Possible relationship of cholesterol accumulation and collagen synthesis in rabbit aortic tissues.

Abstract:

:Male adult New Zealand rabbits were fed a 2% cholesterol diet for 60 days followed by 10, 20, or 30 days of normal low cholesterol diet. Collagen synthesis was estimated by measuring aortic prolyl hydroxylase activity. Tissue cholesterol accumulation rates were estimated by dividing total tissue cholesterol by the number of experimental days. It was found there was a high degree of correlation between aortic collagen synthetic activity and the rate of aortic cholesterol accumulation. These data were interpreted as suggesting that increased collagen synthesis may be associated with the accumulation and/or retention of increased aortic cholesterol.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Modrak JB,Langner RO

doi

10.1016/0021-9150(80)90006-4

subject

Has Abstract

pub_date

1980-10-01 00:00:00

pages

211-8

issue

2

eissn

0021-9150

issn

1879-1484

pii

0021-9150(80)90006-4

journal_volume

37

pub_type

杂志文章
  • Lipoprotein particle profiles compared with standard lipids in association with coronary artery calcification in the general Japanese population.

    abstract:OBJECTIVE:The utility of lipoprotein particle profiles measured by nuclear magnetic resonance (NMR) spectroscopy beyond standard serum lipids remains inconclusive. Furthermore, few studies have compared NMR measurements with standard lipids in association with coronary artery calcification (CAC) in Japanese, where the ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.07.019

    authors: Hisamatsu T,Fujiyoshi A,Miura K,Ohkubo T,Kadota A,Kadowaki S,Kadowaki T,Yamamoto T,Miyagawa N,Zaid M,Torii S,Takashima N,Murakami Y,Okamura T,Horie M,Ueshima H,SESSA Research Group.

    更新日期:2014-10-01 00:00:00

  • Small dense low-density lipoprotein cholesterol concentration and carotid atherosclerosis.

    abstract::Low-density lipoprotein cholesterol (LDL-C) and the small dense LDL (SdLDL) phenotype are both predictors for ischemic heart disease. We examined whether cholesterol of SdLDL (SdLDL-C) is more closely associated with carotid artery intima-media thickness (CA-IMT), a surrogate measure of atherosclerosis, than LDL-C and...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2008.04.042

    authors: Shoji T,Hatsuda S,Tsuchikura S,Shinohara K,Kimoto E,Koyama H,Emoto M,Nishizawa Y

    更新日期:2009-02-01 00:00:00

  • Increased urinary cystatin C indicated higher risk of cardiovascular death in a community cohort.

    abstract:OBJECTIVES:Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death. METHODS:The association betwe...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.02.020

    authors: Helmersson-Karlqvist J,Ärnlöv J,Carlsson AC,Härmä J,Larsson A

    更新日期:2014-05-01 00:00:00

  • Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives.

    abstract:OBJECTIVES:To explore the therapeutic potential of fibrates to attenuate premature atherosclerosis and cardiovascular disease in the atherogenic dyslipidemias typical of Type II diabetes, Metabolic Syndrome, and the Type IIB (mixed) lipid phenotype; such dyslipidemias frequently feature peripheral insulinoresistance. ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/s0021-9150(03)00156-4

    authors: Chapman MJ

    更新日期:2003-11-01 00:00:00

  • Different apoprotein(a) isoform proportions in serum and carotid plaque.

    abstract:INTRODUCTION:Cardio- and/or cerebro-vascular risk are associated with high lipoprotein (a) [Lp(a)] levels and low-molecular-weight (LMW) apo(a) isoforms. Aims of this study were to evaluate the deposition of apo(a) isoforms and apoprotein B (apo B) in atherosclerotic plaque from patients (males and females) who had car...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2006.06.006

    authors: Baldo G,Giunco S,Kontothanassis D,Baiocchi MR,Valerio A,Frego M

    更新日期:2007-07-01 00:00:00

  • Effect of a 4-year workplace-based physical activity intervention program on the blood lipid profiles of participating employees: the high-risk and population strategy for occupational health promotion (HIPOP-OHP) study.

    abstract::Individuals who are physically fit or engage in regular physical activity have a lower incidence of cardiovascular disease and risk of mortality. We conducted a large-scale controlled trial of interventions to decrease cardiovascular risk factors, during which we assessed the effect of a workplace-based intervention p...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1016/j.atherosclerosis.2007.07.026

    authors: Naito M,Nakayama T,Okamura T,Miura K,Yanagita M,Fujieda Y,Kinoshita F,Naito Y,Nakagawa H,Tanaka T,Ueshima H,HIPOP-OHP Research Group.

