Abstract:
:Coronary arteries with and without atheroma are compared histologically to ask what kind of artery encourages atheroma. When atheroma obliterates the structures that preceded and invited its intrusion, the sites remaining for observation form a censored data set. How to assess media-like island effects using the censored data set is the objective here. Full length of right coronary artery is prepared for H&E-stained paraffin sections. At sites lacking atheroma, measurements are taken for intimal thickness (FT), SMC numbers (CT), and their ratio, fibroplastic thickness per SMC, FC = FT/CT. Arteries with atheroma tend to have greater values for all three variables, FC, FT, and CT. Mathematical models compensating for data set censoring imply that atheroma selectively favors sites with much fibroplasia and few SMCs, i.e. high FC. Frequently encountered media-like islands in the coronary intima showed ambiguous evidence of weakly repelling atheroma. Fibroplastic intimal thickening measured by FC progresses relentlessly with age. The sites with the greatest fibroplasia seem to be the most prone to selective obliteration by atheroma. Media-like islands seem to protect only the local sites and not the whole artery from atheroma.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Tracy REdoi
10.1016/j.atherosclerosis.2004.08.011keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
49-56issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(04)00425-3journal_volume
178pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract::Abundant data is present to implicate oxidatively modified low-density lipoprotein (oxLDL) in enhanced atherogenesis. Among the factors involved in LDL oxidation, an important role has been attributed to human 15-lipoxygenase (LO) and its murine analog 12-LO. The expression of these peroxidizing enzymes is under the c...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(00)00418-4
更新日期:2000-12-01 00:00:00
abstract::Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(98)00241-x
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND/AIM:In type 2 diabetes and other insulin-resistant conditions, postprandial hypertriglyceridaemia is an important metabolic perturbation. To further elucidate alterations in the clearance of triglyceride-rich lipoproteins in type 2 diabetes we focused on the nutritional regulation of adipose tissue lipoprote...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章
doi:10.1016/s0021-9150(02)00366-0
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:The plasma level of soluble CD40 ligand (sCD40L), which induces pro-inflammatory and pro-atherogenic responses, is known to be elevated in atherosclerotic patients. In this study, we investigated the mechanism of sCD40L release from human platelets, focusing on the involvement of thromboxane (TX) A(2). METHO...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2009.10.024
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND AND AIMS:South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. METHODS:Am...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2020.09.010
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIMS:The exact mechanism of premature atherosclerosis in diabetes is still unclear. Inappropriate activation of the renin-aldosterone-angiotensin system may be an important risk factor for cardiovascular disease. We investigated whether renin and aldosterone are associated with vasoactive peptides midreg...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2016.07.905
更新日期:2016-09-01 00:00:00
abstract::Acyl-coenzyme A:cholesterol acyltransferase (ACAT) esterifies free cholesterol and stores cholesteryl esters in lipid droplets. Macrophage ACAT1 deficiency results in increased atherosclerotic lesion area in hyperlipidemic mice via disrupted cholesterol efflux, increased lipoprotein uptake, accumulation of intracellul...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.08.005
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.11.033
更新日期:2016-03-01 00:00:00
abstract::The internal mammary artery (IMA) is less prone to intimal thickening than coronary arteries and is routinely used in coronary bypass surgery. To resolve whether morphologic differences can explain why IMA develops less intimal thickening, morphometric measurement of the left anterior descending coronary artery (LAD) ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(90)90169-j
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Clinical interventions targeting nonlipid risk factors are needed given the high residual risk of atherothrombotic events despite effective control of dyslipidemia. Dickkopf-1 (DKK1) plays a lipid-independent role in vascular pathophysiology but its involvement in atherosclerosis development and its...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2020.10.001
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Plaque with dense inflammatory cells, including macrophages, thin fibrous cap and superficial necrotic/lipid core is thought to be prone-to-rupture. We report a time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) technique for detection of such markers of plaque vulnerability in human plaques. ME...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2008.08.035
更新日期:2009-05-01 00:00:00
abstract::Rabbits were continuously exposed to 200 ppm carbon monoxide. Using the same criteria as applied by earlier investigators for morphological myocardial damage, no histotoxic effect on myocardial morphology could be demonstrated when electron-microscopic investigations were performed blindly. Similarly, exposure to 0.5 ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90037-x
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Dementia is a major public health problem because of its high prevalence in elderly individuals, particularly in the growing category of subjects aged 80 years or more. There is accumulating evidence that cholesterol may be implicated in the pathogenesis of dementia, and this has led us to assess the relatio...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2013.07.009
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The pathological process of atherosclerosis is closely related to lipid accumulation at arterial wall caused by lipoproteins transporting lipids through blood. In this study, we investigate the lipid composition in the plasma of apolipoprotein E deficient (ApoE-/-) mice fed a high-fat diet to reveal...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2017.05.010
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Although familial hypercholesterolemia (FH) can be effectively managed using cholesterol-lowering medication, patients often fall short of complete treatment adherence. Identifying the psychological factors associated with self-regulation of FH medication is important to inform interventions to maxi...
