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Cultured bovine aortic endothelial cells show increased histamine metabolism when exposed to oscillatory shear stress.

Abstract：

:Oscillatory shear stress applied to the lining of blood vessels causes endothelial cell injury, one of the essential postulated prerequisites to the development of atherosclerosis. The purpose of this investigation was to study effects of shear stress on bovine aortic endothelial cells (BAEC), in vitro, for varying lengths of time (6 h, 12 h, 24 h) on BAEC histamine content (HC) and histidine decarboxylase activity (HD). Low intensity stress (1.6 dynes/cm2) as well as intermediate and high intensity shear stresses (3.5 dynes/cm2 and 7.6 dynes/cm2) resulted in an accelerated HD (281%) and elevated HC (144%). These data indicate that oscillatory shear stress produces increases in histamine metabolism.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Skarlatos SI,Hollis TM

doi

10.1016/0021-9150(87)90054-2

subject

Has Abstract

pub_date

1987-03-01 00:00:00

pages

55-61

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(87)90054-2

journal_volume

64

pub_type

杂志文章

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