Lipid peroxidation of circulating low density lipoproteins with age, smoking and in peripheral vascular disease.


:In this study, lipid peroxides in plasma and the low density lipoprotein (LDL) fraction and plasma concentrations of vitamin E, lipids and lipoproteins were measured in 22 smokers (mean age 35 years), 26 non-smoking patients with peripheral vascular disease (PVD), mean age 66 years), and 23 younger (ages < or = 55 years) and 26 older (ages > 55 years) healthy subjects. Plasma lipid peroxide concentrations in the PVD patients (105.9 +/- 20.6 vs. 91.8 +/- 15.8 ng malondialdehyde (MDA)/ml plasma, mean +/- S.D.) and the smokers (94.1 +/- vs. 74.0 +/- 13.9 ng MDA/ml plasma) were significantly elevated compared with levels in the appropriate control subjects and levels were significantly higher in older compared with younger control subjects. Plasma LDL lipid peroxides were also significantly raised in patients with PVD and smokers compared with control values (PVD): 37.1 +/- 7.7 vs. 26.3 +/- 4.1 ng MDA/ml plasma; smokers: 30.4 +/- 6.9 vs 24.9 +/- 7.5 ng MDA/ml plasma). The ratio of LDL lipid peroxides: LDL-cholesterol was significantly higher in the smokers, and plasma cholesterol and LDL-cholesterol were significantly higher in patients with PVD compared with other groups of subjects. The ratio of vitamin E: total lipid was not significantly different between the study groups. These data show that lipid peroxide levels in the plasma LDL fraction are elevated along with raised circulating levels in patients with PVD and smokers but that LDL lipid peroxide concentrations were independent of age in the healthy subjects. Elevated LDL lipid peroxide concentrations may may be mainly due to abnormally high LDL levels in PVD patients, whereas in smokers, the concentration of lipid peroxides in the LDL particles is raised and might render the lipoprotein more atherogenic.






Sanderson KJ,van Rij AM,Wade CR,Sutherland WH




Has Abstract


1995-11-01 00:00:00














  • Effect of endothelium on beta-VLDL metabolism by cultured smooth muscle cells of differing phenotype.

    abstract::The effect of endothelial cells (EC) on the binding and internalisation of beta-very low density lipoprotein (beta-VLDL) and the subsequent accumulation of lipid was investigated in cultured smooth muscle cells (SMC) of different phenotype. The following combinations were examined: (i) SMC cultured and incubated with ...


    pub_type: 杂志文章


    authors: Horrigan S,Campbell JH,Campbell GR

    更新日期:1988-05-01 00:00:00

  • The association of adjusted Global AntiphosPholipid Syndrome Score (aGAPSS) with cardiovascular disease in subjects with antiphospholipid antibodies.

    abstract:BACKGROUND AND AIMS:Cardiovascular disease (CVD), including coronary artery disease and stroke/peripheral artery disease, is less commonly reported than venous thromboembolism in subjects with antiphospholipid antibodies (aPLs) and little is known about the association of CVD with adjusted Global AntiphosPholipid Syndr...


    pub_type: 杂志文章


    authors: Di Minno MND,Scalera A,Tufano A,Ambrosino P,Bettiol A,Silvestri E,Emmi G,Prisco D

    更新日期:2018-11-01 00:00:00

  • (Pro)renin receptors and angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor axis in human aortic valve stenosis.

    abstract:BACKGROUND:There is increasing evidence that renin-angiotensin system (RAS) may play a major role in the actively regulated fibrocalcific process in aortic valve stenosis (AS), but the gene expression or function of (pro)renin receptor ((P)RR), prorenin and renin or angiotensin converting enzyme 2(ACE2)/angiotensin-(1-...


    pub_type: 杂志文章


    authors: Peltonen T,Näpänkangas J,Ohtonen P,Aro J,Peltonen J,Soini Y,Juvonen T,Satta J,Ruskoaho H,Taskinen P

    更新日期:2011-05-01 00:00:00

  • Effect of risk factors and antirheumatic drugs on the proliferation of aortic wall cells.

