PPARα activation differently affects microparticle content in atherosclerotic lesions and liver of a mouse model of atherosclerosis and NASH.

abstract：:Previous studies have shown that the A to G transition occurring at position -75 bp upstream of the transcriptional start site in the human apolipoprotein A-I gene may affect plasma high density lipoprotein cholesterol (HDL-C) levels and low density lipoprotein cholesterol (LDL-C) response to changes in amount of diet...

journal_title：Atherosclerosis

authors： Mata P,Lopez-Miranda J,Pocovi M,Alonso R,Lahoz C,Marin C,Garces C,Cenarro A,Perez-Jimenez F,de Oya M,Ordovas JM

更新日期：1998-04-01 00:00:00

abstract：:This study was aimed to test the hypothesis that noninvasive assessment of carotid plaques can be achieved by high-resolution micro-ultrasound imaging in apolipoprotein-E knockout (apoE-KO) mice. Forty-two male apoE-KO mice were fed a high-fat diet and atherosclerotic lesions in the left common carotid artery were ind...

journal_title：Atherosclerosis

authors： Ni M,Zhang M,Ding SF,Chen WQ,Zhang Y

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The clinical utility of traditional cardiovascular (CV) risk factors to predict coronary artery disease (CAD) is insufficient and limited. Our aim was to evaluate the association between a novel ultrasound index of periarterial fat and adventitia (carotid extra-media thickness; EMT) and the severity of CAD a...

journal_title：Atherosclerosis

authors： Haberka M,Gąsior Z

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:To investigate SCM-198 (also known as "leonurine"), a compound in Herba leonuri, as well as its effect on the progression of atherosclerosis in hypercholesterolemic rabbits and underlying mechanisms. METHODS:Thirty New Zealand male White rabbits (5 groups, n = 6) were fed either a normal diet or a high-chole...

journal_title：Atherosclerosis

authors： Zhang Y,Guo W,Wen Y,Xiong Q,Liu H,Wu J,Zou Y,Zhu Y

更新日期：2012-09-01 00:00:00

abstract：:We investigated the effects of fenofibrate, peroxisome proliferator-activated receptors (PPARs) agonist, on endothelial function in patients with hypertriglyceridemia. We administered placebo or fenofibrate 200 mg daily to 25 patients with hypertriglyceridemia for 8 weeks. This study was randomized, double-blind, plac...

journal_title：Atherosclerosis

authors： Kon Koh K,Yeal Ahn J,Hwan Han S,Kyu Jin D,Sik Kim H,Cheon Lee K,Kyun Shin E,Sakuma I

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:Lipoprotein distribution of non-cholesterol sterols was studied to evaluate in which lipoproteins they are carried in type 2 diabetes with body weight ranging from normal to overweight. METHODS:Serum and lipoprotein squalene and non-cholesterol sterols were quantitated with gas-liquid chromatography in 33 d...

journal_title：Atherosclerosis

authors： Simonen PP,Gylling H,Miettinen TA

更新日期：2007-09-01 00:00:00

abstract：:Macrophage scavenger receptors class A (MSR) are thought to play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins by macrophages in the vessel wall leading to foam cell formation. To investigate the in vivo role of the MSR in this process, a transgenic mouse model expres...

journal_title：Atherosclerosis

authors： de Winther MP,van Dijk KW,van Vlijmen BJ,Gijbels MJ,Heus JJ,Wijers ER,van den Bos AC,Breuer M,Frants RR,Havekes LM,Hofker MH

更新日期：1999-12-01 00:00:00

abstract：AIMS:Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. METHODS AND RESULTS:Absolute concentrations of iron, copper, zinc and calcium, and p...

journal_title：Atherosclerosis

authors： Stadler N,Heeneman S,Vöö S,Stanley N,Giles GI,Gang BP,Croft KD,Mori TA,Vacata V,Daemen MJ,Waltenberger J,Davies MJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:A hallmark feature of atherosclerosis is inflammation mediated by prostaglandins (PGs) catalyzed by the enzyme cyclooxygenase (COX). The present study explored whether the COX-2 G-765C polymorphism contributes to increased incidence of coronary heart disease (CHD) or stroke in the large prospective Atheroscl...

journal_title：Atherosclerosis

authors： Kohsaka S,Volcik KA,Folsom AR,Wu KK,Ballantyne CM,Willerson JT,Boerwinkle E

