Abstract:
OBJECTIVE:The purpose of this study was to evaluate whether the extent of epicardial adipose tissue (EAT) thickness or the presence of descending thoracic aortic calcification on multi-detector CT (MDCT) can predict the presence of significant coronary artery stenosis in patients with negative coronary artery calcium (CAC). METHODS:We enrolled 90 patients with negative CAC in whom both coronary CT angiography (CTA) and conventional angiography had been performed. Group 1 consisted of patients (n=27) with significant coronary artery stenosis (≥50%), whereas group 2 (n=63) had non-obstructive coronary artery stenosis (<50%) on conventional angiography. We analyzed whether or not there is a significant difference in EAT thickness or the incidence of calcification of descending thoracic aorta among the two groups. RESULTS:There was no significant difference between EAT thickness on MDCT among the two groups. There was also no significant difference in the incidence of descending thoracic aortic calcification between group 1 (7/27, 25.9%) and group 2 (14/63, 22.2%) (p>0.05). CONCLUSIONS:Neither the presence of abundant EAT nor calcification of descending thoracic aorta is a marker of significant coronary artery stenosis in patients with negative CAC.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Lee HY,Song IS,Yoo SM,Rho JY,Moon JY,White CSdoi
10.1016/j.atherosclerosis.2010.01.047subject
Has Abstractpub_date
2010-10-01 00:00:00pages
495-500issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(10)00096-1journal_volume
212pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract::Chylomicron catabolism in the bloodstream consists of lipolysis by lipoprotein lipase and uptake of remnants by the liver. In rats, triglyceride-rich emulsions can mimic chylomicron metabolism. To further validate this model in man, the emulsion was injected intravenously into fasting and into subjects previously fed ...
journal_title:Atherosclerosis
pub_type: 临床试验,杂志文章
doi:10.1016/0021-9150(96)05889-3
更新日期:1996-09-27 00:00:00
abstract::Sitostanol (24-ethyl-5 alpha-cholestan-3 beta-ol), a hydrogenated derivative of sitosterol, was administered in a low dose (1.5 g/day) for 4 weeks to 6 patients with hypercholesterolemia. Total cholesterol was reduced significantly after 3 and 4 weeks by 10 and 15%, respectively. The reduction of total cholesterol was...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(86)90141-3
更新日期:1986-09-01 00:00:00
abstract:BACKGROUND:We undertook a study to determine whether peripheral vascular disease of the lower extremity (PVD) per se affects the arterial viscoelastic properties and intima-media thickness (IMT) of the carotid and femoral arteries. METHODS:Thirty-five patients with PVD, 35 age- and gender-matched control subjects were...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(02)00042-4
更新日期:2002-09-01 00:00:00
abstract::In general, plasma concentrations of high density lipoproteins (HDL) are inversely related to the incidence of coronary artery disease. One exception to this trend is individuals with apolipoprotein A-I(Milano) (apo A-IM), a molecular variant of apo A-I, which results in very low plasma apo A-I and HDL-cholesterol lev...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(97)00195-0
更新日期:1998-01-01 00:00:00
abstract::Elevated plasma LDL-cholesterol (LDL-C) levels are associated with an increased risk of coronary artery disease (CAD). Familial hypercholesterolemia (FH), a monogenic trait due to mutations in the LDL-receptor (R) gene is characterized by raised plasma LDL-C levels and premature CAD. The aim of the present investigati...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(98)00268-8
更新日期:1999-03-01 00:00:00
abstract::A chondroitin sulfate-dermatan sulfate proteoglycan was isolated from bovine aorta intima by extraction of the tissue with 4 M guanidine hydrochloride. The proteoglycan was purified by CsCl isopycnic centrifugation followed by gel filtration and ion exchange chromatography. A monoclonal antibody C8F4 was developed to ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(93)90127-g
