Abstract:
:Vascular smooth muscle cell (VSMC) migration and proliferation are critical events in the development of neointima following vascular injury. In this study, we found that CD9 is constitutively expressed in the VSMC of the neointima of injured carotid arteries. The in vitro migration and proliferation of human coronary artery smooth muscle (hCASM) cells were reduced by 40% and 63%, respectively, by treatment with a CD9 specific monoclonal antibody mAb7 when compared to control antibody treatment. In a mouse carotid ligation injury model, a single application of a neutralizing anti-mouse CD9 antibody resulted in a 31% (day 14, n=8, p<0.05), and 32% (day 28, n=5, p<0.01) reduction in neointima formation. In support of these findings, exogenous expression of human CD9 by CD9-adenoviral transduction led to 43% increases in neointima (p<0.05, n=6). Upon investigation of the mechanisms underlying CD9 mediated VSMC phenotypic events we found that integrin alpha5beta1 was a constitutive partner of CD9 and that CD9 significantly augmented PI-3 kinase dependent Akt phosphorylation. Furthermore, enhanced Akt phosphorylation was attenuated by mAb7 binding. Cumulatively, a functional link between CD9, alpha5beta1, PI3-K/Akt activity and enhanced VSMC migratory and proliferative phenotypes has been demonstrated. These studies suggest that agents that modulate CD9 mediated VSMC phenotypes may emerge as novel strategies for the treatment of abnormal vascular injury response.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Kotha J,Zhang C,Longhurst CM,Lu Y,Jacobs J,Cheng Y,Jennings LKdoi
10.1016/j.atherosclerosis.2008.07.036subject
Has Abstractpub_date
2009-04-01 00:00:00pages
377-86issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(08)00525-Xjournal_volume
203pub_type
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