Effects of fenofibrate on lipoproteins, vasomotor function, and serological markers of inflammation, plaque stabilization, and hemostasis.

abstract：:Tendon xanthoma are a hallmark of familial hypercholesterolemia and are among its earliest clinical manifestations. Achilles tendon size, advanced to a generally accepted marker, is virtually specific for the disease and easily accessible for measurement. Hypercholesterolemic patients with coronary heart disease have ...

journal_title：Atherosclerosis

authors： Steinmetz A,Schmitt W,Schuler P,Kleinsorge F,Schneider J,Kaffarnik H

更新日期：1988-12-01 00:00:00

abstract：:This report concerns a heart transplant patient with hypercholesterolemia who showed rapid development of a severe transplant coronary artery disease. The patient received 10 mg pravastatine per day. Quantitative coronary angiography analyses of 4 serial angiograms clearly demonstrated that in the first 2.5 years foll...

journal_title：Atherosclerosis

authors： Park JW,Vermeltfoort M,Braun P,May E,Merz M

更新日期：1995-05-01 00:00:00

abstract：:The hypolipidemic efficacy of ciprofibrate was evaluated in patients with type II hypercholesterolemia. Patients were randomized to placebo or ciprofibrate (50 mg or 100 mg/day) and, after a 6-week baseline period, received medication for a period of 12 weeks. Blood samples were analyzed every 2 weeks. Twenty patients...

journal_title：Atherosclerosis

authors： Illingworth DR,Olsen GD,Cook SF,Sexton GJ,Wendel HA,Connor WE

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolaemia (FH) is a powerful risk factor for cardiovascular (CV) events. High levels of low-density lipoprotein cholesterol (LDL-C) since birth are linked to the early onset of atherosclerotic disease. A genetic mutation determining FH is present in about one subject out of 250;...

journal_title：Atherosclerosis

authors： Gulizia MM,Maggioni AP,Abrignani MG,Bilato C,Mangiacapra F,Sanchez FA,Piovaccari G,Montagna L,Marini M,De Biasio M,Averna M,Casula M,Colivicchi F,Fabbri G,Lucci D,Zampoleri V,Catapano AL,POSTER Investigators.

更新日期：2020-09-01 00:00:00

abstract：:Recent work identified a high prevalence of modifiable risk factors for cardiovascular disease (CVD) among urban black South Africans. The aim was to track the progression of CVD risk factors in a multi-ethnic sample of South Africans. Participants were 173 black (aged 47.5 ± 7.8 yrs) and 186 white teachers (aged 49.6...

journal_title：Atherosclerosis

authors： Hamer M,von Känel R,Reimann M,Malan NT,Schutte AE,Huisman HW,Malan L

更新日期：2015-01-01 00:00:00

abstract：:We investigated the influence of fish oil on cholesterol induced atherosclerosis in rabbits. Group I, a control group was fed a cholesterol-free diet, group II was fed a diet supplemented with 1.5% cholesterol, group III received in addition to cholesterol supplementation a purified fish oil concentrate (Maxepa, 2 ml/...

journal_title：Atherosclerosis

authors： Thiery J,Seidel D

更新日期：1987-01-01 00:00:00

abstract：:The mechanisms of inflammation responsible for the myocardial tissue damage seen after an acute myocardial infarction (AMI) have not been clearly identified. Recent lines of evidence, demonstrating depressed sera levels of individual complement components in patients after myocardial infarction, have suggested involve...

journal_title：Atherosclerosis

authors： Langlois PF,Gawryl MS

更新日期：1988-03-01 00:00:00

abstract：:Familial combined hyperlipidemia (FCHL) is one of the most common inherited lipid disorders. Resistance of adipocytes to the effects of acylation stimulating protein (ASP) may contribute to ineffective triglyceride synthesis and thereby prolonged postprandial lipemia and increased fatty acid flux to the liver seen in ...

journal_title：Atherosclerosis

authors： Ylitalo K,Porkka KV,Meri S,Nuotio I,Suurinkeroinen L,Vakkilainen J,Pajukanta P,Viikari JS,Peltonen L,Ehnholm C,Taskinen MR

更新日期：1997-03-21 00:00:00

abstract：:Macrophage scavenger receptors class A (MSR) are thought to play an important role in atherogenesis by mediating the unrestricted uptake of modified lipoproteins by macrophages in the vessel wall leading to foam cell formation. To investigate the in vivo role of the MSR in this process, a transgenic mouse model expres...

journal_title：Atherosclerosis

authors： de Winther MP,van Dijk KW,van Vlijmen BJ,Gijbels MJ,Heus JJ,Wijers ER,van den Bos AC,Breuer M,Frants RR,Havekes LM,Hofker MH

