Abstract：
:Aging, which is an independent risk factor for heart disease, alters body fat mass and its function. Epicardial fat plays an important physiological and pathophysiological role on cardiac structure and function. This study investigated if aging altered the abundance of epicardial (EF) and abdominal fat (AF) derived mediators in a sex dependent manner in female and male Fischer 344×Brown Norway hybrid (FBN) rats. EF and AF were obtained from 48 female and male, young (6 months), aged (26/30 months) and very aged (30/36 months) FBN rats. Adipose derived anti-inflammatory and pro-inflammatory mediators were measured using ELISA, adipokine array and real-time qPCR. No dramatic changes in circulating lipids other than a higher triglyceride and high density lipoprotein in aged females and a significantly increased circulating adiponectin (p<0.005) in aged rats were observed. Real time PCR results showed that compared to 6 months old female rats, the aged (26 months) and very aged (30 months) rats had significantly lower levels of EF genes: adiponectin (p<0.005), PPARγ (p<0.01, 0.005), IL-6 (p<0.01) and PAI-1 (p<0.01, 0.01), respectively, but not in AF. In contrast, the male rats exhibited an increase in IL-6 in EF (p<0.005) but a decrease in adiponectin and PPARγ in AF with aging. These changes might be attributed to differences in adipocyte make-up or macrophage infiltration. In conclusion, aging had a more profound impact on EF derived mediators in female rather than male rats, which might help explain the increased risk to cardiovascular disease seen in older women.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Fei J,Cook C,Blough E,Santanam Ndoi
10.1016/j.atherosclerosis.2010.06.044subject
Has Abstractpub_date
2010-10-01 00:00:00pages
488-94issue
2eissn
0021-9150issn
1879-1484pii
S0021-9150(10)00501-0journal_volume
212pub_type
杂志文章相关文献
ATHEROSCLEROSIS文献大全abstract：:Human preadipocytes and adipocytes are known to produce the proatherogenic factor PAI-1 and proinflammatory cytokines, and obesity was found to be state of increased adipose production of these factors. In the present study, we investigated the effect of rosuvastatin on the regulation of PAI-1 gene expression in human...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.06.005
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Risk factors of cardiovascular disease such as lipid aberrations, hypertension, abdominal adiposity and elevations in systemic inflammation, are prominent aetiologies in hyperlipidemia. Supplementation with n-3 PUFA is associated with a reduction in cardiovascular events through its hypotriglyceridemic, anti...
journal_title：Atherosclerosis
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.atherosclerosis.2008.09.020
更新日期：2009-06-01 00:00:00
abstract：:The effect of the apolipoprotein C-II/C-III1 ratio on the capacity of purified bovine milk lipoprotein lipase to hydrolyse triglycerides was measured in a controlled model of pyrene-labeled nonanoyltriglycerides (1-2 ditetradecyl 3-pyrene nonanoyl glyceride) monolayer vesicles. Monolayer was composed of triglycerides,...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(96)05955-2
更新日期：1996-12-20 00:00:00
abstract：:Studies were performed to determine if serum bilirubin, when combined with various lipid and lipoprotein risk factors, enhances our ability to predict coronary artery disease (CAD). This hypothesis was tested in a retrospective study of 644 middle-aged males who had undergone coronary angiography. The traditional risk...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(99)00387-1
更新日期：2000-06-01 00:00:00
abstract：AIMS:Leukocyte telomere length (LTL) is shortened in patients with clinical atherosclerosis (AS). Here we aimed to explore the contribution of elevated homocysteine (Hcy) level to LTL shortening in AS patients and the underlying mechanism. METHODS:Circulating leukocytes were collected from 197 patients with AS and 165...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2013.08.029
更新日期：2013-11-01 00:00:00
abstract：OBJECTIVE:Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. We tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits. METHODS:We studied 274...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2013.03.037
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND AND AIMS:Proteoglycan 4 (Prg4) has a high structural similarity with the established atherosclerosis-modulating proteoglycan versican, but its role in atherogenesis is still unknown. Therefore, the impact of Prg4 deficiency on macrophage function in vitro and atherosclerosis susceptibility in vivo was invest...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2018.05.008
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND & AIMS:Dysbiosis of the gut microbiota is associated with increased levels of circulating lipopolysaccharide (LPS) and subsequent activation of systemic inflammation. Diet is an important modulator of the gut microbiome. We aimed to investigate whether circulating markers of gut-related inflammation, LPS bin...