    abstract::The proliferation of aortic smooth muscle cells (ASMC) of Wistar rats, impaired by risk factors such as arterial hypertension, diabetes mellitus, atherogenic diet and staphylolysin injections and of normal Wistar rats treated with antirheumatic drugs such as prednisolone and acetylsalicylic acid was investigated. The ...


    pub_type: 杂志文章


    authors: Hauss WH,Mey J,Schulte H

    更新日期:1979-10-01 00:00:00

  • Rice bran oil lowers serum total and low density lipoprotein cholesterol and apo B levels in nonhuman primates.

    abstract::The hypolipidemic response of rice bran oil (RBO) was investigated in nonhuman primates fed semi-purified diets containing blends of oils which included RBO at 0-35% Kcals as dietary fat. The studies demonstrated the following: (a) the degree of reduction of serum total cholesterol (TC) and low density lipoprotein cho...


    pub_type: 杂志文章


    authors: Nicolosi RJ,Ausman LM,Hegsted DM

    更新日期:1991-06-01 00:00:00

  • Rebound inflammatory response during the acute phase of myocardial infarction after simvastatin withdrawal.

    abstract:OBJECTIVE:The present study aimed to verify the existence of a rebound inflammatory effect after statin withdrawal in the acute phase of myocardial infarction (MI). METHODS:In a prospective observational cohort, changes in C-reactive protein (CRP) between the first and the fifth day after MI were evaluated in 249 cons...


    pub_type: 杂志文章


    authors: Sposito AC,Carvalho LS,Cintra RM,Araújo AL,Ono AH,Andrade JM,Coelho OR,Quinaglia e Silva JC,Brasilia Heart Study Group.

    更新日期:2009-11-01 00:00:00

  • Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels.

    abstract:BACKGROUND:Oxidation processes play an important role in atherogenesis. Bilirubin IXalpha is recognised as a potent antioxidant. In the present study, we assessed the role of elevated serum bilirubin levels in the prevention of ischemic heart disease (IHD). METHODS:The occurrence of IHD was determined in Gilbert syndr...


    pub_type: 杂志文章


    authors: Vítek L,Jirsa M,Brodanová M,Kalab M,Marecek Z,Danzig V,Novotný L,Kotal P

    更新日期:2002-02-01 00:00:00

  • Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters.

    abstract::We investigated the differences between the hypocholesterolemic effects induced by dietary linoleic acid and those induced by oleic acid in hamsters. Addition of 5% linoleic acid or oleic acid to a 0.1% cholesterol-supplemented diet diminished the increases in plasma total and low density lipoprotein (LDL) cholesterol...


    pub_type: 杂志文章


    authors: Kurushima H,Hayashi K,Toyota Y,Kambe M,Kajiyama G

    更新日期:1995-04-24 00:00:00

  • Comparative effects of cholesteryl ester transfer protein inhibition, statin or ezetimibe on lipid factors: The ACCENTUATE trial.

    abstract:BACKGROUND AND AIMS:The optimal approaches to management of patients treated with moderate statin doses on lipid parameters are unknown. The ACCENTUATE study aimed to compare the effects of adding the cholesteryl ester transfer protein inhibitor (CETP) evacetrapib, ezetimibe or increasing statin dose in atorvastatin-tr...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Nicholls SJ,Ray KK,Ballantyne CM,Beacham LA,Miller DL,Ruotolo G,Nissen SE,Riesmeyer JS,ACCENTUATE Investigators.

