Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease.


:In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 years) and 26 older (ages > 55 years) healthy subjects. Plasma lipid peroxide concentrations in the PVD patients (105.9 +/- 20.6 vs. 91.8 +/- 15.8 ng malondialdehyde (MDA)/ml plasma, mean +/- S.D.) and the smokers (94.1 +/- vs. 74.0 +/- 13.9 ng MDA/ml plasma) were significantly elevated compared with levels in the appropriate control subjects and levels were significantly higher in older compared with younger control subjects. Plasma LDL lipid peroxides were also significantly raised in patients with PVD and smokers compared with control values (PVD): 37.1 +/- 7.7 vs. 26.3 +/- 4.1 ng MDA/ml plasma; smokers: 30.4 +/- 6.9 vs 24.9 +/- 7.5 ng MDA/ml plasma). The ratio of LDL lipid peroxides: LDL-cholesterol was significantly higher in the smokers, and plasma cholesterol and LDL-cholesterol were significantly higher in patients with PVD compared with other groups of subjects. The ratio of vitamin E: total lipid was not significantly different between the study groups. These data show that lipid peroxide levels in the plasma LDL fraction are elevated along with raised circulating levels in patients with PVD and smokers but that LDL lipid peroxide concentrations were independent of age in the healthy subjects. Elevated LDL lipid peroxide concentrations may may be mainly due to abnormally high LDL levels in PVD patients, whereas in smokers, the concentration of lipid peroxides in the LDL particles is raised and might render the lipoprotein more atherogenic.






Sanderson KJ,van Rij AM,Wade CR,Sutherland WH




Has Abstract


1995-11-01 00:00:00














  • MicroRNA-27a/b regulates cellular cholesterol efflux, influx and esterification/hydrolysis in THP-1 macrophages.

    abstract:RATIONALE:Macrophage cholesterol homeostasis maintenance is the result of a balance between influx, endogenous synthesis, esterification/hydrolysis and efflux. Excessive accumulation of cholesterol leads to foam cell formation, which is the major pathology of atherosclerosis. Previous studies have shown that miR-27 (mi...


    pub_type: 杂志文章


    authors: Zhang M,Wu JF,Chen WJ,Tang SL,Mo ZC,Tang YY,Li Y,Wang JL,Liu XY,Peng J,Chen K,He PP,Lv YC,Ouyang XP,Yao F,Tang DP,Cayabyab FS,Zhang DW,Zheng XL,Tian GP,Tang CK

    更新日期:2014-05-01 00:00:00

  • Long non-coding RNAs in the atherosclerotic plaque.

    abstract:BACKGROUND AND AIMS:Genetic and environmental factors are important components of the development of atherosclerosis. Long non-coding RNA (lncRNAs) have emerged as regulators of multiple pathophysiological pathways in the cardiovascular system. Here, we investigated potential associations between lncRNAs and atheroscle...


    pub_type: 杂志文章


    authors: Arslan S,Berkan Ö,Lalem T,Özbilüm N,Göksel S,Korkmaz Ö,Çetin N,Devaux Y,Cardiolinc™ network.

    更新日期:2017-11-01 00:00:00

  • Effect of gemfibrozil on composition of lipoproteins and distribution of LDL subspecies.

    abstract::We studied the effect of gemfibrozil on the compositions of VLDL, LDL and distribution of LDL subspecies in type II hyperlipidemic patients. Gemfibrozil significantly lowered serum triglyceride levels in this group of patients who had normal to moderately elevated triglyceride prior to therapy. Gemfibrozil also change...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Tsai MY,Yuan J,Hunninghake DB

    更新日期:1992-07-01 00:00:00

  • RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes.

    abstract::Previous studies demonstrated that induction of diabetes with streptozotocin (stz) accelerated atherosclerosis in hyperlipidemic apo E null (-/-) mice. Blockade of the Receptor for Advanced Glycation Endproducts (RAGE) in those animals suppressed acceleration of atherosclerotic lesion area, in a manner independent of ...


    pub_type: 杂志文章


    authors: Wendt T,Harja E,Bucciarelli L,Qu W,Lu Y,Rong LL,Jenkins DG,Stein G,Schmidt AM,Yan SF

    更新日期:2006-03-01 00:00:00

  • High-sensitivity cardiac troponin T in patients with intermittent claudication and its relation with cardiovascular events and all-cause mortality--the CAVASIC Study.

    abstract:BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...