journal_title：Atherosclerosis
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.atherosclerosis.2019.05.004
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Dementia is a major public health problem because of its high prevalence in elderly individuals, particularly in the growing category of subjects aged 80 years or more. There is accumulating evidence that cholesterol may be implicated in the pathogenesis of dementia, and this has led us to assess the relatio...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2013.07.009
更新日期：2013-10-01 00:00:00
abstract：:The metabolism of homocysteine requires contributions of several enzymes and vitamin cofactors. Earlier studies identified a common polymorphism of methylenetetrahydrofolate reductase that was associated with mild hyperhomocysteinemia. Common variants of two other enzymes involved in homocysteine metabolism, methionin...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(02)00204-6
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Carbohydrates and fat intake have both been linked to development of atherosclerosis. We examined associations between glycemic index (GI) and fat intake with carotid atherosclerosis. METHODS:The Atherosclerosis Risk in Communities (ARIC) cohort enrolled participants during the period 1987-1989 and...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2016.05.024
更新日期：2016-08-01 00:00:00
abstract：:Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(00)00544-x
更新日期：2001-03-01 00:00:00
abstract：:Subendothelial cells (SEC) were obtained from the inner intimal layer of adult human aorta by collagenase treatment. SEC were identified in primary culture either as smooth muscle cells by staining with FITC-labeled antisera against human smooth muscle myosin or as macrophages, foam cells and contaminating endothelial...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(88)90301-2
更新日期：1988-05-01 00:00:00
abstract：:Blood serum of most patients with coronary heart disease (CHD) caused a 2-5-fold increase in the total cholesterol content of smooth muscle cells cultured from unaffected human aortic intima, i.e. possessed an atherogenic potential manifested in culture. Removal of immunoglobulins G and M from an atherogenic serum bro...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(90)90065-q
更新日期：1990-04-01 00:00:00
abstract：:Familial hypobetalipoproteinemia is an autosomal co-dominant disorder, which in a minority of cases is due to a truncation producing mutation in the apoB gene. We have identified an apoB mutation in a 40-year old hypobetalipoproteinemic man with Type II diabetes mellitus. Immunoblotting of plasma revealed a major band...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(97)00222-0
更新日期：1998-02-01 00:00:00
abstract：:The relationships between plasma lecithin:cholesterol acyltransferase (LCAT) mass concentrations and lipids, apolipoprotein, and lipoprotein subfraction concentrations were studied in men assigned at random to a one-year exercise program (n = 48) and to a sedentary control condition (n = 31). Exercise training did not...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0021-9150(90)90143-7
更新日期：1990-05-01 00:00:00
abstract：:An attempt was made to explore the reasons why men develop coronary heart disease (CHD) despite being at low risk on the basis of established risk factors. A case control study was designed to take place after the end of a longitudinal study in which both low- and high-risk men who had developed CHD over the course of...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(83)90196-x
更新日期：1983-11-01 00:00:00
abstract：:The role of the immune system in modulating atherosclerosis has recently been the subject of intensive research. Several previous authors have put forward a paradigm of the autoimmune process occurring in the vicinity of the plaque. Two recent studies have shown that immunization of rabbits with homologous modified lo...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(98)00015-x
更新日期：1998-05-01 00:00:00
abstract：:In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(91)90257-4
更新日期：1991-05-01 00:00:00
abstract：:Oxidative stress is associated with atherosclerosis. Familial combined hyperlipidemia (FCH) is considered as a human model of primary dyslipidemia and atherosclerosis frequently associated with insulin resistance (IR), but there are few data on its possible relation to oxidative stress. The objective of this study was...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.11.023
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:The putative association between the novel oxidized low-density lipoprotein markers, serum amyloid A-LDL (SAA-LDL) and alpha1-antitrypsin-LDL (AT-LDL), and obesity and the metabolic syndrome (MetS) has not been previously studied. In the present report, we investigated the levels of SAA-LDL and AT-LDL in rel...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究
doi：10.1016/j.atherosclerosis.2008.09.017
更新日期：2009-06-01 00:00:00
abstract：:The fractional catabolic rate (FCR) for low density lipoprotein (LDL) apolipoprotein B (apo B) was studied to explore the variations in apo B as a possible cause of hypercholesterolemia. The FCR of radioiodine labelled autologous LDL and homologous LDL isolated from a normocholesterolemic subject were compared in fort...