更新日期：1999-12-01 00:00:00

abstract：:Hypothyroidism is associated with hypercholesterolemia and increased risk for atherosclerotic disease. The European badger exhibits large seasonal changes in thyroid activity and the annual minimum of plasma thyroxine level in this species occurs at the same period of the year (i.e. late fall) as a pronounced hypercho...

journal_title：Atherosclerosis

authors： Laplaud PM,Beaubatie L,Maurel D,Catanzano G

更新日期：1984-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS:To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. th...

journal_title：Atherosclerosis

authors： Vilne B,Skogsberg J,Foroughi Asl H,Talukdar HA,Kessler T,Björkegren JLM,Schunkert H

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Familial hypercholesterolemia (FH) is the most common and severe autosomal dominant lipid metabolism dysfunction, which causes xanthoma, atherosclerosis and coronary heart disease. Earlier studies showed that mutations in LDLR, APOB and PCSK9 cause FH. Although more than 75% of the population in Eur...

journal_title：Atherosclerosis

authors： Xiang R,Fan LL,Lin MJ,Li JJ,Shi XY,Jin JY,Liu YX,Chen YQ,Xia K,Zhao SP

更新日期：2017-03-01 00:00:00

abstract：:We describe a rapid screening procedure to identify known DNA sequence changes in individuals diagnosed as having heterozygous familial hypercholesterolaemia (FH). The screening is made possible by combining a rapid DNA extraction protocol and small scale polymerase chain reaction DNA amplification, followed by oligon...

journal_title：Atherosclerosis

authors： Talmud P,Tybjaerg-Hansen A,Bhatnagar D,Mbewu A,Miller JP,Durrington P,Humphries S

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Cell adhesion molecules (CAMs) are implicated in the initiation and progression of atherosclerosis, but their association with risk of type 2 diabetes remains inconsistent. This meta-analysis aimed to quantify this association with dose-response analysis in the general population without type 2 diab...

journal_title：Atherosclerosis

authors： Qiu S,Cai X,Liu J,Yang B,Zügel M,Steinacker JM,Sun Z,Schumann U

更新日期：2019-08-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of fluvastatin on the microcirculation of patients with hyperlipidaemia (low-density lipoprotein cholesterol > 160 mg/dL, triglycerides < 350 mg/dl) inadequately controlled by diet. After a dietary run-in of 4 weeks, patients were randomised in a double-blind stu...

journal_title：Atherosclerosis

authors： Haak E,Abletshauser C,Weber S,Goedicke C,Martin N,Hermanns N,Lackner K,Kusterer K,Usadel KH,Haak T

更新日期：2001-04-01 00:00:00

abstract：:Mevinolin (MK-803) is a potent inhibitor of HMG-CoA reductase. After a placebo run-in period, mevinolin 5,15 or 50 mg, or placebo was given twice daily for 7-11 days under double -blind conditions ot 4 groups of 6 normocholesterolemic male volunteers. After 7 days, mean serum cholesterol fell 14%, 25% and 24% on 5, 15...

journal_title：Atherosclerosis

authors： Tobert JA,Hitzenberger G,Kukovetz WR,Holmes IB,Jones KH

更新日期：1982-01-01 00:00:00

abstract：:Using a simple, standardized denaturing gradient gel electrophoresis (DGGE) based mutation screening technique, a novel G-to-A mutation in the last base of the intron 12 splice acceptor site of the LDL receptor gene was found in 2 Danish families with familial hypercholesterolemia (FH). The mutation is shown to result...

journal_title：Atherosclerosis

authors： Nissen H,Hansen AB,Guldberg P,Petersen NE,Hansen TS,Hørder M

更新日期：1997-01-03 00:00:00

abstract：:Variations of circulating C-reactive protein (CRP) levels are supposed to reflect chronic inflammatory process of the cardiovascular system. In particular, it has been reported that high-sensitivity CRP (hsCRP) is a promising marker of coronary heart disease. In the present study, we assessed the relationship between ...

journal_title：Atherosclerosis

authors： Saito M,Ishimitsu T,Minami J,Ono H,Ohrui M,Matsuoka H

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:In chronic kidney disease (CKD), high FGF23 concentrations are associated with left ventricular hypertrophy (LVH), cardiovascular events, and death. The associations of FGF23 with left ventricular mass (LVM) and LVH in the general population and the influence of CKD remains uncertain. METHODS:C-terminal pla...

journal_title：Atherosclerosis

authors： Jovanovich A,Ix JH,Gottdiener J,McFann K,Katz R,Kestenbaum B,de Boer IH,Sarnak M,Shlipak MG,Mukamal KJ,Siscovick D,Chonchol M

更新日期：2013-11-01 00:00:00

abstract：:A synergistic interaction between the insertion/deletion (I/D) polymorphism within the angiotensin-converting enzyme (ACE) gene and an A/C transversion at nucleotide position 1166 within the angiotensin II sub-type 1 receptor (AT1R) gene on risk of myocardial infarction has been reported. The risk associated with the ...

