Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women.

abstract：BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...

journal_title：Atherosclerosis

authors： Li W,Wang D,Chi Y,Wang R,Zhang F,Ma G,Chen Z,Li J,Liu Z,Matsuura E,Liu Q

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. We tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits. METHODS:We studied 274...

journal_title：Atherosclerosis

authors： Lim S,Hong J,Liu CT,Hivert MF,White CC,Murabito JM,O'Donnell CJ,Dupuis J,Florez JC,Meigs JB

更新日期：2013-07-01 00:00:00

abstract：:Secretory non-pancreatic (group II) phospholipase A2 (sPLA2) releases precursors of important mediators of inflammation from phospholipids. Based on the inflammatory character of atherosclerosis we previously described the identification of sPLA2 in human atherosclerotic plaques. In vitro studies on lipoproteins have ...

journal_title：Atherosclerosis

authors： Schiering A,Menschikowski M,Mueller E,Jaross W

更新日期：1999-05-01 00:00:00

abstract：:The proteolytic activity of proinflammatory matrix metalloproteinases (MMPs) is elevated in lipid-rich atherosclerotic plaques, thereby contributing to plaque fragility and rupture. We hypothesized that changes in circulating levels of MMPs and their specific inhibitors (TIMPs) could reflect the atherosclerotic proces...

journal_title：Atherosclerosis

authors： Beaudeux JL,Giral P,Bruckert E,Bernard M,Foglietti MJ,Chapman MJ

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Experimental evidence indicates that circulating insulin-like growth factor-1 (IGF-1) counteracts vascular aging and atherosclerosis, for which increased carotid artery intima-media thickness (IMT) is a marker. Yet, IGF-1 concentrations have been inconsistently associated with carotid IMT in epidemiological s...

journal_title：Atherosclerosis

authors： Ameri P,Canepa M,Fabbi P,Leoncini G,Milaneschi Y,Mussap M,AlGhatrif M,Balbi M,Viazzi F,Murialdo G,Pontremoli R,Brunelli C,Ferrucci L

更新日期：2014-10-01 00:00:00

abstract：:The formation of atherosclerotic lesions requires the migration of vascular smooth muscle cells from the media into the intima of the artery and their proliferation. These events, which are preceded and accompanied by inflammation, are modulated by integrin receptors linking vascular smooth muscle cells to extracellul...

journal_title：Atherosclerosis

authors： Barillari G,Albonici L,Incerpi S,Bogetto L,Pistritto G,Volpi A,Ensoli B,Manzari V

更新日期：2001-02-01 00:00:00

abstract：OBJECTIVE:Diabetes and atherosclerosis may share common genetic determinants. A prior study in Hispanics found association of haplotypes in the diabetes gene calpain-10 (CAPN10) with carotid artery intima-media thickness (CIMT). This study sought to replicate this association in an independent cohort. METHODS:Four CAP...

journal_title：Atherosclerosis

authors： Goodarzi MO,Taylor KD,Jones MR,Fang B,Guo X,Xiang AH,Buchanan TA,Hodis HN,Raffel LJ,Rotter JI

更新日期：2009-08-01 00:00:00

abstract：:This study was undertaken to determine whether sialic acid removal alters the catabolism of low density lipoprotein in humans. Human low density lipoproteins labeled in vitro with 125I were incubated in the presence (termed desialylated) or absence (sialylated) of neuraminidase. The treatment with neuraminidase from C...

journal_title：Atherosclerosis

authors： Malmendier CL,Delcroix C,Fontaine M

更新日期：1980-10-01 00:00:00

abstract：OBJECTIVE:The goal of the study was to examine possible sex-related differences in the clinical characteristics and risk factors in Japanese patients with peripheral arterial disease (PAD). METHODS:Sex-related differences in clinical profiles, risk factors and treatments were examined in 730 consecutive patients with ...

journal_title：Atherosclerosis

authors： Kumakura H,Kanai H,Araki Y,Kasama S,Sumino H,Ito T,Iwasaki T,Takayama Y,Ichikawa S,Fujita K,Nakashima K,Minami K

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIMS:A potential increased risk of cardiovascular events has been suggested for proton pump inhibitors (PPIs), the most commonly prescribed drugs for the management of upper gastrointestinal disorders. We aimed to estimate the risk of hospitalization for cardio/cerebrovascular (CV) events in a cohort of ...

journal_title：Atherosclerosis

authors： Casula M,Scotti L,Galimberti F,Mozzanica F,Tragni E,Corrao G,Catapano AL

