Risk of myocardial infarction in patients with rhinosinusitis.

Abstract:

:Research has indicated that inflammation promote all phases of atherosclerosis. The current study tested the hypothesis that rhinosinusitis is a risk marker for myocardial infarction (MI). Data on the general population were obtained from the Taiwan Longitudinal Health Insurance Database 2005 (LHID2005). The study cohort comprised patients who had received a recorded diagnosis of rhinosinusitis (N = 52,930) between January 1, 2004 and December 31, 2004. The comparison group consisted of patients who had not received a rhinosinusitis diagnosis, and who were matched for age and sex with the study group at a ratio of 4 controls to 1 study patient (1:4) (N = 211,720). Each patient's condition was followed using database entries until the end of 2006. Cox proportional hazard regressions were used to evaluate the 3-year MI-free survival rates, after adjusting for known confounding factors. We found that patients with rhinosinusitis were more likely than the control group to have MI, after adjusting for potential confounders [adjusted hazard ratio (HR), 1.84; 95% confidence interval (CI), 1.44 ∼ 2.40]. Of the total 264 650 patients, 290 experienced MI during the 3-year follow-up period, including 8 acute sinusitis patients, 77 chronic sinusitis patients, and 205 control patients. The incidence rate of MI was 6.19 (95% CI 5.01-7.65) per 10,000 person-years for rhinosinusitis patients, compared to 3.51 (95% CI, 3.06-4.02) for the control patients. From this study, rhinosinusitis may be associated with MI. Further research in this important area of public health is warranted.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Hao WR,Lin HW,Chao PZ,Wu CW,Yen TH,Liu JC,Liou TH

doi

10.1016/j.atherosclerosis.2012.10.058

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

263-8

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(12)00744-7

journal_volume

226

pub_type

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