Lipids, lipoproteins, women and cardiovascular disease.

abstract：:The enhanced production of endothelin-1 (ET-1) in atherosclerotic arteries may be related to increased activity of the endothelin converting enzyme (ECE) which converts big ET-1 to ET-1. The purpose of the present study was to investigate whether the vasoconstrictor activity of big ET-1 is altered as a result of incre...

journal_title：Atherosclerosis

authors： Böhm F,Johansson BL,Hedin U,Alving K,Pernow J

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Prospective studies have supported the beneficial effects of n-3 fatty acid consumption on cardiac deaths, but limited data focused on atherosclerosis. We investigated the associations between n-3 fatty acids in erythrocytes and atherosclerosis in middle-aged and older Chinese. METHODS:847 subjects (285 men ...

journal_title：Atherosclerosis

authors： Dai XW,Zhang B,Wang P,Chen CG,Chen YM,Su YX

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Statins inhibit cholesterol synthesis but can upregulate cholesterol absorption, with higher doses producing larger effects. Ezetimibe inhibits cholesterol absorption but also upregulates synthesis. We tested whether ezetimibe added to on-going statin therapy would be most effective in lowering LDL-cholestero...

journal_title：Atherosclerosis

authors： Thongtang N,Lin J,Schaefer EJ,Lowe RS,Tomassini JE,Shah AK,Tershakovec AM

更新日期：2012-12-01 00:00:00

abstract：:The effects of niceritrol, a nicotinic acid derivative, on the levels of HDL-cholesterol (HDL-Ch) and a mixture of VLDL- and LDL-Ch (VLDL- + LDL-Ch) were studied in hyperlipidemic patients. Serum total cholesterol (sTC) and serum triglyceride (sTG) were significantly reduced during niceritrol administration. Lipoprote...

journal_title：Atherosclerosis

authors： Kibata M,Ishida M,Asano K,Uehara H,Saito K,Fuchimoto T,Ugaki K,Murakami H,Matoba K,Kotakemori Y,Shirai K,Yoshioka H,Nanba M,Yasuda M,Ishizaki M,Kitagawa N,Ikejiri K,Inohara R,Lee BJ,Saino S,Sakado J,Matuzaka H,

更新日期：1980-11-01 00:00:00

abstract：:Bezafibrate in a dosage of 200 mg 3 times daily was given to 24 patients with type II A (n = 8), II B (n = 1) and IV (n = 15) hyperlipoproteinaemia for 4.5 years. In type II A the content of total cholesterol and that of low density lipoprotein in serum decreased by 10-23 and 11-34 percent over the years compared to p...

journal_title：Atherosclerosis

authors： Olsson AG,Lang PD,Vollmar J

更新日期：1985-05-01 00:00:00

abstract：:Genetic variation in ABCA1 significantly affects HDL levels and atherosclerotic risk. The aim of this study was to examine lifestyle factors influencing ABCA1 expression in human leukocytes and skeletal muscle. A fasting venous blood sample and a vastus lateralis muscle biopsy were taken from 30 volunteers (53+/-1 yea...

journal_title：Atherosclerosis

authors： Hoang A,Tefft C,Duffy SJ,Formosa M,Henstridge DC,Kingwell BA,Sviridov D

更新日期：2008-03-01 00:00:00

abstract：:A chondroitin sulfate-dermatan sulfate proteoglycan was isolated from bovine aorta intima by extraction of the tissue with 4 M guanidine hydrochloride. The proteoglycan was purified by CsCl isopycnic centrifugation followed by gel filtration and ion exchange chromatography. A monoclonal antibody C8F4 was developed to ...

journal_title：Atherosclerosis

authors： Radhakrishnamurthy B,Jeansonne N,Tracy RE,Berenson GS

更新日期：1993-01-25 00:00:00

abstract：:Free radical mediated oxidation of apoB lipoproteins in the arterial intima appears to contribute to atherogenicity of the entrapped particles. A plausible pathogenic mechanism for oxidation is the one induced by heme leaking from erythrocytes that is then carried into the arterial wall by its high affinity for lipopr...

journal_title：Atherosclerosis

authors： Fernandez AZ,López F,Tablante A,Romano E,Hurt-Camejo E,Camejo G,Apitz-Castro R

更新日期：2001-09-01 00:00:00

abstract：:HMG-CoA reductase inhibitors have been shown to be effective in primary and secondary prevention of coronary heart disease. Their mechanism of action is attributed to their cholesterol lowering activity but recent results seem to indicate additional effects related to the modulation of other processes that regulate th...