    更新日期:2017-06-01 00:00:00

  • Effect of ursodeoxycholic acid on hepatic LDL binding and uptake in dietary hypercholesterolemic hamsters.

    abstract::Administration of ursodeoxycholic acid (UDCA) has been shown to decrease serum total and low density lipoprotein (LDL) cholesterol in hypercholesterolemic patients with primary biliary cirrhosis. Results of previous studies prompted us to postulate that the cholesterol-lowering effect of UDCA may be due, at least in p...


    pub_type: 杂志文章


    authors: Ceryak S,Bouscarel B,Malavolti M,Robins SJ,Caslow KL,Fromm H

    更新日期:2000-11-01 00:00:00

  • Socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK: the Whitehall II prospective cohort study.

    abstract:BACKGROUND:We examined socioeconomic and ethnic differences in use of lipid-lowering drugs after deregulation of simvastatin in the UK for adults with moderate or high risk of coronary heart disease. METHODS:3631 participants in the Whitehall II cohort study (mean age 62.7 years, 91% white) were informed of their risk...


    pub_type: 杂志文章


    authors: Forde I,Chandola T,Raine R,Marmot MG,Kivimaki M

    更新日期:2011-03-01 00:00:00

  • ACAT inhibitor pactimibe sulfate (CS-505) reduces and stabilizes atherosclerotic lesions by cholesterol-lowering and direct effects in apolipoprotein E-deficient mice.

    abstract::The objective of the present study was to determine whether a novel acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, pactimibe sulfate (CS-505), could reduce atherosclerotic lesions beyond and independent of the reduction achieved by cholesterol lowering alone from two different types of lesions. (1) Early lesio...


    pub_type: 杂志文章


    authors: Terasaka N,Miyazaki A,Kasanuki N,Ito K,Ubukata N,Koieyama T,Kitayama K,Tanimoto T,Maeda N,Inaba T

    更新日期:2007-02-01 00:00:00

  • Impaired carotid and femoral viscoelastic properties and elevated intima-media thickness in peripheral vascular disease.

    abstract:BACKGROUND:We undertook a study to determine whether peripheral vascular disease of the lower extremity (PVD) per se affects the arterial viscoelastic properties and intima-media thickness (IMT) of the carotid and femoral arteries. METHODS:Thirty-five patients with PVD, 35 age- and gender-matched control subjects were...


    pub_type: 杂志文章


    authors: Cheng KS,Tiwari A,Baker CR,Morris R,Hamilton G,Seifalian AM

    更新日期:2002-09-01 00:00:00

  • Quantitative morphologic study of intimal thickening at the human carotid bifurcation: I. Axial and circumferential distribution of maximum intimal thickening in asymptomatic, uncomplicated plaques.

    abstract::The spatial distribution of intimal thickening was determined for each of 42 carotid bifurcations removed at autopsy from patients with no clinical or anatomic evidence of cerebrovascular disease. Both right and left specimens were available for six of the individuals. Each bifurcation was removed intact and included ...


    pub_type: 杂志文章


    authors: Masawa N,Glagov S,Zarins CK

    更新日期:1994-06-01 00:00:00

  • Abnormal capillary permeability and endothelial dysfunction in hypertension with comorbid Metabolic Syndrome.

    abstract:PURPOSE:Metabolic Syndrome as defined by ATP III criteria, a constellation of risk factors associated with insulin resistance, predisposes to premature atherosclerosis and early coronary events. Whether that negative risk profile is associated with endothelial dysfunction remains to be established. MATERIALS AND METHO...


    pub_type: 杂志文章


    authors: Dell'Omo G,Penno G,Pucci L,Mariani M,Del Prato S,Pedrinelli R

    更新日期:2004-02-01 00:00:00

  • HDL2 and HDL3 lipid levels in coronary artery disease.

    abstract::The concentrations of cholesterol (C) and phospholipid (PL) levels in the high density lipoprotein (HDL) fraction and the HDL2 and HDL3 subfractions were determined in 74 men with incapacitating angina pectoris and coronary artery disease (CAD) verified by angiography. An equal number of randomly sampled healthy men m...


    pub_type: 杂志文章


    authors: Wallentin L,Sundin B

    更新日期:1986-02-01 00:00:00

  • Leukocyte count is an independent predictor for risk of acute myocardial infarction in middle-aged Japanese men.

    abstract:BACKGROUND:Leukocyte count is recognized as an inflammatory marker and a predictor of cardiovascular events. However, it is uncertain whether the contribution of leukocyte count to the risk of cardiovascular disease is independent of smoking. METHODS:The subjects were 4492 male employees aged 40-59 years who worked fo...