    pub_type: 杂志文章


    authors: Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

    更新日期:2014-12-01 00:00:00

  • The relation between plasma cysteine, plasma homocysteine and coronary atherosclerosis.

    abstract::Several studies have reported that elevated plasma levels of total homocysteine (tHcy) are related to an increased risk of cardiovascular disease. Only a few studies have looked at the effect of cysteine, another amino thiol, on cardiovascular disease risk. Therefore, in the present case-control study we compared plas...


    pub_type: 杂志文章


    authors: van den Brandhof WE,Haks K,Schouten EG,Verhoef P

    更新日期:2001-08-01 00:00:00

  • Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation.

    abstract::Recent studies suggest that the beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins) in reducing cardiovascular events may in part, be independent of their capacity to lower plasma lipids. To test this hypothesis, simvastatin (50 mg/kg/d) was administered to 30-week-old ...


    pub_type: 杂志文章


    authors: Bea F,Blessing E,Shelley MI,Shultz JM,Rosenfeld ME

    更新日期:2003-04-01 00:00:00

  • Lack of effect of probucol on atheroma formation in cholesterol-fed rabbits kept at comparable plasma cholesterol levels.

    abstract::Rabbits were fed cholesterol for 14 weeks to study the effect of probucol on atheroma formation. Three groups of animals were investigated: group CHOL was fed 1% cholesterol and served as control for group P + CHOL. fed 1% cholesterol and 1% probucol from the onset till the end of the experiment: group CHOL + P receiv...


    pub_type: 杂志文章


    authors: Stein Y,Stein O,Delplanque B,Fesmire JD,Lee DM,Alaupovic P

    更新日期:1989-02-01 00:00:00

  • Associations between retinal microvascular structure and the severity and extent of coronary artery disease.

    abstract:OBJECTIVE:Microvascular mechanisms are increasingly recognized as being involved in a significant proportion of coronary artery disease (CAD) cases, but their exact contribution or role is unclear. We aimed to define the association between retinal microvascular signs and both CAD extent and severity. METHODS:1120 par...


    pub_type: 杂志文章


    authors: Gopinath B,Chiha J,Plant AJ,Thiagalingam A,Burlutsky G,Kovoor P,Liew G,Mitchell P

    更新日期:2014-09-01 00:00:00

  • Effect of fatty acid structure on neutrophil adhesion, degranulation and damage to endothelial cells.

    abstract::Neutrophils have been implicated in ischaemic heart disease, unstable angina pectoris and acute myocardial infarction. Alterations in dietary levels of specific 18- and 20-carbon polyunsaturated fatty acids have significant clinical benefits in cardiovascular disease. However, to date there has been no concerted effor...


    pub_type: 杂志文章


    authors: Bates EJ,Ferrante A,Smithers L,Poulos A,Robinson BS

    更新日期:1995-08-01 00:00:00

  • Nitric oxide synthase II (NOS II) gene expression correlates with atherosclerotic intimal thickening. Preventive effects of HMG-CoA reductase inhibitors.

    abstract::HMG-CoA reductase inhibitors have been shown to be effective in primary and secondary prevention of coronary heart disease. Their mechanism of action is attributed to their cholesterol lowering activity but recent results seem to indicate additional effects related to the modulation of other processes that regulate th...


    pub_type: 杂志文章


    authors: Alfon J,Guasch JF,Berrozpe M,Badimon L

    更新日期:1999-08-01 00:00:00

  • Desialylated low density lipoprotein--naturally occurring modified lipoprotein with atherogenic potency.

    abstract::We have recently established that low density lipoprotein (LDL) of most patients with coronary atherosclerosis differs from the LDL of most healthy subjects by its ability to cause primary atherosclerotic changes, i.e. the accumulation of intracellular cholesterol in the cells of smooth muscle origin cultured from una...


    pub_type: 杂志文章


    authors: Orekhov AN,Tertov VV,Mukhin DN

    更新日期:1991-02-01 00:00:00

  • Human triglyceride-rich lipoprotein apo E kinetics and its relationship to LDL apo B-100 metabolism.

    abstract::Apolipoprotein (apo) E is a multifunctional protein that can act as a ligand for lipoprotein receptors. The receptor-mediated clearance of the triglyceride-rich lipoproteins (TRL) chylomicrons and VLDL from plasma is, in part, dependent on apo E. Enrichment of VLDL with apo E is thought to enhance receptor-mediated cl...


    pub_type: 杂志文章


    authors: Millar JS,Lichtenstein AH,Ordovas JM,Dolnikowski GG,Schaefer EJ

    更新日期:2001-04-01 00:00:00

  • Passive smoking and mortality from aortic dissection or aneurysm.

    abstract:BACKGROUND AND AIMS:Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. METHODS:The Japan Collaborative Cohort (JACC) Study is a prospective comm...


    pub_type: 杂志文章


    authors: Kihara T,Yamagishi K,Iso H,Tamakoshi A,JACC Study Group.