journal_title：Atherosclerosis

authors： Steeds RP,Wardle A,Smith PD,Martin D,Channer KS,Samani NJ

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known. Here we examine cross-sectional associations between objectively measured physical activity and sedentary time with ...

journal_title：Atherosclerosis

authors： Jones PR,Rajalahti T,Resaland GK,Aadland E,Steene-Johannessen J,Anderssen SA,Bathen TF,Andreassen T,Kvalheim OM,Ekelund U

更新日期：2019-09-01 00:00:00

abstract：:Vascular calcification is associated with increased risk of cardiovascular events that are the most common cause of death in patients with end-stage renal disease. Clinical and experimental studies indicate that hyperphosphatemia is a risk factor for vascular calcification and cardiovascular mortality in these patient...

journal_title：Atherosclerosis

authors： Li X,Yang HY,Giachelli CM

更新日期：2008-08-01 00:00:00

abstract：:The effects of lovastatin therapy on concentrations and compositions of lipoproteins were examined in 14 patients with heterozygous familial hypercholesterolemia. The drug lowered plasma levels of cholesterol in total plasma, very low density + intermediate density lipoproteins (VLDL + IDL) and low density lipoprotein...

journal_title：Atherosclerosis

authors： Nozaki S,Vega GL,Haddox RJ,Dolan ET,Grundy SM

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:Urinary cystatin C (u-CysC) is a new biomarker for acute tubular kidney dysfunction and may also indicate chronic tubular dysfunction. Chronic kidney disease is an important cardiovascular risk factor, however it is not known if u-CysC is a risk marker for cardiovascular death. METHODS:The association betwe...

journal_title：Atherosclerosis

authors： Helmersson-Karlqvist J,Ärnlöv J,Carlsson AC,Härmä J,Larsson A

更新日期：2014-05-01 00:00:00

abstract：:Despite numerous studies, the precise role of dietary n-6 polyunsaturated fatty acids in the pathogenesis of atherosclerosis remains controversial. It has been shown that feeding an n-6-enriched diet resulted in decreased atherosclerosis in African green monkeys and was associated with a reduction in LDL levels. Howev...

journal_title：Atherosclerosis

authors： George J,Mulkins M,Casey S,Schatzman R,Sigal E,Harats D

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Abdominal aortic aneurysms (AAA) is a chronic inflammatory disease in which signal transducer and activator of transcription 3 (STAT3), and disintegrin and metalloproteinase 17 (ADAM17) play important roles. However, it remains unclear whether ursolic acid (UA), a natural pentacyclic triterpenoid ca...

journal_title：Atherosclerosis

authors： Zhai M,Guo J,Ma H,Shi W,Jou D,Yan D,Liu T,Tao J,Duan J,Wang Y,Li S,Lv J,Li C,Lin J,Zhang C,Lin L

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Metabolic Syndrome as defined by ATP III criteria, a constellation of risk factors associated with insulin resistance, predisposes to premature atherosclerosis and early coronary events. Whether that negative risk profile is associated with endothelial dysfunction remains to be established. MATERIALS AND METHO...

journal_title：Atherosclerosis

authors： Dell'Omo G,Penno G,Pucci L,Mariani M,Del Prato S,Pedrinelli R

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The identification of mutations in PCSK9 (proprotein convertase subtilisin kexin9) in autosomal dominant hypercholesterolemia (ADH), has revealed the existence of a new player in cholesterol homeostasis. PCSK9 has been shown to enhance the degradation of the LDL receptor (LDLR) at the cell surface. Gain-of-f...

journal_title：Atherosclerosis

authors： Abifadel M,Guerin M,Benjannet S,Rabès JP,Le Goff W,Julia Z,Hamelin J,Carreau V,Varret M,Bruckert E,Tosolini L,Meilhac O,Couvert P,Bonnefont-Rousselot D,Chapman J,Carrié A,Michel JB,Prat A,Seidah NG,Boileau C

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Monocyte recruitment into the vessel wall is a crucial initial step in vascular repair, arteriogenesis and atherogenesis. Two distinct human monocyte subpopulations can be classified according to their CD14/16 surface expression, namely CD14++CD16-monocytes (CD16-mo) and CD14+CD16+ monocytes (CD16+mo). We in...

journal_title：Atherosclerosis

authors： Czepluch FS,Olieslagers S,van Hulten R,Vöö SA,Waltenberger J

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVES:We conducted the meta-analysis to compare the diagnostic accuracies of carotid plaque and carotid intima-media thickness (CIMT) measured by B-mode ultrasonography for the prediction of coronary artery disease (CAD) events. METHODS:Two reviewers independently searched electronic databases to identify relevan...

journal_title：Atherosclerosis

authors： Inaba Y,Chen JA,Bergmann SR

更新日期：2012-01-01 00:00:00