Adiposity has no direct effect on carotid intima-media thickness in adolescents and young adults: Use of structural equation modeling to elucidate indirect & direct pathways.

abstract：UNLABELLED:In the last few years it has been proved that risk factors for atherosclerosis are present in children and adolescents, and that already at this early age they are connected with anatomic, atheromatous changes in vessels. These changes can not be fully explained as occurring in young people exhibiting tradit...

journal_title：Atherosclerosis

authors： Glowinska B,Urban M,Koput A,Galar M

更新日期：2003-04-01 00:00:00

abstract：:Variation in the APOA5 gene has been shown to be associated with triglyceride levels in several independent population studies. It was our objective to determine if a relationship existed between selected genotypes or haplotypes of the APOA5 gene and findings on selective coronary angiography (SCA) in an independent c...

journal_title：Atherosclerosis

authors： Lee KW,Ayyobi AF,Frohlich JJ,Hill JS

更新日期：2004-09-01 00:00:00

abstract：:The effect of a fish lipid concentrate rich in eicosapentaenoic acid was studied in 107 subjects for periods up to 2 years. Ninety-two had heart disease or hyper-lipidaemia and 15 had no history of heart disease. Serum triglyceride levels were rapidly reduced, cholesterol fell more slowly but high density lipoprotein ...

journal_title：Atherosclerosis

authors： Saynor R,Verel D,Gillott T

更新日期：1984-01-01 00:00:00

abstract：:Intimal proliferation and functional changes involving vascular smooth muscle cells are key events in the development of atherosclerosis, including restenosis after percutaneous transluminal angioplasty. Nonmuscle myosin (NMM) is required for cytokinesis and has been shown in cultures of vascular smooth muscle cells t...

journal_title：Atherosclerosis

authors： Nikol S,Murakami N,Pickering JG,Kearney M,Leclerc G,Höfling B,Isner JM,Weir L

更新日期：1997-04-01 00:00:00

abstract：:Cholesteryl esters (CE) exchange between lipoproteins through the action of cholesteryl ester transfer protein (CETP). Situations at high risk for atherosclerosis are often accompanied by an accelerated net mass CE transfer (CET) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL...

journal_title：Atherosclerosis

authors： Elchebly M,Porokhov B,Pulcini T,Berthezène F,Ponsin G

更新日期：1996-06-01 00:00:00

abstract：OBJECTIVE:Diabetes and atherosclerosis may share common genetic determinants. A prior study in Hispanics found association of haplotypes in the diabetes gene calpain-10 (CAPN10) with carotid artery intima-media thickness (CIMT). This study sought to replicate this association in an independent cohort. METHODS:Four CAP...

journal_title：Atherosclerosis

authors： Goodarzi MO,Taylor KD,Jones MR,Fang B,Guo X,Xiang AH,Buchanan TA,Hodis HN,Raffel LJ,Rotter JI

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Apolipoprotein E (apoE) has been implicated as conveying increased risk for coronary artery disease (CAD). Previous studies suggest a role of apoE as a modulator of immune response and inflammatory properties. We hypothesized that the presence of apo E4 is associated with an increased inflammatory burden in s...

journal_title：Atherosclerosis

authors： Gungor Z,Anuurad E,Enkhmaa B,Zhang W,Kim K,Berglund L

更新日期：2012-07-01 00:00:00

abstract：:Hyperapobetalipoproteinemia (hyperapo B), a common disorder associated with coronary artery disease, is characterized by an increased number of small, dense, low density lipoprotein (LDL) particles. The cellular mechanisms responsible for early atherosclerosis in hyperapo B are unknown. We tested the hypothesis that h...

journal_title：Atherosclerosis

authors： Kafonek SD,Raikhel I,Bachorik PS,Kwiterovich PO Jr

更新日期：1993-08-01 00:00:00

abstract：:A solid phase radioimmunoassay (RIA) has been developed for apolipoprotein B (apoB), a major constituent of very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in man. Antisera were prepared against apoB in goats and rabbits, coupled to bromoacetyle cellulose, and the complex was incubated with [125I...

journal_title：Atherosclerosis

authors： Thompson GR,Birnbaumer ME,Levy RI,Gotto AM Jr

更新日期：1976-07-01 00:00:00

abstract：:In vitro incubations of human low density lipoproteins (LDL), high density lipoproteins (HDL) and lipoprotein-free plasma at 37 degrees for 6 h revealed no significant net mass transfers of esterified cholesterol from either lipoprotein fraction to the other. Observed transfers of esterified [3H]cholesterol from LDL t...

journal_title：Atherosclerosis

authors： Barter PJ,Jones ME

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Allergic asthma can accelerate atherosclerosis, a disease in which plaque is deposited onto arterial walls and that may lead to coronary artery disease (CAD). Eosinophils are the most important effector cells in allergic asthma and are likely to become novel biomarkers for risk stratification of pat...