journal_title：Atherosclerosis
pub_type： 临床试验,杂志文章
doi：10.1016/s0021-9150(99)00106-9
更新日期：1999-09-01 00:00:00
abstract：OBJECTIVE:To compare the prevalence of lower extremity peripheral artery disease (PAD) and to assess whether age-associated progression in ankle-brachial index (ABI) differs between individuals with chronic immune-mediated inflammatory diseases (CIID) and the general population. METHODS:Pooled analysis with data from ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2015.06.054
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Little is known about the relationship between dietary patterns and peripheral arterial disease (PAD). Our aim was to estimate the association between nutrient intake and diagnosis of PAD. METHODS AND RESULTS:We assessed the nutrient intake of 1251 home-dwelling subjects enrolled in the InCHIANTI study, mea...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.atherosclerosis.2005.07.016
更新日期：2006-05-01 00:00:00
abstract：BACKGROUND:Familial dysbetalipoproteinemia (FD), also known as type III hyperlipoproteinemia, is a genetic dyslipidemia characterized by elevated very low density lipoprotein (VLDL) and chylomicron remnant particles that confers increased risk of cardiovascular disease (CVD). The objective of this study was to evaluate...
journal_title：Atherosclerosis
pub_type： 杂志文章,多中心研究
doi：10.1016/j.atherosclerosis.2015.02.046
更新日期：2015-05-01 00:00:00
abstract：:The newly identified apoprotein AV (apoAV) gene was suggested to have a significant effect on triglyceride (TG) metabolism in Caucasians. We studied the genetic effect of this gene on serum TG in a Japanese population. Participants (481 male and 412 female) were recruited at a health examination. A T/C single nucleoti...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(02)00252-6
更新日期：2002-12-01 00:00:00
abstract：OBJECTIVE:Effective systemic drugs against restenosis upon percutaneous transluminal coronary angioplasty (PTCA) are largely lacking. Polyphenols have been suggested to ameliorate post-angioplasty restenosis. Hawthorn (Crataegus spp.) extracts, which are among the most frequently used herbal medicinal products against ...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2010.04.003
更新日期：2010-08-01 00:00:00
abstract：OBJECTIVE:Vasa vasorum (VV) have been implicated to play a role in the pathogenesis of atherosclerosis. This study was designed to describe the distribution of VV density in different vascular beds in humans and to investigate the association between VV density and the known distribution of atherosclerosis in human art...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/j.atherosclerosis.2007.09.015
更新日期：2008-07-01 00:00:00
abstract：:Endurance exercise training is known to produce favorable changes in the metabolic profile including reduced plasma triglyceride (TG) and increased high-density lipoprotein (HDL) cholesterol concentrations. These metabolic improvements are likely to contribute to the reduced coronary heart disease (CHD) risk often obs...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/s0021-9150(01)00515-9
更新日期：2001-12-01 00:00:00
abstract：:Polar coordinate mapping was used to determine the rate of growth of individual sudanophilic lesions on the aortic wall around several major branches of the aortae of cholesterol fed rabbits. Four groups, with 6 8-month old male albino white rabbits in each, were used in the study. One group served as a control and th...
journal_title：Atherosclerosis
pub_type： 杂志文章
doi：10.1016/0021-9150(76)90043-5
更新日期：1976-10-01 00:00:00
