Circulating cadmium concentration and risk of aortic aneurysms: A nested case-control study within the Malmö Diet and Cancer cohort.


BACKGROUND AND AIMS:Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether blood Cd levels, a valid measure of Cd exposure, are associated with increased risk of abdominal aortic aneurysm (AAA). METHODS:All middle-aged men and women enrolled in the Malmö Diet and Cancer study (n = 30 447) were followed from the baseline examination in 1991-1996 through 2009. A total of 297 cases with AAA and two randomly selected control subjects for each case, matched for age and sex, were included. Blood Cd was analysed by inductively coupled plasma mass spectrometry. Diagnoses of AAA, thoracic aortic aneurysm and aortic dissection were obtained from registers. RESULTS:Increased blood Cd was associated with increased risk of incident AAA after adjustment for smoking and other established risk factors for AAA. The highest tertile of blood Cd concentrations had a rate ratio of 2.5 (95% confidence interval 1.3, 5.0) for incident AAA. Concentration of blood Cd (log transformed) was not associated with AAA in never-smokers (n = 24). CONCLUSIONS:Blood Cd levels corresponding to the upper tertile of the distribution in the age- and sex-matched control group were associated with a 2.5-fold increase in rate ratio for incident AAA. This relationship was not found in the small group of never-smokers.






Fagerberg B,Borné Y,Sallsten G,Smith JG,Acosta S,Persson M,Melander O,Forsgard N,Gottsäter A,Hedblad B,Barregard L,Engström G




Has Abstract


2017-06-01 00:00:00












  • Homocysteine mediated endothelial cell toxicity and its amelioration.

    abstract::In response to homocysteine induced toxicity in human umbilical vein endothelial cells, minimal changes in the concentration of cellular protein thiols but substantial changes in the concentration of intracellular soluble thiols were observed. The latter correlated closely with changes in cellular glutathione levels. ...


    pub_type: 杂志文章


    authors: Blundell G,Jones BG,Rose FA,Tudball N

    更新日期:1996-05-01 00:00:00

  • Serum selenium and coronary heart disease risk factors in southern Italian men.

    abstract::The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...


    pub_type: 杂志文章


    authors: Jossa F,Trevisan M,Krogh V,Farinaro E,Giumetti D,Fusco G,Galasso R,Panico S,Frascatore S,Mellone C

    更新日期:1991-04-01 00:00:00

  • The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease.

    abstract::Increased oxidative stress (SOX), inflammation and prevalence of cardiovascular disease (CVD) have been reported in end-stage renal disease (ESRD), but their associations with kynurenine (KYN) pathway activation remain unknown. We determined the plasma concentrations of tryptophan (TRP), KYN, 3-hydroxykynurenine (3-HK...


    pub_type: 杂志文章


    authors: Pawlak K,Domaniewski T,Mysliwiec M,Pawlak D

    更新日期:2009-05-01 00:00:00

  • Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype.

    abstract::Angiotensin II (ATII)-mediated hypertension increases the risk for acute coronary events, which may be caused by augmented collagen degradation. Interstitial fibers of collagen type I in the plaque can be degraded by MMP8 and MMP13 specifically. Indeed high MMP8 levels have been correlated with ruptured plaques in pat...


    pub_type: 杂志文章


    authors: Cheng C,Tempel D,van Haperen R,van Damme L,Algür M,Krams R,de Crom R

    更新日期:2009-05-01 00:00:00

  • Inhibition of pericellular plasminogen activation by apolipoprotein(a): Roles of urokinase plasminogen activator receptor and integrins αMβ2 and αVβ3.

    abstract:BACKGROUND AND AIMS:Lipoprotein(a) (Lp(a)) is a causal risk factor for cardiovascular disorders including coronary heart disease and calcific aortic valve stenosis. Apolipoprotein(a) (apo(a)), the unique glycoprotein component of Lp(a), contains sequences homologous to plasminogen. Plasminogen activation is markedly ac...


    pub_type: 杂志文章


    authors: Romagnuolo R,Scipione CA,Bazzi ZA,Boffa MB,Koschinsky ML

    更新日期:2018-08-01 00:00:00

  • (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis.

    abstract:BACKGROUND:There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting enzyme 2(ACE2)/angiotensin-(1-...