    更新日期:2008-04-01 00:00:00

  • Carotid artery intima-media thickness in college students: race/ethnicity matters.

    abstract:OBJECTIVE:Racial/ethnic differences in common carotid artery intima-media thickness (CIMT) and in risk factors associated with CIMT have been predominantly observed in middle-aged and older individuals. We aimed to characterize racial/ethnic differences CIMT and other cardiovascular risk factors in a healthy, young-adu...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2011.05.022

    authors: Breton CV,Wang X,Mack WJ,Berhane K,Lopez M,Islam TS,Feng M,Hodis HN,Künzli N,Avol E

    更新日期:2011-08-01 00:00:00

  • Correlates of endothelial function and the peak systolic blood pressure response to a graded maximal exercise test.

    abstract:PURPOSE:An elevated systolic blood pressure (SBP) response to a graded maximal exercise stress test (GEST) may be a predictor of endothelial dysfunction and hypertension. We examined relationships among the GEST peak SBP response and indicators of endothelial function. METHODS:Men (n=48, 43.7±1.4 yr) with high BP (145...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2012.01.027

    authors: Olson KM,Augeri AL,Seip RL,Tsongalis GJ,Thompson PD,Pescatello LS

    更新日期:2012-05-01 00:00:00

  • Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid.

    abstract:OBJECTIVE:To analyze the possible role of arachidonic acid (AA) in macrophage cholesterol biosynthesis and in PON2 expression. METHODS AND RESULTS:We used peritoneal macrophages (MPM) from the 6-DS KO mice that were fed a diet without or with AA. Macrophage cholesterol biosynthesis rate and HMGCoA-reductase mRNA level...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2009.11.044

    authors: Rosenblat M,Volkova N,Roqueta-Rivera M,Nakamura MT,Aviram M

    更新日期:2010-06-01 00:00:00

  • Multiple complex stenoses, high neutrophil count and C-reactive protein levels in patients with chronic stable angina.

    abstract:UNLABELLED:Inflammation plays an important role in atherosclerosis and the genesis of acute coronary syndromes, i.e., atheromatous plaque disruption. Neutrophil count and C-reactive protein (CRP) levels are markers of ongoing inflammation and predictors of cardiovascular risk. We sought to assess whether these inflamma...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2004.03.013

    authors: Avanzas P,Arroyo-Espliguero R,Cosín-Sales J,Quiles J,Zouridakis E,Kaski JC

    更新日期:2004-07-01 00:00:00

  • Atherosclerotic lesion development and Toll like receptor 2 and 4 responsiveness.

    abstract:BACKGROUND:Toll like receptors (TLR) have been recognized for their role in atherosclerotic lesion development and progression. Endogenous TLR ligands that are also expressed in atherosclerotic tissues have been shown to promote atherosclerosis in mice. Since repetitive stimulation of TLR induces an attenuated inflamma...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2007.08.004

    authors: Schoneveld AH,Hoefer I,Sluijter JP,Laman JD,de Kleijn DP,Pasterkamp G

    更新日期:2008-03-01 00:00:00

  • The association of serum lipid and lipoprotein levels with total and differential leukocyte counts: Results of a cross-sectional and longitudinal analysis of the UK Biobank.

    abstract:BACKGROUND AND AIMS:There is some evidence of a cross-sectional, and possibly causal, relationship of lipid levels with leukocyte counts in mice and humans. This study investigates the cross-sectional and longitudinal relationship of blood lipid and lipoprotein levels with leukocyte counts in the UK Biobank cohort. ME...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2020.12.016

    authors: Tucker B,Sawant S,McDonald H,Rye KA,Patel S,Ong KL,Cochran BJ

    更新日期:2020-12-21 00:00:00

  • Diabetes mellitus abolishes ethnic differences in cardiovascular risk factors: lessons from a multi-ethnic population.

    abstract:AIMS:To compare cardiovascular risk factors in diabetic subjects of different ethnic groups, and between new and known diabetic subjects, in the Singapore National Health Survey '92. METHODS:Disproportionate stratified sampling followed by systematic sampling were used in 3568 (total) respondents of whom 2743 were non...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(00)00534-7

    authors: Tan CE,Emmanuel SC,Tan BY,Tai ES,Chew SK

    更新日期:2001-03-01 00:00:00

  • Familial ligand-defective apolipoprotein B-100: detection, biochemical features and haplotype analysis of the R3531C mutation in the UK.

    abstract::Familial ligand-defective apolipoprotein (apo) B-100 (FDB) is an autosomal codominant disorder which may give rise to hypercholesterolaemia. It is caused by the substitution of glutamine for arginine at codon 3500 of the apo B gene (apo B R3500Q), resulting in decreased binding of low density lipoprotein (LDL) to the ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(96)06029-7

    authors: Wenham PR,Henderson BG,Penney MD,Ashby JP,Rae PW,Walker SW

    更新日期:1997-03-21 00:00:00

  • A study of DNA polymorphism in the apolipoprotein B gene in a Japanese population.