journal_title:Atherosclerosis
pub_type: 杂志文章,多中心研究
doi:10.1016/j.atherosclerosis.2018.06.010
更新日期:2018-10-01 00:00:00
abstract::Methylamine can be converted by semicarbazide-sensitive amine oxidase (SSAO) to formaldehyde and hydrogen peroxide, which have been proven to be toxic towards cultured endothelial cells. We investigated whether or not these deaminated products from methylamine can exert potentially hazardous toxic effects in vivo. Lon...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(95)05701-3
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Peripheral artery disease (PAD) is associated with poor mobility and fatigue, but the relationship between preclinical ankle-brachial index (ABI) and early markers of fatigue and functional decline has not been defined. METHODS:570 adults, 50 and older, from the Baltimore Longitudinal Study of Agin...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.03.037
更新日期:2018-05-01 00:00:00
abstract::Essential polyunsaturated fatty acids (PUFA) of the omega-3 family are believed to protect against cardiovascular disease. A rich source of omega-3 PUFA is found in fish and marine mammals (seal, walrus, whale), which are a large part of the traditional diet of Alaska Natives (Eskimo, American Indians, Aleuts), a grou...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.01.019
更新日期:2005-08-01 00:00:00
abstract::Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90088-5
更新日期:1981-04-01 00:00:00
abstract:BACKGROUND AND AIMS:We aimed at developing a novel risk prediction model for death from cardiovascular disease (CVD) for Chinese individuals, based upon a large cohort from Taiwan. METHODS:This Chinese cohort came from Taiwan, with 381,963 individuals free from CVD, recruited from a private health surveillance program...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2017.07.016
更新日期:2017-09-01 00:00:00
abstract::Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(93)90130-m
更新日期:1993-01-25 00:00:00
abstract:BACKGROUND AND AIMS:Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker associated with cardiovascular disease. Statins lower both low-density lipoprotein (LDL)-cholesterol and C-reactive protein (CRP), resulting in improved outcomes. However, whether lipid-lowering therapy also lowers su...
journal_title:Atherosclerosis
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.atherosclerosis.2018.03.030
更新日期:2018-05-01 00:00:00
abstract::Atherosclerosis is a major underlying cause of ischemic heart diseases, ischemic stroke, and peripheral artery disease. Atherosclerotic plaque progression is characterized by chronic progressive inflammation of the arterial wall, endothelial cell dysfunction, and subendothelial lipoprotein retention. Incretin drugs, g...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2018.09.011
更新日期:2018-11-01 00:00:00
abstract::Arterial specimens were obtained from 12 patients during arterial repair surgery and 3 patients during nephrectomy following a bolus injection of autologous radio-iodinated very low density lipoprotein (VLDL) up to 30 h before surgery. Radioactivity in apoprotein B (apo B) was determined in lipoprotein fractions isola...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90073-3
更新日期:1981-05-01 00:00:00
abstract::A marked reduction of serum cholesterol was obtained by treatment with probucol in heterozygous as well as in homozygous cases of familial hypercholesterolemia. A strict dietary regimen (low-fat, low-calories) intensified the hypocholesterolemic effect of the drug. The drug was also useful in diminishing the rebound o...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(83)90102-8
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2014.07.019
更新日期:2014-10-01 00:00:00
abstract::The ultrastructural effects of a single brief intra-arterial infusion of palmitic, linoleic and acetoacetic acid on the arterial endothelium of the rat were investigated, and the following results obtained: (1) Palmitic acid, infused at a concentration of 4 mM/l, damaged the arterial lining by producing large cytoplas...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(81)90047-2
更新日期:1981-02-01 00:00:00
abstract::Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00081-6
更新日期:1997-07-25 00:00:00
abstract::The serum concentrations of testosterone, androstenedione, oestradiol and total low polar oestrogens, mainly oestradiol and oestrone, were measured in 26 healthy male subjects. The subjects were divided into two groups each of them with low (less than 1.04 mmol/l) and high (greater than 1.56 mmol/l) levels of serum HD...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(79)90067-4
更新日期:1979-12-01 00:00:00
abstract::29 autogenous vein grafts, from 26 patients with peripheral arterial disease, were studied. 4 grafts of Group I (less than 3 months duration) were patent and removed for reasons other than graft failure. These showed 'arterialisation' only; 4 grafts of Group II (duration 5-18 months) showed thrombotic occlusion; 21 gr...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(85)90153-4
更新日期:1985-01-01 00:00:00