson JS,Baxter BT,Xiong W

    更新日期：2015-12-01 00:00:00

  • Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging.

    abstract：BACKGROUND:Unstable carotid plaques are associated with an increased incidence of embolic complications after carotid artery stenting (CAS) or carotid endarterectomy (CEA). The aim of this study was to elucidate the relationship between the tissue components of carotid plaques and the incidence of new ipsilateral silen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.01.002

    authors： Yamada K,Yoshimura S,Kawasaki M,Enomoto Y,Asano T,Hara A,Minatoguchi S,Iwama T

    更新日期：2011-04-01 00:00:00

  • Cerivastatin: pharmacology of a novel synthetic and highly active HMG-CoA reductase inhibitor.

    abstract：:The pyridine derivative cerivastatin is a new entirely synthetic and enantiomerically pure inhibitor of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase. As a sodium salt cerivastatin is present in the active, open ring form. Cerivastatin inhibited the membrane-bound (non-solubilized) HMG-CoA reductase of the native...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00188-3

    authors： Bischoff H,Angerbauer R,Bender J,Bischoff E,Faggiotto A,Petzinna D,Pfitzner J,Porter MC,Schmidt D,Thomas G

    更新日期：1997-11-01 00:00:00

  • LncRNA HOXA-AS2 represses endothelium inflammation by regulating the activity of NF-κB signaling.

    abstract：BACKGROUND AND AIMS:Endothelium inflammation, which can lead to endothelial activation and dysfunction, is widely accepted as the major event in multiple vascular disorders. The lncRNA HOXA-AS2 was previously reported to be involved in multiple inflammation-linked cancers. However, the role of HOXA-AS2 in endothelium i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.12.012

    authors： Zhu X,Liu Y,Yu J,Du J,Guo R,Feng Y,Zhong G,Jiang Y,Lin J

    更新日期：2019-02-01 00:00:00

  • pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque.

    abstract：BACKGROUND:Atherosclerotic plaques are heterogeneous with respect to inflammation, calcification, vascularity, oxygen, and temperature. We hypothesized that they also vary in pH and measured pH in living human carotid endarterectomized atherosclerotic plaques (CEA), Watanabe heritable hyperlipidemic (WHHL) rabbit aorta...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(02)00018-7

    authors： Naghavi M,John R,Naguib S,Siadaty MS,Grasu R,Kurian KC,van Winkle WB,Soller B,Litovsky S,Madjid M,Willerson JT,Casscells W

    更新日期：2002-09-01 00:00:00

  • Galectin-3 binding protein plasma levels are associated with long-term mortality in coronary artery disease independent of plaque morphology.

    abstract：BACKGROUND AND AIMS:Galectin-3 binding protein (Gal-3BP) is a secreted protein associated with inflammation and carotid atherosclerosis. We hypothesized that high Gal-3BP levels may indicate unfavorable plaque morphology and outcome in coronary artery disease (CAD). METHODS:Gal-3BP plasma levels were measured by ELISA...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2016.06.002

    authors： Gleissner CA,Erbel C,Linden F,Domschke G,Akhavanpoor M,Doesch AO,Buss SJ,Giannitsis E,Katus HA,Korosoglou G

    更新日期：2016-08-01 00:00:00

  • Psychological stress impairs ischemia-induced neovascularization: Protective effect of fluoxetine.

    abstract：BACKGROUND:Psychological stress (PS) has been associated with the development of cardiovascular diseases and adverse long-term outcomes after ischemic events. However, the precise mechanisms involved are not completely understood. Here we investigated the effect of PS on ischemia-induced neovascularization, and the pot...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.06.010

    authors： Maingrette F,Dussault S,Dhahri W,Desjarlais M,Mathieu R,Turgeon J,Haddad P,Groleau J,Perez G,Rivard A

    更新日期：2015-08-01 00:00:00

  • Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients.

    abstract：:Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(99)00160-4

    authors： Porreca E,Sergi R,Baccante G,Reale M,Orsini L,Febbo CD,Caselli G,Cuccurullo F,Bertini R

    更新日期：1999-10-01 00:00:00

  • Modified low density lipoprotein is a potent stimulus for smooth muscle cell outgrowth from rat aortic explant in vitro.