    更新日期:2017-08-01 00:00:00

  • Simvastatin-induced decrease in the transfer of cholesterol esters from high density lipoproteins to very low and low density lipoproteins in normolipidemic subjects.

    abstract::Hyperlipidemic patients often have an accelerated esterified cholesterol transfer (ECT) from high density lipoproteins (HDL) to very low (VLDL) and low density lipoproteins (LDL). We investigated the effect of simvastatin on ECT in twelve normolipidemic subjects. After 6 weeks of simvastatin administration, ECT was de...


    pub_type: 杂志文章


    authors: Ahnadi CE,Berthezène F,Ponsin G

    更新日期:1993-03-01 00:00:00

  • Effect of probucol on the composition of lipoproteins and on VLDL apoprotein B turnover.

    abstract::We studied the effect of probucol on lipoprotein composition and VLDL apo B turnover. In 7 hypercholesterolemic subjects, probucol therapy lowered mean total cholesterol, HDL cholesterol and HDL triglycerides, raised LDL triglycerides and did not change LDL cholesterol. LDL cholesterol:LDL triglycerides mass ratios fe...


    pub_type: 杂志文章


    authors: Lock DR,Kuisk I,Gonen B,Patsch W,Schonfeld G

    更新日期:1983-06-01 00:00:00

  • Risk of myocardial infarction in patients with rhinosinusitis.

    abstract::Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study coh...


    pub_type: 杂志文章


    authors: Hao WR,Lin HW,Chao PZ,Wu CW,Yen TH,Liu JC,Liou TH

    更新日期:2013-01-01 00:00:00

  • Genetic variation in paraoxonase-1 and paraoxonase-2 is associated with variation in plasma lipoproteins in Alberta Hutterites.

    abstract::In a sample taken from the genetically isolated Alberta Hutterites, we previously found that PON1 variation was associated with variation in plasma lipoprotein traits, including LDL and HDL cholesterol. With the recent cloning of the PON1-related gene PON2, we undertook studies of the association between genetic varia...


    pub_type: 杂志文章


    authors: Boright AP,Connelly PW,Brunt JH,Scherer SW,Tsui LC,Hegele RA

    更新日期:1998-07-01 00:00:00

  • Resequencing the apolipoprotein A5 (APOA5) gene in patients with various forms of hypertriglyceridemia.

    abstract:OBJECTIVE:Genomewide association studies (GWAS), conventional association studies and the characterization of families with ApoA5 deficiency have shown that variation in the apolipoprotein A5 (APOA5) gene is associated with plasma triglyceride levels. The aim of this study was to determine the frequency of rare variant...


    pub_type: 杂志文章


    authors: Evans D,Aberle J,Beil FU

    更新日期:2011-12-01 00:00:00

  • Actions of vitamins A and E and some nicotinic acid derivatives on plasma lipids and on lipid infiltration of aorta in cholesterol-fed rabbits.

    abstract::Marked hypercholesterolemia and moderate lipid infiltration of the aorta were induced by feeding rabbits a diet containing 1% cholesterol + 3% corn oil for 70 days. In the liver the concentration and pool size of cholesterol increased and those of triglycerides (TG) decreased. On dietary addition of vitamin A and vita...


    pub_type: 杂志文章


    authors: Brattsand R

    更新日期:1975-07-01 00:00:00

  • C-reactive protein and e-selectin levels are related to vasodilation in resistance, but not conductance arteries in the elderly: the prospective investigation of the Vasculature in Uppsala Seniors (PIVUS) study.

    abstract:BACKGROUND:Divergent results have emerged in the past when relating single markers of inflammation to measures of vascular reactivity. The aim of the present study is to relate a wide range of inflammatory markers to vasoreactivity in both resistance and conductance arteries. METHODS:In the Prospective Investigation o...


    pub_type: 临床试验,杂志文章


    authors: Lind L,Siegbahn A,Hulthe J,Elmgren A

    更新日期:2008-07-01 00:00:00

  • Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis.

