当前位置： SCI文献检索 > ATHEROSCLEROSIS期刊下所有文献 > Serum cholesterol levels in patients with familial hypercholesterolemia confirmed by tissue culture.

Serum cholesterol levels in patients with familial hypercholesterolemia confirmed by tissue culture.

Abstract：

:Sixty-two subjects from 23 families were evaluated by serum lipid analyses and tissue culture biochemistry in skin fibroblasts. In 53 cases from 19 families with proven familial hypercholesterolemia (FHC), fibroblast cultures were successful. In 45 of these cases (85%) the clinical diagnosis of hyper- or normocholesterolemia was in accordance with the tissue culture findings. Four patients 2-38 years old, had hypercholesterolemia but normal tissue culture results. Four patients, 18-44 years old, had normal serum cholesterol levels for their age and sex, but were heterozygotes according to tissue culture results. In the remaining four families only the propositus had hypercholesterolemia. All members of the families including the propositus had normal tissue culture determinations indicating that not all cases of idiopathic hypercholesterolemia are due to the Goldstein-Brown mechanism of defective LDL receptor function.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Keller C,Harders-Spengel K,Spengel F,Wieczorek A,Wolfram G,Zöllner N

doi

10.1016/0021-9150(81)90088-5

subject

Has Abstract

pub_date

1981-04-01 00:00:00

pages

51-9

issue

1

eissn

0021-9150

issn

1879-1484

pii

0021-9150(81)90088-5

journal_volume

39

pub_type

杂志文章

相关文献

ATHEROSCLEROSIS文献大全
  • Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136-->Ser) variant in multigenerational pedigree studies.

    abstract：:In the process of screening apolipoprotein (apo) E genotypes in a population of subjects with lipid abnormalities, we have identified five subjects (one homozygote and four heterozygotes) with an abnormal 109 base pairs band following apo E restriction isotyping of amplified DNA with the restriction endonuclease CfoI....

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(95)06745-0

    authors： Pocovi M,Cenarro A,Civeira F,Myers RH,Casao E,Esteban M,Ordovas JM

    更新日期：1996-04-26 00:00:00

  • C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

    abstract：BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation o...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.atherosclerosis.2007.09.038

    authors： Lind L,Siegbahn A,Hulthe J,Elmgren A

    更新日期：2008-07-01 00:00:00

  • Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia.

    abstract：BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2012.04.006

    authors： Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

    更新日期：2012-08-01 00:00:00

  • Endothelium-dependent and -independent functions are impaired in patients with coronary heart disease.

    abstract：:Endothelium plays a pivotal role in the development of atherosclerosis. Endothelial dysfunction participates in the course of acute coronary event. Using high-resolution ultrasound technique, endothelial dysfunction has been demonstrated in patients with atherosclerosis and risk factors for coronary disease, such as h...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(99)00288-9

    authors： Zhang X,Zhao SP,Li XP,Gao M,Zhou QC

    更新日期：2000-03-01 00:00:00

  • The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes.

    abstract：BACKGROUND:Lipoprotein distribution of non-cholesterol sterols was studied to evaluate in which lipoproteins they are carried in type 2 diabetes with body weight ranging from normal to overweight. METHODS:Serum and lipoprotein squalene and non-cholesterol sterols were quantitated with gas-liquid chromatography in 33 d...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2006.07.030

    authors： Simonen PP,Gylling H,Miettinen TA

    更新日期：2007-09-01 00:00:00

  • The effect of the duration of cholesterol feeding on the development of sudanophilic lesions in the rabbit aorta.

    abstract：:Polar coordinate mapping was used to determine the rate of growth of individual sudanophilic lesions on the aortic wall around several major branches of the aortae of cholesterol fed rabbits. Four groups, with 6 8-month old male albino white rabbits in each, were used in the study. One group served as a control and th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(76)90043-5

    authors： Roach MR,Fletcher J,Cornhill JF

    更新日期：1976-10-01 00:00:00

  • Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men.

