Effect of sialic acid removal on human low density lipoprotein catabolism in vivo.

abstract：:Oxidation of low density lipoproteins (LDL) is considered a key event in the pathogenesis of atherosclerotic lesions. Disturbed generation of coagulatory and anticoagulatory factors by endothelial cells contributes to thrombosis and the progression of atherosclerosis in coronary arteries. In this study, the effects of...

journal_title：Atherosclerosis

authors： Gräfe M,Auch-Schwelk W,Hertel H,Terbeek D,Steinheider G,Loebe M,Fleck E

更新日期：1998-03-01 00:00:00

abstract：:Familial dysbetalipoproteinemia is characterized by hyperlipidemia, increases in beta-migrating, very low density lipoproteins (beta-VLDL), and homozygosity for apolipoprotein E2 (apo E2). In this study, 3 patients with familial dysbetalipoproteinemia were treated with lovastatin, and kinetics for apolipoprotein B (ap...

journal_title：Atherosclerosis

authors： Vega GL,East C,Grundy SM

更新日期：1988-03-01 00:00:00

abstract：:Recent studies suggest that the beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) in reducing cardiovascular events may in part, be independent of their capacity to lower plasma lipids. To test this hypothesis, simvastatin (50 mg/kg/d) was administered to 30-week-old ...

journal_title：Atherosclerosis

authors： Bea F,Blessing E,Shelley MI,Shultz JM,Rosenfeld ME

更新日期：2003-04-01 00:00:00

abstract：:The composition of very low density lipoproteins (VLDL: d less than 1.019) of New Zealand male rabbits reciving cholesterol (2 g/day) and metformin (135 mg/kg/day) is investigated. These rabbits, while showing only a slight reduction of plasma cholesterol levels, as compared to cholesterol-fed (h.c.) animals, show a m...

journal_title：Atherosclerosis

authors： Sirtori CR,Catapano A,Ghiselli GC,Innocenti AL,Rodriguez J

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:Dozens of single nucleotide polymorphisms (SNPs) in the lipoprotein lipase (LPL) gene have been reported to be associated with lipid concentrations. The aim of this study was to validate the association between rs1059611 in the LPL gene and serum lipid concentrations in the Chinese Han population and explore ...

journal_title：Atherosclerosis

authors： Mo X,Liu X,Wang L,Li H,Lu X,Huang J,Chen J,Cao J,Li J,Chen S,Tang Y,Peng X,Gu D

更新日期：2013-08-01 00:00:00

abstract：:The relationship of fetal plasma cholesterol levels to aortic free and esterified cholesterol concentration was determined in the rabbit during gestation. Plasma cholesterol levels (mg/dl) in early fetuses were markedly high and decreased at term. While aortic free cholesterol content increased with fetal age, cholest...

journal_title：Atherosclerosis

authors： Cayatte AJ,Subbiah MT

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND AND AIMS:This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular...

journal_title：Atherosclerosis

authors： Yamamoto H,Yoshida N,Shinke T,Otake H,Kuroda M,Sakaguchi K,Hirota Y,Toba T,Takahashi H,Terashita D,Uzu K,Tahara N,Shinkura Y,Kuroda K,Nagasawa Y,Nagano Y,Tsukiyama Y,Yanaka KI,Emoto T,Sasaki N,Yamashita T,Ogawa

更新日期：2018-02-01 00:00:00

abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

journal_title：Atherosclerosis

authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

更新日期：2020-08-01 00:00:00

abstract：:To clarify age-related and lipid-related hemostatic abnormalities in the elderly, we measured the plasma levels of active PAI-1 antigen (aPAI-1), tPA-PAI-1 complex (TPC), plasminogen, alpha 2-plasmin inhibitor (alpha 2-PI), plasmin-alpha 2-PI complex (PIC), and D-dimer, together with the plasma levels of fibrinogen, f...

journal_title：Atherosclerosis

authors： Kario K,Matsuo T

更新日期：1993-11-01 00:00:00

abstract：:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial,...

journal_title：Atherosclerosis

authors： Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

更新日期：2011-12-01 00:00:00

abstract：:Inflammatory cytokines, including tumor necrosis factor-alpha (TNF-alpha) have been implicated in atherogenesis. However, the precise role of TNF-alpha in atherogenesis is still unclear. To examine the effect of TNF-alpha on atherogenesis, we generated compound-deficient mice in apolipoprotein E (apoE) and TNF-alpha (...

