Menopausal estrogen therapy counteracts normal aging effects on intima thickness, media thickness and intima/media ratio in carotid and femoral arteries. An investigation using noninvasive high-frequency ultrasound.

abstract：OBJECTIVE:Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variab...

journal_title：Atherosclerosis

authors： Prudente S,Morini E,Larmon J,Andreozzi F,Di Pietro N,Nigro A,Gervino EV,Mannino GC,Bacci S,Hauser TH,Bellacchio E,Formoso G,Pellegrini F,Proto V,Menzaghi C,Frittitta L,Pandolfi A,Sesti G,Doria A,Trischitta V

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:the extracellular matrix (ECM) is an important determinant of plaque instability. Since tissue transglutaminase (tTG) and elafin act as stabilizing factors, they might play a crucial role in the pathogenesis of acute coronary syndrome. We examined their expression in human coronary arteries and the regulatio...

journal_title：Atherosclerosis

authors： Sumi Y,Inoue N,Azumi H,Seno T,Okuda M,Hirata K,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：2002-01-01 00:00:00

abstract：:Interleukin-8 is a cytokine produced by mononuclear cells that is involved in polymorphonuclear neutrophil leukocyte (PMN) recruitment and activation. Several studies have previously demonstrated a leukocyte activation during hypercholesterolemia and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors...

journal_title：Atherosclerosis

authors： Porreca E,Sergi R,Baccante G,Reale M,Orsini L,Febbo CD,Caselli G,Cuccurullo F,Bertini R

更新日期：1999-10-01 00:00:00

abstract：:Variations of circulating C-reactive protein (CRP) levels are supposed to reflect chronic inflammatory process of the cardiovascular system. In particular, it has been reported that high-sensitivity CRP (hsCRP) is a promising marker of coronary heart disease. In the present study, we assessed the relationship between ...

journal_title：Atherosclerosis

authors： Saito M,Ishimitsu T,Minami J,Ono H,Ohrui M,Matsuoka H

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The beneficial effect of statin therapy has been well established for both primary and secondary prevention of cardiovascular disease. Nevertheless, it remains under-used among patients with chronic kidney disease (CKD). We aimed to investigate the impact of statin therapy across a wide spectrum of ...

journal_title：Atherosclerosis

authors： Natanzon SS,Matetzky S,Beigel R,Iakobishvili Z,Goldenberg I,Shechter M,Acute Coronary Syndrome Israel Survey (ACSIS) investigators.

更新日期：2019-07-01 00:00:00

abstract：:Dyslipidemias are strongly linked to the development of atherosclerotic cardiovascular disease. Most dyslipidemias find their origin in the liver. In recent years, the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells has provided a versatile platform for the functional study of vari...

journal_title：Atherosclerosis

authors： Larsen LE,Smith MA,Abbey D,Korn A,Reeskamp LF,Hand NJ,Holleboom AG

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:The aim of this systematic review was to perform a meta-analysis of randomized controlled trials (RCTs) examining the efficacy of fibrate therapy in reducing plasma concentration or activity of plasminogen activator inhibitor 1 (PAI-1). METHODS:Scopus and MEDLINE databases were searched (up to October 15, 20...

journal_title：Atherosclerosis

authors： Sahebkar A,Simental-Mendía LE,Watts GF,Golledge J

更新日期：2015-05-01 00:00:00

abstract：:Two specific endothelial cell products, von Willebrand factor and soluble E-selectin, were measured together with serum lipids, lipoprotein(a), systolic and diastolic blood pressure (SHP, DBP) in a follow up study of 162 patients attending a dedicated lipid clinic. Patients were further classified by the presence or a...

journal_title：Atherosclerosis

authors： Blann AD,Miller JP,McCollum CN

更新日期：1997-07-25 00:00:00

abstract：:We describe a rapid screening procedure to identify known DNA sequence changes in individuals diagnosed as having heterozygous familial hypercholesterolaemia (FH). The screening is made possible by combining a rapid DNA extraction protocol and small scale polymerase chain reaction DNA amplification, followed by oligon...

journal_title：Atherosclerosis

authors： Talmud P,Tybjaerg-Hansen A,Bhatnagar D,Mbewu A,Miller JP,Durrington P,Humphries S

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Diet and smoking expose the general population to cadmium (Cd), which is a toxic metal that accumulates in the arterial wall. In experimental studies, Cd causes reductions in proliferation of smooth muscle cells and cellular synthesis of procollagen. The aim of this study was to examine whether bloo...

journal_title：Atherosclerosis

authors： Fagerberg B,Borné Y,Sallsten G,Smith JG,Acosta S,Persson M,Melander O,Forsgard N,Gottsäter A,Hedblad B,Barregard L,Engström G

