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Markers of endothelial dysfunction and low-grade inflammation are associated in the offspring of type 2 diabetic subjects.

Abstract：

:The offspring of type 2 diabetic patients are at elevated risk for type 2 diabetes and cardiovascular disease. The aim of our study was to characterize the role of various biomarkers of endothelial activation in a cohort of offspring of type 2 diabetic subjects and to assess the association of adhesion molecules with inflammatory markers and metabolic parameters. Cytokine and adhesion molecule levels were measured in 19 healthy subjects and in 129 offspring of patients with type 2 diabetes (109 with normal glucose tolerance and 20 with impaired glucose tolerance). Insulin sensitivity was determined with the hyperinsulinemic-euglycemic clamp, insulin secretion with the intravenous glucose tolerance test, and abdominal fat distribution with computed tomography. The levels of vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-Selectin and vascular adhesion protein-1 were not increased in offspring of type 2 diabetic subjects, but they correlated with inflammatory markers (C-reactive protein, tumor necrosis-alpha, interleukin-6, interleukin-1 beta, interleukin-1 receptor antagonist, interleukin-8, interleukin-10 and interleukin-18). In conclusion, the levels of adhesion molecules were not elevated in the prediabetic state. Inflammatory markers and adhesion molecules were correlated suggesting that low-grade inflammation may precede the elevation of levels of adhesion molecules.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Ruotsalainen E,Vauhkonen I,Salmenniemi U,Pihlajamäki J,Punnonen K,Kainulainen S,Jalkanen S,Salmi M,Laakso M

doi

10.1016/j.atherosclerosis.2007.04.021

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

271-7

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(07)00262-6

journal_volume

197

pub_type

杂志文章

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