    pub_type: 杂志文章


    authors: Imano H,Sato S,Kitamura A,Kiyama M,Ohira T,Shimamoto T,Iso H

    更新日期:2007-11-01 00:00:00

  • A common methylenetetrahydrofolate reductase gene mutation and longevity.

    abstract::Homozygotes (TT genotype) for the C677T mutation in the gene of methylenetetrahydrofolate reductase (C677T/MTHFR mutation) constitute about 12% of the Caucasian population. They have mild hyperhomocysteinemia which is an established risk factor for cardiovascular disease. If the mutation is associated with premature d...


    pub_type: 杂志文章


    authors: Brattström L,Zhang Y,Hurtig M,Refsum H,Ostensson S,Fransson L,Jonés K,Landgren F,Brudin L,Ueland PM

    更新日期:1998-12-01 00:00:00

  • High-sensitivity cardiac troponin T in patients with intermittent claudication and its relation with cardiovascular events and all-cause mortality--the CAVASIC Study.

    abstract:BACKGROUND:Serum concentrations of high-sensitivity cardiac troponin T (hs-cTnT) are elevated in various diseases. The role of this marker in peripheral arterial disease (PAD) has not been fully investigated. METHODS:Hs-cTnT was measured in the CAVASIC Study, a male cohort of 235 patients diagnosed with intermittent c...


    pub_type: 杂志文章


    authors: Pohlhammer J,Kronenberg F,Rantner B,Stadler M,Peric S,Hammerer-Lercher A,Klein-Weigel P,Fraedrich G,Kollerits B

    更新日期:2014-12-01 00:00:00

  • Sialic acid-containing components of lipoproteins influence lipoprotein-proteoglycan interactions.

    abstract::Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. Sialic acid has been hypothesised to play an anti-atherogenic role in lipoprotein metabolism through the electrostatic inhibition of lipoprotein interactions with chondroitin-6-sulphate-rich arterial proteoglycans...


    pub_type: 杂志文章


    authors: Millar JS,Anber V,Shepherd J,Packard CJ

    更新日期:1999-08-01 00:00:00

  • Flow-mediated, endothelium-dependent vasodilatation is impaired in male body builders taking anabolic-androgenic steroids.

    abstract::Self-administration of anabolic-androgenic steroids to increase muscular strength and lean body mass has been used widely among athletes. Flow mediated dilatation (FMD) determined by ultrasound of the brachial artery is accepted as both an in vivo index of endothelial function and an indicator for future atheroscleros...


    pub_type: 杂志文章


    authors: Ebenbichler CF,Sturm W,Gänzer H,Bodner J,Mangweth B,Ritsch A,Sandhofer A,Lechleitner M,Föger B,Patsch JR

    更新日期:2001-10-01 00:00:00

  • Heightened inflammation is linked to carotid intima-media thickness and endothelial activation in HIV-infected children.

    abstract:OBJECTIVES:HIV+ patients are at increased risk of cardiovascular disease (CVD). Inflammation plays a role in adults, but has not yet been assessed in HIV+ children. We compared proinflammatory cytokines and adhesion molecules in HIV+ children versus healthy controls, and assessed their relationship to carotid intima-me...


    pub_type: 杂志文章


    authors: Ross AC,O'Riordan MA,Storer N,Dogra V,McComsey GA

    更新日期:2010-08-01 00:00:00

  • Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr-/- mice.

    abstract:BACKGROUND AND AIMS:Atherosclerosis is a chronic inflammatory disease of medium and large vessels and is typically characterized by the predominant accumulation of low-density lipoprotein (LDL)-cholesterol inside macrophages that reside in the vessel walls. Previous studies clearly demonstrated an association specifica...


    pub_type: 杂志文章


    authors: Jeurissen MLJ,Walenbergh SMA,Houben T,Gijbels MJJ,Li J,Hendrikx T,Oligschlaeger Y,van Gorp PJ,Binder CJ,Donners MMPC,Shiri-Sverdlov R