    pub_type: 杂志文章


    authors: Peltonen T,Näpänkangas J,Ohtonen P,Aro J,Peltonen J,Soini Y,Juvonen T,Satta J,Ruskoaho H,Taskinen P

    更新日期:2011-05-01 00:00:00

  • Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.

    abstract:BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...


    pub_type: 杂志文章


    authors: Vítek L,Jirsa M,Brodanová M,Kalab M,Marecek Z,Danzig V,Novotný L,Kotal P

    更新日期:2002-02-01 00:00:00

  • Diabetes mellitus abolishes ethnic differences in cardiovascular risk factors: lessons from a multi-ethnic population.

    abstract:AIMS:To compare cardiovascular risk factors in diabetic subjects of different ethnic groups, and between new and known diabetic subjects, in the Singapore National Health Survey '92. METHODS:Disproportionate stratified sampling followed by systematic sampling were used in 3568 (total) respondents of whom 2743 were non...


    pub_type: 杂志文章


    authors: Tan CE,Emmanuel SC,Tan BY,Tai ES,Chew SK

    更新日期:2001-03-01 00:00:00

  • Prostacyclin-dependent differences in TXA2 formation by platelets from normal and atherosclerotic rabbits.

    abstract::Intact platelets from atherosclerotic rabbits release more thromboxane B2 (TXB2) and 12-hydroxyeicosatetraenoic acid (HETE) than platelets from normal rabbits following incubation with [14C]arachidonic acid (AA). In contrast, no difference is found between homogenates of platelets from normal and atherosclerotic anima...


    pub_type: 杂志文章


    authors: Dembińska-Kièć A,Rücker W,Schönhöfer PS

    更新日期:1979-06-01 00:00:00

  • Ciprofibrate in the therapy of type II hypercholesterolemia. A double-blind trial.

    abstract::The hypolipidemic efficacy of ciprofibrate was evaluated in patients with type II hypercholesterolemia. Patients were randomized to placebo or ciprofibrate (50 mg or 100 mg/day) and, after a 6-week baseline period, received medication for a period of 12 weeks. Blood samples were analyzed every 2 weeks. Twenty patients...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Illingworth DR,Olsen GD,Cook SF,Sexton GJ,Wendel HA,Connor WE

    更新日期:1982-08-01 00:00:00

  • Endothelium-dependent vasodilation, insulin resistance and the metabolic syndrome in an elderly cohort: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

    abstract:BACKGROUND:Only a few previous studies have investigated endothelium-dependent vasodilation in the metabolic syndrome (MetS). In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, different techniques to assess vasodilation in conduit and resistance arteries were evaluated in relation to the Met...


    pub_type: 杂志文章


    authors: Lind L

    更新日期:2008-02-01 00:00:00

  • Identification of intimal subendothelial cells from human aorta in primary culture.

    abstract::Subendothelial cells (SEC) were obtained from the inner intimal layer of adult human aorta by collagenase treatment. SEC were identified in primary culture either as smooth muscle cells by staining with FITC-labeled antisera against human smooth muscle myosin or as macrophages, foam cells and contaminating endothelial...


    pub_type: 杂志文章


    authors: Babaev VR,Antonov AS,Zacharova OS,Romanov YA,Krushinsky AV,Tsibulsky VP,Shirinsky VP,Repin VS,Smirnov VN

    更新日期:1988-05-01 00:00:00

  • Lipoprotein particle distribution and size, insulin resistance, and metabolic syndrome in Alaska Eskimos: the GOCADAN study.

    abstract:BACKGROUND:Metabolic syndrome (MS) is associated with dyslipidemia, and insulin resistance (IR) may be a main determinant of this dyslipidemia. OBJECTIVE:To determine how lipoprotein particle concentration and size are related to MS and IR in a population-based sample of Alaska Eskimos. DESIGN:Participants underwent ...


    pub_type: 杂志文章


    authors: Rivellese AA,Patti L,Kaufman D,Zhu J,Annuzzi G,Vaccaro O,Ebbesson SO,Howard WJ,Riccardi G,Howard BV

    更新日期:2008-10-01 00:00:00

  • Leukocyte count is associated with incidence of coronary events, but not with stroke: a prospective cohort study.

    abstract:OBJECTIVE:Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS:A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascu...


    pub_type: 杂志文章


    authors: Li C,Engström G,Hedblad B

    更新日期:2010-04-01 00:00:00

  • The effect of hypercholesterolemia on aortic endothelium studied en face.

