Abstract：
:Factor XIII is a transglutaminase that crosslinks fibrin in the last steps of the coagulation process. A few polymorphic sites have been identified in this gene, one of them being a point mutation (FXIII Val34Leu), leading to an amino acid change of valine to leucine. Recently, in British patients, FXIII 34Leu allele was suggested to be associated with a decreased incidence of myocardial infarction (MI). PAI-1 4G/4G genotype seemed to lessen the beneficial effect of FXIII 34Leu allele. The aim of our study was to further investigate the possible protective role of the FXIII 34Leu allele against MI and its suggested interaction with the PAI-1 4G/5G polymorphism. We carried out genotype analyses for FXIII Val34Leu using solid-phase minisequencing in two independent Finnish study groups. In our study, the FXIII 34Leu allele was associated with a lower risk of MI (P = 0.009), however, the PAI-1 4G allele showed no interaction with this polymorphism. To establish the population frequency of the FXIII 34Leu allele and to study the possible variations in Finland four DNA pools from different geographical areas of Finland were genotyped. No significant differences in the allele frequencies were observed (21-28%) except in the Eastern Kainuu area (13%), an area with an increased risk of mortality from coronary artery disease (CAD), supporting the results presented above. The association of FXIII 34Leu variant with a lower incidence of myocardial infarction suggests a new role for FXIII in a polygenic thrombotic disease.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Wartiovaara U,Perola M,Mikkola H,Tötterman K,Savolainen V,Penttilä A,Grant PJ,Tikkanen MJ,Vartiainen E,Karhunen PJ,Peltonen L,Palotie Adoi
10.1016/s0021-9150(98)00241-xkeywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
295-300issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(98)00241-Xjournal_volume
142pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract：:The association between serum selenium concentration and a number of coronary heart disease risk factors is studied in 364 males from southern Italy participating in the Olivetti Heart Study. Selenium correlates positively and significantly with serum cholesterol (r = 0.120; P = 0.022), and this positive association p...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(91)90015-u
更新日期：1991-04-01 00:00:00
abstract：:The aim of this work was to study how CETP expression affects whole body cholesterol homeostasis. Thus, tissue uptake and plasma removal rates of labeled HDL-cholesteryl ester (CE), VLDL secretion rates, and biliary lipid secretion and fecal bile acid content were compared between human CETP transgenic (Tg) and non-tr...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2006.05.036
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Previous studies have indicated that sleep duration is associated with total mortality in a U-shaped fashion. The purpose of the current study was to examine the relationship between self-reported sleep duration and carotid artery atherosclerosis in a Japanese population. METHODS:In 2009-2010, a total of 24...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.02.029
更新日期：2011-08-01 00:00:00
abstract：:The fatty acid composition of adipose tissue from 4114 men and women across 22 districts of Scotland is described. A biopsy of subcutaneous adipose tissue was obtained from the upper arm using a skin biopsy punch. Overall the proportion of saturated fatty acids was lower in women and those of monounsaturated and polyu...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(92)90241-8
更新日期：1992-06-01 00:00:00
abstract：OBJECTIVE:To investigate the statin eligibility and the predictabilities for cardiovascular disease between AHA/ACC and ATPIII guidelines, comparing those results to concomitant coronary artery calcium scores (CACS) in a large cohort of Korean individuals who met statin-eligibility criteria. METHODS:Among 19,920 parti...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2015.03.006
更新日期：2015-05-01 00:00:00
abstract：:Vascular endothelial cell death contributes to the progression of atherosclerotic lesion, and several transcriptional regulators are involved in the process. Activating transcription factor 3/liver regenerating factor-1 (ATF3/LRF-1), a stress-inducible transcriptional repressor, was shown to be highly expressed in vas...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00639-6
更新日期：2002-04-01 00:00:00
abstract：:Apolipoprotein (apo) E is a multifunctional protein that can act as a ligand for lipoprotein receptors. The receptor-mediated clearance of the triglyceride-rich lipoproteins (TRL) chylomicrons and VLDL from plasma is, in part, dependent on apo E. Enrichment of VLDL with apo E is thought to enhance receptor-mediated cl...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00589-x
更新日期：2001-04-01 00:00:00
abstract：:Coronary heart disease (CHD) is one of the leading disorders with the highest mortality rate. Percutaneous angioplasty and stent implantation are the currently available standard methods for the treatment of obstructive coronary artery disease. However, the stent being an exogenous substance causes several complicatio...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2018.03.036
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:Significant sex differences exist in cardiovascular diseases. Although an impact of gonadal hormones is presumed, it is largely unknown whether sexually dimorphic gene expression also plays a role and whether cells themselves show intrinsic sex differences. METHODS:We performed whole genome expression analys...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2015.02.018
更新日期：2015-05-01 00:00:00
abstract：:We describe a rapid screening procedure to identify known DNA sequence changes in individuals diagnosed as having heterozygous familial hypercholesterolaemia (FH). The screening is made possible by combining a rapid DNA extraction protocol and small scale polymerase chain reaction DNA amplification, followed by oligon...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(91)90053-6
更新日期：1991-08-01 00:00:00
abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0021-9150(02)00424-0
更新日期：2003-03-01 00:00:00
abstract：:Platelet-derived growth factor (PDGF) A-chain contributes to the pathogenesis of cardiovascular proliferative diseases, such as hypertensive vascular disease, atherosclerosis, and re-stenosis of an artery after angioplasty. To develop a ribozyme against human PDGF A-chain mRNA as a gene therapy for human arterial prol...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00451-8