journal_title：Atherosclerosis

authors： Alfon J,Guasch JF,Berrozpe M,Badimon L

更新日期：1999-08-01 00:00:00

abstract：:Ezetimibe (Zetia(®), Ezetrol(®), Merck, Whitehouse Station, NJ) is a potent inhibitor of sterol absorption, which selectively blocks the uptake of biliary and dietary cholesterol in the small intestine. Clinical trials have demonstrated the beneficial effects of ezetimibe on the reduction of atherogenic lipoproteins a...

journal_title：Atherosclerosis

authors： Davis HR Jr,Lowe RS,Neff DR

更新日期：2011-04-01 00:00:00

abstract：:The purpose of the present study was to examine the relationship between the changes in the expressions of several mRNAs and changes in endothelial function in streptozotocin-induced diabetic and chronic short-term insulin-treated rats. Aortas from later-stage (10 week) diabetics, but not those from their insulin-trea...

journal_title：Atherosclerosis

authors： Kobayashi T,Oishi K,Hayashi Y,Matsumoto T,Kamata K

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH), which leads to premature cardiovascular events, still remains underrecognized and undertreated in most countries. Untreated FH individuals aged 20-39 years are at 100-fold higher risk of mortality from coronary heart disease compared to those of a general populati...

journal_title：Atherosclerosis

authors： Mickiewicz A,Chmara M,Futema M,Fijalkowski M,Chlebus K,Galaska R,Bandurski T,Pajkowski M,Zuk M,Wasag B,Limon J,Rynkiewicz A,Gruchala M

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascula...

journal_title：Atherosclerosis

authors： Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney B

更新日期：2009-03-01 00:00:00

abstract：:The hydrolysis of lipoprotein triglycerides is catalyzed by lipoprotein lipase (LPL), an enzyme found in many tissues. We have examined tissue LPL activity (LPLA) in rats with experimentally-induced hyperthyroidism. In younger, lighter rats, hyperthyroidism was accompanied by a decrease in LPL in adipose tissue wherea...

journal_title：Atherosclerosis

authors： Wilson DE,Jubiz W,Flowers CM,Carlile SI,Adolf AM

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) is a pro-inflammatory cytokine implicated in atherosclerotic plaque formation. We investigated whether circulating TNFalpha is prospectively associated with myocardial infarction (MI) or stroke in the older general population, independently of established cardiovascula...

journal_title：Atherosclerosis

authors： Jefferis BJ,Whincup PH,Welsh P,Wannamethee SG,Rumley A,Lennon LT,Thomson AG,Carson C,Ebrahim S,Lowe GD

更新日期：2009-07-01 00:00:00

abstract：:The internal mammary artery (IMA) is less prone to intimal thickening than coronary arteries and is routinely used in coronary bypass surgery. To resolve whether morphologic differences can explain why IMA develops less intimal thickening, morphometric measurement of the left anterior descending coronary artery (LAD) ...

journal_title：Atherosclerosis

authors： Svendsen E,Dregelid E,Eide GE

更新日期：1990-08-01 00:00:00

abstract：OBJECTIVE:Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine with chemokine-like functions that plays a role in several inflammatory diseases including atherosclerosis. We recently demonstrated that in addition to macrophages and endothelial cells, platelets are a source of MIF. However, the funct...

journal_title：Atherosclerosis

authors： Wirtz TH,Tillmann S,Strüßmann T,Kraemer S,Heemskerk JW,Grottke O,Gawaz M,von Hundelshausen P,Bernhagen J

更新日期：2015-03-01 00:00:00

abstract：:We previously reported linkage for plasma levels of high-density lipoprotein cholesterol (HDL-C) on 15q21 in Caucasian families from the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS). Hepatic lipase gene (LIPC), which has a major role in lipoprotein metabolism, resides within the linkage reg...

journal_title：Atherosclerosis

authors： Feitosa MF,Myers RH,Pankow JS,Province MA,Borecki IB

更新日期：2009-05-01 00:00:00

abstract：:We investigated the effect of transmembrane form of tumor necrosis factor-alpha (TNF) on atherosclerosis in mice. We compared the development of early atherosclerotic lesions in the aortic sinus of (1) TNF-deficient mice that express only a non-cleavable transmembrane form of TNF (tmTNF), (2) wild-type (WT) C57BL/6 mi...

journal_title：Atherosclerosis

authors： Canault M,Peiretti F,Mueller C,Kopp F,Morange P,Rihs S,Portugal H,Juhan-Vague I,Nalbone G

更新日期：2004-02-01 00:00:00

abstract：:Inflammation is thought to play a central role in the etiology and outcome of atherosclerosis. Animal studies as well as in vitro and in vivo human studies suggest that host factors modulate the magnitude and extent of inflammatory responses. We investigated familial aggregation of three systemic markers of inflammati...