    abstract：:The insulin response to a standard oral glucose tolerance test (OGTT) and other anthropometric and biochemical risk factors for coronary heart disease (CHD) were measured in a random sample of 107 Edinburgh men, who were initially studied in 1976 when they were 40 and who were reexamined in 1988-89. Fasting glucose an...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(92)90188-m

    authors： Hargreaves AD,Logan RL,Elton RA,Buchanan KD,Oliver MF,Riemersma RA

    更新日期：1992-05-01 00:00:00

  • Atorvastatin increases low-density lipoprotein size and enhances high-density lipoprotein cholesterol concentration in male, but not in female patients with familial hypercholesterolemia.

    abstract：:The effects of atorvastatin (Lipitor) were evaluated in 40 patients with familial hypercholesterolemia (FH). Following a 6 week drug-free baseline period 20 male and 20 female patients were treated with atorvastatin 40 mg once daily (QD) for the initial 6 weeks increasing to 80 mg QD during the following 6 weeks. Ator...

    journal_title：Atherosclerosis

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0021-9150(99)00125-2

    authors： Hoogerbrugge N,Jansen H

    更新日期：1999-09-01 00:00:00

  • Periodontal bacteria in human carotid atherothrombosis as a potential trigger for neutrophil activation.

    abstract：OBJECTIVE:Epidemiological, biological and clinical links between periodontal and cardiovascular diseases are now well established. Several human studies have detected bacterial DNA corresponding to periodontal pathogens in cardiovascular samples. Intraplaque hemorrhage has been associated with a higher risk of atherosc...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.07.034

    authors： Rangé H,Labreuche J,Louedec L,Rondeau P,Planesse C,Sebbag U,Bourdon E,Michel JB,Bouchard P,Meilhac O

    更新日期：2014-10-01 00:00:00

  • Human umbilical vein endothelial cells promote the inhibitory activation of CD4(+)CD25(+)Foxp3(+) regulatory T cells via PD-L1.

    abstract：BACKGROUND:Atherosclerosis (AS) is a chronic inflammation characterized by massive infiltration of inflammatory cells in arterial wall plaques. Programmed death ligand-1 (PD-L1), a co-stimulatory molecule, plays a vital role in regulating immune responses. We investigated the role and mechanisms of PD-L1 expressed on o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2015.11.002

    authors： Chen WJ,Hu XF,Yan M,Zhang WY,Mao XB,Shu YW

    更新日期：2016-01-01 00:00:00

  • Histamine as an activator of cell growth and extracellular matrix reconstruction for human vascular smooth muscle cells.

    abstract：:Atherosclerosis is characterised by unusual growth of vascular smooth muscle cells (VSMCs) in the intima. We examined the effects of histamine on human VSMCs and the VSMC-derived cell line, ISS10. Histamine enhanced phosphoinositide hydrolysis, increased cytoplasmic Ca2+ level and stimulated the transcription of c-fos...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(94)90067-1

    authors： Satoh T,Sugama K,Matsuo A,Kato S,Ito S,Hatanaka M,Sasaguri Y

    更新日期：1994-09-30 00:00:00

  • The relation of exposure to shift work with atherosclerosis and myocardial infarction in a general population.

    abstract：OBJECTIVES:We tested the hypothesis that working shifts is related to atherosclerosis and myocardial infarction. BACKGROUND:The number of shift workers is continuously increasing. Shift work is discussed to be related with cardiovascular heart disease. METHODS:A total of 2510 subjects recruited for the population-bas...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.12.059

    authors： Haupt CM,Alte D,Dörr M,Robinson DM,Felix SB,John U,Völzke H

    更新日期：2008-11-01 00:00:00

  • BMP-2 promotes phosphate uptake, phenotypic modulation, and calcification of human vascular smooth muscle cells.

    abstract：:Vascular calcification is associated with increased risk of cardiovascular events that are the most common cause of death in patients with end-stage renal disease. Clinical and experimental studies indicate that hyperphosphatemia is a risk factor for vascular calcification and cardiovascular mortality in these patient...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.11.031

    authors： Li X,Yang HY,Giachelli CM

    更新日期：2008-08-01 00:00:00

  • Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women.

    abstract：OBJECTIVE:The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status. DESIGN AND METHODS:The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2008.11.006

    authors： Kassi E,Dalamaga M,Faviou E,Hroussalas G,Kazanis K,Nounopoulos Ch,Dionyssiou-Asteriou A

    更新日期：2009-07-01 00:00:00

  • Adipose tissue triglyceride fatty acids and atherosclerosis in Alaska Natives and non-Natives.