更新日期：2017-06-01 00:00:00

abstract：:Intact platelets from atherosclerotic rabbits release more thromboxane B2 (TXB2) and 12-hydroxyeicosatetraenoic acid (HETE) than platelets from normal rabbits following incubation with [14C]arachidonic acid (AA). In contrast, no difference is found between homogenates of platelets from normal and atherosclerotic anima...

journal_title：Atherosclerosis

authors： Dembińska-Kièć A,Rücker W,Schönhöfer PS

更新日期：1979-06-01 00:00:00

abstract：:Oxidation of low density lipoprotein (LDL) leads to more rapid uptake by arterial wall macrophages and foam cell formation. Inhibiting LDL oxidation may impede these processes and offers a new mechanism to retard atherogenesis. The 21-aminosteroids, derived from methylprednisolone, are potent inhibitors of free radica...

journal_title：Atherosclerosis

authors： Fisher M,Levine PH,Doyle EM,Arpano MM,Hoogasian JJ

更新日期：1991-10-01 00:00:00

abstract：:Secretory non-pancreatic (group II) phospholipase A2 (sPLA2) releases precursors of important mediators of inflammation from phospholipids. Based on the inflammatory character of atherosclerosis we previously described the identification of sPLA2 in human atherosclerotic plaques. In vitro studies on lipoproteins have ...

journal_title：Atherosclerosis

authors： Schiering A,Menschikowski M,Mueller E,Jaross W

更新日期：1999-05-01 00:00:00

abstract：:To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo)...

journal_title：Atherosclerosis

authors： Song J,Wan Y,Rolfe BE,Campbell JH,Campbell GR

更新日期：1998-09-01 00:00:00

abstract：:Apolipoprotein F (ApoF) is a sialoglycoprotein that is a component of the HDL and LDL fractions of human serum. We sought to test the hypothesis that ApoF plays an important role in atherosclerosis in mice by modulating lipoprotein function. Atherosclerosis was assessed in male low density lipoprotein receptor knockou...

journal_title：Atherosclerosis

authors： Lagor WR,Fields DW,Bauer RC,Crawford A,Abt MC,Artis D,Wherry EJ,Rader DJ

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:Dozens of single nucleotide polymorphisms (SNPs) in the lipoprotein lipase (LPL) gene have been reported to be associated with lipid concentrations. The aim of this study was to validate the association between rs1059611 in the LPL gene and serum lipid concentrations in the Chinese Han population and explore ...

journal_title：Atherosclerosis

authors： Mo X,Liu X,Wang L,Li H,Lu X,Huang J,Chen J,Cao J,Li J,Chen S,Tang Y,Peng X,Gu D

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIMS:In Switzerland, the prevalence of familial hypercholesterolemia (FH) due to pathogenic apolipoprotein B-100 gene (APOB) variants was known, but not the prevalence of FH due to pathogenic low-density lipoprotein-receptor gene (LDLR) variants. Phenotypic differences (LDLR versus APOB) might affect the...

journal_title：Atherosclerosis

authors： Miserez AR,Martin FJ,Spirk D

更新日期：2018-10-01 00:00:00

abstract：:The effect of immunological injury upon the early in vivo changes in aortic connective tissue metabolism was studied. It was found that a single antigen (bovine serum albumin), when administered in multiple doses, activated collagen synthesis and increased the rate of lgycosaminoglycan synthesis in the arterial wall. ...

journal_title：Atherosclerosis

authors： Rokosova B,Bentley JP

更新日期：1979-04-01 00:00:00

abstract：:While statin treatment may transiently mobilize endothelial progenitor cells (EPCs), the dose-dependent effects of a continuous statin therapy on EPCs in patients with chronic coronary artery disease (CAD) have not been analyzed. In 209 patients with angiographically documented CAD, 144 of which received 10-40 mg/day ...

journal_title：Atherosclerosis

authors： Hristov M,Fach C,Becker C,Heussen N,Liehn EA,Blindt R,Hanrath P,Weber C

更新日期：2007-06-01 00:00:00

abstract：:Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulating protein that impairs LDL clearance by promoting the LDL receptor (LDLR) degradation. PCSK9 has emerged as a new pharmacological target for hypercholesterolemia, and different PCSK9 inhibitors are now evaluated in clinical trials. Here, we propose a...

journal_title：Atherosclerosis

authors： Cariou B,Le May C,Costet P

更新日期：2011-06-01 00:00:00

abstract：:Collagenous components were extracted from bovine aorta by pepsin digestion. Differential salt precipitations separated the interstitial from the basement membrane (BM) collagens, and the latter were subsequently separated into three distinct types. Ion exchange chromatography, SDS-slab gel electrophoresis, cyanogen b...