    abstract:OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...


    pub_type: 杂志文章,meta分析,评审


    authors: Inaba Y,Chen JA,Bergmann SR

    更新日期:2012-01-01 00:00:00

  • Analysis of serum lipid levels in Japanese men and women according to body mass index. Increase in risk of atherosclerosis in postmenopausal women. Research Group on Serum Lipid Survey 1990 in Japan.

    abstract::Relatively low serum lipid levels are thought to be an important factor contributing to the low incidence of ischemic heart diseases (IHD) in Japanese. It has been proven that obesity or overweight constitutes a basal condition for several risk factors in atherosclerosis. The purpose of this study is to obtain data on...


    pub_type: 杂志文章


    authors: Yamamoto A,Horibe H,Mabuchi H,Kita T,Matsuzawa Y,Saito Y,Nakaya N,Fujioka T,Tenba H,Kawaguchi A,Nakamura H,Goto Y

    更新日期:1999-03-01 00:00:00

  • Cardiovascular implications of HIV-induced dyslipidemia.

    abstract::Cardiovascular disease (CVD) is currently the second most frequent cause of death (after cancer) among HIV-positive subjects. The clinical use of highly active antiretroviral therapy (HAART) has dramatically reduced mortality and morbidity in HIV-positive population, leading to prolonged and improved quality of life. ...


    pub_type: 杂志文章,评审


    authors: Giannarelli C,Klein RS,Badimon JJ

    更新日期:2011-12-01 00:00:00

  • Triiodothyronine stimulates prostacyclin production by rat aortic smooth muscle cells in culture.

    abstract::The effect of triiodothyronine (T3) on prostacyclin production in rat aortic smooth muscle cells was investigated by using an intact cell assay system. T3 at its physiological concentrations has no significant effect on smooth muscle cell proliferation, but it does significantly stimulate prostacyclin production by th...


    pub_type: 杂志文章


    authors: Nakao J,Chang WC,Murota S,Orimo H

    更新日期:1981-07-01 00:00:00

  • Accumulation of cholesteryl esters in macrophages incubated with human lipoprotein-antibody autoimmune complex.

    abstract::The interaction of mouse peritoneal and human pericardial macrophages with lipoprotein (LP)-antibody (Ab) immune complex isolated from the serum of ischemic heart disease (IHD) patients has been studied. It is shown that the Ab of the autoimmune complex belongs to IgG class, and the antigen is the LP with d less than ...


    pub_type: 杂志文章


    authors: Klimov AN,Denisenko AD,Vinogradov AG,Nagornev VA,Pivovarova YI,Sitnikova OD,Pleskov VM

    更新日期:1988-11-01 00:00:00

  • The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells.

    abstract:OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...


    pub_type: 杂志文章,多中心研究


    authors: Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

    更新日期:2011-12-01 00:00:00

  • The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation.

    abstract::The ATP-binding cassette transporters, ABCA1 and ABCG1, are LXR-target genes that participate in the removal of cholesterol from lipid-laden macrophages, a crucial anti-atherogenic mechanism. Statins are currently the most efficacious therapy for the treatment of hypercholesterolemia and cardiovascular disease. We and...


    pub_type: 杂志文章


    authors: Wong J,Quinn CM,Gelissen IC,Jessup W,Brown AJ

    更新日期:2008-01-01 00:00:00

  • Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2.

    abstract:OBJECTIVE:To examine whether the beneficial effects of PJ consumption by mice on their macrophages are mediated via PJ-induced increment in serum paraoxonase 1 (PON1) activity and/or in macrophage PON2 expression. METHODS AND RESULTS:We performed studies in peritoneal macrophages (MPM) from C57BL/6 control mice, or fr...


    pub_type: 杂志文章


    authors: Rosenblat M,Volkova N,Aviram M

    更新日期:2010-09-01 00:00:00

  • Prediction of cardiovascular events with levels of proprotein convertase subtilisin/kexin type 9: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIMS:Inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) reduces atherogenic lipoproteins and could lead to reduction of cardiovascular (CV) events. However, it is unclear whether blood PCSK9 levels predict future CV events. We performed a meta-analysis of all longitudinal studies to dete...


    pub_type: 杂志文章,meta分析,评审


    authors: Vlachopoulos C,Terentes-Printzios D,Georgiopoulos G,Skoumas I,Koutagiar I,Ioakeimidis N,Stefanadis C,Tousoulis D

    更新日期:2016-09-01 00:00:00