journal_title：Atherosclerosis

authors： Pankow JS,Folsom AR,Cushman M,Borecki IB,Hopkins PN,Eckfeldt JH,Tracy RP

更新日期：2001-02-15 00:00:00

abstract：BACKGROUND:Uric acid is frequently elevated in hypertension. In addition to renal and metabolic disturbances, lower limb ischemia might contribute to hyperuricemia among hypertensives complicated by peripheral arterial disease (PAD). OBJECTIVE:To test the hypothesis that uric acid status is related to lower limb funct...

journal_title：Atherosclerosis

authors： Langlois M,De Bacquer D,Duprez D,De Buyzere M,Delanghe J,Blaton V

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:The possible cause of accelerated atherosclerosis in NAFLD may be the relationship with the MetS and its components. Our primary goal was to evaluate the relationship between NAFLD and subclinical atherosclerosis in adult male patients between 20 and 40 years of age. Moreover, we aimed to investigate the c...

journal_title：Atherosclerosis

authors： Ozturk K,Uygun A,Guler AK,Demirci H,Ozdemir C,Cakir M,Sakin YS,Turker T,Sari S,Demirbas S,Karslıoğlu Y,Saglam M

更新日期：2015-06-01 00:00:00

abstract：:Neutrophils have been implicated in ischaemic heart disease, unstable angina pectoris and acute myocardial infarction. Alterations in dietary levels of specific 18- and 20-carbon polyunsaturated fatty acids have significant clinical benefits in cardiovascular disease. However, to date there has been no concerted effor...

journal_title：Atherosclerosis

authors： Bates EJ,Ferrante A,Smithers L,Poulos A,Robinson BS

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:Th1 activation and regulatory T (Treg) cell suppression have been observed in acute coronary syndrome (ACS), including unstable angina (UA) and acute myocardial infarction (AMI). However, the role of Th17 cell or IL-17A remains controversial in ACS patients, and little is known about the role of recently disc...

journal_title：Atherosclerosis

authors： Zhao Z,Wu Y,Cheng M,Ji Y,Yang X,Liu P,Jia S,Yuan Z

更新日期：2011-08-01 00:00:00

abstract：:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholeste...

journal_title：Atherosclerosis

authors： Keller C,Harders-Spengel K,Spengel F,Wieczorek A,Wolfram G,Zöllner N

更新日期：1981-04-01 00:00:00

abstract：OBJECTIVE:Previous studies have shown increases in ambulatory short-term blood pressure (BP) variability to be related to cardiovascular disease. In this study, we examined whether an angiotensin II type 1 receptor blocker losartan would improve ambulatory short-term BP variability in hypertensive patients on hemodialy...

journal_title：Atherosclerosis

authors： Mitsuhashi H,Tamura K,Yamauchi J,Ozawa M,Yanagi M,Dejima T,Wakui H,Masuda S,Azuma K,Kanaoka T,Ohsawa M,Maeda A,Tsurumi-Ikeya Y,Okano Y,Ishigami T,Toya Y,Tokita Y,Ohnishi T,Umemura S

更新日期：2009-11-01 00:00:00

abstract：:The number of low density platelets was found to be increased in patients with hypercholesterolemia, as compared with the number in controls. The percentage increase of the low density platelet subpopulation was even more pronounced in patients with hypercholesterolemia when compared with that in patients suffering fr...

journal_title：Atherosclerosis

authors： Opper C,Clement C,Schwarz H,Krappe J,Steinmetz A,Schneider J,Wesemann W

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Exercise training (ET) helps treat atherosclerosis. However, many patients stop regular ET for various reasons. The effect of detraining on atherosclerosis is not well studied. We examined the effects of ET vs. short-term detraining on atheromatous matrix-metalloproteinase (MMP) activity in preexist...

journal_title：Atherosclerosis

authors： Kim J,Jang HJ,Schellingerhout D,Kang JW,Choi S,Oh H,Kim EJ,Lee SK,Lee JS,Kwon IC,Kim K,Koh YJ,Ryu WS,Kim DE

更新日期：2020-04-01 00:00:00

abstract：:The effect of guar (15.6 g/day), a dietary fibre, and simultaneous administration of bezafibrate (600 mg/day) during dietetic treatment on the plasma lipoproteins and apolipoproteins was investigated in 12 patients with familial hypercholesterolemia (corresponding to the HLP type IIa pattern). Either bezafibrate alone...

journal_title：Atherosclerosis

authors： Wirth A,Middelhoff G,Braeuning C,Schlierf G

更新日期：1982-12-01 00:00:00

abstract：:In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals...

journal_title：Atherosclerosis

authors： Baliarsingh S,Beg ZH,Ahmad J

更新日期：2005-10-01 00:00:00