journal_title：Atherosclerosis

authors： Gao S,Deng Y,Wu J,Zhang L,Deng F,Zhou J,Yuan Z,Wang L

更新日期：2019-07-01 00:00:00

abstract：:Lipoprotein-lipase activity (LPL) was measured in biopsies of adipose tissue and skeletal muscle of normal human subjects, and the results were related to concentrations of cholesterol and triglycerides in plasma lipoproteins. Adipose-tissue LPL activity was significantly higher in females than in males, whereas no se...

journal_title：Atherosclerosis

authors： Nikkilä EA,Taskinen MR,Kekki M

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND:CD36 signal transductions have been reported by a variety of lipid moiety of oxidized low-density lipoprotein (oxLDL), however, CD36 signal induced by 7-ketocholesteryl-9-carboxynonanoate (oxLig-1), a lipid moiety of oxLDL has not been elucidated. METHODS AND RESULTS:OxLig-1 leads to activation and recruitm...

journal_title：Atherosclerosis

authors： Li W,Wang D,Chi Y,Wang R,Zhang F,Ma G,Chen Z,Li J,Liu Z,Matsuura E,Liu Q

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Peroxisome proliferator-activated receptors alpha (PPARalpha) is a target gene for atherosclerosis and cardiovascular diseases. However, effects of PPARalpha on endothelial nitric oxide synthase (eNOS) remain unknown. We investigated the eNOS regulation by bezafibrate, a ligand of PPARalpha, and involved sign...

journal_title：Atherosclerosis

authors： Wang Y,Wang Y,Yang Q,Yan JT,Zhao C,Cianflone K,Wang DW

更新日期：2006-08-01 00:00:00

abstract：:The purpose of the present study was to examine the relationship between the changes in the expressions of several mRNAs and changes in endothelial function in streptozotocin-induced diabetic and chronic short-term insulin-treated rats. Aortas from later-stage (10 week) diabetics, but not those from their insulin-trea...

journal_title：Atherosclerosis

authors： Kobayashi T,Oishi K,Hayashi Y,Matsumoto T,Kamata K

更新日期：2006-03-01 00:00:00

abstract：:Plasma apo B and apo A-I were determined in 477 subjects (206 males and 271 females) by laser immuno-nephelometry. Measurements of VLDL- + LDL-cholesterol, HDL-cholesterol and triglycerides were done simultaneously. VLDL- + LDL-cholesterol and apo B values were similar in males and females and increased with age. HDL-...

journal_title：Atherosclerosis

authors： Dedonder-Decoopman E,Fievet-Desreumaux C,Campos E,Moulin S,Dewailly P,Sezille G,Jaillard J

更新日期：1980-12-01 00:00:00

abstract：:In animal model studies, the uptake of chylomicron remnants after entering in the space of Disse occurs mainly by low-density lipoprotein (LDL) receptor and LDL receptor-related protein (LRP). In subjects, the relative importance of each one of these receptors for the clearance of chylomicron remnants is not fully und...

journal_title：Atherosclerosis

authors： Sposito AC,Santos RD,Hueb W,Ventura LI,Vinagre CC,Ramires JA,Maranhão RC

更新日期：2002-04-01 00:00:00

abstract：BACKGROUND AND PURPOSE:γ-butyrobetaine (γBB) is a metabolite from dietary Carnitine, involved in the gut microbiota-dependent conversion from Carnitine to the pro-atherogenic metabolite trimethylamine-N-oxide (TMAO). Orally ingested γBB has a pro-atherogenic effect in experimental studies, but γBB has not been studied ...

journal_title：Atherosclerosis

authors： Skagen K,Trøseid M,Ueland T,Holm S,Abbas A,Gregersen I,Kummen M,Bjerkeli V,Reier-Nilsen F,Russell D,Svardal A,Karlsen TH,Aukrust P,Berge RK,Hov JE,Halvorsen B,Skjelland M

更新日期：2016-04-01 00:00:00

abstract：:Oxidant signalling and lipoprotein oxidation may play important roles in atherosclerotic lesion development. Given coincident localization of 15-lipoxygenase (15-LO), stereospecific products of 15-LO and epitopes of modified LDL in atherosclerotic lesions, we hypothesized that inhibition of 15-LO by PD146176, an inhib...

journal_title：Atherosclerosis

authors： Bocan TM,Rosebury WS,Mueller SB,Kuchera S,Welch K,Daugherty A,Cornicelli JA

更新日期：1998-02-01 00:00:00

abstract：:Familial defective apolipoprotein B-100 (FDB) is a dominantly inherited disorder associated with hypercholesterolemia, in which substitution of the amino acid glutamine for arginine at position 3500 in the apoprotein B molecule results in LDL particles which bind poorly to the LDL receptor. To date, patients with FDB ...