更新日期:1993-01-25 00:00:00
abstract:OBJECTIVE:Vascular calcification is an active deposition process of calcium phosphate which resembles bone formation and is highly regulated by osteoblast-like cells. Existing studies demonstrate that advanced glycation end-products (AGEs) may play a pathogenic role in the vascular calcification process. However, their...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.01.019
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.11.033
更新日期:2016-03-01 00:00:00
abstract::Large (Sf greater than 100) and small (Sf 100-20) very low density lipoprotein (VLDL) particles were isolated by density gradient ultracentrifugation and characterized chemically in 8 patients with primary hypertriglyceridemia before and after 6 weeks treatment with 4 grammes daily of nicotinic acid (NA). Concomitant ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(90)90094-y
更新日期:1990-10-01 00:00:00
abstract::We evaluated a 69-year-old Japanese woman with apolipoprotein (apo) A-I deficiency, high levels of low-density lipoprotein (LDL)-cholesterol, hypertension and impaired glucose tolerance. The patient had corneal opacity, but neither xanthomas, xanthelasma, nor tonsillar hypertrophy. She was not symptomatic for coronary...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(01)00724-9
更新日期:2002-06-01 00:00:00
abstract::Polar coordinate mapping was used to determine the rate of growth of individual sudanophilic lesions on the aortic wall around several major branches of the aortae of cholesterol fed rabbits. Four groups, with 6 8-month old male albino white rabbits in each, were used in the study. One group served as a control and th...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(76)90043-5
更新日期:1976-10-01 00:00:00
abstract::The risk factors for cardiovascular disease are related directly or indirectly in women, as in men, to lipid and lipoprotein levels. But women have the advantage of the beneficial effects of either endogenous or exogenous estrogen on these levels throughout most of their lives. Behaviors such as smoking or diseases su...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/0021-9150(94)90154-6
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Atherosclerosis (AS) is a chronic inflammation characterized by massive infiltration of inflammatory cells in arterial wall plaques. Programmed death ligand-1 (PD-L1), a co-stimulatory molecule, plays a vital role in regulating immune responses. We investigated the role and mechanisms of PD-L1 expressed on o...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.11.002
更新日期:2016-01-01 00:00:00
abstract::Neutrophils have been implicated in ischaemic heart disease, unstable angina pectoris and acute myocardial infarction. Alterations in dietary levels of specific 18- and 20-carbon polyunsaturated fatty acids have significant clinical benefits in cardiovascular disease. However, to date there has been no concerted effor...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(95)05553-9
更新日期:1995-08-01 00:00:00
abstract::Lysosomal acid lipase deficiency (LAL-D) is a rare autosomal recessive lysosomal storage disease caused by deleterious mutations in the LIPA gene. The age at onset and rate of progression vary greatly and this may relate to the nature of the underlying mutations. Patients presenting in infancy have the most rapidly pr...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2014.04.003
更新日期:2014-07-01 00:00:00
abstract::Remnant lipoproteins are known to promote atherosclerosis especially in patients with type III hyperlipoproteinemia (HLP). In the current study, the effects of atorvastatin were investigated with special reference to the exogenous and endogenous apolipoprotein (apo) B-containing lipoprotein metabolism in type III HLP....