    abstract：:Essential polyunsaturated fatty acids (PUFA) of the omega-3 family are believed to protect against cardiovascular disease. A rich source of omega-3 PUFA is found in fish and marine mammals (seal, walrus, whale), which are a large part of the traditional diet of Alaska Natives (Eskimo, American Indians, Aleuts), a grou...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2005.01.019

    authors： McLaughlin J,Middaugh J,Boudreau D,Malcom G,Parry S,Tracy R,Newman W

    更新日期：2005-08-01 00:00:00

  • Compositional changes in serum lipoproteins during developing hypercholesterolemia induced in rabbits by cholesterol-free, semipurified diets.

    abstract：:Changes in the concentration and composition of serum very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were studied in rabbits transferred from chow diet to cholesterol-free, semipurified diets containing casein or isolated soy protein. The fat and fibre content of ...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(89)90220-7

    authors： Kurowska EM,Hrabek-Smith JM,Carroll KK

    更新日期：1989-08-01 00:00:00

  • Bradykinin stimulates endothelial cell fatty acid oxidation by CaMKK-dependent activation of AMPK.

    abstract：:Endothelial cell lipotoxicity mediated by accumulation of free fatty acids is an early event in the pathogenesis of atherosclerosis. The energy-sensor AMP-activated protein kinase (AMPK) is a key regulator of endothelial cell lipid metabolism. To test the hypothesis that bradykinin (BK) regulates AMPK and fatty acid o...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2007.12.003

    authors： Mount PF,Lane N,Venkatesan S,Steinberg GR,Fraser SA,Kemp BE,Power DA

    更新日期：2008-09-01 00:00:00

  • Lipoprotein (a) and aortic valve calcium in South Asians compared to other race/ethnic groups.

    abstract：BACKGROUND AND AIMS:South Asians are at increased risk for cardiovascular disease (CVD). Aortic valve calcium (AVC) is associated with CVD risk and aortic stenosis. Elevated Lp(a) is a heritable risk factor for CVD and AVC. AVC prevalence and its association with Lp(a) have not been studied in South Asians. METHODS:Am...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2020.09.010

    authors： Makshood M,Joshi PH,Kanaya AM,Ayers C,Budoff M,Tsai MY,Blaha M,Michos ED,Post WS

    更新日期：2020-11-01 00:00:00

  • Cationic peptides neutralize Ox-LDL, prevent its uptake by macrophages, and attenuate inflammatory response.

    abstract：OBJECTIVE:Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due to their ability to reduce atherosclerosis and exhibit antioxidant, anti-inflammatory, and hypolipidemic properties. In this study, we tested whether three distinct and unrelated cationic peptides would inhibit...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2014.06.020

    authors： Aluganti Narasimhulu C,Selvarajan K,Brown M,Parthasarathy S

    更新日期：2014-09-01 00:00:00

  • The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system.

    abstract：BACKGROUND AND AIMS:This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS:Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and t...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2018.01.043

    authors： Kim EN,Kim MY,Lim JH,Kim Y,Shin SJ,Park CW,Kim YS,Chang YS,Yoon HE,Choi BS

    更新日期：2018-03-01 00:00:00

  • Interleukin (IL)-4 deficiency does not influence fatty streak formation in C57BL/6 mice.

    abstract：:Abundant data is present to implicate oxidatively modified low-density lipoprotein (oxLDL) in enhanced atherogenesis. Among the factors involved in LDL oxidation, an important role has been attributed to human 15-lipoxygenase (LO) and its murine analog 12-LO. The expression of these peroxidizing enzymes is under the c...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(00)00418-4

    authors： George J,Mulkins M,Shaish A,Casey S,Schatzman R,Sigal E,Harats D

    更新日期：2000-12-01 00:00:00

  • von Willebrand factor and soluble E-selectin in the prediction of cardiovascular disease progression in hyperlipidaemia.

    abstract：:Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(97)00081-6

    authors： Blann AD,Miller JP,McCollum CN

    更新日期：1997-07-25 00:00:00

  • PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH.