更新日期：2001-10-01 00:00:00
abstract：:Numerous epidemiological studies have shown that lipoprotein(a) (Lp(a)) is an independent risk factor for the premature development of cardiovascular disease. In spite of such evidence, the structural and functional features of this atherogenic, cholesterol-rich particle are not clearly understood. We have demonstrate...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/s0021-9150(97)00111-1
更新日期：1997-08-01 00:00:00
abstract：:The pathogenesis of retinal vein occlusion (RVO), has not been well understood. Recent data have shown the efficacy of an anticoagulant therapy with LMWHs in the treatment of acute RVO suggesting the presence of a hypercoagulable state in these patients. New global tests for detection of hypercoagulability and hypofib...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2012.06.053
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND AND AIMS:Sarpogrelate, a 5-hydroxytryptamine type 2A antagonist, is a potential antiplatelet agent. We performed a randomized study to evaluate the effect of sarpogrelate on vascular health in Korean patients with diabetes. METHODS:Forty diabetic patients aged 58.6 ± 6.8 years with 10-75% coronary artery st...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.atherosclerosis.2016.12.011
更新日期：2017-02-01 00:00:00
abstract：:The lecithin:cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of cholesteryl esters in human plasma and plays a critical role in high density lipoprotein (HDL) metabolism. Genetic LCAT deficiency is a rare metabolic disorder characterized by low HDL cholesterol levels. This paper reviews the ...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2011.11.034
更新日期：2012-06-01 00:00:00
abstract：:Apolipoprotein B-100 (apo B-100) is the protein component of low density lipoprotein (LDL) responsible for its binding and clearance by LDL receptors (LDL-R). In familial defective apo B-100 (FDB), a mutation in apo B-100 at residue 3500 markedly reduces its affinity for LDL-R, often causing accumulation of defective ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(95)05598-q
更新日期：1995-11-01 00:00:00
abstract：BACKGROUND AND AIMS:Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular cal...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.06.011
更新日期：2016-08-01 00:00:00
abstract：:Oscillatory shear stress applied to the lining of blood vessels causes endothelial cell injury, one of the essential postulated prerequisites to the development of atherosclerosis. The purpose of this investigation was to study effects of shear stress on bovine aortic endothelial cells (BAEC), in vitro, for varying le...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(87)90054-2
更新日期：1987-03-01 00:00:00
abstract：OBJECTIVE:Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-cholestero...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.atherosclerosis.2012.09.001
更新日期：2012-12-01 00:00:00
abstract：:The oxidation of low density lipoprotein (LDL) is believed to be an important process in the development and progression of atherosclerosis. In this study, human subjects were supplemented daily with one of: 6 g raw garlic; 2.4 g aged garlic extract (AGE); or 0.8 g DL-alpha-tocopherol acetate for 7 days to determine t...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0021-9150(98)00293-7
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND AND AIMS:The association between cholesterol and stroke has been inconsistent. This study aimed to examine the association between total cholesterol (TC) and mortality from total stroke and stroke subtypes. METHODS:503,340 Korean adults aged 40-80 years without a history of heart disease or stroke participa...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2017.12.003
更新日期：2018-03-01 00:00:00
abstract：:The effects of lovastatin therapy on concentrations and compositions of lipoproteins were examined in 14 patients with heterozygous familial hypercholesterolemia. The drug lowered plasma levels of cholesterol in total plasma, very low density + intermediate density lipoproteins (VLDL + IDL) and low density lipoprotein...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0021-9150(90)90079-x
更新日期：1990-10-01 00:00:00
abstract：:Ultrasound measurements are both surrogate markers and risk factors for atherosclerosis end points. Carotid intima-media thickness (IMT) is most commonly used, but ultrasound can also define structures in higher spatial dimensions, such as total plaque area (TPA) and total plaque volume (TPV). Because there are minima...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2004.08.016
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2010.04.003
更新日期：2010-08-01 00:00:00
abstract：:We describe a new method for the rapid fractionation of plasma lipoproteins, which makes use of a new non-ionic, iodinated, density gradient medium, iodixanol, commercially available as Optiprep(TM). The method is simple: plasma or serum is mixed with iodixanol followed by centrifugation in a vertical or near vertical...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(96)05797-8
更新日期：1996-07-01 00:00:00
abstract：OBJECTIVE:Atherosclerosis is an inflammatory process resulting from the interaction between genetic and environmental factors. Leukotrienes are inflammatory mediators generated from arachidonic acid, and genetic polymorphisms involved in leukotriene metabolism are implicated in atherosclerosis. The objectives of this s...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2012.10.048
更新日期：2013-01-01 00:00:00
abstract：:Although calcific aortic stenosis is a very common disease with major adverse cardiovascular events and healthcare costs, there are no effective medical interventions to delay or halt its progression. Cardiometabolic risk factors, including smoking and male sex, are linked to aortic stenosis. Emerging studies have ide...
journal_title：Atherosclerosis
pub_type： 杂志文章,评审
doi：10.1016/j.atherosclerosis.2018.08.029
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVE:Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS:Patients that underwent femoral or carot...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2011.02.004
更新日期：2011-06-01 00:00:00
abstract：OBJECTIVE:To determine whether endogenous sex hormones (estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and follicle stimulating hormone (FSH)) are longitudinally associated with progression of atherosclerosis among women at midlife. METHODS:249 Pre- or early peri-menopausal women (42-57 years) ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2012.07.025
更新日期：2012-11-01 00:00:00