    abstract::The aortic endothelium of rabbits fed a stock diet containing 1 or 2% cholesterol for intervals of 1 day to 21 weeks was compared with that of normal rabbits on a stock diet without cholesterol. The endothelium was examined en face using the Häutchen technique. The aortic endothelium of the experimental animals reveal...


    pub_type: 杂志文章


    authors: Silkworth JB,McLean B,Stehbens WE

    更新日期:1975-11-01 00:00:00

  • Associations between serum lipoprotein(a) levels and the severity of coronary and aortic atherosclerosis.

    abstract::To elucidate the associations between Lp(a) levels and coronary and aortic atherosclerosis, we performed aortic MRI in 143 patients undergoing coronary angiography. Severity of aortic atherosclerosis was represented as plaque scores. Of the 143 patients, 104 had coronary artery disease (CAD). Thoracic and abdominal ao...


    pub_type: 杂志文章


    authors: Momiyama Y,Ohmori R,Fayad ZA,Tanaka N,Kato R,Taniguchi H,Nagata M,Ohsuzu F

    更新日期:2012-05-01 00:00:00

  • Exclusive expression of transmembrane TNF-alpha in mice reduces the inflammatory response in early lipid lesions of aortic sinus.

    abstract::We investigated the effect of transmembrane form of tumor necrosis factor-alpha (TNF) on atherosclerosis in mice. We compared the development of early atherosclerotic lesions in the aortic sinus of (1) TNF-deficient mice that express only a non-cleavable transmembrane form of TNF (tmTNF), (2) wild-type (WT) C57BL/6 mi...


    pub_type: 杂志文章


    authors: Canault M,Peiretti F,Mueller C,Kopp F,Morange P,Rihs S,Portugal H,Juhan-Vague I,Nalbone G

    更新日期:2004-02-01 00:00:00

  • Familial ligand-defective apolipoprotein B-100: detection, biochemical features and haplotype analysis of the R3531C mutation in the UK.

    abstract::Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by the substitution of glutamine for arginine at codon 3500 of the apo B gene (apo B R3500Q), resulting in decreased binding of low density lipoprotein (LDL) to the ...


    pub_type: 杂志文章


    authors: Wenham PR,Henderson BG,Penney MD,Ashby JP,Rae PW,Walker SW

    更新日期:1997-03-21 00:00:00

  • Exercise tolerance test for predicting coronary heart disease in asymptomatic individuals: A review.

    abstract::In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of E...


    pub_type: 杂志文章,评审


    authors: Mégnien JL,Simon A

    更新日期:2009-08-01 00:00:00

  • Accurate quantification of atherosclerotic plaque volume by 3D vascular ultrasound using the volumetric linear array method.

    abstract:INTRODUCTION:Direct quantification of atherosclerotic plaque volume by three-dimensional vascular ultrasound (3DVUS) is more reproducible than 2DUS-based three-dimensional (2D/3D) techniques that generate pseudo-3D volumes from summed 2D plaque areas; however, its accuracy has not been reported. We aimed to determine 3...


    pub_type: 杂志文章


    authors: López-Melgar B,Fernández-Friera L,Sánchez-González J,Vilchez JP,Cecconi A,Mateo J,Peñalvo JL,Oliva B,García-Ruiz JM,Kauffman S,Jiménez-Borreguero LJ,Ruiz-Cabello J,Fernández-Ortiz A,Ibáñez B,Fuster V

    更新日期:2016-05-01 00:00:00

  • Carotid artery and left ventricular structural relationship in asymptomatic men at risk for cardiovascular disease.

    abstract::To determine whether a relationship between echographically assessed carotid artery and left ventricular (LV) structures existed in asymptomatic men at risk for cardiovascular disease, we evaluated carotid and LV parameters in 69 subjects (23-62 years) without LV hypertrophy. The right common carotid far wall intima-m...


    pub_type: 杂志文章


    authors: Linhart A,Gariepy J,Giral P,Levenson J,Simon A

    更新日期:1996-11-15 00:00:00

  • Experimental atherosclerosis of the heart valves in rats following a long-term atherogenic regimen.

    abstract::Male and female rats kept on a long-term atherogenic regimen for periods up to 15 months developed marked atherosclerotic changes of cardiac valves in 100% of cases. The degree and the topography of valvular atherosclerotic plaques corresponded widely to that seen in human atherosclerotic valvular disease. The regular...