    abstract::A Japanese group comprising 53 hyperlipidemic and 54 normolipidemic subjects was genotyped for DNA restriction fragment length polymorphisms (RFLPs) at the apo B gene locus. The polymorphisms with XbaI and PvuII were present at allelic frequencies of 0.04 (X1 allele) and 0.96 (X2 allele), 0.94 (P1 allele) and 0.06 (P2...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(88)90064-0

    authors: Aburatani H,Matsumoto A,Itoh H,Yamada N,Murase T,Takaku F,Itakura H

    更新日期:1988-07-01 00:00:00

  • Effect of endothelium on beta-VLDL metabolism by cultured smooth muscle cells of differing phenotype.

    abstract::The effect of endothelial cells (EC) on the binding and internalisation of beta-very low density lipoprotein (beta-VLDL) and the subsequent accumulation of lipid was investigated in cultured smooth muscle cells (SMC) of different phenotype. The following combinations were examined: (i) SMC cultured and incubated with ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(88)90302-4

    authors: Horrigan S,Campbell JH,Campbell GR

    更新日期:1988-05-01 00:00:00

  • Carotid atherosclerosis in chronic renal failure-the central role of increased plaque burden.

    abstract::Studies on carotid artery atherosclerosis have been performed in order to understand the high risk for cardiovascular disease in chronic renal failure (CRF). The purpose of this study was to evaluate the extent and nature of carotid artery atherosclerosis in patients with CRF. Of the 135 patients with CRF (52 +/- 11 y...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2003.08.010

    authors: Leskinen Y,Lehtimäki T,Loimaala A,Lautamatti V,Kallio T,Huhtala H,Salenius JP,Saha H

    更新日期:2003-12-01 00:00:00

  • Framingham risk score is related to carotid artery intima-media thickness in both white and black young adults: the Bogalusa Heart Study.

    abstract::The Framingham risk score (FRS), developed in a white cohort aged 30-74 years, is increasingly used in the early risk identification for coronary artery disease (CAD). This study examines the relationship between FRS and carotid artery intima-media thickness (IMT), a surrogate marker of coronary atherosclerosis, in bl...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(03)00244-2

    authors: Kieltyka L,Urbina EM,Tang R,Bond MG,Srinivasan SR,Berenson GS

    更新日期:2003-09-01 00:00:00

  • Hypercholesterolemia impairs megakaryopoiesis and platelet production in scavenger receptor BI knockout mice.

    abstract:BACKGROUND AND AIMS:Thrombocytopenia in scavenger receptor BI (SR-BI) knockout mice is suggested to result from augmented platelet clearance induced by elevated intracellular unesterified cholesterol (UC) levels. We hypothesize that SR-BI deficiency may also influence platelet production at the level of its precursor c...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2018.09.019

    authors: Ouweneel AB,Hoekstra M,van der Wel EJ,Schaftenaar FH,Snip OSC,Hassan J,Korporaal SJA,Van Eck M

    更新日期:2019-03-01 00:00:00

  • Genetic variation in the apolipoprotein D gene among African blacks and its significance in lipid metabolism.

    abstract::Apolipoprotein D (APOD, gene; apoD, protein) is a plasma high-density lipoprotein (HDL)-associated glycoprotein, with a putative role in the cholesterol (CHOL) transport pathway. An apoD protein polymorphism has been previously reported by us. The cathodically shifted pattern seen on isoelectric focusing gels, control...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/s0021-9150(02)00012-6

    authors: Desai PP,Bunker CH,Ukoli FA,Kamboh MI

    更新日期:2002-08-01 00:00:00

  • Comparison of hypocholesterolemic effects induced by dietary linoleic acid and oleic acid in hamsters.

    abstract::We investigated the differences between the hypocholesterolemic effects induced by dietary linoleic acid and those induced by oleic acid in hamsters. Addition of 5% linoleic acid or oleic acid to a 0.1% cholesterol-supplemented diet diminished the increases in plasma total and low density lipoprotein (LDL) cholesterol...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/0021-9150(94)05486-3

    authors: Kurushima H,Hayashi K,Toyota Y,Kambe M,Kajiyama G

    更新日期:1995-04-24 00:00:00

  • Coronary artery calcium and cardiovascular risk in diabetes.

    abstract::Measurement of coronary artery calcium score (CACS) by electron beam tomography has been shown to a powerful predictor of coronary heart disease events in asymptomatic non-diabetic subjects. In type 2 diabetes, measurement of CACS was found to be a powerful predictor of cardiovascular events which could enhance predic...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2009.11.026

    authors: Elkeles RS

    更新日期:2010-06-01 00:00:00

  • Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist.