    更新日期:2016-12-01 00:00:00

  • High density lipoprotein and apolipoprotein A-i during physical inactivity. Demonstration at low levels in patients with spine fracture.

    abstract::Lack of physical activity appears to have deleterious effects on serum lipoproteins. Twenty-three patients who were completely immobilised by traumatic fracture of the spine had significantly lower (P < 0.001) plasma high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I levels than normally mobile paired...


    pub_type: 杂志文章


    authors: Nikkilä EA,Kuusi T,Myllynen P

    更新日期:1980-11-01 00:00:00

  • Removal of fatty acid labelled cholesterol ester, phospholipid and triglyceride from atherosclerotic rabbit aorta in vitro.

    abstract::An organ culture technique was used to investigate the removal of fatty acids incorporated into various lipid fractions in intimal segments of atherosclerotic rabbit aorta. Segments of aorta were pulse-labelled in vitro with [9,10-3H]oleic acid and [1-14C]linoleic acid for 24 h. The incubation medium was replaced with...


    pub_type: 杂志文章


    authors: Hudson K,Day AJ,Horsch AK

    更新日期:1977-12-01 00:00:00

  • Effects of ezetimibe on atherosclerosis in preclinical models.

    abstract::Ezetimibe (Zetia(®), Ezetrol(®), Merck, Whitehouse Station, NJ) is a potent inhibitor of sterol absorption, which selectively blocks the uptake of biliary and dietary cholesterol in the small intestine. Clinical trials have demonstrated the beneficial effects of ezetimibe on the reduction of atherogenic lipoproteins a...


    pub_type: 杂志文章,评审


    authors: Davis HR Jr,Lowe RS,Neff DR

    更新日期:2011-04-01 00:00:00

  • Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid.

    abstract::Degranulated mast cells are present in the human arterial intima. After degranulation of rat serosal mast cells, the secreted neutral serine protease chymase remains bound to the heparin proteoglycan matrix of the exocytosed granules, forming granule remnants. Addition of granule remnants to human aortic intimal fluid...


    pub_type: 杂志文章


    authors: Lindstedt L,Lee M,Kovanen PT

    更新日期:2001-03-01 00:00:00

  • Acid cholesteryl ester hydrolase activity of mononuclear leukocytes in patients with non-insulin-dependent diabetes mellitus: studies before and after treatment of diabetes.

    abstract::The change of acid cholesteryl ester hydrolase activity in mononuclear leukocyte following treatment of diabetes mellitus was studied in 21 patients with non-insulin-dependent diabetes mellitus (NIDDM). Enzyme activity before treatment in the patients was significantly lower than that in 14 age-matched healthy subject...


    pub_type: 杂志文章


    authors: Onuma T,Tsutsui M,Boku A,Yanada A,Ochiai S,Takebe K

    更新日期:1992-02-01 00:00:00

  • The effect of chlorthalidone on serum lipids and lipoproteins.

    abstract::The effect of chlorthalidone treatment on serum lipids and lipoproteins was investigated in 21 hypertensive patients. Chlorthalidone caused an increase in total serum and low density lipoprotein (LDL) cholesterol, but not in high density lipoprotein (HDL) cholesterol. Serum and lipoprotein triglycerides also increased...


    pub_type: 杂志文章


    authors: Rosenthal T,Holtzman E,Segal P

    更新日期:1980-05-01 00:00:00

  • White blood cell count and the metabolic syndrome in older Chinese: the Guangzhou Biobank Cohort Study.

    abstract:AIMS:To examine the association between white blood cell count (WBC) and metabolic syndrome (MS) in an older Chinese population. METHODS:Three thousand and twenty men and 7,256 women aged 50-85 years were recruited and received a medical check-up including measurement of complete blood count, blood pressure, obesity i...


    pub_type: 杂志文章


    authors: Lao XQ,Neil Thomas G,Jiang C,Zhang W,Adab P,Lam TH,Cheng KK

    更新日期:2008-12-01 00:00:00