journal_title：Atherosclerosis

authors： Ohta H,Wada H,Niwa T,Kirii H,Iwamoto N,Fujii H,Saito K,Sekikawa K,Seishima M

更新日期：2005-05-01 00:00:00

abstract：:Male adult New Zealand rabbits were fed a 2% cholesterol diet for 60 days followed by 10, 20, or 30 days of normal low cholesterol diet. Collagen synthesis was estimated by measuring aortic prolyl hydroxylase activity. Tissue cholesterol accumulation rates were estimated by dividing total tissue cholesterol by the num...

journal_title：Atherosclerosis

authors： Modrak JB,Langner RO

更新日期：1980-10-01 00:00:00

abstract：:In response to homocysteine induced toxicity in human umbilical vein endothelial cells, minimal changes in the concentration of cellular protein thiols but substantial changes in the concentration of intracellular soluble thiols were observed. The latter correlated closely with changes in cellular glutathione levels. ...

journal_title：Atherosclerosis

authors： Blundell G,Jones BG,Rose FA,Tudball N

更新日期：1996-05-01 00:00:00

abstract：:In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 yea...

journal_title：Atherosclerosis

authors： Sanderson KJ,van Rij AM,Wade CR,Sutherland WH

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascula...

journal_title：Atherosclerosis

authors： Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney B

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:The EPA/AA ratio has emerged as a predictor of mortality endpoints in cardiac disease; however, its prognostic value in peripheral artery disease (PAD) patients is unclear. We assessed the serum eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio in patients with PAD caused by femoropopliteal artery l...

journal_title：Atherosclerosis

authors： Hishikari K,Kimura S,Yamakami Y,Kojima K,Sagawa Y,Otani H,Sugiyama T,Kuwahara T,Hikita H,Takahashi A,Isobe M

更新日期：2015-04-01 00:00:00

abstract：:Modified lipoproteins induce autoimmune responses including the synthesis of autoantibodies with pro-inflammatory characteristics. Circulating modified lipoprotein autoantibodies combine with circulating antigens and form immune complexes (IC). We now report the results of a study investigating the role of circulating...

journal_title：Atherosclerosis

authors： Lopes-Virella MF,McHenry MB,Lipsitz S,Yim E,Wilson PF,Lackland DT,Lyons T,Jenkins AJ,Virella G,DCCT\/EDIC Research Group.

更新日期：2007-02-01 00:00:00

abstract：AIM:The present clinical study tested the hypothesis that oil-rich fish consumption improves CHD risk factors. METHODS:Forty-eight (16 men) non-obese, healthy adults aged 20-55, consumed 125 g/day of salmon for a 4-week period followed by a 4-week period with no-fish (41 completers). Subjects were instructed to mainta...

journal_title：Atherosclerosis

authors： Lara JJ,Economou M,Wallace AM,Rumley A,Lowe G,Slater C,Caslake M,Sattar N,Lean ME

更新日期：2007-07-01 00:00:00

abstract：:The effect of administering blackgram (Phaseolus mungo) fiber (isolated as neutral detergent residue) at the 30% dietary level has been studied with regard to lipid concentration in the tissues and that of biliary and fecal bile acids and sterols. Rats were fed a high fat-cholesterol diet and compared with those fed a...

journal_title：Atherosclerosis

authors： Jayakumari N,Kurup PA

更新日期：1979-05-01 00:00:00

abstract：:In a randomized, double-blind, crossover trial of 5-week treatment period with placebo or rosuvastatin (10 or 40 mg/day) with 2-week placebo wash-outs between treatments, the dose-dependent effect of rosuvastatin on apolipoprotein (apo) B-100 kinetics in metabolic syndrome subjects were studied. Compared with placebo,...

journal_title：Atherosclerosis

authors： Ooi EM,Barrett PH,Chan DC,Nestel PJ,Watts GF

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Lowering low-density lipoprotein cholesterol (LDL-C) with statins reduces cardiovascular events and slows plaque progression. While this therapeutic approach has been reported to favorably modify plaque composition, this is not well characterized in humans. Also, the benefit of achieving LDL-C levels below cu...