journal_title：Atherosclerosis

authors： Schmidt EB,Illingworth DR,Bacon S,Mahley RW,Weisgraber KH

更新日期：1993-01-25 00:00:00

abstract：OBJECTIVE:To compare lipid-lowering efficacy of adding alirocumab to rosuvastatin versus other treatment strategies (NCT01730053). METHODS:Patients receiving baseline rosuvastatin regimens (10 or 20 mg) were randomized to: add-on alirocumab 75 mg every-2-weeks (Q2W) (1-mL subcutaneous injection via pre-filled pen); ad...

journal_title：Atherosclerosis

authors： Farnier M,Jones P,Severance R,Averna M,Steinhagen-Thiessen E,Colhoun HM,Du Y,Hanotin C,Donahue S

更新日期：2016-01-01 00:00:00

abstract：:Electrocardiographic and cardiovascular responses during maximal exercise were evaluated in 103 normal children and in 82 children with familial hyperlipoproteinemia. The normal and hyperlipidemic children were comparable in regards to age, weight--height index, resting and exercise blood pressures, and maximal workin...

journal_title：Atherosclerosis

authors： James FW,Glueck CJ,Fallat RW,Millett F,Kaplan S

更新日期：1976-10-01 00:00:00

abstract：:Prolonged exposure of rats to cigarette smoke resulted in significant alterations in the metabolism of lipids. There was a significant increase in the concentration of cholesterol, triglycerides and phospholipids in most of the tissues, particularly the heart, aorta and lungs. Cholesterol, triglycerides and phospholip...

journal_title：Atherosclerosis

authors： Latha MS,Vijayammal PL,Kurup PA

更新日期：1988-04-01 00:00:00

abstract：:The objective of the study was to evaluate the association between heart valve calcification and atherosclerosis and outcome in systemic lupus erythematosus (SLE). One-hundred and seven patients with SLE (mean age 45.9 +/- 14.7 years) were studied by 2D transthoracic echocardiography. Mitral annulus calcification (MAC...

journal_title：Atherosclerosis

authors： Molad Y,Levin-Iaina N,Vaturi M,Sulkes J,Sagie A

更新日期：2006-04-01 00:00:00

abstract：:To determine whether high prevalence of small dense low-density lipoprotein (LDL) in non-insulin-dependent diabetes (NIDDM) with nephropathy is directly associated with kidney damage, we measured LDL particle size by non-denaturing 2-16% gradient polyacrylamide gel electrophoresis in non-diabetic patients with primary...

journal_title：Atherosclerosis

authors： Hirano T,Oi K,Sakai S,Kashiwazaki K,Adachi M,Yoshino G

更新日期：1998-11-01 00:00:00

abstract：:High density lipoproteins (HDL) induce prostacyclin (PGI(2)) release in vascular smooth muscle cells (VSMC) by up-regulation of cyclooxygenase-2 (Cox-2). Our goal was to analyse the mechanisms underlying this effect, and its potential modulation by HMG-CoA reductase inhibition in human VSMC. The contribution of mitoge...

journal_title：Atherosclerosis

authors： Martínez-González J,Escudero I,Badimon L

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The putative association between the novel oxidized low-density lipoprotein markers, serum amyloid A-LDL (SAA-LDL) and alpha1-antitrypsin-LDL (AT-LDL), and obesity and the metabolic syndrome (MetS) has not been previously studied. In the present report, we investigated the levels of SAA-LDL and AT-LDL in rel...

journal_title：Atherosclerosis

authors： Kotani K,Satoh N,Kato Y,Araki R,Koyama K,Okajima T,Tanabe M,Oishi M,Yamakage H,Yamada K,Hattori M,Shimatsu A,Japan Obesity and Metabolic Syndrome Study Group.

更新日期：2009-06-01 00:00:00

abstract：:Homocysteine is associated with coronary disease (CAD). However, the strength of the association after accounting for traditional and emerging risk factors is unclear, particularly since flour fortification with folate was mandated in the USA. We analyzed the association between traditional and emerging risk factors a...

journal_title：Atherosclerosis

authors： Brilakis ES,McConnell JP,Ballman KV,Klee GG,Berger PB

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:A common gain-of-function LPL variant, LPLS447X, has favorable clinical features and involves a C→G base change at nucleotide 1595 of the LPL cDNA, along with a haplotype, which includes other non-coding SNPs. The mechanism for the LPL gain-in-function is not clear. LPL translation is regulated by epinephrine...

journal_title：Atherosclerosis

authors： Ranganathan G,Unal R,Pokrovskaya ID,Tripathi P,Rotter JI,Goodarzi MO,Kern PA

更新日期：2012-03-01 00:00:00

abstract：:Ischaemic heart disease (IHD) is the leading cause of death in women as in men, although presentation in women is on average 7-10 years later. Recent temporal trends show declining IHD incidence and mortality among men but not among women. Other gender differences concern the prevalence of underlying mechanisms. Women...

journal_title：Atherosclerosis

authors： Crea F,Battipaglia I,Andreotti F

更新日期：2015-07-01 00:00:00