Abstract:
BACKGROUND:It is uncertain whether the novel single nucleotide polymorphisms (SNPs) that have recently been associated with coronary artery disease (CAD) in genome-wide studies also influence carotid atheroma and stroke risk. The mechanisms of their association with CAD are unknown; relationships to other cardiovascular phenotypes may give mechanistic clues. Carotid artery intima-media thickness (CIMT) is a subclinical marker of atherosclerosis associated with stroke. We investigated association of reported CAD risk variants with CIMT, and with other intermediate phenotypes that may implicate causative pathways. METHODS:We studied 1425 members of 248 British Caucasian families ascertained through a hypertensive proband. We genotyped CAD risk SNPs on chromosomes 9 (rs1333049, rs7044859, rs496892, rs7865618), 6 (rs6922269) and 2 (rs2943634) using TaqMan. Merlin software was used for family-based association testing. RESULTS:No significant association was found between genotype at any SNP and CIMT in 846 individuals with acceptable measurements. Nor were SNPs significantly associated with blood pressure, obesity, cholesterol, CRP, interleukin-6, TNF-alpha, or leptin. CONCLUSIONS:These novel CAD variants are not associated with CIMT and do not appear to mediate the risk of atherothrombosis through known risk factors.
journal_name
Atherosclerosisjournal_title
Atherosclerosisauthors
Cunnington MS,Mayosi BM,Hall DH,Avery PJ,Farrall M,Vickers MA,Watkins H,Keavney Bdoi
10.1016/j.atherosclerosis.2008.06.025subject
Has Abstractpub_date
2009-03-01 00:00:00pages
41-4issue
1eissn
0021-9150issn
1879-1484pii
S0021-9150(08)00453-Xjournal_volume
203pub_type
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