journal_title：Atherosclerosis

authors： Kataoka Y,Hammadah M,Puri R,Duggal B,Uno K,Kapadia SR,Murat Tuzcu E,Nissen SE,Nicholls SJ

更新日期：2015-10-01 00:00:00

abstract：:Two groups of patients were administered either 4.5 X 10(6) U or 90 X 10(6) U each of recombinant DNA-derived interferon-beta serine (IFN-beta ser) i.v. daily for 10 days. IFN-beta ser affected lipoprotein lipids of patients in a dose dependent fashion. A decrease in plasma total cholesterol concentration occurred 24 ...

journal_title：Atherosclerosis

authors： Rosenzweig IB,Wiebe DA,Borden EC,Storer B,Shrago ES

更新日期：1987-10-01 00:00:00

abstract：:In order to study the connection between homocysteine and lipid metabolism in atherosclerosis, homocysteine was determined in lipoprotein fractions from men with hypercholesterolemia. All lipoprotein fractions contain a considerably higher level of homocysteine in hypercholesterolemia, compared to normolipemic men, va...

journal_title：Atherosclerosis

authors： Olszewski AJ,McCully KS

更新日期：1991-05-01 00:00:00

abstract：:The proband is a 50 year-old woman born from a consanguineous marriage. She has been suffering from angina pectoris since the age of 38 and underwent coronary bypass surgery for three-vessel disease at 48. The presence of low plasma levels of total cholesterol and high density lipoprotein (HDL) cholesterol (2.4 and 0....

journal_title：Atherosclerosis

authors： Bertolini S,Pisciotta L,Seri M,Cusano R,Cantafora A,Calabresi L,Franceschini G,Ravazzolo R,Calandra S

更新日期：2001-02-15 00:00:00

abstract：:Studies on carotid artery atherosclerosis have been performed in order to understand the high risk for cardiovascular disease in chronic renal failure (CRF). The purpose of this study was to evaluate the extent and nature of carotid artery atherosclerosis in patients with CRF. Of the 135 patients with CRF (52 +/- 11 y...

journal_title：Atherosclerosis

authors： Leskinen Y,Lehtimäki T,Loimaala A,Lautamatti V,Kallio T,Huhtala H,Salenius JP,Saha H

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:A direct correlation between blood glucose levels and the microvascular complications of diabetes is well established. However, the effects of hyperglycaemia on the vasa vasorum, a microvascular network which surrounds and supplies the walls of large arteries, is not known. The objective of this study is to i...

journal_title：Atherosclerosis

authors： Veerman KJ,Venegas-Pino DE,Shi Y,Khan MI,Gerstein HC,Werstuck GH

更新日期：2013-04-01 00:00:00

abstract：:Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study coh...

journal_title：Atherosclerosis

authors： Hao WR,Lin HW,Chao PZ,Wu CW,Yen TH,Liu JC,Liou TH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Detection of inflamed atherosclerotic plaques is of crucial importance. The carotid artery cuff-model in ApoE(-/-) mice results in shear-stress induced atherosclerosis with inflamed plaques upstream (US) and 'stable' plaques downstream (DS) of the cuff. We evaluated the potential of F-18-FDG PET/CT to differ...

journal_title：Atherosclerosis

authors： Wenning C,Kloth C,Kuhlmann MT,Jacobs AH,Schober O,Hermann S,Schäfers MA

更新日期：2014-06-01 00:00:00

abstract：:Fifty-seven sections of human vessels, collected in the Pathobiological Determinants of Atherosclerosis in Youth study from individuals aged 25-34, were stained with two monoclonal antibodies to oxidatively-modified lysine. Intensity and extent of immunoreactivity were graded by three pathologists. Aorta from a Watana...

journal_title：Atherosclerosis

authors： Sloop GD,Fallon KB,Lipscomb G,Takei H,Zieske A

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:ATP binding cassette transporter A1 (ABCA1) is a member of the ATP-binding cassette transporter family. It plays an essential role in mediating the efflux of excess cholesterol. It is known that peroxisome proliferator-activated receptor gamma (PPARγ) promoted ABCA1 expression. We previously found 7-ketochol...

journal_title：Atherosclerosis

authors： Chi Y,Wang L,Liu Y,Ma Y,Wang R,Han X,Qiao H,Lin J,Matsuura E,Liu S,Liu Q

更新日期：2014-06-01 00:00:00