journal_title：Atherosclerosis

authors： Leushner JR,Haust MD

更新日期：1984-01-01 00:00:00

abstract：:Epidemiological evidence supports the use of non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B-100 (apoB), and low-density lipoprotein particles as markers of atherogenic risk. Treatment guidelines also identify these as additional targets of lipid-modifying intervention in patients with elevated ...

journal_title：Atherosclerosis

authors： Rosenson RS

更新日期：2009-12-01 00:00:00

abstract：:The effects of the artificial triglyceride-phospholipid emulsion (10% intralipid) on HDL subfraction were studied in vivo. After a 14-h fast, subjects received intralipid via a 4-h infusion. Serum lipoproteins were analyzed before and at 4 and 6 h after the start of the infusion. At 4-h the following acute changes by ...

journal_title：Atherosclerosis

authors： Sakuma N,Lin C,Matsumoto Y,Ikeuchi R,Ichikawa T,Hirata H,Noguchi Y,Fujinami T

更新日期：1988-11-01 00:00:00

abstract：:In type 2 diabetics, the progression of atherosclerosis is more rapid than the general population and 80% of these patients will die of an atherosclerotic event. Since in these patients hyperglycemia per se confers increased risk for cardiovascular disease (CVD), the presence of even borderline-high-risk LDL-C signals...

journal_title：Atherosclerosis

authors： Baliarsingh S,Beg ZH,Ahmad J

更新日期：2005-10-01 00:00:00

abstract：:Atherosclerotic lesion progression is associated with intimal calcification. The earliest lesion that shows calcification is pathologic intimal thickening in which calcifications appear as microcalcifications that vary in size from <0.5 to 15 μm. The calcifications become larger as plaques progress, becoming punctate ...

journal_title：Atherosclerosis

authors： Jinnouchi H,Sato Y,Sakamoto A,Cornelissen A,Mori M,Kawakami R,Gadhoke NV,Kolodgie FD,Virmani R,Finn AV

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Various infectious agents are associated with atherosclerosis. This analysis was performed to investigate relation between seropositivity for anti-Borrelia IgG and carotid atherosclerosis. METHODS:The cross-sectional Study of Health in Pomerania was conducted in a general community living in a region with e...

journal_title：Atherosclerosis

authors： Völzke H,Wolff B,Lüdemann J,Guertler L,Kramer A,John U,Felix SB

更新日期：2006-01-01 00:00:00

abstract：:We studied the cytotoxic effect of copper-oxidized LDL in human primary human umbilical vein endothelial cells (HUVEC) and the immortalized EA.hy 926 cell line. Copper oxidized LDL (50-200 microg apoB/ml) induced concentration-dependent apoptotic cell death in HUVEC but did not induce apoptosis in EA.hy 926 cells. Onl...

journal_title：Atherosclerosis

authors： Claise C,Edeas M,Chaouchi N,Chalas J,Capel L,Kalimouttou S,Vazquez A,Lindenbaum A

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:P-selectin is a cellular adhesion molecule that has been shown to be crucial in development of coronary heart disease (CHD). We sought to determine the role of P-selectin on the risk of atherosclerosis in a large multi-ethnic population. METHODS:Data from the Multi-Ethnic Study of Atherosclerosis (MESA), inc...

journal_title：Atherosclerosis

authors： Bielinski SJ,Berardi C,Decker PA,Kirsch PS,Larson NB,Pankow JS,Sale M,de Andrade M,Sicotte H,Tang W,Hanson NQ,Wassel CL,Polak JF,Tsai MY

更新日期：2015-05-01 00:00:00

abstract：:The efflux of cholesterol from cells and its incorporation into HDL is believed to be the initial step in reverse cholesterol transport. This report addresses the question of whether there is a relationship between the ability of serum to promote efflux of cholesterol from cells in culture and the severity of coronary...

journal_title：Atherosclerosis

authors： Mikkola TS,Anthony MS,Clarkson TB,St Clair RW

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:It is indicated that total/HDL cholesterol and LDL/HDL cholesterol ratios have more predictive power for cardiovascular disease compared to classic lipid parameters. However, there have been few reports about the usefulness of these indices for the assessment of early stage atherosclerosis in Japanese type 2 ...

journal_title：Atherosclerosis

authors： Katakami N,Kaneto H,Osonoi T,Saitou M,Takahara M,Sakamoto F,Yamamoto K,Yasuda T,Matsuoka TA,Matsuhisa M,Yamasaki Y,Shimomura I

更新日期：2011-02-01 00:00:00