    abstract::MGL-3196 is an oral, liver-targeted selective agonist for the thyroid hormone receptor-β (THR-β) that is being developed for the treatment of dyslipidemia. The safety profile and tolerability of THR-β agonist MGL-3196 was assessed in first-in humans studies, including a single ascending dose study (NCT01367873) in whi...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.atherosclerosis.2013.07.056

    authors: Taub R,Chiang E,Chabot-Blanchet M,Kelly MJ,Reeves RA,Guertin MC,Tardif JC

    更新日期:2013-10-01 00:00:00

  • Understanding the role of non-coding RNA (ncRNA) in stent restenosis.

    abstract::Coronary heart disease (CHD) is one of the leading disorders with the highest mortality rate. Percutaneous angioplasty and stent implantation are the currently available standard methods for the treatment of obstructive coronary artery disease. However, the stent being an exogenous substance causes several complicatio...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2018.03.036

    authors: Liu S,Yang Y,Jiang S,Tang N,Tian J,Ponnusamy M,Tariq MA,Lian Z,Xin H,Yu T

    更新日期:2018-05-01 00:00:00

  • Aging, smooth muscle cells and vascular pathobiology: implications for atherosclerosis.

    abstract::Epidemiological and autopsy studies suggest a close link between aging and the clinical manifestation of atherosclerosis. Several experiments show increased arterial susceptibility to atherogenetic stimuli in aged subjects. All together, these findings support the concept that aging represents an independent atherogen...

    journal_title:Atherosclerosis

    pub_type: 杂志文章,评审

    doi:10.1016/j.atherosclerosis.2006.01.018

    authors: Orlandi A,Bochaton-Piallat ML,Gabbiani G,Spagnoli LG

    更新日期:2006-10-01 00:00:00

  • Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.

    abstract::The cysteine protease cathepsin L is one of the most potent mammalian elastases and collagenases, widely expressed at basal levels in most tested tissues and cell types, and regulated by pro-inflammatory stimuli. The inflammatory arterial diseases abdominal aortic aneurysm (AAA) and atherosclerosis involve extensive v...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2005.05.012

    authors: Liu J,Sukhova GK,Yang JT,Sun J,Ma L,Ren A,Xu WH,Fu H,Dolganov GM,Hu C,Libby P,Shi GP

    更新日期:2006-02-01 00:00:00

  • Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women.

    abstract:OBJECTIVE:The aim of the present study was to estimate circulating oxidized low-density lipoprotein (oxLDL) levels in postmenopausal women and evaluate their association with obesity and smoking status. DESIGN AND METHODS:The study included 135 postmenopausal women aged 52-75 years. Forty of them were overweight (BMI ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2008.11.006

    authors: Kassi E,Dalamaga M,Faviou E,Hroussalas G,Kazanis K,Nounopoulos Ch,Dionyssiou-Asteriou A

    更新日期:2009-07-01 00:00:00

  • Ciprofibrate in the therapy of type II hypercholesterolemia. A double-blind trial.

    abstract::The hypolipidemic efficacy of ciprofibrate was evaluated in patients with type II hypercholesterolemia. Patients were randomized to placebo or ciprofibrate (50 mg or 100 mg/day) and, after a 6-week baseline period, received medication for a period of 12 weeks. Blood samples were analyzed every 2 weeks. Twenty patients...

    journal_title:Atherosclerosis

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0021-9150(82)90115-0

    authors: Illingworth DR,Olsen GD,Cook SF,Sexton GJ,Wendel HA,Connor WE

    更新日期:1982-08-01 00:00:00

  • Induction of inducible nitric oxide synthase (iNOS) expression by oxLDL inhibits macrophage derived foam cell migration.

    abstract:OBJECTIVE:Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here, we addressed wh...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2014.04.020

    authors: Huang H,Koelle P,Fendler M,Schröttle A,Czihal M,Hoffmann U,Conrad M,Kuhlencordt PJ

    更新日期:2014-07-01 00:00:00

  • Prevalence of lower extremity peripheral arterial disease in individuals with chronic immune mediated inflammatory disorders.

    abstract:OBJECTIVE:To compare the prevalence of lower extremity peripheral artery disease (PAD) and to assess whether age-associated progression in ankle-brachial index (ABI) differs between individuals with chronic immune-mediated inflammatory diseases (CIID) and the general population. METHODS:Pooled analysis with data from ...

    journal_title:Atherosclerosis

    pub_type: 杂志文章

    doi:10.1016/j.atherosclerosis.2015.06.054

    authors: Agüero F,González-Zobl G,Baena-Díez JM,Dégano IR,Garcia-Gil M,Alzamora MT,Marrugat J,Comas-Cufí M,Pera G,Elosua R,Ramos R,Grau M

    更新日期:2015-09-01 00:00:00