The determination of carotid intima medial thickness in adults--a population-based twin study.

abstract：:Five out of 15 homozygotes and 41 out of 527 heterozygotes of familial hypercholesterolemia (FH) died during the past 10 years. Sudden death or heart failure was the cause of death in each of the 5 deceased homozygotes. Twenty heterozygotes died of myocardial infarction, 9 of sudden death, and 1 died after AC bypass s...

journal_title：Atherosclerosis

authors： Mabuchi H,Miyamoto S,Ueda K,Oota M,Takegoshi T,Wakasugi T,Takeda R

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Carotid intima-media thickness (cIMT) is associated with CV events in adults. Thicker cIMT is found in youth with CV risk factors including obesity. Which risk factors have the most effect upon cIMT in youth and whether obesity has direct or indirect effects is not known. We used structural equation modeling...

journal_title：Atherosclerosis

authors： Gao Z,Khoury PR,McCoy CE,Shah AS,Kimball TR,Dolan LM,Urbina EM

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AND AIMS:We aimed to identify a blood-based gene expression score (GES) to predict the severity of coronary artery stenosis in patients with known or suspected coronary artery disease (CAD) by integrative use of gene network construction, Support Vector Machine (SVM) algorithm, and multi-cohort validation. ...

journal_title：Atherosclerosis

authors： Wang XB,Cui NH,Liu X,Ming L

更新日期：2019-12-01 00:00:00

abstract：:Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived me...

journal_title：Atherosclerosis

authors： Fei J,Cook C,Blough E,Santanam N

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E genotype (APOE) polymorphism affects lipid levels and coronary heart disease (CHD) risk. However, these associations may be modified by lifestyle factors. Therefore, we studied whether smoking, physical inactivity or overweight interact with APOE on cholesterol levels and CHD risk. METHODS:C...

journal_title：Atherosclerosis

authors： Gustavsson J,Mehlig K,Leander K,Strandhagen E,Björck L,Thelle DS,Lissner L,Blennow K,Zetterberg H,Nyberg F

更新日期：2012-02-01 00:00:00

abstract：:The antiatherogenic properties of pomegranate juice (PJ) were attributed to its antioxidant potency and to its capacity to decrease macrophage oxidative stress, the hallmark of early atherogeneis. PJ polyphenols and sugar-containing polyphenolic anthocyanins were shown to confer PJ its antioxidant capacity. In the pre...

journal_title：Atherosclerosis

authors： Rozenberg O,Howell A,Aviram M

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

journal_title：Atherosclerosis

authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Endostatin is implicated in the atherosclerosis process and serves as a promising cardiovascular biomarker, while its clinical significance in ischemic stroke patients remains unclear. We aimed to examine the association between endostatin and mortality and disability after ischemic stroke. METHODS...

journal_title：Atherosclerosis

authors： Zhang C,Qian S,Zhang R,Guo D,Wang A,Peng Y,Peng H,Li Q,Ju Z,Geng D,Chen J,Zhang Y,He J,Zhong C,Xu T

更新日期：2020-01-01 00:00:00

abstract：:In 137 living subjects, arteriosclerotic change in the human abdominal aorta was examined in relation to coronary heart disease (CHD) using a new ultrasonic method. The pressure strain elastic modulus (Ep) was calculated as an index of elastic properties from which arteriosclerotic change in the aorta was estimated. T...

journal_title：Atherosclerosis

authors： Imura T,Yamamoto K,Satoh T,Mikami T,Yasuda H

更新日期：1988-10-01 00:00:00

abstract：:The offspring of type 2 diabetic patients are at elevated risk for type 2 diabetes and cardiovascular disease. The aim of our study was to characterize the role of various biomarkers of endothelial activation in a cohort of offspring of type 2 diabetic subjects and to assess the association of adhesion molecules with ...

journal_title：Atherosclerosis

authors： Ruotsalainen E,Vauhkonen I,Salmenniemi U,Pihlajamäki J,Punnonen K,Kainulainen S,Jalkanen S,Salmi M,Laakso M

更新日期：2008-03-01 00:00:00

abstract：:Local accumulation of cells (hypercellularity) in the intima of the arterial wall as a result of cell proliferation is recognized as one of the major manifestations of human atherosclerosis. In the present study we have used a monoclonal antibody against PCNA to identify the proliferative activity, in uninvolved intim...