    pub_type: 杂志文章


    authors: Záhor Z,Czabanová V

    更新日期:1977-05-01 00:00:00

  • Risk of myocardial infarction in patients with rhinosinusitis.

    abstract::Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study coh...


    pub_type: 杂志文章


    authors: Hao WR,Lin HW,Chao PZ,Wu CW,Yen TH,Liu JC,Liou TH

    更新日期:2013-01-01 00:00:00

  • Seasonal variation in parameters related to coronary heart disease risk in young men.

    abstract::Seasonal variation in the plasma lipids and lipoproteins is reported in the literature. Whether this variation is the result of changes in diet or other factors has not been adequately addressed. We investigated the effects of a controlled diet on the seasonal variation in the levels of plasma lipids and apolipoprotei...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mustad V,Derr J,Reddy CC,Pearson TA,Kris-Etherton PM

    更新日期:1996-09-27 00:00:00

  • Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease.

    abstract::In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 yea...


    pub_type: 杂志文章


    authors: Sanderson KJ,van Rij AM,Wade CR,Sutherland WH

    更新日期:1995-11-01 00:00:00

  • HDL2 and HDL3 lipid levels in coronary artery disease.

    abstract::The concentrations of cholesterol (C) and phospholipid (PL) levels in the high density lipoprotein (HDL) fraction and the HDL2 and HDL3 subfractions were determined in 74 men with incapacitating angina pectoris and coronary artery disease (CAD) verified by angiography. An equal number of randomly sampled healthy men m...


    pub_type: 杂志文章


    authors: Wallentin L,Sundin B

    更新日期:1986-02-01 00:00:00

  • Diabetic state as a crucial factor for impaired arterial elastic properties in patients with peripheral arterial disease.

    abstract:BACKGROUND:Increased arterial stiffness is associated with greater risk of cardiovascular events and mortality. However, in patients with peripheral arterial disease (PAD) who have severe atherosclerotic disorder or risk clustering, the major determinants of increased stiffness have been not clarified. METHODS:This st...


    pub_type: 杂志文章


    authors: Makita S,Matsui H,Naganuma Y,Abiko A,Tamada M,Nakamura M

    更新日期:2010-01-01 00:00:00

  • Enhanced synthesis of collagen and total protein by smooth muscle cells from atherosclerotic rabbit aortas in culture.

    abstract::Protein synthesis in smooth muscle cells from normal and atherosclerotic rabbit aortas was studied. Cultures of cells from the third passage were incubated with [3H]proline and the synthesis rates of collagen and total protein measured from the radioactivities incorporated into protein-bound hydroxyproline and proline...


    pub_type: 杂志文章


    authors: Pietilä K,Nikkari T

    更新日期:1980-09-01 00:00:00

  • The effects of diet and lovastatin on regression of fatty streak lesions and on hepatic and intestinal mRNA levels for the LDL receptor and HMG CoA reductase in F1B hamsters.

    abstract::This study examined the effects of lovastatin supplementation (25 mg/kg per day) in conjunction with an atherogenic diet (10% coconut oil (w/w), 0.05% cholesterol) on regression of pre-existing foam cells and on hepatic and intestinal LDL receptor and HMG CoA reductase mRNA levels. F1B hamsters fed the atherogenic die...


    pub_type: 杂志文章


    authors: Pitman WA,Osgood DP,Smith D,Schaefer EJ,Ordovas JM

    更新日期:1998-05-01 00:00:00

  • Effect of losartan on ambulatory short-term blood pressure variability and cardiovascular remodeling in hypertensive patients on hemodialysis.

    abstract:OBJECTIVE:Previous studies have shown increases in ambulatory short-term blood pressure (BP) variability to be related to cardiovascular disease. In this study, we examined whether an angiotensin II type 1 receptor blocker losartan would improve ambulatory short-term BP variability in hypertensive patients on hemodialy...


    pub_type: 杂志文章,随机对照试验


    authors: Mitsuhashi H,Tamura K,Yamauchi J,Ozawa M,Yanagi M,Dejima T,Wakui H,Masuda S,Azuma K,Kanaoka T,Ohsawa M,Maeda A,Tsurumi-Ikeya Y,Okano Y,Ishigami T,Toya Y,Tokita Y,Ohnishi T,Umemura S

    更新日期:2009-11-01 00:00:00