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Hematoporphyrin binding to cultured aortic smooth muscle cells from spontaneously atherosclerotic turkey.

Abstract：

:Porphyrins are known to be accumulated in vivo by tumors and atherosclerotic plaques. We studied the interaction of cultured aortic smooth muscle cells (SMC) from spontaneously atherosclerotic Broad Breasted White Turkeys (BBWT) with free hematoporphyrin (Hp) and low density lipoprotein (LDL)-Hp complexes. A significantly higher binding of LDL-Hp to SMC as compared to free Hp was observed. These data indicate that porphyrin binding to vascular SMC represents a possible mechanism for porphyrin accumulation by atherosclerotic plaques. This process is mediated, at least in part, by LDL.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Scannapieco G,Pagnan A,Pauletto P,Mattiello A,Biffanti S,Jori G,Dal Palù C

doi

10.1016/0021-9150(88)90086-x

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

241-4

issue

2-3

eissn

0021-9150

issn

1879-1484

pii

0021-9150(88)90086-X

journal_volume

72

pub_type

杂志文章

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