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinases (MMPs) are implicated in the pathogenesis of atherosclerosis. However, the relationship between blood levels of MMPs and the extent of carotid atherosclerosis remains uncertain. We assessed blood levels of active MMPs in relation to the extent of carotid plaque formation and intima-m...

journal_title：Atherosclerosis

authors： Lien LM,Hsieh YC,Bai CH,Chen WH,Chiu HC,Hsieh FI,Shyu KG,Chiou HY,Hsu CY

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Estrogen therapy that is started at the time of menopause seems to protect against the development of atherosclerosis and cardiovascular diseases, in contrast to the initial increased cardiovascular risk when hormone therapy is initiated in older women. With increased aging and degree of atherosclerosis, the...

journal_title：Atherosclerosis

authors： Naessen T,Rodriguez-Macias K

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Serum γ-glutamyl transferase (GGT) levels are known to be positively associated with obesity. We aimed at verifying an association between baseline GGT levels and the development of obesity in Korean men. PATIENTS AND METHODS:This prospective cohort study was performed on 18,510 initially non-...

journal_title：Atherosclerosis

authors： Suh YJ,Park SK,Choi JM,Ryoo JH

更新日期：2013-04-01 00:00:00

abstract：:LDL and HDL became more fluid when health, free-living, premenopausal women were fed reduced fat diets with higher proportions of polyunsaturated fatty acids. Lipoproteins were isolated from plasma of 31 female subjects fed one of two sets of diets from typical U.S.A. foods with P/S ratios of 0.3 or 1.0. All subjects ...

journal_title：Atherosclerosis

authors： Berlin E,Judd JT,Nair PP,Jones DY,Taylor PR

更新日期：1991-02-01 00:00:00

abstract：:The relationship of ischaemic heart disease (IHD) to seasonal and latitude variation has prompted speculation that exposure to the ultraviolet component of solar radiation may reduce IHD risk. This hypothesis was partially tested by exposing 14 post-myocardial infarction patients to a 6 week course of artificial whole...

journal_title：Atherosclerosis

authors： Clark P,Cockburn F,Cowan RA,Czapla K,Dunnigan MG,Farish E,Hughes E

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Patients with hyperlipidemia who are unable to tolerate optimal statin therapy are at increased cardiovascular risk due to ongoing elevations in low-density lipoprotein cholesterol (LDL-C). The objective of CLEAR Tranquility (NCT03001076) was to evaluate the efficacy and safety of bempedoic acid whe...

journal_title：Atherosclerosis

authors： Ballantyne CM,Banach M,Mancini GBJ,Lepor NE,Hanselman JC,Zhao X,Leiter LA

更新日期：2018-10-01 00:00:00

abstract：:High level of plasma very low-density lipoprotein (VLDL) has been identified as a risk factor for coronary heart disease. Recent evidence suggests that excess VLDL induces inflammatory responses in macrophages and vascular endothelial cells. The Japan EPA Lipid Intervention Study (JELIS), a large scale clinical trial,...

journal_title：Atherosclerosis

authors： Jinno Y,Nakakuki M,Kawano H,Notsu T,Mizuguchi K,Imada K

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:The influence of the quality of dietary fat on some aspects of lipid metabolism-i.e. lipoprotein concentrations, post-prandial lipids and LDL size-is not completely understood, especially in healthy individuals. OBJECTIVES:Aim of this study was to evaluate the effects of different types of dietary fat (mono...

journal_title：Atherosclerosis

authors： Rivellese AA,Maffettone A,Vessby B,Uusitupa M,Hermansen K,Berglund L,Louheranta A,Meyer BJ,Riccardi G

更新日期：2003-03-01 00:00:00

abstract：:Apolipoprotein E (apo E) is a component of all the classes of lipoproteins and can be distributed among apo B- (LpB) and non apo B-containing lipoproteins (Lp-non-B). Using a new electroimmunoassay kit, plasma apo E, apo E in Lp-non-B (apo E-Lp-non-B) and apo E in LpB (apo E-LpB) levels were measured in healthy contro...

journal_title：Atherosclerosis

authors： Luc G,Ducimetiere P,Bard JM,Arveiler D,Evans A,Cambien F,Fruchart JC,Fievet C

更新日期：1997-06-01 00:00:00

abstract：:Intact and ovariectomized, non-arteriosclerotic female rats and arteriosclerotic, breeder female rats were subjected to myocardial infarction by the administration of 2 subcutaneous injections, 24 hr apart, of the beta-adrenergic stimulator, isoproterenol. The animals were sacrificed at regular hourly intervals follow...

