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Effect of estrogen on vascular smooth muscle cells is dependent upon cellular phenotype.

Abstract：

:To investigate the growth-regulating action of estrogen on vascular smooth muscle cells (SMC), effects of beta-17-estradiol (beta-E2) on phenotypic modulation and proliferation of rabbit aortic SMC were observed in vitro. At 10(-8)M, beta-E2 significantly slowed the decrease in volume fraction of myofilaments (Vv myo) of freshly dispersed SMCs in primary culture, indicating an inhibitory effect of beta-E2 on spontaneous phenotypic modulation of SMC from a contractile to a synthetic phenotype. Freshly dispersed SMCs treated with beta-E2 also had a relatively longer quiescent phase than control cells before intense proliferation occurred. This was in contrast to SMCs in passage 2 3 (synthetic state), where beta-E2-treated cells replicated significantly faster than untreated cells. beta-E2 also markedly enhanced the serum-induced DNA synthesis of synthetic SMCs in a concentration-dependent manner within physiological range (10(-10)to 10(-8)M). These findings indicate that the growth-regulating effect of estrogen on vascular SMC is dependent on the cell's phenotypic state. It delays the cell cycle re-entry of the contractile SMCs by retarding their phenotypic modulation: however, once cells have modulated to the synthetic phenotype, it promotes their replication.

journal_name

Atherosclerosis

journal_title

Atherosclerosis

authors

Song J,Wan Y,Rolfe BE,Campbell JH,Campbell GR

doi

10.1016/s0021-9150(98)00122-1

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

97-104

issue

1

eissn

0021-9150

issn

1879-1484

pii

S0021-9150(98)00122-1

journal_volume

140

pub_type

杂志文章

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