    abstract：BACKGROUND:Atherosclerosis and non-alcoholic fatty liver disease (NAFLD) are complex pathologies characterized by lipid accumulation, chronic inflammation and extensive tissue remodelling. Microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, might not only be biomarkers, but also fun...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.03.009

    authors： Baron M,Leroyer AS,Majd Z,Lalloyer F,Vallez E,Bantubungi K,Chinetti-Gbaguidi G,Delerive P,Boulanger CM,Staels B,Tailleux A

    更新日期：2011-09-01 00:00:00

  • Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study.

    abstract：OBJECTIVE:Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. We tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits. METHODS:We studied 274...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2013.03.037

    authors： Lim S,Hong J,Liu CT,Hivert MF,White CC,Murabito JM,O'Donnell CJ,Dupuis J,Florez JC,Meigs JB

    更新日期：2013-07-01 00:00:00

  • Relation of plasma high-density lipoprotein cholesterol to lipoprotein-lipase activity in adipose tissue and skeletal muscle of man.

    abstract：:Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/0021-9150(78)90178-8

    authors： Nikkilä EA,Taskinen MR,Kekki M

    更新日期：1978-04-01 00:00:00

  • Arterial stiffness is associated with low thigh muscle mass in middle-aged to elderly men.

    abstract：OBJECTIVE:Sarcopenia of legs is an important cause of physical dysfunctions, frailty and dependence. Many predisposing and underlying mechanisms of sarcopenia, including age, sedentary life style, oxidative stress, insulin resistance, and low testosterone levels, are also known to be related to atherosclerosis, which i...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2010.05.026

    authors： Ochi M,Kohara K,Tabara Y,Kido T,Uetani E,Ochi N,Igase M,Miki T

    更新日期：2010-09-01 00:00:00

  • Effects of thrice weekly nocturnal hemodialysis on arterial stiffness.

    abstract：OBJECTIVE:In this study, we compared the changes in arterial stiffness in chronic hemodialysis patients treated with 8-h vs. 4-h thrice weekly in-center hemodialysis. METHODS:Sixty prevalent chronic hemodialysis patients assigned to 8-h nocturnal in-center thrice weekly HD (NHD) and 60 control cases assigned to 4-h th...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2011.11.015

    authors： Demirci MS,Celik G,Ozkahya M,Tumuklu M,Toz H,Asci G,Duman S,Basci A,Kircelli F,Ozdogan O,Demirci C,Can L,Isik IO,Ok E,Long Dialysis Group.

    更新日期：2012-02-01 00:00:00

  • Deficiency of receptor-associated protein attenuates angiotensin II-induced atherosclerosis in hypercholesterolemic mice without influencing abdominal aortic aneurysms.

    abstract：OBJECTIVE:Receptor-associated protein (RAP) was initially described as a regulator of low density lipoprotein receptor-related protein 1 (LRP1), but is now known to regulate many proteins. Since the direct effects of RAP on vascular pathologies have not been studied, this study determined whether RAP deficiency influen...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/j.atherosclerosis.2011.11.013

    authors： Wang S,Subramanian V,Lu H,Howatt DA,Moorleghen JJ,Charnigo R,Cassis LA,Daugherty A

    更新日期：2012-02-01 00:00:00

  • Longitudinal association between toenail selenium levels and measures of subclinical atherosclerosis: the CARDIA trace element study.

    abstract：OBJECTIVES:To examine the longitudinal association between toenail selenium levels and subclinical atherosclerosis over an 18-year period. METHODS:Toenail selenium concentrations were examined among 3112 Americans age 20-32 years in 1987 and measured by instrumental neutron-activation analysis. Subclinical atheroscler...

    journal_title：Atherosclerosis

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.atherosclerosis.2010.01.021

    authors： Xun P,Liu K,Morris JS,Daviglus ML,He K

    更新日期：2010-06-01 00:00:00

  • Recombinant proapoA-I(Lys107del) shows impaired lipid binding associated with reduced binding to plasma high density lipoprotein.

    abstract：:In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation. Dimyristoyl phosphatidylcholine (DMPC) binding...

    journal_title：Atherosclerosis

    pub_type： 杂志文章

    doi：10.1016/s0021-9150(01)00496-8

    authors： Huang W,Matsunaga A,Li W,Han H,Hoang A,Kugi M,Koga T,Sviridov D,Fidge N,Sasaki J

    更新日期：2001-11-01 00:00:00