journal_title：Atherosclerosis

authors： Orekhov AN,Andreeva ER,Mikhailova IA,Gordon D

更新日期：1998-07-01 00:00:00

abstract：:Homozygotes (TT genotype) for the C677T mutation in the gene of methylenetetrahydrofolate reductase (C677T/MTHFR mutation) constitute about 12% of the Caucasian population. They have mild hyperhomocysteinemia which is an established risk factor for cardiovascular disease. If the mutation is associated with premature d...

journal_title：Atherosclerosis

authors： Brattström L,Zhang Y,Hurtig M,Refsum H,Ostensson S,Fransson L,Jonés K,Landgren F,Brudin L,Ueland PM

更新日期：1998-12-01 00:00:00

abstract：:The negative correlation between percent flow-mediated dilation (FMD%) and baseline diameter (D(base)) has only recently been recognised as a fundamental ratio-scaling problem, which is not resolved by significance-testing of D(base) inequality between groups/conditions, nor by covariate-adjusting FMD% itself by D(bas...

journal_title：Atherosclerosis

authors： Atkinson G,Batterham AM

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein A1 (ApoA1) and apolipoprotein E (ApoE) mimetic peptides have attracted attention due to their ability to reduce atherosclerosis and exhibit antioxidant, anti-inflammatory, and hypolipidemic properties. In this study, we tested whether three distinct and unrelated cationic peptides would inhibit...

journal_title：Atherosclerosis

authors： Aluganti Narasimhulu C,Selvarajan K,Brown M,Parthasarathy S

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...

journal_title：Atherosclerosis

authors： Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

更新日期：2012-06-01 00:00:00

abstract：:Variations of circulating C-reactive protein (CRP) levels are supposed to reflect chronic inflammatory process of the cardiovascular system. In particular, it has been reported that high-sensitivity CRP (hsCRP) is a promising marker of coronary heart disease. In the present study, we assessed the relationship between ...

journal_title：Atherosclerosis

authors： Saito M,Ishimitsu T,Minami J,Ono H,Ohrui M,Matsuoka H

更新日期：2003-03-01 00:00:00

abstract：:We investigated the effect of transmembrane form of tumor necrosis factor-alpha (TNF) on atherosclerosis in mice. We compared the development of early atherosclerotic lesions in the aortic sinus of (1) TNF-deficient mice that express only a non-cleavable transmembrane form of TNF (tmTNF), (2) wild-type (WT) C57BL/6 mi...

journal_title：Atherosclerosis

authors： Canault M,Peiretti F,Mueller C,Kopp F,Morange P,Rihs S,Portugal H,Juhan-Vague I,Nalbone G

更新日期：2004-02-01 00:00:00

abstract：:Atherosclerosis is a major underlying cause of ischemic heart diseases, ischemic stroke, and peripheral artery disease. Atherosclerotic plaque progression is characterized by chronic progressive inflammation of the arterial wall, endothelial cell dysfunction, and subendothelial lipoprotein retention. Incretin drugs, g...

journal_title：Atherosclerosis

authors： Gallego-Colon E,Wojakowski W,Francuz T

更新日期：2018-11-01 00:00:00

abstract：:The primary objective of this study was to determine the variability in cholesterol carrying capacity of low density lipoproteins (LDLs) and other apolipoprotein B (apo B)-containing lipoproteins in normolipidemic men. One hundred and fifty-nine normolipidemic men, ages 21 to 73 years, were enrolled. In addition to de...

journal_title：Atherosclerosis

authors： Abate N,Vega GL,Grundy SM

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Generally, immoderate alcohol consumption is associated with variant angina and accepted as one of the risk factors for coronary artery spasm (CAS), but evidence is lacking in this regard. The aim of this study is to evaluate the impact of alcohol consumption and drinking pattern on CAS by acetylcho...

journal_title：Atherosclerosis

authors： Sohn SM,Choi BG,Choi SY,Byun JK,Mashaly A,Park Y,Jang WY,Kim W,Choi JY,Park EJ,Na JO,Choi CU,Lim HE,Kim EJ,Park CG,Seo HS,Oh DJ,Rha SW

更新日期：2018-01-01 00:00:00

abstract：AIM:Serum paraoxonase 1 (PON1) is an HDL-associated lipolactonase and its association with hypertension is controversial. We studied the possible role of PON1 in blood pressure (BP) regulation, by using PON1 knockout (PON1KO) mice. METHODS AND RESULTS:Both, systolic and diastolic BPs were lower in PON1KO compared to W...