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(03)00136-9
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:Coronary computed tomography angiography (CTA) describes several features of coronary plaques, i.e. location, severity, and composition. Integrated CTA scores are able to identify individual patterns of higher risk. We sought to test whether circulating biomarkers related with metabolism and inflammation cou...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2015.04.811
更新日期:2015-07-01 00:00:00
abstract::The importance of platelets for cardiovascular disease was established as early as the 19th century. Their therapeutic inhibition stands alongside the biggest achievements in medicine. Still, certain aspects of platelet pathophysiology remain unclear. This includes platelet resistance to antiplatelet therapy and the c...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/j.atherosclerosis.2020.05.022
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Chronic ethanol consumption is associated with hypertension and atherosclerosis. Vascular oxidative stress is described as an important mechanism whereby ethanol predisposes to atherosclerosis. We hypothesized that nebivolol would prevent ethanol-induced hypertension and vascular oxidative stress. ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.04.041
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVES:To examine whether serum concentrations of carotenoids are related to the risk of sudden cardiac death (SCD) in middle-aged men. METHODS:The study population consisted of 1031 Finnish men aged 46-65 years of the Kuopio Ischemic Heart Disease Risk Factor (KIHD) cohort. Serum concentrations of carotenoids wer...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.10.077
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Nonalcoholic fatty liver disease (NAFLD) may be associated with a wide spectrum of cardiac abnormalities, which share many metabolic risk factors. This study aimed to evaluate whether NAFLD is associated with left ventricular (LV) diastolic dysfunction independent of other classical risk factors. M...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2018.03.027
更新日期:2018-05-01 00:00:00
abstract::Endothelial cells (EC) were harvested by 0.1% collagenase treatment for adult human thoracic aortas obtained 1-3 h after sudden death. At least 35-70% of EC were removed from the intimal surface of aorta, 90-95% of them being viable. Plating efficiency was 70-80%. Monolayer formation was achieved at a seeding density ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(86)90027-4
更新日期:1986-01-01 00:00:00
abstract::Recent studies have clarified the significance of chemokines in cardiovascular diseases, such as development of atherosclerosis, atheromatous plaque rupture and restenosis after coronary angioplasty. We investigated changes in chemokine expression in the coronary circulation induced by percutaneous transluminal corona...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(00)00611-0
更新日期:2001-05-01 00:00:00
abstract:AIMS:Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. METHODS AND RESULTS:Absolute concentrations of iron, copper, zinc and calcium, and p...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2012.03.015
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To summarize the evidence with respect to sugar sweetened beverages (SSBs) consumption and risk of coronary heart disease (CHD) and to recommend field standards for future analysis on this topic. METHODS:We searched for articles published up to February 2013 through PubMed, EMbase, and Cochrane Library Datab...
journal_title:Atherosclerosis
pub_type: 杂志文章,meta分析
doi:10.1016/j.atherosclerosis.2014.01.037
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:We used cardiac surgery as a model of acute inflammatory response to evaluate the role of the inflammatory mediators in influencing the number of circulating endothelial progenitor cells (EPCs). METHODS:In 38 coronary artery by-pass grafting (CABG) [28M/10F] and in 54 valvular [28M/26F] patients the numbers ...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2007.09.045
更新日期:2008-07-01 00:00:00
abstract::Exercise affects lipoprotein metabolism and apolipoprotein E (Apo E) genotype may alter changes in lipoprotein subclasses that occur with exercise. The present study examined the effects of Apo E genotype (APOE) on the response of lipoprotein subclass concentrations to long-term exercise. A prospective longitudinal st...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/j.atherosclerosis.2005.06.050
更新日期:2006-09-01 00:00:00
abstract::Hypothyroidism is associated with hypercholesterolemia and increased risk for atherosclerotic disease. The European badger exhibits large seasonal changes in thyroid activity and the annual minimum of plasma thyroxine level in this species occurs at the same period of the year (i.e. late fall) as a pronounced hypercho...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/0021-9150(84)90190-4
更新日期:1984-11-01 00:00:00
abstract::The aim of this review was to bring together results obtained from studies on different aspects of HDL as related to CHD and atherosclerosis. As atherosclerosis is a multistep process, the various components of HDL can intervene at different stages, such as induction of monocyte adhesion molecules, prevention of LDL m...
journal_title:Atherosclerosis
pub_type: 杂志文章,评审
doi:10.1016/s0021-9150(99)00065-9
更新日期:1999-06-01 00:00:00
abstract::Cilostazol is an antiplatelet drug, which has beneficial effects in treatment of intermittent claudication and decreases serum triacyiglycerol level in these patients. In this study, we examined adipogenic potency of cilostazol using 3T3-L1 preadipocyte cell line because cilostazol is one of the tissue specific phosph...
journal_title:Atherosclerosis
pub_type: 杂志文章
doi:10.1016/s0021-9150(00)00760-7
更新日期:2001-09-01 00:00:00