更新日期：2018-10-01 00:00:00

abstract：:Whole blood and plasma viscosity, red cell aggregability and deformability, and plasma fibrinogen have been compared between 20 patients with heterozygous familial hypercholesterolaemia (FH), without clinical arterial disease, and 20 age- and sex-matched controls. Plasma fibrinogen was elevated in FH, associated with ...

journal_title：Atherosclerosis

authors： Jay RH,Rampling MW,Betteridge DJ

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the role of liver enzymes as predictors of non-liver-related morbidity and mortality. The ideal cardiovascular health (CVH) score proposed by the American Heart Association (AHA) can be used to predict mortality and morbidity. We investigated the association of the CVH score wi...

journal_title：Atherosclerosis

authors： Mazidi M,Katsiki N,Mikhailidis DP,Banach M

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Peroxisome proliferator-activated receptors alpha (PPARalpha) is a target gene for atherosclerosis and cardiovascular diseases. However, effects of PPARalpha on endothelial nitric oxide synthase (eNOS) remain unknown. We investigated the eNOS regulation by bezafibrate, a ligand of PPARalpha, and involved sign...

journal_title：Atherosclerosis

authors： Wang Y,Wang Y,Yang Q,Yan JT,Zhao C,Cianflone K,Wang DW

更新日期：2006-08-01 00:00:00

abstract：:Inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) have been implicated in atherogenesis. However, the precise role of TNF-alpha in atherogenesis is still unclear. To examine the effect of TNF-alpha on atherogenesis, we generated compound-deficient mice in apolipoprotein E (apoE) and TNF-alpha (...

journal_title：Atherosclerosis

authors： Ohta H,Wada H,Niwa T,Kirii H,Iwamoto N,Fujii H,Saito K,Sekikawa K,Seishima M

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:Increased lipid accumulation in cells and tissues is a key phenomenon in the development of obesity, insulin resistance, and atherosclerosis. In the regulation of lipid content of cells and tissues the SREBPs play a dominant role as transcription factors. METHODS:Since growth hormone (GH) affects lipid metab...

journal_title：Atherosclerosis

authors： Kotzka J,Knebel B,Avci H,Jacob S,Nitzgen U,Jockenhovel F,Heeren J,Haas J,Muller-Wieland D

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:The present study aimed to verify the existence of a rebound inflammatory effect after statin withdrawal in the acute phase of myocardial infarction (MI). METHODS:In a prospective observational cohort, changes in C-reactive protein (CRP) between the first and the fifth day after MI were evaluated in 249 cons...

journal_title：Atherosclerosis

authors： Sposito AC,Carvalho LS,Cintra RM,Araújo AL,Ono AH,Andrade JM,Coelho OR,Quinaglia e Silva JC,Brasilia Heart Study Group.

更新日期：2009-11-01 00:00:00

abstract：:Two groups of patients were administered either 4.5 X 10(6) U or 90 X 10(6) U each of recombinant DNA-derived interferon-beta serine (IFN-beta ser) i.v. daily for 10 days. IFN-beta ser affected lipoprotein lipids of patients in a dose dependent fashion. A decrease in plasma total cholesterol concentration occurred 24 ...

journal_title：Atherosclerosis

authors： Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:To examine whether genetic polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) confer an increased risk to angiographically proven coronary artery disease (CAD) in a case-control study of a Midwestern population in the US. METHODS:We genotyped 7 SNPs (SG13S25, SG13S89, SG13S41, SG13S377, SG13S35...

journal_title：Atherosclerosis

authors： Tsai AK,Li N,Hanson NQ,Tsai MY,Tang W

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIMS:A few studies examined association between familial hypercholesterolemia (FH) and atherosclerotic cardiovascular disease (ASCVD) in Asians with low levels of serum cholesterol. The objectives of this study were to estimate the prevalence of familial hypercholesterolemia phenotype (FH-P) and examined...

journal_title：Atherosclerosis

authors： Jung KJ,Koh H,Choi Y,Lee SJ,Ji E,Jee SH

更新日期：2018-11-01 00:00:00

abstract：:In symptom-free subjects, exercise tolerance testing (ETT) has a doubtful utility for detecting latent coronary heart disease (CHD) because of frequent false positives, but it may be valuable for predicting future CHD. To clarify the latter question, we calculated CHD incidence associated with presence or absence of E...

