Plasma lipoprotein changes in humans induced by beta-interferon.

Abstract:

:Two groups of patients were administered either 4.5 X 10(6) U or 90 X 10(6) U each of recombinant DNA-derived interferon-beta serine (IFN-beta ser) i.v. daily for 10 days. IFN-beta ser affected lipoprotein lipids of patients in a dose dependent fashion. A decrease in plasma total cholesterol concentration occurred 24 h after therapy was initiated, regardless of dose. A dose-related decrease in plasma cholesterol concentration of 9% and 23% for patients on the low dose and high dose respectively occurred after 9 days of therapy. The plasma total cholesterol concentration decrease resulted primarily from a decrease in LDL cholesterol of 28% and 50% for patients on low and high doses respectively of IFN-beta ser. HDL-cholesterol was not significantly affected by IFN-beta ser administration. A dose-related increase in plasma triglyceride concentration occurred during IFN-beta ser, increasing 74% for patients on low dose and 136% for patients on high doses. This increase was only observed after 9 days on IFN-beta ser. Cholesterol reduction and triglyceride increases followed different time courses indicating different mechanisms may be involved.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

doi

10.1016/0021-9150(87)90287-5

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

261-7

issue

2-3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(87)90287-5

journal_volume

67

pub_type

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