journal_title：Atherosclerosis

authors： Lewis BK,Wexler BC

更新日期：1975-05-01 00:00:00

abstract：:We investigated the effects of estrogen and simvastatin, administered both alone and in combination, on the plasma lipid levels and lipoprotein-related enzymes in 45 postmenopausal women with type IIa hypercholesterolemia. They received 0.625 mg conjugated equine estrogen (n=15), 5 mg simvastatin (n=15), or the combin...

journal_title：Atherosclerosis

authors： Wakatsuki A,Okatani Y,Ikenoue N

更新日期：2000-05-01 00:00:00

abstract：:In vitro incubations of human low density lipoproteins (LDL), high density lipoproteins (HDL) and lipoprotein-free plasma at 37 degrees for 6 h revealed no significant net mass transfers of esterified cholesterol from either lipoprotein fraction to the other. Observed transfers of esterified [3H]cholesterol from LDL t...

journal_title：Atherosclerosis

authors： Barter PJ,Jones ME

更新日期：1979-09-01 00:00:00

abstract：:The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labele...

journal_title：Atherosclerosis

authors： Terpstra AH

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To examine whether genetic polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) confer an increased risk to angiographically proven coronary artery disease (CAD) in a case-control study of a Midwestern population in the US. METHODS:We genotyped 7 SNPs (SG13S25, SG13S89, SG13S41, SG13S377, SG13S35...

journal_title：Atherosclerosis

authors： Tsai AK,Li N,Hanson NQ,Tsai MY,Tang W

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVES:We conducted a meta-analysis of relevant randomized trials to assess whether folic acid supplementation reduces the progression of atherosclerosis as measured by carotid intima-media thickness (CIMT). METHODS:This analysis included 2052 subjects from ten folic acid randomized trials with the change in CIMT ...

journal_title：Atherosclerosis

authors： Qin X,Xu M,Zhang Y,Li J,Xu X,Wang X,Xu X,Huo Y

更新日期：2012-06-01 00:00:00

abstract：:This study examined the effects of various polyunsaturated fatty acid (PUFA, P)/saturated fatty acid (SFA, S) ratio versus PUFA + monounsaturated fatty acid (MUFA, M)/SFA ratio on lipid metabolism. The P/S ratio of dietary fat was fixed at a certain level (0.5, 1, 2, or 4, respectively) for each of four pairs of rat g...

journal_title：Atherosclerosis

authors： Chang NW,Huang PC

更新日期：1999-01-01 00:00:00

abstract：:Outgrowth of vascular wall cells from rat aortic tissue explant was studied. In addition to fresh rat serum (3%), the complete culture medium contained either low density lipoprotein (LDL) separated from rat plasma (n-LDL, 100 microg/ml) or rat LDL modified either by activated rat polymorphonuclear leucocytes (pmn-LDL...

journal_title：Atherosclerosis

authors： Görög P

更新日期：1997-02-28 00:00:00

abstract：:Circulating soluble intercellular adhesion molecule-1 (sICAM-1) is a biochemical marker of inflammation. We performed variance-components-based quantitative genetic analyses in SOLAR of sICAM-1 in 1170 individuals from Mexican American families in the San Antonio Family Heart Study. The trait is heritable (h(2)=0.50+/...

journal_title：Atherosclerosis

authors： Kent JW Jr,Mahaney MC,Comuzzie AG,Göring HH,Almasy L,Dyer TD,Cole SA,MacCluer JW,Blangero J

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

journal_title：Atherosclerosis

authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIMS:The beneficial effect of statin therapy has been well established for both primary and secondary prevention of cardiovascular disease. Nevertheless, it remains under-used among patients with chronic kidney disease (CKD). We aimed to investigate the impact of statin therapy across a wide spectrum of ...

journal_title：Atherosclerosis

authors： Natanzon SS,Matetzky S,Beigel R,Iakobishvili Z,Goldenberg I,Shechter M,Acute Coronary Syndrome Israel Survey (ACSIS) investigators.

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Evidence has demonstrated profound influence of genetic background on cardiovascular phenotypes. Murine models in Marfan syndrome (MFS) have shown that genetic background-related variations affect thoracic aortic aneurysm formation, rupture, and lifespan of mice. MFS mice with C57Bl/6 genetic background are l...

journal_title：Atherosclerosis

authors： Dale MA,Suh MK,Zhao S,Meisinger T,Gu L,Swier VJ,Agrawal DK,Greiner TC,Carson JS,Baxter BT,Xiong W

更新日期：2015-12-01 00:00:00