journal_title：Atherosclerosis

authors： Mégnien JL,Simon A

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To investigate associations of a oxidative balance score (OBS) with blood levels of total cholesterol, low-density lipoprotein- (LDL)-cholesterol, high-density lipoprotein- (HDL) cholesterol and triglycerides, and biomarkers of inflammation (serum C-reactive protein [CRP], albumin and venous total white blood...

journal_title：Atherosclerosis

authors： Lakkur S,Judd S,Bostick RM,McClellan W,Flanders WD,Stevens VL,Goodman M

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND AND AIMS:This study evaluated the effects of resveratrol on arterial aging and the renin-angiotensin system (RAS) in mice and vascular smooth muscle cells (VSMCs). METHODS:Aging mice were divided into control and resveratrol groups. Histological changes, inflammation, oxidative stress, RAS components, and t...

journal_title：Atherosclerosis

authors： Kim EN,Kim MY,Lim JH,Kim Y,Shin SJ,Park CW,Kim YS,Chang YS,Yoon HE,Choi BS

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Atherosclerosis is a chronic disease characterized by two main features, lipid retention and inflammation. The 12/15-lipoxygenases play a two-faced role in atherosclerosis with pro-inflammatory effects through oxidation of LDL and anti-inflammatory effects through lipid mediator synthesis. In cells involved ...

journal_title：Atherosclerosis

authors： Wuest SJ,Crucet M,Gemperle C,Loretz C,Hersberger M

更新日期：2012-11-01 00:00:00

abstract：:Porphyrins are known to be accumulated in vivo by tumors and atherosclerotic plaques. We studied the interaction of cultured aortic smooth muscle cells (SMC) from spontaneously atherosclerotic Broad Breasted White Turkeys (BBWT) with free hematoporphyrin (Hp) and low density lipoprotein (LDL)-Hp complexes. A significa...

journal_title：Atherosclerosis

authors： Scannapieco G,Pagnan A,Pauletto P,Mattiello A,Biffanti S,Jori G,Dal Palù C

更新日期：1988-08-01 00:00:00

abstract：:A total of 1200 patients with angina were cardiac catheterized establishing that 63% had 70-100% stenosis, 12% had 10-69% stenosis of one or more of their coronary arteries and 25% had microvascular angina listed as 0% stenosis. Prior to catheterization 10 ml of blood was drawn and the plasma subjected to analysis for...

journal_title：Atherosclerosis

authors： Kummerow FA,Olinescu RM,Fleischer L,Handler B,Shinkareva SV

更新日期：2000-03-01 00:00:00

abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

journal_title：Atherosclerosis

authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Oxidation of low-density lipoprotein (LDL) and oxidized LDL-mediated activation of the innate immune system have been recognized as early key events during the pathogenesis of atherosclerosis. Recent evidence identified eosinophils as a major source of enzymatic lipid oxidation and suggested a poten...

journal_title：Atherosclerosis

authors： Hofheinz K,Seibert F,Ackermann JA,Dietel B,Tauchi M,Oszvar-Kozma M,Kühn H,Schett G,Binder CJ,Krönke G

更新日期：2020-10-01 00:00:00

abstract：:Homocysteine may promote atherogenesis and thrombogenesis by enhancing leukocyte-endothelium interactions. We explored this hypothesis in an acute hyperhomocysteinemia rat model, which was created by a continuous venous homocysteine infusion (4 ml/h/kg body weight) with 2.5 and 10 mg/ml D,L-homocysteine upto 90 min. V...

journal_title：Atherosclerosis

authors： Fu WY,Dudman NP,Perry MA,Wang XL

更新日期：2002-03-01 00:00:00

abstract：INTRODUCTION:Although cardiovascular events are known to cluster in families it is unclear the extent to which atherosclerosis per se is genetically determined. The aim of this study was to assess the heritability of carotid intima media thickness (IMT) measurements, a surrogate marker of early atherosclerosis, using a...

journal_title：Atherosclerosis

authors： Swan L,Birnie DH,Inglis G,Connell JM,Hillis WS

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Detection of inflamed atherosclerotic plaques is of crucial importance. The carotid artery cuff-model in ApoE(-/-) mice results in shear-stress induced atherosclerosis with inflamed plaques upstream (US) and 'stable' plaques downstream (DS) of the cuff. We evaluated the potential of F-18-FDG PET/CT to differ...

journal_title：Atherosclerosis

authors： Wenning C,Kloth C,Kuhlmann MT,Jacobs AH,Schober O,Hermann S,Schäfers MA

更新日期：2014-06-01 00:00:00