journal_title：Atherosclerosis

authors： Gamliel-Lazarovich A,Abassi Z,Khatib S,Tavori H,Vaya J,Aviram M,Keidar S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Various infectious agents are associated with atherosclerosis. This analysis was performed to investigate relation between seropositivity for anti-Borrelia IgG and carotid atherosclerosis. METHODS:The cross-sectional Study of Health in Pomerania was conducted in a general community living in a region with e...

journal_title：Atherosclerosis

authors： Völzke H,Wolff B,Lüdemann J,Guertler L,Kramer A,John U,Felix SB

更新日期：2006-01-01 00:00:00

abstract：:We have previously reported that mouse peritoneal macrophages have three types of modified low density lipoprotein (LDL) receptors. One is specific for acetylated LDL (Ac-LDL), the second is for oxidized LDL (Ox-LDL), and the third recognizes both (Arai, H. et al. (1989) Biochem. Biophys. Res. Commun. 159, 1375-1382)....

journal_title：Atherosclerosis

authors： Ueda Y,Arai H,Kawashima A,Nagano Y,Cho M,Tanaka M,Kita T

更新日期：1993-06-01 00:00:00

abstract：:The potential interest of serum elastase activity (SEA) as a marker of vascular aging and atherosclerosis was studied as part of an epidemiological study on vascular and cognitive aging (EVA Study). SEA was measured in 555 men and 774 women aged 59-71 years with a synthetic substrate, suc(ala)3pNA, according to a modi...

journal_title：Atherosclerosis

authors： Bizbiz L,Bonithon-Kopp C,Ducimetierè P,Berr C,Alperovitch A,Robert L

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis. Its expression is increased during inflammation and by inflammatory cytokines. Sulforaphane (SFN) is a natura...

journal_title：Atherosclerosis

authors： Kivelä AM,Mäkinen PI,Jyrkkänen HK,Mella-Aho E,Xia Y,Kansanen E,Leinonen H,Verma IM,Ylä-Herttuala S,Levonen AL

更新日期：2010-11-01 00:00:00

abstract：:Abundant data is present to implicate oxidatively modified low-density lipoprotein (oxLDL) in enhanced atherogenesis. Among the factors involved in LDL oxidation, an important role has been attributed to human 15-lipoxygenase (LO) and its murine analog 12-LO. The expression of these peroxidizing enzymes is under the c...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Shaish A,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-12-01 00:00:00

abstract：RATIONALE:Obstructive sleep apnea results in nocturnal intermittent hypoxia (IH) as a main trigger for cardiovascular morbidity, including atherosclerosis. IH induces hemodynamic, hormono-metabolic and also immuno-inflammatory alterations that could differentially contribute to atherosclerosis. Our study aimed at exami...

journal_title：Atherosclerosis

authors： Arnaud C,Poulain L,Lévy P,Dematteis M

更新日期：2011-12-01 00:00:00

abstract：:In the present study apoA-I (Lys 107del), a naturally occurring human apoA-I variant with a deletion of Lys 107, was expressed in E. coli to examine the effect of this mutation on lipid binding, cholesterol efflux and lecithin:cholesterol acyltranferase (LCAT) activation. Dimyristoyl phosphatidylcholine (DMPC) binding...

journal_title：Atherosclerosis

authors： Huang W,Matsunaga A,Li W,Han H,Hoang A,Kugi M,Koga T,Sviridov D,Fidge N,Sasaki J

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:This study examined whether combined ultrasound assessment of plaque size and echolucency in the carotid artery had an additive effect for predicting coronary events in patients with coronary artery disease (CAD). Ultrasound assessment of either plaque size or echolucency of carotid artery provides prognosti...

journal_title：Atherosclerosis

authors： Hirano M,Nakamura T,Kitta Y,Sano K,Kodama Y,Kobayashi T,Fujioka D,Saito Y,Yano T,Watanabe K,Watanabe Y,Kawabata K,Obata JE,Kugiyama K

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy. In search for underlying mechanisms for this BM dysfunction, accelerated cellular senescence was explored. METHODS:We ana...

journal_title：Atherosclerosis

authors： Nollet E,Hoymans VY,Rodrigus IR,De Bock D,Dom M,Van Hoof VOM,Vrints CJ,Van Craenenbroeck EM

更新日期：2017-05-01 00:00:00