    abstract：:Outgrowth of vascular wall cells from rat aortic tissue explant was studied. In addition to fresh rat serum (3%), the complete culture medium contained either low density lipoprotein (LDL) separated from rat plasma (n-LDL, 100 microg/ml) or rat LDL modified either by activated rat polymorphonuclear leucocytes (pmn-LDL...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(96)06000-5

    authors： Görög P

    更新日期：1997-02-28 00:00:00

  • Crocus sativus L. aqueous extract reduces atherogenesis, increases atherosclerotic plaque stability and improves glucose control in diabetic atherosclerotic animals.

    abstract：BACKGROUND AND AIMS:We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE-/-) mice. METHODS:Fifty male, ApoE-/- mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, eut...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2017.10.032

    authors： Christodoulou E,Kadoglou NPE,Stasinopoulou M,Konstandi OA,Kenoutis C,Kakazanis ZI,Rizakou A,Kostomitsopoulos N,Valsami G

    更新日期：2018-01-01 00:00:00

  • Is inflammation prior to renal transplantation predictive for cardiovascular and renal outcomes?

    abstract：OBJECTIVES:Markers of non-specific inflammation, such as C-reactive protein (CRP) or leukocyte count are increased in end-stage renal disease patients. Recent studies have shown positive associations between inflammatory markers and cardiovascular mortality in kidney transplant recipients, but these analyses had been l...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.01.004

    authors： Krüger B,Walberer A,Debler J,Böger CA,Farkas S,Reinhold SW,Obed A,Schlitt HJ,Fischereder M,Banas B,Krämer BK

    更新日期：2010-06-01 00:00:00

  • Metabolic responses following isoproterenol-induced myocardial infarction in arteriosclerotic breeder vs. non-arteriosclerotic virgin and ovariectomized female rats.

    abstract：:Intact and ovariectomized, non-arteriosclerotic female rats and arteriosclerotic, breeder female rats were subjected to myocardial infarction by the administration of 2 subcutaneous injections, 24 hr apart, of the beta-adrenergic stimulator, isoproterenol. The animals were sacrificed at regular hourly intervals follow...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(75)90049-0

    authors： Lewis BK,Wexler BC

    更新日期：1975-05-01 00:00:00

  • Flow-mediated, endothelium-dependent vasodilatation is impaired in male body builders taking anabolic-androgenic steroids.

    abstract：:Self-administration of anabolic-androgenic steroids to increase muscular strength and lean body mass has been used widely among athletes. Flow mediated dilatation (FMD) determined by ultrasound of the brachial artery is accepted as both an in vivo index of endothelial function and an indicator for future atheroscleros...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00465-8

    authors： Ebenbichler CF,Sturm W,Gänzer H,Bodner J,Mangweth B,Ritsch A,Sandhofer A,Lechleitner M,Föger B,Patsch JR

    更新日期：2001-10-01 00:00:00

  • Intravascular hemolysis increases atherogenicity of diet-induced hypercholesterolemia in rabbits in spite of heme oxygenase-1 gene and protein induction.

    abstract：:Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00422-1

    authors： Fernandez AZ,López F,Tablante A,Romano E,Hurt-Camejo E,Camejo G,Apitz-Castro R

    更新日期：2001-09-01 00:00:00

  • Postprandial effects of a high salt meal on serum sodium, arterial stiffness, markers of nitric oxide production and markers of endothelial function.

    abstract：AIM:The aim of the study was to determine if a high salt meal containing 65 mmol Na causes a rise in sodium concentrations and a reduction in plasma nitrate/nitrite concentrations (an index of nitric oxide production). Secondary aims were to determine the effects of a high salt meal on augmentation index (AIx) a measur...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.atherosclerosis.2013.10.032

    authors： Dickinson KM,Clifton PM,Burrell LM,Barrett PH,Keogh JB

    更新日期：2014-01-01 00:00:00

  • One-month administration of hydroxytyrosol, a phenolic antioxidant present in olive oil, to hyperlipemic rabbits improves blood lipid profile, antioxidant status and reduces atherosclerosis development.

    abstract：:The present study analysed the effects of hydroxytyrosol (HT) on blood lipids, antioxidant status and the progression of aortic lesions in hyperlipemic rabbits. Sixty-four rabbits were distributed into eight groups of animals (n = 8). Animal groups C, A and H were fed for 1-month with a control diet containing sunflow...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.10.022

    authors： González-Santiago M,Martín-Bautista E,Carrero JJ,Fonollá J,Baró L,Bartolomé MV,Gil-Loyzaga P,López-Huertas E

    更新日期：2006-09-01 00:00:00